Aa_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane amino acid transporter protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7J2_LEIBR

TriTrypDb:

LbrM.14.0330 , LBRM2903_140008500

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H7J2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7J2

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	1
GO:0006810	transport	3	1
GO:0006865	amino acid transport	5	1
GO:0009987	cellular process	1	1
GO:0015849	organic acid transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:1903825	organic acid transmembrane transport	3	1
GO:1905039	carboxylic acid transmembrane transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005342	organic acid transmembrane transporter activity	3	1
GO:0015171	amino acid transmembrane transporter activity	5	1
GO:0022857	transmembrane transporter activity	2	1
GO:0046943	carboxylic acid transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.515
CLV_C14_Caspase3-7	712	716	PF00656	0.362
CLV_C14_Caspase3-7	75	79	PF00656	0.440
CLV_NRD_NRD_1	142	144	PF00675	0.723
CLV_NRD_NRD_1	180	182	PF00675	0.710
CLV_NRD_NRD_1	599	601	PF00675	0.245
CLV_NRD_NRD_1	663	665	PF00675	0.263
CLV_NRD_NRD_1	90	92	PF00675	0.725
CLV_PCSK_FUR_1	178	182	PF00082	0.722
CLV_PCSK_KEX2_1	142	144	PF00082	0.723
CLV_PCSK_KEX2_1	180	182	PF00082	0.753
CLV_PCSK_KEX2_1	599	601	PF00082	0.245
CLV_PCSK_KEX2_1	663	665	PF00082	0.260
CLV_PCSK_KEX2_1	90	92	PF00082	0.576
CLV_PCSK_SKI1_1	105	109	PF00082	0.638
CLV_PCSK_SKI1_1	275	279	PF00082	0.584
CLV_PCSK_SKI1_1	314	318	PF00082	0.584
CLV_PCSK_SKI1_1	329	333	PF00082	0.471
CLV_PCSK_SKI1_1	54	58	PF00082	0.624
CLV_PCSK_SKI1_1	599	603	PF00082	0.253
CLV_PCSK_SKI1_1	666	670	PF00082	0.269
DEG_SPOP_SBC_1	263	267	PF00917	0.452
DEG_SPOP_SBC_1	414	418	PF00917	0.362
DOC_CDC14_PxL_1	296	304	PF14671	0.446
DOC_CKS1_1	115	120	PF01111	0.540
DOC_CKS1_1	38	43	PF01111	0.506
DOC_CKS1_1	62	67	PF01111	0.418
DOC_CKS1_1	93	98	PF01111	0.395
DOC_CYCLIN_RxL_1	51	59	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	337	343	PF00134	0.253
DOC_CYCLIN_yCln2_LP_2	653	659	PF00134	0.299
DOC_MAPK_gen_1	453	463	PF00069	0.503
DOC_MAPK_gen_1	529	537	PF00069	0.460
DOC_MAPK_JIP1_4	614	620	PF00069	0.469
DOC_MAPK_MEF2A_6	483	490	PF00069	0.197
DOC_MAPK_MEF2A_6	556	565	PF00069	0.197
DOC_PP1_RVXF_1	315	322	PF00149	0.288
DOC_PP1_RVXF_1	671	678	PF00149	0.469
DOC_PP2B_LxvP_1	337	340	PF13499	0.237
DOC_PP2B_LxvP_1	439	442	PF13499	0.323
DOC_PP2B_LxvP_1	653	656	PF13499	0.299
DOC_PP4_FxxP_1	631	634	PF00568	0.359
DOC_PP4_FxxP_1	93	96	PF00568	0.380
DOC_USP7_MATH_1	232	236	PF00917	0.567
DOC_USP7_MATH_1	263	267	PF00917	0.467
DOC_USP7_MATH_1	310	314	PF00917	0.429
DOC_USP7_MATH_1	359	363	PF00917	0.383
DOC_USP7_MATH_1	414	418	PF00917	0.379
DOC_USP7_MATH_1	462	466	PF00917	0.383
DOC_USP7_UBL2_3	373	377	PF12436	0.469
DOC_WW_Pin1_4	114	119	PF00397	0.542
DOC_WW_Pin1_4	137	142	PF00397	0.563
DOC_WW_Pin1_4	15	20	PF00397	0.530
DOC_WW_Pin1_4	190	195	PF00397	0.431
DOC_WW_Pin1_4	26	31	PF00397	0.422
DOC_WW_Pin1_4	32	37	PF00397	0.546
DOC_WW_Pin1_4	491	496	PF00397	0.332
DOC_WW_Pin1_4	61	66	PF00397	0.556
DOC_WW_Pin1_4	92	97	PF00397	0.426
LIG_14-3-3_CanoR_1	142	151	PF00244	0.438
LIG_14-3-3_CanoR_1	197	201	PF00244	0.469
LIG_14-3-3_CanoR_1	253	258	PF00244	0.387
LIG_14-3-3_CanoR_1	532	536	PF00244	0.319
LIG_14-3-3_CanoR_1	556	561	PF00244	0.197
LIG_14-3-3_CanoR_1	571	580	PF00244	0.303
LIG_Actin_WH2_2	558	573	PF00022	0.321
LIG_Actin_WH2_2	655	672	PF00022	0.312
LIG_APCC_ABBA_1	382	387	PF00400	0.437
LIG_APCC_ABBAyCdc20_2	317	323	PF00400	0.279
LIG_APCC_ABBAyCdc20_2	381	387	PF00400	0.497
LIG_BRCT_BRCA1_1	234	238	PF00533	0.463
LIG_BRCT_BRCA1_1	324	328	PF00533	0.387
LIG_BRCT_BRCA1_1	495	499	PF00533	0.305
LIG_Clathr_ClatBox_1	475	479	PF01394	0.383
LIG_deltaCOP1_diTrp_1	395	403	PF00928	0.437
LIG_EH1_1	403	411	PF00400	0.323
LIG_eIF4E_1	385	391	PF01652	0.586
LIG_eIF4E_1	397	403	PF01652	0.263
LIG_eIF4E_1	404	410	PF01652	0.211
LIG_EVH1_1	61	65	PF00568	0.417
LIG_FHA_1	193	199	PF00498	0.480
LIG_FHA_1	276	282	PF00498	0.449
LIG_FHA_1	332	338	PF00498	0.265
LIG_FHA_1	405	411	PF00498	0.236
LIG_FHA_1	513	519	PF00498	0.383
LIG_FHA_1	555	561	PF00498	0.267
LIG_FHA_1	588	594	PF00498	0.359
LIG_FHA_1	62	68	PF00498	0.505
LIG_FHA_1	93	99	PF00498	0.522
LIG_FHA_2	197	203	PF00498	0.483
LIG_FHA_2	296	302	PF00498	0.342
LIG_FHA_2	38	44	PF00498	0.463
LIG_HP1_1	448	452	PF01393	0.383
LIG_IRF3_LxIS_1	638	643	PF10401	0.269
LIG_LIR_Gen_1	356	365	PF02991	0.372
LIG_LIR_Gen_1	496	507	PF02991	0.279
LIG_LIR_Gen_1	525	535	PF02991	0.552
LIG_LIR_Gen_1	538	547	PF02991	0.398
LIG_LIR_Gen_1	626	636	PF02991	0.299
LIG_LIR_Gen_1	679	689	PF02991	0.460
LIG_LIR_Nem_3	252	257	PF02991	0.352
LIG_LIR_Nem_3	325	331	PF02991	0.377
LIG_LIR_Nem_3	356	360	PF02991	0.372
LIG_LIR_Nem_3	395	400	PF02991	0.570
LIG_LIR_Nem_3	496	502	PF02991	0.342
LIG_LIR_Nem_3	525	530	PF02991	0.557
LIG_LIR_Nem_3	538	542	PF02991	0.381
LIG_LIR_Nem_3	548	553	PF02991	0.330
LIG_LIR_Nem_3	608	613	PF02991	0.520
LIG_LIR_Nem_3	626	631	PF02991	0.299
LIG_LIR_Nem_3	632	638	PF02991	0.407
LIG_LIR_Nem_3	674	680	PF02991	0.491
LIG_LYPXL_yS_3	397	400	PF13949	0.323
LIG_MAD2	381	389	PF02301	0.520
LIG_MLH1_MIPbox_1	495	499	PF16413	0.305
LIG_PDZ_Class_3	712	717	PF00595	0.416
LIG_Pex14_1	393	397	PF04695	0.512
LIG_Pex14_2	324	328	PF04695	0.387
LIG_Pex14_2	677	681	PF04695	0.398
LIG_PTB_Apo_2	398	405	PF02174	0.383
LIG_PTB_Phospho_1	398	404	PF10480	0.383
LIG_SH2_CRK	527	531	PF00017	0.469
LIG_SH2_CRK	58	62	PF00017	0.477
LIG_SH2_CRK	636	640	PF00017	0.237
LIG_SH2_CRK	689	693	PF00017	0.359
LIG_SH2_STAP1	364	368	PF00017	0.325
LIG_SH2_STAT3	482	485	PF00017	0.269
LIG_SH2_STAT5	162	165	PF00017	0.434
LIG_SH2_STAT5	192	195	PF00017	0.429
LIG_SH2_STAT5	369	372	PF00017	0.484
LIG_SH2_STAT5	622	625	PF00017	0.359
LIG_SH2_STAT5	661	664	PF00017	0.460
LIG_SH2_STAT5	680	683	PF00017	0.267
LIG_SH3_1	112	118	PF00018	0.435
LIG_SH3_2	484	489	PF14604	0.303
LIG_SH3_3	112	118	PF00018	0.487
LIG_SH3_3	173	179	PF00018	0.538
LIG_SH3_3	24	30	PF00018	0.516
LIG_SH3_3	35	41	PF00018	0.539
LIG_SH3_3	481	487	PF00018	0.324
LIG_SH3_3	518	524	PF00018	0.520
LIG_SH3_3	59	65	PF00018	0.553
LIG_Sin3_3	574	581	PF02671	0.362
LIG_SUMO_SIM_anti_2	465	472	PF11976	0.342
LIG_SUMO_SIM_anti_2	582	587	PF11976	0.323
LIG_SUMO_SIM_par_1	351	356	PF11976	0.376
LIG_SUMO_SIM_par_1	459	465	PF11976	0.477
LIG_SUMO_SIM_par_1	466	472	PF11976	0.323
LIG_SUMO_SIM_par_1	514	519	PF11976	0.362
LIG_SUMO_SIM_par_1	561	567	PF11976	0.272
LIG_SUMO_SIM_par_1	638	643	PF11976	0.303
LIG_TRAF2_1	199	202	PF00917	0.492
LIG_TRAF2_1	50	53	PF00917	0.489
LIG_TRAF2_1	9	12	PF00917	0.493
LIG_TYR_ITIM	383	388	PF00017	0.479
LIG_TYR_ITIM	56	61	PF00017	0.426
LIG_TYR_ITIM	620	625	PF00017	0.359
LIG_TYR_ITIM	633	638	PF00017	0.260
LIG_UBA3_1	423	430	PF00899	0.305
LIG_UBA3_1	474	483	PF00899	0.212
LIG_ULM_U2AF65_1	663	668	PF00076	0.469
LIG_WRC_WIRS_1	328	333	PF05994	0.281
LIG_WRC_WIRS_1	354	359	PF05994	0.312
LIG_WRC_WIRS_1	625	630	PF05994	0.212
MOD_CDK_SPK_2	137	142	PF00069	0.441
MOD_CDK_SPxK_1	137	143	PF00069	0.442
MOD_CDK_SPxxK_3	114	121	PF00069	0.600
MOD_CDK_SPxxK_3	190	197	PF00069	0.427
MOD_CDK_SPxxK_3	92	99	PF00069	0.395
MOD_CK1_1	136	142	PF00069	0.546
MOD_CK1_1	164	170	PF00069	0.469
MOD_CK1_1	18	24	PF00069	0.436
MOD_CK1_1	273	279	PF00069	0.454
MOD_CK1_1	28	34	PF00069	0.401
MOD_CK1_1	514	520	PF00069	0.424
MOD_CK1_1	559	565	PF00069	0.293
MOD_CK1_1	708	714	PF00069	0.460
MOD_CK1_1	81	87	PF00069	0.471
MOD_CK2_1	119	125	PF00069	0.570
MOD_CK2_1	164	170	PF00069	0.551
MOD_CK2_1	196	202	PF00069	0.458
MOD_CK2_1	37	43	PF00069	0.465
MOD_CK2_1	491	497	PF00069	0.277
MOD_CMANNOS	393	396	PF00535	0.320
MOD_GlcNHglycan	121	124	PF01048	0.828
MOD_GlcNHglycan	136	139	PF01048	0.813
MOD_GlcNHglycan	217	220	PF01048	0.676
MOD_GlcNHglycan	257	260	PF01048	0.633
MOD_GlcNHglycan	275	278	PF01048	0.719
MOD_GlcNHglycan	547	550	PF01048	0.399
MOD_GlcNHglycan	566	569	PF01048	0.534
MOD_GlcNHglycan	574	577	PF01048	0.266
MOD_GlcNHglycan	642	645	PF01048	0.384
MOD_GlcNHglycan	699	702	PF01048	0.423
MOD_GlcNHglycan	81	84	PF01048	0.702
MOD_GlcNHglycan	86	89	PF01048	0.653
MOD_GSK3_1	113	120	PF00069	0.512
MOD_GSK3_1	132	139	PF00069	0.550
MOD_GSK3_1	145	152	PF00069	0.435
MOD_GSK3_1	161	168	PF00069	0.409
MOD_GSK3_1	192	199	PF00069	0.421
MOD_GSK3_1	21	28	PF00069	0.531
MOD_GSK3_1	242	249	PF00069	0.421
MOD_GSK3_1	273	280	PF00069	0.493
MOD_GSK3_1	327	334	PF00069	0.293
MOD_GSK3_1	359	366	PF00069	0.365
MOD_GSK3_1	39	46	PF00069	0.579
MOD_GSK3_1	507	514	PF00069	0.316
MOD_GSK3_1	531	538	PF00069	0.504
MOD_GSK3_1	545	552	PF00069	0.235
MOD_GSK3_1	638	645	PF00069	0.277
MOD_GSK3_1	705	712	PF00069	0.369
MOD_GSK3_1	74	81	PF00069	0.596
MOD_N-GLC_1	190	195	PF02516	0.631
MOD_N-GLC_1	3	8	PF02516	0.633
MOD_N-GLC_1	44	49	PF02516	0.688
MOD_N-GLC_1	554	559	PF02516	0.487
MOD_NEK2_1	255	260	PF00069	0.460
MOD_NEK2_1	324	329	PF00069	0.325
MOD_NEK2_1	331	336	PF00069	0.247
MOD_NEK2_1	415	420	PF00069	0.348
MOD_NEK2_1	502	507	PF00069	0.390
MOD_NEK2_1	531	536	PF00069	0.458
MOD_NEK2_1	545	550	PF00069	0.270
MOD_NEK2_1	56	61	PF00069	0.475
MOD_NEK2_1	561	566	PF00069	0.217
MOD_NEK2_1	579	584	PF00069	0.323
MOD_NEK2_1	602	607	PF00069	0.517
MOD_NEK2_1	623	628	PF00069	0.284
MOD_NEK2_1	638	643	PF00069	0.247
MOD_NEK2_1	705	710	PF00069	0.270
MOD_PIKK_1	454	460	PF00454	0.477
MOD_PIKK_1	602	608	PF00454	0.398
MOD_PK_1	556	562	PF00069	0.197
MOD_PKA_2	196	202	PF00069	0.594
MOD_PKA_2	531	537	PF00069	0.477
MOD_Plk_1	44	50	PF00069	0.450
MOD_Plk_1	478	484	PF00069	0.362
MOD_Plk_4	145	151	PF00069	0.459
MOD_Plk_4	21	27	PF00069	0.456
MOD_Plk_4	242	248	PF00069	0.367
MOD_Plk_4	265	271	PF00069	0.547
MOD_Plk_4	353	359	PF00069	0.326
MOD_Plk_4	440	446	PF00069	0.351
MOD_Plk_4	469	475	PF00069	0.386
MOD_Plk_4	502	508	PF00069	0.381
MOD_Plk_4	556	562	PF00069	0.277
MOD_ProDKin_1	114	120	PF00069	0.542
MOD_ProDKin_1	137	143	PF00069	0.565
MOD_ProDKin_1	15	21	PF00069	0.529
MOD_ProDKin_1	190	196	PF00069	0.428
MOD_ProDKin_1	26	32	PF00069	0.423
MOD_ProDKin_1	37	43	PF00069	0.556
MOD_ProDKin_1	491	497	PF00069	0.332
MOD_ProDKin_1	61	67	PF00069	0.558
MOD_ProDKin_1	92	98	PF00069	0.432
MOD_SUMO_rev_2	313	319	PF00179	0.339
TRG_ENDOCYTIC_2	211	214	PF00928	0.439
TRG_ENDOCYTIC_2	385	388	PF00928	0.483
TRG_ENDOCYTIC_2	397	400	PF00928	0.373
TRG_ENDOCYTIC_2	527	530	PF00928	0.463
TRG_ENDOCYTIC_2	58	61	PF00928	0.426
TRG_ENDOCYTIC_2	610	613	PF00928	0.477
TRG_ENDOCYTIC_2	622	625	PF00928	0.323
TRG_ENDOCYTIC_2	635	638	PF00928	0.238
TRG_ENDOCYTIC_2	680	683	PF00928	0.339
TRG_ENDOCYTIC_2	689	692	PF00928	0.272
TRG_ER_diArg_1	141	143	PF00400	0.441
TRG_ER_diArg_1	178	181	PF00400	0.525
TRG_ER_diArg_1	599	601	PF00400	0.445
TRG_ER_diArg_1	662	664	PF00400	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C5	Leptomonas seymouri	68%	98%
A0A0N1PBG3	Leptomonas seymouri	33%	85%
A0A0S4ISI1	Bodo saltans	45%	100%
A0A3S7WST2	Leishmania donovani	74%	100%
A4HVX5	Leishmania infantum	74%	100%
E9APM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QFV2	Leishmania major	69%	100%