Putative amino acid permease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Polyamine transporter 1, putative

Species:

Leishmania braziliensis

UniProt:

A4H7J1_LEIBR

TriTrypDb:

LbrM.14.0320 , LBRM2903_140008300

Length:

752

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15
GO:0005886	plasma membrane	3	1
GO:0000323	lytic vacuole	6	1
GO:0005764	lysosome	7	1
GO:0005773	vacuole	5	1
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H7J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7J1

Function

Biological processes
Term	Name	Level	Count
GO:0000296	spermine transport	6	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0009987	cellular process	1	1
GO:0015695	organic cation transport	5	1
GO:0015846	polyamine transport	5	1
GO:0015847	putrescine transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:1902047	polyamine transmembrane transport	3	1
GO:1903710	spermine transmembrane transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	15
GO:0015203	polyamine transmembrane transporter activity	3	15
GO:0022857	transmembrane transporter activity	2	15
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015101	organic cation transmembrane transporter activity	5	1
GO:0015489	putrescine transmembrane transporter activity	4	1
GO:0015606	spermidine transmembrane transporter activity	4	1
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	304	306	PF00675	0.344
CLV_NRD_NRD_1	62	64	PF00675	0.479
CLV_NRD_NRD_1	686	688	PF00675	0.481
CLV_NRD_NRD_1	81	83	PF00675	0.446
CLV_NRD_NRD_1	87	89	PF00675	0.443
CLV_PCSK_FUR_1	684	688	PF00082	0.483
CLV_PCSK_KEX2_1	48	50	PF00082	0.534
CLV_PCSK_KEX2_1	62	64	PF00082	0.467
CLV_PCSK_KEX2_1	686	688	PF00082	0.481
CLV_PCSK_KEX2_1	81	83	PF00082	0.392
CLV_PCSK_KEX2_1	87	89	PF00082	0.443
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.419
CLV_PCSK_SKI1_1	265	269	PF00082	0.379
CLV_PCSK_SKI1_1	305	309	PF00082	0.346
CLV_PCSK_SKI1_1	361	365	PF00082	0.546
CLV_PCSK_SKI1_1	448	452	PF00082	0.301
DEG_APCC_DBOX_1	95	103	PF00400	0.546
DEG_Nend_UBRbox_1	1	4	PF02207	0.780
DEG_SPOP_SBC_1	594	598	PF00917	0.654
DOC_CKS1_1	411	416	PF01111	0.360
DOC_CKS1_1	588	593	PF01111	0.599
DOC_CYCLIN_RxL_1	445	455	PF00134	0.325
DOC_CYCLIN_yCln2_LP_2	411	417	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	466	472	PF00134	0.502
DOC_CYCLIN_yCln2_LP_2	483	489	PF00134	0.355
DOC_MAPK_DCC_7	410	420	PF00069	0.546
DOC_MAPK_gen_1	62	69	PF00069	0.740
DOC_MAPK_JIP1_4	468	474	PF00069	0.546
DOC_MAPK_MEF2A_6	265	272	PF00069	0.489
DOC_MAPK_MEF2A_6	310	317	PF00069	0.479
DOC_MAPK_MEF2A_6	62	69	PF00069	0.759
DOC_PP1_RVXF_1	271	278	PF00149	0.560
DOC_PP2B_LxvP_1	584	587	PF13499	0.666
DOC_PP2B_PxIxI_1	415	421	PF00149	0.417
DOC_PP4_FxxP_1	21	24	PF00568	0.607
DOC_USP7_MATH_1	156	160	PF00917	0.506
DOC_USP7_MATH_1	173	177	PF00917	0.360
DOC_USP7_MATH_1	329	333	PF00917	0.360
DOC_USP7_MATH_1	498	502	PF00917	0.334
DOC_USP7_MATH_1	507	511	PF00917	0.359
DOC_USP7_MATH_1	593	597	PF00917	0.754
DOC_USP7_MATH_1	607	611	PF00917	0.603
DOC_USP7_MATH_1	656	660	PF00917	0.762
DOC_USP7_MATH_1	696	700	PF00917	0.705
DOC_USP7_UBL2_3	306	310	PF12436	0.460
DOC_WW_Pin1_4	410	415	PF00397	0.506
DOC_WW_Pin1_4	571	576	PF00397	0.729
DOC_WW_Pin1_4	587	592	PF00397	0.585
DOC_WW_Pin1_4	666	671	PF00397	0.707
DOC_WW_Pin1_4	727	732	PF00397	0.741
DOC_WW_Pin1_4	739	744	PF00397	0.776
LIG_14-3-3_CanoR_1	592	600	PF00244	0.703
LIG_14-3-3_CanoR_1	687	693	PF00244	0.741
LIG_14-3-3_CanoR_1	7	16	PF00244	0.617
LIG_14-3-3_CanoR_1	96	105	PF00244	0.511
LIG_Actin_WH2_2	61	76	PF00022	0.730
LIG_APCC_ABBAyCdc20_2	265	271	PF00400	0.489
LIG_BIR_III_4	620	624	PF00653	0.683
LIG_BRCT_BRCA1_1	259	263	PF00533	0.489
LIG_BRCT_BRCA1_2	259	265	PF00533	0.412
LIG_deltaCOP1_diTrp_1	358	365	PF00928	0.336
LIG_eIF4E_1	445	451	PF01652	0.325
LIG_FHA_1	129	135	PF00498	0.301
LIG_FHA_1	181	187	PF00498	0.360
LIG_FHA_1	381	387	PF00498	0.309
LIG_FHA_1	433	439	PF00498	0.375
LIG_FHA_1	477	483	PF00498	0.355
LIG_FHA_1	614	620	PF00498	0.618
LIG_FHA_1	641	647	PF00498	0.602
LIG_FHA_1	670	676	PF00498	0.714
LIG_FHA_1	74	80	PF00498	0.668
LIG_FHA_1	99	105	PF00498	0.460
LIG_FHA_2	572	578	PF00498	0.805
LIG_FHA_2	7	13	PF00498	0.618
LIG_LIR_Apic_2	18	24	PF02991	0.612
LIG_LIR_Apic_2	672	676	PF02991	0.762
LIG_LIR_Gen_1	176	185	PF02991	0.356
LIG_LIR_Gen_1	274	284	PF02991	0.507
LIG_LIR_Gen_1	285	296	PF02991	0.494
LIG_LIR_Gen_1	433	440	PF02991	0.379
LIG_LIR_Gen_1	510	518	PF02991	0.423
LIG_LIR_Gen_1	519	528	PF02991	0.490
LIG_LIR_LC3C_4	131	134	PF02991	0.274
LIG_LIR_Nem_3	176	180	PF02991	0.356
LIG_LIR_Nem_3	183	188	PF02991	0.353
LIG_LIR_Nem_3	193	197	PF02991	0.274
LIG_LIR_Nem_3	274	280	PF02991	0.504
LIG_LIR_Nem_3	285	291	PF02991	0.515
LIG_LIR_Nem_3	318	323	PF02991	0.301
LIG_LIR_Nem_3	358	362	PF02991	0.286
LIG_LIR_Nem_3	433	437	PF02991	0.309
LIG_LIR_Nem_3	462	466	PF02991	0.534
LIG_LIR_Nem_3	510	514	PF02991	0.368
LIG_LIR_Nem_3	519	525	PF02991	0.422
LIG_LYPXL_yS_3	194	197	PF13949	0.324
LIG_LYPXL_yS_3	463	466	PF13949	0.506
LIG_NRBOX	446	452	PF00104	0.360
LIG_PCNA_PIPBox_1	400	409	PF02747	0.399
LIG_Pex14_1	140	144	PF04695	0.360
LIG_Pex14_1	277	281	PF04695	0.559
LIG_Pex14_2	105	109	PF04695	0.305
LIG_Pex14_2	259	263	PF04695	0.517
LIG_PTB_Apo_2	188	195	PF02174	0.360
LIG_PTB_Phospho_1	188	194	PF10480	0.385
LIG_SH2_CRK	453	457	PF00017	0.310
LIG_SH2_CRK	470	474	PF00017	0.566
LIG_SH2_CRK	522	526	PF00017	0.613
LIG_SH2_GRB2like	288	291	PF00017	0.468
LIG_SH2_NCK_1	288	292	PF00017	0.464
LIG_SH2_NCK_1	470	474	PF00017	0.489
LIG_SH2_PTP2	323	326	PF00017	0.460
LIG_SH2_SRC	288	291	PF00017	0.414
LIG_SH2_STAP1	201	205	PF00017	0.346
LIG_SH2_STAP1	453	457	PF00017	0.366
LIG_SH2_STAT3	201	204	PF00017	0.346
LIG_SH2_STAT3	635	638	PF00017	0.699
LIG_SH2_STAT5	323	326	PF00017	0.369
LIG_SH2_STAT5	445	448	PF00017	0.301
LIG_SH2_STAT5	522	525	PF00017	0.544
LIG_SH3_3	298	304	PF00018	0.506
LIG_SH3_3	458	464	PF00018	0.483
LIG_SH3_3	479	485	PF00018	0.419
LIG_SH3_CIN85_PxpxPR_1	587	592	PF14604	0.592
LIG_SUMO_SIM_anti_2	251	257	PF11976	0.423
LIG_SUMO_SIM_anti_2	422	429	PF11976	0.365
LIG_SUMO_SIM_anti_2	479	485	PF11976	0.331
LIG_SUMO_SIM_par_1	130	136	PF11976	0.210
LIG_SUMO_SIM_par_1	313	319	PF11976	0.336
LIG_SxIP_EBH_1	410	421	PF03271	0.546
LIG_TRAF2_1	626	629	PF00917	0.697
LIG_TRAF2_1	707	710	PF00917	0.787
LIG_TRAF2_1	711	714	PF00917	0.779
LIG_TRFH_1	727	731	PF08558	0.599
LIG_TYR_ITIM	451	456	PF00017	0.301
LIG_TYR_ITIM	461	466	PF00017	0.464
LIG_WRC_WIRS_1	174	179	PF05994	0.313
LIG_WRC_WIRS_1	185	190	PF05994	0.280
LIG_WRC_WIRS_1	508	513	PF05994	0.210
LIG_WW_1	670	673	PF00397	0.622
MOD_CDK_SPK_2	587	592	PF00069	0.585
MOD_CK1_1	282	288	PF00069	0.471
MOD_CK1_1	422	428	PF00069	0.360
MOD_CK1_1	436	442	PF00069	0.360
MOD_CK1_1	494	500	PF00069	0.349
MOD_CK1_1	516	522	PF00069	0.377
MOD_CK1_1	58	64	PF00069	0.719
MOD_CK1_1	640	646	PF00069	0.786
MOD_CK1_1	659	665	PF00069	0.689
MOD_CK1_1	669	675	PF00069	0.704
MOD_CK1_1	742	748	PF00069	0.697
MOD_CK2_1	41	47	PF00069	0.752
MOD_CK2_1	555	561	PF00069	0.692
MOD_CK2_1	648	654	PF00069	0.747
MOD_CK2_1	704	710	PF00069	0.745
MOD_GlcNHglycan	124	127	PF01048	0.542
MOD_GlcNHglycan	160	163	PF01048	0.264
MOD_GlcNHglycan	331	334	PF01048	0.349
MOD_GlcNHglycan	370	373	PF01048	0.388
MOD_GlcNHglycan	421	424	PF01048	0.210
MOD_GlcNHglycan	43	46	PF01048	0.481
MOD_GlcNHglycan	496	499	PF01048	0.422
MOD_GlcNHglycan	515	518	PF01048	0.171
MOD_GlcNHglycan	541	544	PF01048	0.467
MOD_GlcNHglycan	57	60	PF01048	0.432
MOD_GlcNHglycan	639	642	PF01048	0.561
MOD_GlcNHglycan	650	653	PF01048	0.490
MOD_GlcNHglycan	658	661	PF01048	0.436
MOD_GlcNHglycan	698	701	PF01048	0.560
MOD_GlcNHglycan	706	709	PF01048	0.519
MOD_GlcNHglycan	710	713	PF01048	0.502
MOD_GlcNHglycan	734	737	PF01048	0.518
MOD_GSK3_1	152	159	PF00069	0.464
MOD_GSK3_1	180	187	PF00069	0.376
MOD_GSK3_1	376	383	PF00069	0.358
MOD_GSK3_1	422	429	PF00069	0.416
MOD_GSK3_1	432	439	PF00069	0.345
MOD_GSK3_1	487	494	PF00069	0.260
MOD_GSK3_1	704	711	PF00069	0.747
MOD_GSK3_1	738	745	PF00069	0.691
MOD_N-GLC_1	190	195	PF02516	0.464
MOD_N-GLC_1	236	241	PF02516	0.479
MOD_N-GLC_1	648	653	PF02516	0.522
MOD_NEK2_1	164	169	PF00069	0.543
MOD_NEK2_1	315	320	PF00069	0.301
MOD_NEK2_1	375	380	PF00069	0.365
MOD_NEK2_1	419	424	PF00069	0.362
MOD_NEK2_1	426	431	PF00069	0.357
MOD_NEK2_1	432	437	PF00069	0.302
MOD_NEK2_1	440	445	PF00069	0.376
MOD_NEK2_1	491	496	PF00069	0.404
MOD_NEK2_1	648	653	PF00069	0.761
MOD_NEK2_1	738	743	PF00069	0.661
MOD_NEK2_2	679	684	PF00069	0.679
MOD_PIKK_1	338	344	PF00454	0.260
MOD_PIKK_1	742	748	PF00454	0.623
MOD_PKA_1	398	404	PF00069	0.464
MOD_PKA_1	48	54	PF00069	0.622
MOD_PKA_2	48	54	PF00069	0.622
MOD_PKA_2	6	12	PF00069	0.616
MOD_PKA_2	607	613	PF00069	0.732
MOD_PKA_2	73	79	PF00069	0.650
MOD_PKA_2	95	101	PF00069	0.481
MOD_Plk_1	190	196	PF00069	0.305
MOD_Plk_1	236	242	PF00069	0.212
MOD_Plk_1	338	344	PF00069	0.243
MOD_Plk_1	432	438	PF00069	0.321
MOD_Plk_1	679	685	PF00069	0.712
MOD_Plk_2-3	716	722	PF00069	0.677
MOD_Plk_4	133	139	PF00069	0.349
MOD_Plk_4	173	179	PF00069	0.361
MOD_Plk_4	180	186	PF00069	0.339
MOD_Plk_4	236	242	PF00069	0.331
MOD_Plk_4	251	257	PF00069	0.384
MOD_Plk_4	422	428	PF00069	0.328
MOD_Plk_4	433	439	PF00069	0.335
MOD_Plk_4	440	446	PF00069	0.431
MOD_Plk_4	452	458	PF00069	0.247
MOD_Plk_4	491	497	PF00069	0.386
MOD_Plk_4	507	513	PF00069	0.389
MOD_Plk_4	516	522	PF00069	0.361
MOD_Plk_4	595	601	PF00069	0.652
MOD_ProDKin_1	410	416	PF00069	0.506
MOD_ProDKin_1	571	577	PF00069	0.729
MOD_ProDKin_1	587	593	PF00069	0.586
MOD_ProDKin_1	666	672	PF00069	0.709
MOD_ProDKin_1	727	733	PF00069	0.743
MOD_ProDKin_1	739	745	PF00069	0.776
MOD_SUMO_rev_2	44	50	PF00179	0.666
TRG_DiLeu_BaLyEn_6	125	130	PF01217	0.460
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.481
TRG_ENDOCYTIC_2	194	197	PF00928	0.346
TRG_ENDOCYTIC_2	288	291	PF00928	0.414
TRG_ENDOCYTIC_2	362	365	PF00928	0.301
TRG_ENDOCYTIC_2	453	456	PF00928	0.301
TRG_ENDOCYTIC_2	463	466	PF00928	0.464
TRG_ENDOCYTIC_2	522	525	PF00928	0.568
TRG_ER_diArg_1	685	687	PF00400	0.728
TRG_ER_diArg_1	80	82	PF00400	0.640
TRG_ER_diArg_1	86	88	PF00400	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3U3	Leptomonas seymouri	68%	93%
A0A1X0NNQ0	Trypanosomatidae	62%	100%
A0A3R7M6P3	Trypanosoma rangeli	63%	100%
A0A3S7WSV4	Leishmania donovani	79%	94%
A0A3S7XA01	Leishmania donovani	34%	100%
A4HNB0	Leishmania braziliensis	35%	100%
A4HVX4	Leishmania infantum	79%	94%
A4IBY1	Leishmania infantum	35%	100%
E9AFR8	Leishmania major	35%	100%
E9APM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	94%
E9B6X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
Q5C8V6	Leishmania major	78%	100%
V5DDZ5	Trypanosoma cruzi	61%	100%