BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7J8_LEIBR

TriTrypDb:

LbrM.14.0390 , LBRM2903_140009100

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7J8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.462
CLV_C14_Caspase3-7	231	235	PF00656	0.594
CLV_C14_Caspase3-7	36	40	PF00656	0.246
CLV_NRD_NRD_1	207	209	PF00675	0.409
CLV_PCSK_SKI1_1	116	120	PF00082	0.449
CLV_PCSK_SKI1_1	196	200	PF00082	0.357
CLV_PCSK_SKI1_1	20	24	PF00082	0.415
CLV_PCSK_SKI1_1	47	51	PF00082	0.261
CLV_Separin_Metazoa	87	91	PF03568	0.306
DOC_CDC14_PxL_1	150	158	PF14671	0.302
DOC_MAPK_gen_1	47	57	PF00069	0.386
DOC_MAPK_MEF2A_6	121	129	PF00069	0.338
DOC_MAPK_MEF2A_6	50	57	PF00069	0.348
DOC_MAPK_NFAT4_5	50	58	PF00069	0.288
DOC_PP1_RVXF_1	259	265	PF00149	0.506
DOC_PP1_RVXF_1	45	52	PF00149	0.462
DOC_PP4_FxxP_1	69	72	PF00568	0.269
DOC_USP7_MATH_1	163	167	PF00917	0.387
DOC_USP7_MATH_1	98	102	PF00917	0.533
DOC_USP7_UBL2_3	192	196	PF12436	0.283
LIG_14-3-3_CanoR_1	20	25	PF00244	0.267
LIG_14-3-3_CanoR_1	208	214	PF00244	0.329
LIG_14-3-3_CanoR_1	261	265	PF00244	0.451
LIG_14-3-3_CanoR_1	90	98	PF00244	0.429
LIG_BIR_III_4	221	225	PF00653	0.415
LIG_BRCT_BRCA1_1	165	169	PF00533	0.356
LIG_BRCT_BRCA1_1	77	81	PF00533	0.231
LIG_eIF4E_1	170	176	PF01652	0.283
LIG_FHA_1	122	128	PF00498	0.422
LIG_FHA_1	21	27	PF00498	0.326
LIG_FHA_1	214	220	PF00498	0.318
LIG_FHA_1	266	272	PF00498	0.569
LIG_FHA_1	294	300	PF00498	0.628
LIG_FHA_2	34	40	PF00498	0.262
LIG_FHA_2	94	100	PF00498	0.420
LIG_LIR_Apic_2	148	154	PF02991	0.374
LIG_LIR_Gen_1	197	206	PF02991	0.434
LIG_LIR_Gen_1	304	310	PF02991	0.517
LIG_LIR_Gen_1	78	89	PF02991	0.255
LIG_LIR_LC3C_4	122	127	PF02991	0.310
LIG_LIR_Nem_3	197	202	PF02991	0.370
LIG_LIR_Nem_3	225	230	PF02991	0.315
LIG_LIR_Nem_3	23	27	PF02991	0.423
LIG_LIR_Nem_3	78	84	PF02991	0.354
LIG_Pex14_2	65	69	PF04695	0.235
LIG_PTB_Apo_2	45	52	PF02174	0.249
LIG_SH2_CRK	77	81	PF00017	0.425
LIG_SH2_STAP1	77	81	PF00017	0.352
LIG_SH2_STAT5	160	163	PF00017	0.451
LIG_SH2_STAT5	170	173	PF00017	0.352
LIG_SH2_STAT5	201	204	PF00017	0.440
LIG_SH2_STAT5	228	231	PF00017	0.449
LIG_SH2_STAT5	66	69	PF00017	0.381
LIG_SH2_STAT5	79	82	PF00017	0.371
LIG_SH3_3	69	75	PF00018	0.431
LIG_SUMO_SIM_anti_2	122	130	PF11976	0.267
LIG_SUMO_SIM_anti_2	174	179	PF11976	0.244
LIG_SUMO_SIM_anti_2	216	221	PF11976	0.417
LIG_SUMO_SIM_par_1	122	130	PF11976	0.390
LIG_SUMO_SIM_par_1	215	221	PF11976	0.269
LIG_SUMO_SIM_par_1	294	301	PF11976	0.621
LIG_UBA3_1	202	209	PF00899	0.370
LIG_WRC_WIRS_1	128	133	PF05994	0.455
MOD_CK1_1	31	37	PF00069	0.496
MOD_CK2_1	289	295	PF00069	0.588
MOD_CK2_1	93	99	PF00069	0.515
MOD_GlcNHglycan	236	239	PF01048	0.574
MOD_GlcNHglycan	33	36	PF01048	0.556
MOD_GSK3_1	179	186	PF00069	0.399
MOD_GSK3_1	260	267	PF00069	0.339
MOD_GSK3_1	27	34	PF00069	0.314
MOD_GSK3_1	289	296	PF00069	0.599
MOD_N-GLC_1	20	25	PF02516	0.351
MOD_N-GLC_1	250	255	PF02516	0.342
MOD_N-GLC_1	27	32	PF02516	0.380
MOD_N-GLC_2	108	110	PF02516	0.381
MOD_NEK2_1	169	174	PF00069	0.338
MOD_NEK2_1	22	27	PF00069	0.263
MOD_NEK2_1	264	269	PF00069	0.603
MOD_NEK2_1	53	58	PF00069	0.381
MOD_PIKK_1	250	256	PF00454	0.322
MOD_PKA_1	208	214	PF00069	0.443
MOD_PKA_2	207	213	PF00069	0.304
MOD_PKA_2	260	266	PF00069	0.314
MOD_Plk_1	121	127	PF00069	0.452
MOD_Plk_1	20	26	PF00069	0.397
MOD_Plk_1	293	299	PF00069	0.726
MOD_Plk_2-3	134	140	PF00069	0.405
MOD_Plk_4	121	127	PF00069	0.419
MOD_Plk_4	145	151	PF00069	0.297
MOD_Plk_4	171	177	PF00069	0.453
MOD_Plk_4	33	39	PF00069	0.365
MOD_Plk_4	75	81	PF00069	0.358
MOD_SUMO_rev_2	111	118	PF00179	0.464
MOD_SUMO_rev_2	139	148	PF00179	0.327
MOD_SUMO_rev_2	295	305	PF00179	0.603
TRG_DiLeu_BaEn_1	304	309	PF01217	0.488
TRG_ENDOCYTIC_2	201	204	PF00928	0.461
TRG_ENDOCYTIC_2	227	230	PF00928	0.535
TRG_ENDOCYTIC_2	306	309	PF00928	0.520
TRG_ENDOCYTIC_2	66	69	PF00928	0.417
TRG_ENDOCYTIC_2	77	80	PF00928	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0V1	Leptomonas seymouri	53%	100%
A0A0S4KDQ4	Bodo saltans	42%	100%
A0A1X0NQ77	Trypanosomatidae	44%	99%
A0A381MFS8	Leishmania infantum	51%	100%
A0A3Q8I9T1	Leishmania donovani	53%	100%
A0A3R7N2S2	Trypanosoma rangeli	42%	97%
A0A3S7WSX7	Leishmania donovani	51%	100%
C9ZT43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	94%
E9AGK8	Leishmania infantum	53%	100%
E9APN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9APN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9APN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
Q4QFU5	Leishmania major	50%	100%
Q4QFU6	Leishmania major	51%	100%
V5BD72	Trypanosoma cruzi	42%	97%