C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iguana/Dzip1-like DAZ-interacting protein N-terminal, putative

Species:

Leishmania braziliensis

UniProt:

A4H7K2_LEIBR

TriTrypDb:

LbrM.14.0430 , LBRM2903_140009400

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005814	centriole	5	5
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H7K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7K2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.501
CLV_NRD_NRD_1	181	183	PF00675	0.596
CLV_NRD_NRD_1	366	368	PF00675	0.542
CLV_PCSK_KEX2_1	126	128	PF00082	0.645
CLV_PCSK_KEX2_1	183	185	PF00082	0.629
CLV_PCSK_KEX2_1	366	368	PF00082	0.542
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.736
CLV_PCSK_SKI1_1	104	108	PF00082	0.284
CLV_PCSK_SKI1_1	120	124	PF00082	0.389
CLV_PCSK_SKI1_1	127	131	PF00082	0.376
CLV_PCSK_SKI1_1	142	146	PF00082	0.576
CLV_PCSK_SKI1_1	27	31	PF00082	0.425
DEG_APCC_DBOX_1	263	271	PF00400	0.725
DEG_APCC_DBOX_1	365	373	PF00400	0.689
DEG_COP1_1	439	448	PF00400	0.596
DEG_ODPH_VHL_1	673	684	PF01847	0.826
DEG_SCF_FBW7_1	446	453	PF00400	0.595
DEG_SCF_FBW7_1	574	581	PF00400	0.668
DEG_SPOP_SBC_1	294	298	PF00917	0.842
DEG_SPOP_SBC_1	495	499	PF00917	0.613
DEG_SPOP_SBC_1	596	600	PF00917	0.854
DEG_SPOP_SBC_1	654	658	PF00917	0.804
DEG_SPOP_SBC_1	665	669	PF00917	0.663
DEG_SPOP_SBC_1	780	784	PF00917	0.577
DOC_CDC14_PxL_1	768	776	PF14671	0.816
DOC_CKS1_1	400	405	PF01111	0.697
DOC_CKS1_1	451	456	PF01111	0.712
DOC_CKS1_1	542	547	PF01111	0.674
DOC_CKS1_1	56	61	PF01111	0.634
DOC_CKS1_1	704	709	PF01111	0.553
DOC_CYCLIN_RxL_1	123	133	PF00134	0.643
DOC_CYCLIN_yCln2_LP_2	459	462	PF00134	0.712
DOC_CYCLIN_yCln2_LP_2	774	780	PF00134	0.825
DOC_MAPK_gen_1	261	269	PF00069	0.564
DOC_MAPK_gen_1	366	372	PF00069	0.532
DOC_MAPK_MEF2A_6	14	23	PF00069	0.634
DOC_MAPK_MEF2A_6	264	271	PF00069	0.566
DOC_MAPK_MEF2A_6	618	625	PF00069	0.548
DOC_MAPK_NFAT4_5	264	272	PF00069	0.727
DOC_PP1_RVXF_1	12	18	PF00149	0.634
DOC_PP2B_LxvP_1	308	311	PF13499	0.552
DOC_PP2B_LxvP_1	448	451	PF13499	0.863
DOC_PP2B_LxvP_1	459	462	PF13499	0.675
DOC_PP2B_LxvP_1	673	676	PF13499	0.569
DOC_PP2B_LxvP_1	774	777	PF13499	0.812
DOC_PP2B_LxvP_1	795	798	PF13499	0.541
DOC_USP7_MATH_1	221	225	PF00917	0.632
DOC_USP7_MATH_1	274	278	PF00917	0.813
DOC_USP7_MATH_1	313	317	PF00917	0.698
DOC_USP7_MATH_1	319	323	PF00917	0.663
DOC_USP7_MATH_1	381	385	PF00917	0.497
DOC_USP7_MATH_1	444	448	PF00917	0.602
DOC_USP7_MATH_1	485	489	PF00917	0.806
DOC_USP7_MATH_1	507	511	PF00917	0.773
DOC_USP7_MATH_1	516	520	PF00917	0.661
DOC_USP7_MATH_1	524	528	PF00917	0.627
DOC_USP7_MATH_1	576	580	PF00917	0.814
DOC_USP7_MATH_1	663	667	PF00917	0.722
DOC_USP7_MATH_1	711	715	PF00917	0.576
DOC_USP7_MATH_1	732	736	PF00917	0.571
DOC_USP7_MATH_1	748	752	PF00917	0.522
DOC_USP7_MATH_1	798	802	PF00917	0.798
DOC_USP7_MATH_1	811	815	PF00917	0.602
DOC_USP7_UBL2_3	119	123	PF12436	0.634
DOC_WW_Pin1_4	191	196	PF00397	0.703
DOC_WW_Pin1_4	198	203	PF00397	0.769
DOC_WW_Pin1_4	278	283	PF00397	0.855
DOC_WW_Pin1_4	302	307	PF00397	0.800
DOC_WW_Pin1_4	309	314	PF00397	0.588
DOC_WW_Pin1_4	399	404	PF00397	0.811
DOC_WW_Pin1_4	446	451	PF00397	0.694
DOC_WW_Pin1_4	477	482	PF00397	0.592
DOC_WW_Pin1_4	496	501	PF00397	0.567
DOC_WW_Pin1_4	512	517	PF00397	0.749
DOC_WW_Pin1_4	541	546	PF00397	0.791
DOC_WW_Pin1_4	55	60	PF00397	0.634
DOC_WW_Pin1_4	556	561	PF00397	0.528
DOC_WW_Pin1_4	572	577	PF00397	0.592
DOC_WW_Pin1_4	628	633	PF00397	0.644
DOC_WW_Pin1_4	676	681	PF00397	0.807
DOC_WW_Pin1_4	696	701	PF00397	0.493
DOC_WW_Pin1_4	703	708	PF00397	0.569
DOC_WW_Pin1_4	713	718	PF00397	0.503
DOC_WW_Pin1_4	728	733	PF00397	0.638
DOC_WW_Pin1_4	737	742	PF00397	0.795
DOC_WW_Pin1_4	763	768	PF00397	0.825
LIG_14-3-3_CanoR_1	110	118	PF00244	0.634
LIG_14-3-3_CanoR_1	126	130	PF00244	0.603
LIG_14-3-3_CanoR_1	27	37	PF00244	0.634
LIG_14-3-3_CanoR_1	367	373	PF00244	0.426
LIG_14-3-3_CanoR_1	380	390	PF00244	0.448
LIG_14-3-3_CanoR_1	518	523	PF00244	0.707
LIG_14-3-3_CanoR_1	691	695	PF00244	0.699
LIG_Actin_RPEL_3	44	63	PF02755	0.446
LIG_Actin_WH2_2	365	382	PF00022	0.689
LIG_BIR_II_1	1	5	PF00653	0.726
LIG_Clathr_ClatBox_1	20	24	PF01394	0.634
LIG_Clathr_ClatBox_1	369	373	PF01394	0.682
LIG_EVH1_1	460	464	PF00568	0.737
LIG_FHA_1	113	119	PF00498	0.571
LIG_FHA_1	158	164	PF00498	0.665
LIG_FHA_1	440	446	PF00498	0.595
LIG_FHA_1	471	477	PF00498	0.605
LIG_FHA_1	550	556	PF00498	0.731
LIG_FHA_1	560	566	PF00498	0.544
LIG_FHA_1	575	581	PF00498	0.775
LIG_FHA_1	605	611	PF00498	0.843
LIG_FHA_1	668	674	PF00498	0.726
LIG_FHA_1	697	703	PF00498	0.633
LIG_FHA_1	722	728	PF00498	0.606
LIG_FHA_1	785	791	PF00498	0.743
LIG_FHA_1	802	808	PF00498	0.493
LIG_FHA_2	322	328	PF00498	0.692
LIG_FHA_2	330	336	PF00498	0.654
LIG_FHA_2	438	444	PF00498	0.589
LIG_FHA_2	48	54	PF00498	0.465
LIG_FHA_2	744	750	PF00498	0.840
LIG_FHA_2	98	104	PF00498	0.629
LIG_GSK3_LRP6_1	309	315	PF00069	0.628
LIG_LIR_Apic_2	160	165	PF02991	0.646
LIG_LIR_Apic_2	722	726	PF02991	0.546
LIG_LIR_Apic_2	792	796	PF02991	0.816
LIG_LIR_Gen_1	3	13	PF02991	0.527
LIG_LIR_Nem_3	16	20	PF02991	0.482
LIG_LIR_Nem_3	3	9	PF02991	0.527
LIG_MYND_1	306	310	PF01753	0.554
LIG_MYND_1	446	450	PF01753	0.863
LIG_MYND_1	458	462	PF01753	0.661
LIG_MYND_1	700	704	PF01753	0.564
LIG_PTAP_UEV_1	544	549	PF05743	0.577
LIG_PTB_Apo_2	40	47	PF02174	0.634
LIG_SH2_CRK	723	727	PF00017	0.549
LIG_SH2_PTP2	162	165	PF00017	0.633
LIG_SH2_STAP1	132	136	PF00017	0.643
LIG_SH2_STAP1	721	725	PF00017	0.558
LIG_SH2_STAP1	78	82	PF00017	0.634
LIG_SH2_STAT3	528	531	PF00017	0.869
LIG_SH2_STAT5	162	165	PF00017	0.633
LIG_SH2_STAT5	166	169	PF00017	0.589
LIG_SH2_STAT5	472	475	PF00017	0.758
LIG_SH2_STAT5	687	690	PF00017	0.827
LIG_SH2_STAT5	723	726	PF00017	0.546
LIG_SH2_STAT5	75	78	PF00017	0.634
LIG_SH3_1	276	282	PF00018	0.582
LIG_SH3_3	152	158	PF00018	0.505
LIG_SH3_3	199	205	PF00018	0.760
LIG_SH3_3	276	282	PF00018	0.779
LIG_SH3_3	303	309	PF00018	0.761
LIG_SH3_3	338	344	PF00018	0.766
LIG_SH3_3	392	398	PF00018	0.844
LIG_SH3_3	448	454	PF00018	0.859
LIG_SH3_3	455	461	PF00018	0.744
LIG_SH3_3	473	479	PF00018	0.635
LIG_SH3_3	497	503	PF00018	0.659
LIG_SH3_3	539	545	PF00018	0.816
LIG_SH3_3	568	574	PF00018	0.616
LIG_SH3_3	577	583	PF00018	0.787
LIG_SH3_3	584	590	PF00018	0.675
LIG_SH3_3	669	675	PF00018	0.674
LIG_SH3_3	701	707	PF00018	0.789
LIG_SH3_3	738	744	PF00018	0.808
LIG_SH3_3	747	753	PF00018	0.677
LIG_SH3_3	769	775	PF00018	0.680
LIG_SH3_3	802	808	PF00018	0.677
LIG_SUMO_SIM_anti_2	265	271	PF11976	0.726
LIG_SUMO_SIM_par_1	19	24	PF11976	0.634
LIG_SUMO_SIM_par_1	368	373	PF11976	0.553
LIG_UBA3_1	82	89	PF00899	0.634
LIG_WW_2	772	775	PF00397	0.538
MOD_CDC14_SPxK_1	515	518	PF00782	0.595
MOD_CDK_SPxK_1	512	518	PF00069	0.595
MOD_CK1_1	112	118	PF00069	0.531
MOD_CK1_1	176	182	PF00069	0.614
MOD_CK1_1	191	197	PF00069	0.587
MOD_CK1_1	277	283	PF00069	0.849
MOD_CK1_1	293	299	PF00069	0.540
MOD_CK1_1	312	318	PF00069	0.701
MOD_CK1_1	322	328	PF00069	0.834
MOD_CK1_1	382	388	PF00069	0.487
MOD_CK1_1	439	445	PF00069	0.854
MOD_CK1_1	47	53	PF00069	0.634
MOD_CK1_1	480	486	PF00069	0.749
MOD_CK1_1	488	494	PF00069	0.839
MOD_CK1_1	543	549	PF00069	0.621
MOD_CK1_1	559	565	PF00069	0.768
MOD_CK1_1	599	605	PF00069	0.856
MOD_CK1_1	606	612	PF00069	0.827
MOD_CK1_1	626	632	PF00069	0.648
MOD_CK1_1	636	642	PF00069	0.558
MOD_CK1_1	666	672	PF00069	0.735
MOD_CK1_1	686	692	PF00069	0.497
MOD_CK1_1	715	721	PF00069	0.561
MOD_CK1_1	728	734	PF00069	0.516
MOD_CK1_1	784	790	PF00069	0.758
MOD_CK1_1	801	807	PF00069	0.632
MOD_CK1_1	824	830	PF00069	0.743
MOD_CK2_1	321	327	PF00069	0.684
MOD_CK2_1	329	335	PF00069	0.658
MOD_CK2_1	437	443	PF00069	0.582
MOD_CK2_1	47	53	PF00069	0.547
MOD_CK2_1	743	749	PF00069	0.837
MOD_CK2_1	97	103	PF00069	0.545
MOD_CMANNOS	418	421	PF00535	0.496
MOD_GlcNHglycan	146	149	PF01048	0.734
MOD_GlcNHglycan	292	295	PF01048	0.855
MOD_GlcNHglycan	315	318	PF01048	0.630
MOD_GlcNHglycan	321	324	PF01048	0.680
MOD_GlcNHglycan	327	330	PF01048	0.684
MOD_GlcNHglycan	345	349	PF01048	0.642
MOD_GlcNHglycan	384	387	PF01048	0.548
MOD_GlcNHglycan	545	548	PF01048	0.657
MOD_GlcNHglycan	628	631	PF01048	0.783
MOD_GlcNHglycan	783	786	PF01048	0.727
MOD_GlcNHglycan	813	816	PF01048	0.749
MOD_GlcNHglycan	830	833	PF01048	0.693
MOD_GSK3_1	121	128	PF00069	0.718
MOD_GSK3_1	184	191	PF00069	0.790
MOD_GSK3_1	274	281	PF00069	0.803
MOD_GSK3_1	29	36	PF00069	0.615
MOD_GSK3_1	290	297	PF00069	0.844
MOD_GSK3_1	309	316	PF00069	0.684
MOD_GSK3_1	319	326	PF00069	0.758
MOD_GSK3_1	381	388	PF00069	0.480
MOD_GSK3_1	446	453	PF00069	0.593
MOD_GSK3_1	470	477	PF00069	0.779
MOD_GSK3_1	483	490	PF00069	0.714
MOD_GSK3_1	512	519	PF00069	0.719
MOD_GSK3_1	559	566	PF00069	0.819
MOD_GSK3_1	572	579	PF00069	0.616
MOD_GSK3_1	595	602	PF00069	0.856
MOD_GSK3_1	633	640	PF00069	0.582
MOD_GSK3_1	648	655	PF00069	0.740
MOD_GSK3_1	663	670	PF00069	0.613
MOD_GSK3_1	683	690	PF00069	0.759
MOD_GSK3_1	711	718	PF00069	0.670
MOD_GSK3_1	721	728	PF00069	0.657
MOD_GSK3_1	730	737	PF00069	0.508
MOD_GSK3_1	780	787	PF00069	0.704
MOD_GSK3_1	819	826	PF00069	0.797
MOD_N-GLC_1	185	190	PF02516	0.788
MOD_N-GLC_1	352	357	PF02516	0.694
MOD_N-GLC_1	600	605	PF02516	0.857
MOD_N-GLC_1	785	790	PF02516	0.683
MOD_NEK2_1	1	6	PF00069	0.452
MOD_NEK2_1	272	277	PF00069	0.786
MOD_NEK2_1	28	33	PF00069	0.634
MOD_NEK2_1	379	384	PF00069	0.708
MOD_NEK2_1	517	522	PF00069	0.767
MOD_NEK2_1	604	609	PF00069	0.851
MOD_NEK2_1	638	643	PF00069	0.653
MOD_NEK2_1	761	766	PF00069	0.847
MOD_NEK2_1	823	828	PF00069	0.706
MOD_PIKK_1	121	127	PF00454	0.720
MOD_PIKK_1	274	280	PF00454	0.716
MOD_PIKK_1	485	491	PF00454	0.862
MOD_PIKK_1	715	721	PF00454	0.778
MOD_PIKK_1	76	82	PF00454	0.634
MOD_PKA_2	109	115	PF00069	0.606
MOD_PKA_2	125	131	PF00069	0.526
MOD_PKA_2	189	195	PF00069	0.578
MOD_PKA_2	379	385	PF00069	0.714
MOD_PKA_2	47	53	PF00069	0.531
MOD_PKA_2	517	523	PF00069	0.730
MOD_PKA_2	690	696	PF00069	0.767
MOD_PKA_2	711	717	PF00069	0.578
MOD_PKA_2	761	767	PF00069	0.818
MOD_PKB_1	182	190	PF00069	0.773
MOD_Plk_1	112	118	PF00069	0.446
MOD_Plk_1	344	350	PF00069	0.706
MOD_Plk_1	600	606	PF00069	0.856
MOD_Plk_1	785	791	PF00069	0.684
MOD_Plk_4	157	163	PF00069	0.692
MOD_Plk_4	386	392	PF00069	0.785
MOD_Plk_4	683	689	PF00069	0.824
MOD_ProDKin_1	191	197	PF00069	0.705
MOD_ProDKin_1	198	204	PF00069	0.763
MOD_ProDKin_1	278	284	PF00069	0.857
MOD_ProDKin_1	302	308	PF00069	0.801
MOD_ProDKin_1	309	315	PF00069	0.592
MOD_ProDKin_1	399	405	PF00069	0.809
MOD_ProDKin_1	446	452	PF00069	0.694
MOD_ProDKin_1	477	483	PF00069	0.593
MOD_ProDKin_1	496	502	PF00069	0.568
MOD_ProDKin_1	512	518	PF00069	0.752
MOD_ProDKin_1	541	547	PF00069	0.789
MOD_ProDKin_1	55	61	PF00069	0.634
MOD_ProDKin_1	556	562	PF00069	0.533
MOD_ProDKin_1	572	578	PF00069	0.589
MOD_ProDKin_1	628	634	PF00069	0.644
MOD_ProDKin_1	676	682	PF00069	0.809
MOD_ProDKin_1	696	702	PF00069	0.497
MOD_ProDKin_1	703	709	PF00069	0.567
MOD_ProDKin_1	713	719	PF00069	0.502
MOD_ProDKin_1	728	734	PF00069	0.642
MOD_ProDKin_1	737	743	PF00069	0.789
MOD_ProDKin_1	763	769	PF00069	0.822
TRG_DiLeu_BaEn_1	103	108	PF01217	0.634
TRG_DiLeu_BaEn_1	265	270	PF01217	0.722
TRG_DiLeu_BaLyEn_6	455	460	PF01217	0.598
TRG_DiLeu_BaLyEn_6	500	505	PF01217	0.583
TRG_ER_diArg_1	181	184	PF00400	0.612
TRG_ER_diArg_1	245	248	PF00400	0.739
TRG_ER_diArg_1	365	367	PF00400	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSW0	Leishmania donovani	66%	100%
A4HVY5	Leishmania infantum	64%	100%
Q4QFU2	Leishmania major	64%	94%