Putative threonine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

threonine synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7J4_LEIBR

TriTrypDb:

LbrM.14.0350 , LBRM2903_140008700

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7J4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006566	threonine metabolic process	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008652	amino acid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009066	aspartate family amino acid metabolic process	5	2
GO:0009067	aspartate family amino acid biosynthetic process	6	2
GO:0009088	threonine biosynthetic process	7	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1901607	alpha-amino acid biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004795	threonine synthase activity	5	9
GO:0016829	lyase activity	2	9
GO:0016835	carbon-oxygen lyase activity	3	9
GO:0016838	carbon-oxygen lyase activity, acting on phosphates	4	9
GO:0005488	binding	1	2
GO:0019842	vitamin binding	3	2
GO:0030170	pyridoxal phosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0070279	vitamin B6 binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.447
CLV_C14_Caspase3-7	209	213	PF00656	0.623
CLV_NRD_NRD_1	430	432	PF00675	0.344
CLV_PCSK_KEX2_1	430	432	PF00082	0.224
CLV_PCSK_KEX2_1	531	533	PF00082	0.193
CLV_PCSK_KEX2_1	97	99	PF00082	0.599
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.193
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.575
CLV_PCSK_SKI1_1	19	23	PF00082	0.357
CLV_PCSK_SKI1_1	231	235	PF00082	0.237
CLV_PCSK_SKI1_1	340	344	PF00082	0.287
CLV_PCSK_SKI1_1	531	535	PF00082	0.343
CLV_PCSK_SKI1_1	565	569	PF00082	0.571
DEG_Nend_Nbox_1	1	3	PF02207	0.403
DEG_SPOP_SBC_1	459	463	PF00917	0.330
DOC_CKS1_1	196	201	PF01111	0.333
DOC_CYCLIN_RxL_1	340	349	PF00134	0.291
DOC_CYCLIN_RxL_1	470	482	PF00134	0.265
DOC_MAPK_MEF2A_6	15	22	PF00069	0.251
DOC_PP2B_PxIxI_1	463	469	PF00149	0.250
DOC_PP4_FxxP_1	226	229	PF00568	0.558
DOC_PP4_FxxP_1	242	245	PF00568	0.250
DOC_PP4_FxxP_1	400	403	PF00568	0.291
DOC_PP4_FxxP_1	502	505	PF00568	0.392
DOC_PP4_FxxP_1	593	596	PF00568	0.364
DOC_SPAK_OSR1_1	431	435	PF12202	0.167
DOC_USP7_MATH_1	110	114	PF00917	0.237
DOC_USP7_MATH_1	277	281	PF00917	0.318
DOC_USP7_MATH_1	330	334	PF00917	0.373
DOC_USP7_MATH_1	459	463	PF00917	0.263
DOC_USP7_MATH_1	611	615	PF00917	0.504
DOC_USP7_UBL2_3	631	635	PF12436	0.446
DOC_WW_Pin1_4	168	173	PF00397	0.376
DOC_WW_Pin1_4	195	200	PF00397	0.327
DOC_WW_Pin1_4	307	312	PF00397	0.327
DOC_WW_Pin1_4	460	465	PF00397	0.271
LIG_14-3-3_CanoR_1	185	194	PF00244	0.448
LIG_14-3-3_CanoR_1	222	227	PF00244	0.535
LIG_14-3-3_CanoR_1	263	273	PF00244	0.167
LIG_14-3-3_CanoR_1	364	373	PF00244	0.247
LIG_14-3-3_CanoR_1	454	459	PF00244	0.337
LIG_14-3-3_CanoR_1	509	513	PF00244	0.408
LIG_14-3-3_CanoR_1	65	74	PF00244	0.398
LIG_BRCT_BRCA1_1	222	226	PF00533	0.595
LIG_BRCT_BRCA1_1	99	103	PF00533	0.511
LIG_FHA_1	1	7	PF00498	0.385
LIG_FHA_1	196	202	PF00498	0.365
LIG_FHA_1	313	319	PF00498	0.425
LIG_FHA_1	455	461	PF00498	0.413
LIG_FHA_1	484	490	PF00498	0.345
LIG_FHA_1	496	502	PF00498	0.345
LIG_FHA_2	135	141	PF00498	0.448
LIG_FHA_2	207	213	PF00498	0.451
LIG_FHA_2	263	269	PF00498	0.241
LIG_FHA_2	277	283	PF00498	0.250
LIG_FHA_2	339	345	PF00498	0.330
LIG_FHA_2	569	575	PF00498	0.598
LIG_GBD_Chelix_1	488	496	PF00786	0.392
LIG_LIR_Apic_2	223	229	PF02991	0.536
LIG_LIR_Apic_2	240	245	PF02991	0.151
LIG_LIR_Gen_1	112	123	PF02991	0.263
LIG_LIR_Gen_1	271	278	PF02991	0.301
LIG_LIR_Gen_1	440	451	PF02991	0.284
LIG_LIR_Gen_1	475	481	PF02991	0.344
LIG_LIR_Gen_1	587	598	PF02991	0.301
LIG_LIR_Nem_3	112	118	PF02991	0.263
LIG_LIR_Nem_3	173	179	PF02991	0.408
LIG_LIR_Nem_3	246	252	PF02991	0.250
LIG_LIR_Nem_3	271	276	PF02991	0.301
LIG_LIR_Nem_3	370	376	PF02991	0.250
LIG_LIR_Nem_3	440	446	PF02991	0.284
LIG_LIR_Nem_3	475	480	PF02991	0.344
LIG_LIR_Nem_3	56	62	PF02991	0.431
LIG_LIR_Nem_3	587	593	PF02991	0.322
LIG_LYPXL_S_1	175	179	PF13949	0.392
LIG_LYPXL_yS_3	176	179	PF13949	0.392
LIG_PCNA_yPIPBox_3	231	242	PF02747	0.442
LIG_PCNA_yPIPBox_3	339	352	PF02747	0.278
LIG_PCNA_yPIPBox_3	439	447	PF02747	0.392
LIG_PCNA_yPIPBox_3	65	78	PF02747	0.389
LIG_Pex14_2	257	261	PF04695	0.250
LIG_SH2_CRK	443	447	PF00017	0.330
LIG_SH2_PTP2	273	276	PF00017	0.284
LIG_SH2_SRC	154	157	PF00017	0.284
LIG_SH2_STAT5	130	133	PF00017	0.353
LIG_SH2_STAT5	145	148	PF00017	0.248
LIG_SH2_STAT5	154	157	PF00017	0.265
LIG_SH2_STAT5	260	263	PF00017	0.223
LIG_SH2_STAT5	273	276	PF00017	0.284
LIG_SH2_STAT5	383	386	PF00017	0.250
LIG_SH2_STAT5	420	423	PF00017	0.343
LIG_SH2_STAT5	479	482	PF00017	0.304
LIG_SH2_STAT5	626	629	PF00017	0.276
LIG_SH3_1	133	139	PF00018	0.392
LIG_SH3_3	133	139	PF00018	0.327
LIG_SH3_3	193	199	PF00018	0.335
LIG_SH3_3	299	305	PF00018	0.250
LIG_SH3_3	354	360	PF00018	0.330
LIG_SH3_3	388	394	PF00018	0.384
LIG_SH3_3	403	409	PF00018	0.137
LIG_SUMO_SIM_anti_2	298	304	PF11976	0.266
LIG_SUMO_SIM_anti_2	3	8	PF11976	0.220
LIG_SUMO_SIM_anti_2	402	408	PF11976	0.309
LIG_SUMO_SIM_anti_2	465	470	PF11976	0.250
LIG_SUMO_SIM_par_1	158	163	PF11976	0.167
LIG_SUMO_SIM_par_1	456	463	PF11976	0.316
LIG_SUMO_SIM_par_1	580	587	PF11976	0.322
LIG_TRAF2_1	109	112	PF00917	0.167
LIG_TRAF2_1	618	621	PF00917	0.530
LIG_TYR_ITIM	441	446	PF00017	0.343
LIG_TYR_ITSM	172	179	PF00017	0.330
LIG_WRC_WIRS_1	317	322	PF05994	0.392
MOD_CDK_SPxxK_3	195	202	PF00069	0.244
MOD_CK1_1	102	108	PF00069	0.349
MOD_CK1_1	186	192	PF00069	0.420
MOD_CK1_1	280	286	PF00069	0.267
MOD_CK1_1	367	373	PF00069	0.250
MOD_CK1_1	462	468	PF00069	0.418
MOD_CK1_1	537	543	PF00069	0.386
MOD_CK1_1	572	578	PF00069	0.636
MOD_CK1_1	69	75	PF00069	0.479
MOD_CK2_1	234	240	PF00069	0.361
MOD_CK2_1	262	268	PF00069	0.241
MOD_CK2_1	338	344	PF00069	0.330
MOD_CK2_1	469	475	PF00069	0.286
MOD_CK2_1	70	76	PF00069	0.358
MOD_GlcNHglycan	222	225	PF01048	0.633
MOD_GlcNHglycan	279	282	PF01048	0.264
MOD_GlcNHglycan	288	291	PF01048	0.271
MOD_GlcNHglycan	33	36	PF01048	0.516
MOD_GlcNHglycan	366	369	PF01048	0.250
MOD_GlcNHglycan	417	420	PF01048	0.384
MOD_GlcNHglycan	50	54	PF01048	0.480
MOD_GlcNHglycan	535	539	PF01048	0.305
MOD_GlcNHglycan	615	618	PF01048	0.484
MOD_GlcNHglycan	78	81	PF01048	0.403
MOD_GlcNHglycan	99	102	PF01048	0.360
MOD_GSK3_1	110	117	PF00069	0.275
MOD_GSK3_1	134	141	PF00069	0.348
MOD_GSK3_1	166	173	PF00069	0.371
MOD_GSK3_1	216	223	PF00069	0.562
MOD_GSK3_1	27	34	PF00069	0.563
MOD_GSK3_1	276	283	PF00069	0.270
MOD_GSK3_1	312	319	PF00069	0.411
MOD_GSK3_1	363	370	PF00069	0.250
MOD_GSK3_1	454	461	PF00069	0.263
MOD_GSK3_1	479	486	PF00069	0.333
MOD_GSK3_1	561	568	PF00069	0.441
MOD_GSK3_1	570	577	PF00069	0.462
MOD_GSK3_1	66	73	PF00069	0.364
MOD_GSK3_1	97	104	PF00069	0.506
MOD_LATS_1	82	88	PF00433	0.278
MOD_N-GLC_1	234	239	PF02516	0.370
MOD_N-GLC_1	454	459	PF02516	0.305
MOD_NEK2_1	103	108	PF00069	0.179
MOD_NEK2_1	220	225	PF00069	0.366
MOD_NEK2_1	276	281	PF00069	0.262
MOD_NEK2_1	445	450	PF00069	0.273
MOD_NEK2_1	458	463	PF00069	0.250
MOD_NEK2_1	469	474	PF00069	0.245
MOD_NEK2_1	508	513	PF00069	0.263
MOD_NEK2_1	534	539	PF00069	0.410
MOD_NEK2_2	338	343	PF00069	0.250
MOD_NEK2_2	526	531	PF00069	0.284
MOD_PIKK_1	138	144	PF00454	0.250
MOD_PIKK_1	295	301	PF00454	0.392
MOD_PIKK_1	312	318	PF00454	0.392
MOD_PIKK_1	321	327	PF00454	0.367
MOD_PKA_1	97	103	PF00069	0.501
MOD_PKA_2	186	192	PF00069	0.396
MOD_PKA_2	262	268	PF00069	0.179
MOD_PKA_2	363	369	PF00069	0.230
MOD_PKA_2	508	514	PF00069	0.348
MOD_PKA_2	519	525	PF00069	0.280
MOD_PKA_2	8	14	PF00069	0.468
MOD_PKA_2	97	103	PF00069	0.445
MOD_Plk_1	166	172	PF00069	0.262
MOD_Plk_1	183	189	PF00069	0.328
MOD_Plk_1	234	240	PF00069	0.360
MOD_Plk_1	454	460	PF00069	0.400
MOD_Plk_1	49	55	PF00069	0.379
MOD_Plk_1	565	571	PF00069	0.443
MOD_Plk_1	69	75	PF00069	0.270
MOD_Plk_2-3	70	76	PF00069	0.250
MOD_Plk_4	114	120	PF00069	0.165
MOD_Plk_4	171	177	PF00069	0.401
MOD_Plk_4	234	240	PF00069	0.339
MOD_ProDKin_1	168	174	PF00069	0.376
MOD_ProDKin_1	195	201	PF00069	0.330
MOD_ProDKin_1	307	313	PF00069	0.327
MOD_ProDKin_1	460	466	PF00069	0.271
MOD_SUMO_rev_2	11	16	PF00179	0.472
TRG_DiLeu_BaEn_2	110	116	PF01217	0.328
TRG_DiLeu_BaEn_4	111	117	PF01217	0.167
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.377
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.275
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.289
TRG_ENDOCYTIC_2	176	179	PF00928	0.392
TRG_ENDOCYTIC_2	273	276	PF00928	0.249
TRG_ENDOCYTIC_2	443	446	PF00928	0.343
TRG_ENDOCYTIC_2	626	629	PF00928	0.351
TRG_ENDOCYTIC_2	64	67	PF00928	0.340
TRG_ER_diArg_1	185	188	PF00400	0.253
TRG_ER_diArg_1	429	431	PF00400	0.167
TRG_ER_diArg_1	453	456	PF00400	0.284
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	623	628	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZJ2	Leptomonas seymouri	71%	99%
A0A0S4ITY7	Bodo saltans	45%	100%
A0A1X0NNP4	Trypanosomatidae	48%	100%
A0A3Q8II85	Leishmania donovani	85%	100%
A0A422NX69	Trypanosoma rangeli	52%	100%
A4HVX7	Leishmania infantum	85%	100%
C9ZT46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9APM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O24924	Helicobacter pylori (strain ATCC 700392 / 26695)	31%	100%
P16120	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P23669	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	34%	100%
P29363	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	33%	100%
P37145	Methylobacillus glycogenes	32%	100%
Q00063	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	100%
Q2YDP8	Danio rerio	27%	100%
Q42598	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q4QFV0	Leishmania major	84%	100%
Q5M7T9	Rattus norvegicus	30%	100%
Q5R5P3	Pongo abelii	36%	91%
Q5RFE6	Pongo abelii	29%	100%
Q5XH07	Xenopus laevis	28%	100%
Q80W22	Mus musculus	29%	100%
Q86YJ6	Homo sapiens	29%	100%
Q8BH55	Mus musculus	37%	90%
Q8IYQ7	Homo sapiens	35%	91%
Q9BH05	Macaca fascicularis	35%	91%
V5BD69	Trypanosoma cruzi	48%	100%