LeishMANIAdb
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Choline transporter-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Choline transporter-like protein
Gene product:
Plasma-membrane choline transporter, putative
Species:
Leishmania braziliensis
UniProt:
A4H7J7_LEIBR
TriTrypDb:
LbrM.14.0380 , LBRM2903_140009000
Length:
607

Annotations

LeishMANIAdb annotations

Highly homologous to other eukaryotic choline transporters. The protein family expanded in parazitic kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 17
GO:0016020 membrane 2 17
GO:0110165 cellular anatomical entity 1 17
GO:0005737 cytoplasm 2 1
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

A4H7J7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7J7

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0009987 cellular process 1 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 17
GO:0022857 transmembrane transporter activity 2 17

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 443 447 PF00656 0.520
CLV_C14_Caspase3-7 483 487 PF00656 0.425
CLV_NRD_NRD_1 178 180 PF00675 0.571
CLV_NRD_NRD_1 317 319 PF00675 0.370
CLV_NRD_NRD_1 595 597 PF00675 0.462
CLV_NRD_NRD_1 7 9 PF00675 0.394
CLV_PCSK_KEX2_1 178 180 PF00082 0.588
CLV_PCSK_KEX2_1 317 319 PF00082 0.376
CLV_PCSK_KEX2_1 595 597 PF00082 0.462
CLV_PCSK_KEX2_1 7 9 PF00082 0.394
CLV_PCSK_SKI1_1 320 324 PF00082 0.271
CLV_PCSK_SKI1_1 493 497 PF00082 0.309
DEG_MDM2_SWIB_1 369 377 PF02201 0.410
DEG_SPOP_SBC_1 413 417 PF00917 0.304
DOC_CKS1_1 92 97 PF01111 0.613
DOC_CYCLIN_RxL_1 248 258 PF00134 0.505
DOC_CYCLIN_RxL_1 317 326 PF00134 0.512
DOC_CYCLIN_yCln2_LP_2 197 200 PF00134 0.399
DOC_MAPK_DCC_7 359 367 PF00069 0.170
DOC_MAPK_gen_1 317 327 PF00069 0.511
DOC_MAPK_MEF2A_6 359 368 PF00069 0.170
DOC_PP1_RVXF_1 221 228 PF00149 0.222
DOC_PP1_RVXF_1 249 256 PF00149 0.422
DOC_PP2B_LxvP_1 197 200 PF13499 0.399
DOC_PP4_FxxP_1 552 555 PF00568 0.425
DOC_PP4_FxxP_1 92 95 PF00568 0.616
DOC_SPAK_OSR1_1 435 439 PF12202 0.432
DOC_USP7_MATH_1 14 18 PF00917 0.660
DOC_USP7_MATH_1 159 163 PF00917 0.476
DOC_USP7_MATH_1 203 207 PF00917 0.552
DOC_USP7_MATH_1 208 212 PF00917 0.495
DOC_USP7_MATH_1 259 263 PF00917 0.269
DOC_USP7_MATH_1 311 315 PF00917 0.585
DOC_USP7_MATH_1 330 334 PF00917 0.224
DOC_USP7_MATH_1 429 433 PF00917 0.315
DOC_USP7_MATH_1 441 445 PF00917 0.404
DOC_USP7_MATH_1 547 551 PF00917 0.311
DOC_USP7_MATH_1 555 559 PF00917 0.319
DOC_USP7_MATH_1 584 588 PF00917 0.407
DOC_WW_Pin1_4 206 211 PF00397 0.479
DOC_WW_Pin1_4 91 96 PF00397 0.608
LIG_14-3-3_CanoR_1 301 309 PF00244 0.453
LIG_14-3-3_CanoR_1 317 323 PF00244 0.518
LIG_14-3-3_CanoR_1 412 421 PF00244 0.259
LIG_Actin_WH2_2 169 186 PF00022 0.380
LIG_BIR_III_4 166 170 PF00653 0.338
LIG_BRCT_BRCA1_1 16 20 PF00533 0.578
LIG_BRCT_BRCA1_1 332 336 PF00533 0.415
LIG_BRCT_BRCA1_1 500 504 PF00533 0.491
LIG_BRCT_BRCA1_1 548 552 PF00533 0.392
LIG_deltaCOP1_diTrp_1 103 107 PF00928 0.585
LIG_deltaCOP1_diTrp_1 114 121 PF00928 0.444
LIG_eIF4E_1 240 246 PF01652 0.269
LIG_FHA_1 178 184 PF00498 0.377
LIG_FHA_1 216 222 PF00498 0.284
LIG_FHA_1 232 238 PF00498 0.378
LIG_FHA_1 278 284 PF00498 0.373
LIG_FHA_1 310 316 PF00498 0.495
LIG_FHA_1 337 343 PF00498 0.216
LIG_FHA_1 489 495 PF00498 0.452
LIG_FHA_1 507 513 PF00498 0.309
LIG_FHA_1 526 532 PF00498 0.256
LIG_FHA_1 54 60 PF00498 0.739
LIG_FHA_1 560 566 PF00498 0.455
LIG_FHA_2 140 146 PF00498 0.338
LIG_GBD_Chelix_1 125 133 PF00786 0.223
LIG_LIR_Apic_2 549 555 PF02991 0.478
LIG_LIR_Apic_2 91 95 PF02991 0.620
LIG_LIR_Gen_1 114 124 PF02991 0.446
LIG_LIR_Gen_1 17 28 PF02991 0.659
LIG_LIR_Gen_1 211 222 PF02991 0.340
LIG_LIR_Gen_1 333 342 PF02991 0.320
LIG_LIR_Gen_1 432 441 PF02991 0.269
LIG_LIR_Gen_1 561 572 PF02991 0.478
LIG_LIR_Gen_1 580 590 PF02991 0.440
LIG_LIR_Nem_3 114 119 PF02991 0.456
LIG_LIR_Nem_3 154 158 PF02991 0.480
LIG_LIR_Nem_3 333 337 PF02991 0.340
LIG_LIR_Nem_3 360 366 PF02991 0.262
LIG_LIR_Nem_3 415 421 PF02991 0.292
LIG_LIR_Nem_3 432 436 PF02991 0.268
LIG_LIR_Nem_3 490 495 PF02991 0.473
LIG_LIR_Nem_3 550 556 PF02991 0.322
LIG_LIR_Nem_3 561 567 PF02991 0.415
LIG_LIR_Nem_3 577 581 PF02991 0.500
LIG_LYPXL_S_1 362 366 PF13949 0.170
LIG_LYPXL_yS_3 363 366 PF13949 0.269
LIG_PCNA_yPIPBox_3 251 264 PF02747 0.421
LIG_Pex14_1 116 120 PF04695 0.395
LIG_Pex14_2 369 373 PF04695 0.326
LIG_Pex14_2 500 504 PF04695 0.457
LIG_SH2_CRK 158 162 PF00017 0.336
LIG_SH2_CRK 240 244 PF00017 0.381
LIG_SH2_CRK 472 476 PF00017 0.457
LIG_SH2_CRK 553 557 PF00017 0.381
LIG_SH2_CRK 582 586 PF00017 0.515
LIG_SH2_GRB2like 468 471 PF00017 0.446
LIG_SH2_NCK_1 158 162 PF00017 0.542
LIG_SH2_NCK_1 553 557 PF00017 0.360
LIG_SH2_SRC 484 487 PF00017 0.471
LIG_SH2_STAP1 39 43 PF00017 0.696
LIG_SH2_STAP1 582 586 PF00017 0.528
LIG_SH2_STAT3 249 252 PF00017 0.483
LIG_SH2_STAT3 296 299 PF00017 0.360
LIG_SH2_STAT5 28 31 PF00017 0.602
LIG_SH2_STAT5 296 299 PF00017 0.234
LIG_SH2_STAT5 3 6 PF00017 0.606
LIG_SH2_STAT5 394 397 PF00017 0.288
LIG_SH2_STAT5 468 471 PF00017 0.446
LIG_SH2_STAT5 484 487 PF00017 0.446
LIG_SH2_STAT5 592 595 PF00017 0.671
LIG_SH2_STAT5 93 96 PF00017 0.525
LIG_SH3_3 31 37 PF00018 0.560
LIG_SH3_3 399 405 PF00018 0.246
LIG_SUMO_SIM_anti_2 145 150 PF11976 0.407
LIG_SUMO_SIM_anti_2 262 268 PF11976 0.170
LIG_SUMO_SIM_anti_2 312 317 PF11976 0.439
LIG_SUMO_SIM_par_1 262 268 PF11976 0.289
LIG_SUMO_SIM_par_1 323 329 PF11976 0.359
LIG_SUMO_SIM_par_1 364 370 PF11976 0.250
LIG_TYR_ITIM 466 471 PF00017 0.361
LIG_TYR_ITIM 551 556 PF00017 0.360
LIG_TYR_ITSM 359 366 PF00017 0.170
LIG_Vh1_VBS_1 367 385 PF01044 0.371
LIG_WRC_WIRS_1 430 435 PF05994 0.269
LIG_WRC_WIRS_1 515 520 PF05994 0.223
MOD_CDK_SPxxK_3 91 98 PF00069 0.563
MOD_CK1_1 206 212 PF00069 0.451
MOD_CK1_1 262 268 PF00069 0.416
MOD_CK1_1 326 332 PF00069 0.323
MOD_CK1_1 417 423 PF00069 0.316
MOD_CK1_1 425 431 PF00069 0.292
MOD_CK1_1 50 56 PF00069 0.647
MOD_CK1_1 558 564 PF00069 0.468
MOD_CK1_1 70 76 PF00069 0.719
MOD_CK2_1 574 580 PF00069 0.512
MOD_CK2_1 97 103 PF00069 0.657
MOD_GlcNHglycan 16 19 PF01048 0.388
MOD_GlcNHglycan 161 164 PF01048 0.570
MOD_GlcNHglycan 257 260 PF01048 0.373
MOD_GlcNHglycan 267 270 PF01048 0.380
MOD_GlcNHglycan 328 331 PF01048 0.316
MOD_GlcNHglycan 39 42 PF01048 0.327
MOD_GlcNHglycan 500 503 PF01048 0.271
MOD_GlcNHglycan 519 522 PF01048 0.267
MOD_GlcNHglycan 52 55 PF01048 0.573
MOD_GlcNHglycan 586 589 PF01048 0.250
MOD_GSK3_1 14 21 PF00069 0.737
MOD_GSK3_1 206 213 PF00069 0.461
MOD_GSK3_1 255 262 PF00069 0.342
MOD_GSK3_1 326 333 PF00069 0.343
MOD_GSK3_1 413 420 PF00069 0.288
MOD_GSK3_1 425 432 PF00069 0.288
MOD_GSK3_1 437 444 PF00069 0.469
MOD_GSK3_1 46 53 PF00069 0.786
MOD_GSK3_1 525 532 PF00069 0.323
MOD_GSK3_1 542 549 PF00069 0.235
MOD_GSK3_1 554 561 PF00069 0.282
MOD_GSK3_1 66 73 PF00069 0.664
MOD_N-GLC_1 18 23 PF02516 0.551
MOD_N-GLC_1 504 509 PF02516 0.191
MOD_NEK2_1 177 182 PF00069 0.301
MOD_NEK2_1 217 222 PF00069 0.437
MOD_NEK2_1 255 260 PF00069 0.419
MOD_NEK2_1 284 289 PF00069 0.263
MOD_NEK2_1 304 309 PF00069 0.474
MOD_NEK2_1 323 328 PF00069 0.227
MOD_NEK2_1 336 341 PF00069 0.304
MOD_NEK2_1 352 357 PF00069 0.315
MOD_NEK2_1 437 442 PF00069 0.494
MOD_NEK2_1 504 509 PF00069 0.412
MOD_NEK2_1 542 547 PF00069 0.322
MOD_NEK2_1 574 579 PF00069 0.509
MOD_NEK2_1 601 606 PF00069 0.634
MOD_NEK2_2 358 363 PF00069 0.320
MOD_NEK2_2 547 552 PF00069 0.318
MOD_NEK2_2 559 564 PF00069 0.452
MOD_PIKK_1 590 596 PF00454 0.563
MOD_PIKK_1 85 91 PF00454 0.789
MOD_PKA_2 177 183 PF00069 0.374
MOD_PKA_2 411 417 PF00069 0.345
MOD_PKA_2 441 447 PF00069 0.526
MOD_PKA_2 47 53 PF00069 0.653
MOD_PKA_2 97 103 PF00069 0.638
MOD_Plk_1 504 510 PF00069 0.391
MOD_Plk_1 66 72 PF00069 0.679
MOD_Plk_2-3 67 73 PF00069 0.591
MOD_Plk_4 217 223 PF00069 0.329
MOD_Plk_4 232 238 PF00069 0.382
MOD_Plk_4 259 265 PF00069 0.428
MOD_Plk_4 285 291 PF00069 0.332
MOD_Plk_4 304 310 PF00069 0.498
MOD_Plk_4 311 317 PF00069 0.461
MOD_Plk_4 344 350 PF00069 0.312
MOD_Plk_4 358 364 PF00069 0.223
MOD_Plk_4 389 395 PF00069 0.288
MOD_Plk_4 422 428 PF00069 0.288
MOD_Plk_4 429 435 PF00069 0.288
MOD_Plk_4 454 460 PF00069 0.502
MOD_Plk_4 480 486 PF00069 0.494
MOD_Plk_4 514 520 PF00069 0.311
MOD_Plk_4 525 531 PF00069 0.288
MOD_Plk_4 536 542 PF00069 0.270
MOD_Plk_4 547 553 PF00069 0.333
MOD_Plk_4 559 565 PF00069 0.415
MOD_Plk_4 88 94 PF00069 0.601
MOD_ProDKin_1 206 212 PF00069 0.473
MOD_ProDKin_1 91 97 PF00069 0.606
TRG_DiLeu_BaEn_1 490 495 PF01217 0.512
TRG_DiLeu_BaLyEn_6 288 293 PF01217 0.269
TRG_DiLeu_BaLyEn_6 347 352 PF01217 0.194
TRG_ENDOCYTIC_2 158 161 PF00928 0.542
TRG_ENDOCYTIC_2 214 217 PF00928 0.467
TRG_ENDOCYTIC_2 240 243 PF00928 0.377
TRG_ENDOCYTIC_2 363 366 PF00928 0.377
TRG_ENDOCYTIC_2 468 471 PF00928 0.445
TRG_ENDOCYTIC_2 472 475 PF00928 0.446
TRG_ENDOCYTIC_2 553 556 PF00928 0.360
TRG_ENDOCYTIC_2 582 585 PF00928 0.488
TRG_ER_diArg_1 107 110 PF00400 0.664
TRG_ER_diArg_1 177 179 PF00400 0.387
TRG_ER_diArg_1 316 318 PF00400 0.552
TRG_ER_diArg_1 7 9 PF00400 0.589
TRG_Pf-PMV_PEXEL_1 435 439 PF00026 0.312

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA24 Leptomonas seymouri 57% 100%
A0A0S4IW21 Bodo saltans 29% 100%
A0A0S4KHP0 Bodo saltans 32% 100%
A0A1X0P8J3 Trypanosomatidae 36% 100%
A0A3Q8I9V7 Leishmania donovani 77% 100%
A0A3S7XAV8 Leishmania donovani 36% 100%
A4HP90 Leishmania braziliensis 36% 100%
A4HVY0 Leishmania infantum 78% 100%
A4IDJ5 Leishmania infantum 36% 100%
D0A390 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9APN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
E9ASZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
Q12412 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%
Q4PIP8 Ustilago maydis (strain 521 / FGSC 9021) 28% 100%
Q4Q1K0 Leishmania major 36% 100%
Q4QFU7 Leishmania major 77% 100%
Q6CY85 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 22% 100%
Q75EG5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 25% 100%
V5AWF7 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS