Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7K0_LEIBR

TriTrypDb:

LbrM.14.0410 , LBRM2903_140009200

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7K0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.705
CLV_NRD_NRD_1	161	163	PF00675	0.545
CLV_NRD_NRD_1	68	70	PF00675	0.504
CLV_NRD_NRD_1	83	85	PF00675	0.507
CLV_PCSK_FUR_1	109	113	PF00082	0.519
CLV_PCSK_KEX2_1	108	110	PF00082	0.730
CLV_PCSK_KEX2_1	111	113	PF00082	0.726
CLV_PCSK_KEX2_1	161	163	PF00082	0.545
CLV_PCSK_KEX2_1	83	85	PF00082	0.573
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.512
CLV_PCSK_SKI1_1	161	165	PF00082	0.597
CLV_PCSK_SKI1_1	70	74	PF00082	0.532
DEG_SPOP_SBC_1	71	75	PF00917	0.672
DOC_USP7_MATH_1	63	67	PF00917	0.755
DOC_USP7_MATH_1	76	80	PF00917	0.614
DOC_WW_Pin1_4	121	126	PF00397	0.610
DOC_WW_Pin1_4	134	139	PF00397	0.592
DOC_WW_Pin1_4	72	77	PF00397	0.555
LIG_Actin_WH2_2	12	30	PF00022	0.710
LIG_BIR_II_1	1	5	PF00653	0.512
LIG_BIR_III_1	1	5	PF00653	0.512
LIG_BIR_III_2	52	56	PF00653	0.628
LIG_BIR_III_3	1	5	PF00653	0.512
LIG_FHA_2	24	30	PF00498	0.571
LIG_LIR_Gen_1	50	57	PF02991	0.501
LIG_LIR_Gen_1	97	105	PF02991	0.656
LIG_LIR_Nem_3	158	163	PF02991	0.605
LIG_LIR_Nem_3	50	54	PF02991	0.509
LIG_LIR_Nem_3	97	103	PF02991	0.660
LIG_PCNA_yPIPBox_3	58	70	PF02747	0.503
LIG_SH2_CRK	160	164	PF00017	0.602
LIG_SH2_STAP1	98	102	PF00017	0.487
LIG_SH2_STAT5	144	147	PF00017	0.672
LIG_SH3_3	135	141	PF00018	0.762
LIG_SUMO_SIM_par_1	62	68	PF11976	0.689
LIG_TRAF2_1	129	132	PF00917	0.573
LIG_TRAF2_1	188	191	PF00917	0.486
LIG_WRC_WIRS_1	48	53	PF05994	0.512
MOD_CK1_1	124	130	PF00069	0.606
MOD_CK1_1	79	85	PF00069	0.728
MOD_CK2_1	126	132	PF00069	0.571
MOD_CK2_1	185	191	PF00069	0.472
MOD_CK2_1	23	29	PF00069	0.519
MOD_CK2_1	74	80	PF00069	0.704
MOD_Cter_Amidation	106	109	PF01082	0.507
MOD_GlcNHglycan	128	131	PF01048	0.691
MOD_GlcNHglycan	150	153	PF01048	0.576
MOD_GlcNHglycan	187	190	PF01048	0.524
MOD_GlcNHglycan	35	38	PF01048	0.653
MOD_GlcNHglycan	76	79	PF01048	0.716
MOD_GSK3_1	143	150	PF00069	0.654
MOD_GSK3_1	185	192	PF00069	0.480
MOD_GSK3_1	53	60	PF00069	0.747
MOD_GSK3_1	70	77	PF00069	0.484
MOD_NEK2_1	23	28	PF00069	0.612
MOD_NEK2_1	32	37	PF00069	0.671
MOD_ProDKin_1	121	127	PF00069	0.608
MOD_ProDKin_1	134	140	PF00069	0.588
MOD_ProDKin_1	72	78	PF00069	0.556
TRG_ENDOCYTIC_2	160	163	PF00928	0.605
TRG_ER_diArg_1	109	112	PF00400	0.558
TRG_ER_diArg_1	160	162	PF00400	0.550
TRG_NLS_MonoCore_2	107	112	PF00514	0.515
TRG_NLS_MonoExtC_3	107	112	PF00514	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAD9	Leptomonas seymouri	47%	100%
A0A1X0NP94	Trypanosomatidae	31%	85%
A0A3Q8I9Q7	Leishmania donovani	74%	100%
A4HVY3	Leishmania infantum	74%	100%
E9APN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QFU4	Leishmania major	73%	99%