Epimerase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7I8_LEIBR

TriTrypDb:

LbrM.14.0290 , LBRM2903_140008000

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7I8

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	1
GO:0006744	ubiquinone biosynthetic process	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0042180	cellular ketone metabolic process	3	1
GO:0042181	ketone biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901004	ubiquinone-6 metabolic process	6	1
GO:1901006	ubiquinone-6 biosynthetic process	7	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901661	quinone metabolic process	4	1
GO:1901663	quinone biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.415
CLV_NRD_NRD_1	172	174	PF00675	0.294
CLV_NRD_NRD_1	188	190	PF00675	0.639
CLV_PCSK_KEX2_1	188	190	PF00082	0.647
CLV_PCSK_KEX2_1	204	206	PF00082	0.394
CLV_PCSK_KEX2_1	48	50	PF00082	0.414
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.396
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.471
CLV_PCSK_SKI1_1	188	192	PF00082	0.624
CLV_PCSK_SKI1_1	194	198	PF00082	0.358
CLV_PCSK_SKI1_1	209	213	PF00082	0.284
CLV_PCSK_SKI1_1	231	235	PF00082	0.521
CLV_PCSK_SKI1_1	260	264	PF00082	0.554
CLV_PCSK_SKI1_1	3	7	PF00082	0.282
DEG_SPOP_SBC_1	79	83	PF00917	0.768
DOC_CKS1_1	67	72	PF01111	0.467
DOC_CYCLIN_yCln2_LP_2	271	274	PF00134	0.439
DOC_MAPK_MEF2A_6	269	277	PF00069	0.530
DOC_PP1_RVXF_1	1	8	PF00149	0.339
DOC_PP1_RVXF_1	104	111	PF00149	0.313
DOC_PP2B_LxvP_1	247	250	PF13499	0.563
DOC_PP2B_LxvP_1	270	273	PF13499	0.462
DOC_USP7_MATH_1	59	63	PF00917	0.590
DOC_USP7_MATH_1	79	83	PF00917	0.763
DOC_USP7_MATH_1	92	96	PF00917	0.511
DOC_USP7_UBL2_3	194	198	PF12436	0.568
DOC_WW_Pin1_4	38	43	PF00397	0.411
DOC_WW_Pin1_4	66	71	PF00397	0.671
DOC_WW_Pin1_4	74	79	PF00397	0.723
LIG_14-3-3_CanoR_1	245	250	PF00244	0.349
LIG_Actin_WH2_2	208	225	PF00022	0.383
LIG_Actin_WH2_2	303	321	PF00022	0.298
LIG_FHA_1	130	136	PF00498	0.367
LIG_FHA_1	228	234	PF00498	0.471
LIG_FHA_1	244	250	PF00498	0.524
LIG_FHA_1	62	68	PF00498	0.391
LIG_FHA_1	8	14	PF00498	0.313
LIG_FHA_2	114	120	PF00498	0.500
LIG_LIR_Gen_1	107	115	PF02991	0.408
LIG_LIR_Gen_1	119	129	PF02991	0.407
LIG_LIR_Nem_3	107	113	PF02991	0.392
LIG_LIR_Nem_3	119	125	PF02991	0.393
LIG_LIR_Nem_3	181	186	PF02991	0.506
LIG_LIR_Nem_3	23	29	PF02991	0.340
LIG_MAD2	174	182	PF02301	0.414
LIG_SH2_CRK	26	30	PF00017	0.396
LIG_SH2_STAP1	186	190	PF00017	0.612
LIG_SH2_STAT5	177	180	PF00017	0.431
LIG_SH2_STAT5	200	203	PF00017	0.375
LIG_SH3_1	85	91	PF00018	0.510
LIG_SH3_3	160	166	PF00018	0.492
LIG_SH3_3	218	224	PF00018	0.359
LIG_SH3_3	85	91	PF00018	0.746
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.363
LIG_SUMO_SIM_par_1	273	278	PF11976	0.377
LIG_UBA3_1	211	218	PF00899	0.278
MOD_CK2_1	314	320	PF00069	0.585
MOD_Cter_Amidation	202	205	PF01082	0.363
MOD_GlcNHglycan	178	181	PF01048	0.343
MOD_GlcNHglycan	311	314	PF01048	0.384
MOD_GlcNHglycan	82	85	PF01048	0.778
MOD_GSK3_1	109	116	PF00069	0.402
MOD_GSK3_1	38	45	PF00069	0.518
MOD_GSK3_1	59	66	PF00069	0.570
MOD_GSK3_1	74	81	PF00069	0.737
MOD_NEK2_1	234	239	PF00069	0.613
MOD_NEK2_1	63	68	PF00069	0.657
MOD_NEK2_1	7	12	PF00069	0.300
MOD_NEK2_2	92	97	PF00069	0.644
MOD_PKA_2	222	228	PF00069	0.435
MOD_PKA_2	59	65	PF00069	0.512
MOD_Plk_1	129	135	PF00069	0.377
MOD_Plk_1	92	98	PF00069	0.647
MOD_Plk_2-3	109	115	PF00069	0.409
MOD_Plk_4	12	18	PF00069	0.413
MOD_Plk_4	129	135	PF00069	0.441
MOD_Plk_4	222	228	PF00069	0.418
MOD_Plk_4	42	48	PF00069	0.360
MOD_ProDKin_1	38	44	PF00069	0.404
MOD_ProDKin_1	66	72	PF00069	0.676
MOD_ProDKin_1	74	80	PF00069	0.725
TRG_ENDOCYTIC_2	26	29	PF00928	0.396
TRG_ER_diArg_1	188	190	PF00400	0.660
TRG_ER_diLys_1	335	338	PF00400	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I087	Leptomonas seymouri	66%	97%
A0A0S4J2N0	Bodo saltans	32%	100%
A0A1X0NQ86	Trypanosomatidae	34%	100%
A0A3Q8I8Q3	Leishmania donovani	78%	100%
A0A422NX27	Trypanosoma rangeli	43%	100%
A4HVX1	Leishmania infantum	78%	100%
C9ZT51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9APM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QFV6	Leishmania major	82%	100%
Q9FVR6	Arabidopsis thaliana	24%	100%