Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7I9_LEIBR

TriTrypDb:

LbrM.14.0300 , LBRM2903_140008100

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7I9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.545
CLV_C14_Caspase3-7	222	226	PF00656	0.406
CLV_NRD_NRD_1	26	28	PF00675	0.503
CLV_NRD_NRD_1	263	265	PF00675	0.462
CLV_NRD_NRD_1	45	47	PF00675	0.421
CLV_NRD_NRD_1	83	85	PF00675	0.438
CLV_PCSK_KEX2_1	25	27	PF00082	0.510
CLV_PCSK_KEX2_1	263	265	PF00082	0.462
CLV_PCSK_KEX2_1	45	47	PF00082	0.421
DEG_COP1_1	171	182	PF00400	0.536
DEG_Nend_UBRbox_3	1	3	PF02207	0.538
DOC_MAPK_gen_1	295	301	PF00069	0.487
DOC_PP2B_LxvP_1	3	6	PF13499	0.475
DOC_USP7_MATH_1	114	118	PF00917	0.474
DOC_USP7_MATH_1	18	22	PF00917	0.572
DOC_USP7_MATH_1	217	221	PF00917	0.589
DOC_USP7_UBL2_3	296	300	PF12436	0.483
DOC_USP7_UBL2_3	85	89	PF12436	0.458
DOC_WW_Pin1_4	110	115	PF00397	0.465
DOC_WW_Pin1_4	145	150	PF00397	0.566
DOC_WW_Pin1_4	212	217	PF00397	0.648
LIG_14-3-3_CanoR_1	25	30	PF00244	0.475
LIG_14-3-3_CanoR_1	263	268	PF00244	0.441
LIG_14-3-3_CanoR_1	45	55	PF00244	0.411
LIG_Actin_WH2_2	242	259	PF00022	0.487
LIG_BIR_III_2	184	188	PF00653	0.526
LIG_BRCT_BRCA1_1	270	274	PF00533	0.285
LIG_FHA_1	244	250	PF00498	0.439
LIG_FHA_1	264	270	PF00498	0.233
LIG_FHA_1	34	40	PF00498	0.531
LIG_FHA_1	51	57	PF00498	0.395
LIG_FHA_1	81	87	PF00498	0.375
LIG_FHA_2	110	116	PF00498	0.468
LIG_FHA_2	126	132	PF00498	0.475
LIG_LIR_Gen_1	117	127	PF02991	0.476
LIG_LIR_Gen_1	277	284	PF02991	0.427
LIG_LIR_Gen_1	28	35	PF02991	0.454
LIG_LIR_Nem_3	117	123	PF02991	0.468
LIG_LIR_Nem_3	277	281	PF02991	0.396
LIG_LIR_Nem_3	28	32	PF02991	0.459
LIG_LIR_Nem_3	282	288	PF02991	0.373
LIG_NRBOX	139	145	PF00104	0.480
LIG_Pex14_1	104	108	PF04695	0.301
LIG_Pex14_1	72	76	PF04695	0.520
LIG_Pex14_2	274	278	PF04695	0.416
LIG_SH2_CRK	108	112	PF00017	0.313
LIG_SH2_CRK	120	124	PF00017	0.485
LIG_SH2_STAT3	47	50	PF00017	0.386
LIG_SH2_STAT5	120	123	PF00017	0.476
LIG_SH2_STAT5	47	50	PF00017	0.386
LIG_SH2_STAT5	87	90	PF00017	0.389
LIG_SH3_3	174	180	PF00018	0.761
LIG_SUMO_SIM_par_1	36	44	PF11976	0.451
LIG_SxIP_EBH_1	9	23	PF03271	0.479
LIG_TYR_ITIM	118	123	PF00017	0.468
MOD_CDK_SPK_2	145	150	PF00069	0.566
MOD_CK1_1	109	115	PF00069	0.458
MOD_CK1_1	155	161	PF00069	0.689
MOD_CK1_1	211	217	PF00069	0.667
MOD_CK1_1	268	274	PF00069	0.286
MOD_CK1_1	40	46	PF00069	0.536
MOD_CK1_1	71	77	PF00069	0.465
MOD_CK1_1	95	101	PF00069	0.448
MOD_CK2_1	170	176	PF00069	0.683
MOD_CK2_1	249	255	PF00069	0.363
MOD_CK2_1	274	280	PF00069	0.424
MOD_GlcNHglycan	108	111	PF01048	0.259
MOD_GlcNHglycan	14	17	PF01048	0.737
MOD_GlcNHglycan	154	157	PF01048	0.694
MOD_GlcNHglycan	73	76	PF01048	0.549
MOD_GlcNHglycan	94	97	PF01048	0.390
MOD_GSK3_1	106	113	PF00069	0.506
MOD_GSK3_1	114	121	PF00069	0.465
MOD_GSK3_1	208	215	PF00069	0.683
MOD_GSK3_1	245	252	PF00069	0.438
MOD_GSK3_1	33	40	PF00069	0.507
MOD_GSK3_1	46	53	PF00069	0.460
MOD_NEK2_1	118	123	PF00069	0.489
MOD_NEK2_1	245	250	PF00069	0.402
MOD_NEK2_1	41	46	PF00069	0.587
MOD_PIKK_1	46	52	PF00454	0.377
MOD_PKA_1	25	31	PF00069	0.465
MOD_PKA_1	263	269	PF00069	0.435
MOD_PKA_2	25	31	PF00069	0.465
MOD_PKA_2	263	269	PF00069	0.435
MOD_PKB_1	25	33	PF00069	0.464
MOD_Plk_1	279	285	PF00069	0.417
MOD_Plk_4	114	120	PF00069	0.508
MOD_Plk_4	18	24	PF00069	0.476
MOD_Plk_4	245	251	PF00069	0.433
MOD_ProDKin_1	110	116	PF00069	0.468
MOD_ProDKin_1	145	151	PF00069	0.578
MOD_ProDKin_1	212	218	PF00069	0.641
MOD_SUMO_for_1	294	297	PF00179	0.475
TRG_DiLeu_BaEn_1	289	294	PF01217	0.457
TRG_DiLeu_BaEn_2	235	241	PF01217	0.357
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.474
TRG_ENDOCYTIC_2	108	111	PF00928	0.318
TRG_ENDOCYTIC_2	120	123	PF00928	0.476
TRG_ENDOCYTIC_2	242	245	PF00928	0.332
TRG_ER_diArg_1	24	27	PF00400	0.508
TRG_ER_diArg_1	45	47	PF00400	0.421
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F1	Leptomonas seymouri	52%	86%
A0A3Q8IBX5	Leishmania donovani	85%	100%
A4HVX2	Leishmania infantum	85%	100%
C9ZT50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9APM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QFV5	Leishmania major	85%	100%