Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleus and spindle associated protein 3, putative

Species:

Leishmania braziliensis

UniProt:

A4H7I7_LEIBR

TriTrypDb:

LbrM.14.0280 , LBRM2903_140007900

Length:

963

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H7I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7I7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.561
CLV_C14_Caspase3-7	299	303	PF00656	0.363
CLV_C14_Caspase3-7	362	366	PF00656	0.440
CLV_C14_Caspase3-7	673	677	PF00656	0.499
CLV_C14_Caspase3-7	87	91	PF00656	0.524
CLV_C14_Caspase3-7	925	929	PF00656	0.791
CLV_C14_Caspase3-7	930	934	PF00656	0.706
CLV_NRD_NRD_1	167	169	PF00675	0.530
CLV_NRD_NRD_1	222	224	PF00675	0.501
CLV_NRD_NRD_1	438	440	PF00675	0.521
CLV_NRD_NRD_1	459	461	PF00675	0.584
CLV_NRD_NRD_1	467	469	PF00675	0.556
CLV_NRD_NRD_1	540	542	PF00675	0.653
CLV_NRD_NRD_1	562	564	PF00675	0.541
CLV_NRD_NRD_1	599	601	PF00675	0.495
CLV_NRD_NRD_1	614	616	PF00675	0.617
CLV_NRD_NRD_1	634	636	PF00675	0.473
CLV_NRD_NRD_1	662	664	PF00675	0.498
CLV_NRD_NRD_1	772	774	PF00675	0.472
CLV_NRD_NRD_1	918	920	PF00675	0.774
CLV_PCSK_FUR_1	220	224	PF00082	0.465
CLV_PCSK_FUR_1	465	469	PF00082	0.640
CLV_PCSK_FUR_1	919	923	PF00082	0.763
CLV_PCSK_KEX2_1	191	193	PF00082	0.511
CLV_PCSK_KEX2_1	222	224	PF00082	0.500
CLV_PCSK_KEX2_1	438	440	PF00082	0.521
CLV_PCSK_KEX2_1	458	460	PF00082	0.354
CLV_PCSK_KEX2_1	467	469	PF00082	0.556
CLV_PCSK_KEX2_1	540	542	PF00082	0.653
CLV_PCSK_KEX2_1	562	564	PF00082	0.541
CLV_PCSK_KEX2_1	614	616	PF00082	0.617
CLV_PCSK_KEX2_1	634	636	PF00082	0.473
CLV_PCSK_KEX2_1	662	664	PF00082	0.589
CLV_PCSK_KEX2_1	772	774	PF00082	0.478
CLV_PCSK_KEX2_1	897	899	PF00082	0.631
CLV_PCSK_KEX2_1	921	923	PF00082	0.671
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.530
CLV_PCSK_PC1ET2_1	897	899	PF00082	0.713
CLV_PCSK_PC1ET2_1	921	923	PF00082	0.683
CLV_PCSK_PC7_1	630	636	PF00082	0.587
CLV_PCSK_PC7_1	658	664	PF00082	0.567
CLV_PCSK_SKI1_1	161	165	PF00082	0.431
CLV_PCSK_SKI1_1	169	173	PF00082	0.374
CLV_PCSK_SKI1_1	37	41	PF00082	0.492
CLV_PCSK_SKI1_1	397	401	PF00082	0.470
CLV_PCSK_SKI1_1	412	416	PF00082	0.567
CLV_PCSK_SKI1_1	431	435	PF00082	0.519
CLV_PCSK_SKI1_1	562	566	PF00082	0.430
CLV_PCSK_SKI1_1	594	598	PF00082	0.521
CLV_PCSK_SKI1_1	710	714	PF00082	0.472
CLV_PCSK_SKI1_1	823	827	PF00082	0.546
CLV_Separin_Metazoa	233	237	PF03568	0.518
DEG_APCC_DBOX_1	214	222	PF00400	0.439
DEG_APCC_DBOX_1	466	474	PF00400	0.627
DEG_APCC_DBOX_1	641	649	PF00400	0.582
DEG_APCC_DBOX_1	764	772	PF00400	0.430
DEG_COP1_1	205	214	PF00400	0.556
DEG_ODPH_VHL_1	507	519	PF01847	0.608
DEG_SCF_FBW7_1	846	853	PF00400	0.731
DEG_SPOP_SBC_1	860	864	PF00917	0.787
DOC_ANK_TNKS_1	814	821	PF00023	0.343
DOC_CYCLIN_RxL_1	166	176	PF00134	0.521
DOC_CYCLIN_RxL_1	428	437	PF00134	0.654
DOC_CYCLIN_yClb5_NLxxxL_5	349	358	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	354	360	PF00134	0.560
DOC_MAPK_DCC_7	642	650	PF00069	0.553
DOC_MAPK_gen_1	166	173	PF00069	0.493
DOC_MAPK_gen_1	597	606	PF00069	0.456
DOC_MAPK_gen_1	736	745	PF00069	0.450
DOC_MAPK_gen_1	772	778	PF00069	0.442
DOC_MAPK_gen_1	798	806	PF00069	0.447
DOC_MAPK_gen_1	897	907	PF00069	0.534
DOC_MAPK_MEF2A_6	223	232	PF00069	0.487
DOC_MAPK_MEF2A_6	600	608	PF00069	0.445
DOC_MAPK_MEF2A_6	736	745	PF00069	0.427
DOC_MAPK_NFAT4_5	601	609	PF00069	0.443
DOC_MAPK_RevD_3	602	615	PF00069	0.582
DOC_PP1_RVXF_1	50	57	PF00149	0.371
DOC_PP2B_LxvP_1	208	211	PF13499	0.437
DOC_PP2B_LxvP_1	354	357	PF13499	0.561
DOC_PP2B_LxvP_1	358	361	PF13499	0.572
DOC_PP4_FxxP_1	199	202	PF00568	0.597
DOC_PP4_FxxP_1	415	418	PF00568	0.600
DOC_USP7_MATH_1	226	230	PF00917	0.397
DOC_USP7_MATH_1	286	290	PF00917	0.326
DOC_USP7_MATH_1	475	479	PF00917	0.587
DOC_USP7_MATH_1	860	864	PF00917	0.740
DOC_USP7_MATH_1	906	910	PF00917	0.644
DOC_USP7_UBL2_3	187	191	PF12436	0.563
DOC_USP7_UBL2_3	597	601	PF12436	0.490
DOC_WW_Pin1_4	311	316	PF00397	0.669
DOC_WW_Pin1_4	421	426	PF00397	0.580
DOC_WW_Pin1_4	846	851	PF00397	0.706
LIG_14-3-3_CanoR_1	115	121	PF00244	0.334
LIG_14-3-3_CanoR_1	168	174	PF00244	0.501
LIG_14-3-3_CanoR_1	220	226	PF00244	0.545
LIG_14-3-3_CanoR_1	402	407	PF00244	0.562
LIG_14-3-3_CanoR_1	710	719	PF00244	0.384
LIG_14-3-3_CanoR_1	773	779	PF00244	0.482
LIG_14-3-3_CanoR_1	97	101	PF00244	0.512
LIG_APCC_ABBA_1	743	748	PF00400	0.388
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BRCT_BRCA1_1	436	440	PF00533	0.619
LIG_BRCT_BRCA1_1	477	481	PF00533	0.481
LIG_BRCT_BRCA1_1	821	825	PF00533	0.557
LIG_BRCT_BRCA1_1	92	96	PF00533	0.540
LIG_DLG_GKlike_1	402	409	PF00625	0.590
LIG_FHA_1	366	372	PF00498	0.467
LIG_FHA_1	525	531	PF00498	0.657
LIG_FHA_1	547	553	PF00498	0.701
LIG_FHA_1	683	689	PF00498	0.362
LIG_FHA_1	711	717	PF00498	0.400
LIG_FHA_1	724	730	PF00498	0.390
LIG_FHA_1	778	784	PF00498	0.471
LIG_FHA_1	792	798	PF00498	0.506
LIG_FHA_1	80	86	PF00498	0.487
LIG_FHA_1	847	853	PF00498	0.526
LIG_FHA_1	951	957	PF00498	0.707
LIG_FHA_2	183	189	PF00498	0.541
LIG_FHA_2	19	25	PF00498	0.310
LIG_FHA_2	261	267	PF00498	0.490
LIG_FHA_2	863	869	PF00498	0.667
LIG_LIR_Apic_2	196	202	PF02991	0.599
LIG_LIR_Apic_2	413	418	PF02991	0.581
LIG_LIR_Gen_1	181	190	PF02991	0.419
LIG_LIR_Gen_1	277	286	PF02991	0.525
LIG_LIR_Gen_1	374	384	PF02991	0.433
LIG_LIR_Gen_1	405	414	PF02991	0.542
LIG_LIR_Gen_1	442	450	PF02991	0.498
LIG_LIR_Gen_1	478	489	PF02991	0.473
LIG_LIR_Gen_1	496	504	PF02991	0.537
LIG_LIR_Gen_1	777	787	PF02991	0.425
LIG_LIR_Gen_1	840	851	PF02991	0.605
LIG_LIR_LC3C_4	205	210	PF02991	0.579
LIG_LIR_Nem_3	164	170	PF02991	0.382
LIG_LIR_Nem_3	172	177	PF02991	0.395
LIG_LIR_Nem_3	181	186	PF02991	0.427
LIG_LIR_Nem_3	277	282	PF02991	0.496
LIG_LIR_Nem_3	374	380	PF02991	0.452
LIG_LIR_Nem_3	405	409	PF02991	0.560
LIG_LIR_Nem_3	442	446	PF02991	0.481
LIG_LIR_Nem_3	478	484	PF02991	0.457
LIG_LIR_Nem_3	496	500	PF02991	0.507
LIG_LIR_Nem_3	569	575	PF02991	0.519
LIG_LIR_Nem_3	718	722	PF02991	0.509
LIG_LIR_Nem_3	777	782	PF02991	0.412
LIG_LIR_Nem_3	786	791	PF02991	0.548
LIG_LIR_Nem_3	840	846	PF02991	0.597
LIG_MLH1_MIPbox_1	477	481	PF16413	0.481
LIG_MLH1_MIPbox_1	821	825	PF16413	0.557
LIG_PCNA_PIPBox_1	427	436	PF02747	0.634
LIG_REV1ctd_RIR_1	822	830	PF16727	0.589
LIG_SH2_CRK	138	142	PF00017	0.586
LIG_SH2_CRK	183	187	PF00017	0.486
LIG_SH2_CRK	406	410	PF00017	0.519
LIG_SH2_CRK	497	501	PF00017	0.551
LIG_SH2_CRK	637	641	PF00017	0.555
LIG_SH2_CRK	788	792	PF00017	0.540
LIG_SH2_CRK	843	847	PF00017	0.718
LIG_SH2_NCK_1	497	501	PF00017	0.551
LIG_SH2_NCK_1	843	847	PF00017	0.761
LIG_SH2_PTP2	258	261	PF00017	0.580
LIG_SH2_STAP1	138	142	PF00017	0.609
LIG_SH2_STAP1	158	162	PF00017	0.354
LIG_SH2_STAP1	377	381	PF00017	0.431
LIG_SH2_STAP1	788	792	PF00017	0.442
LIG_SH2_STAT5	110	113	PF00017	0.399
LIG_SH2_STAT5	170	173	PF00017	0.500
LIG_SH2_STAT5	258	261	PF00017	0.535
LIG_SH2_STAT5	342	345	PF00017	0.438
LIG_SH2_STAT5	767	770	PF00017	0.480
LIG_SH2_STAT5	781	784	PF00017	0.291
LIG_SH2_STAT5	796	799	PF00017	0.382
LIG_SH3_3	174	180	PF00018	0.526
LIG_SH3_3	250	256	PF00018	0.645
LIG_SH3_3	388	394	PF00018	0.510
LIG_SH3_3	523	529	PF00018	0.609
LIG_SUMO_SIM_anti_2	205	212	PF11976	0.585
LIG_SUMO_SIM_anti_2	448	454	PF11976	0.554
LIG_SUMO_SIM_anti_2	801	808	PF11976	0.533
LIG_SUMO_SIM_anti_2	877	882	PF11976	0.517
LIG_SUMO_SIM_par_1	205	212	PF11976	0.559
LIG_SUMO_SIM_par_1	801	808	PF11976	0.533
LIG_SxIP_EBH_1	238	247	PF03271	0.560
LIG_TRAF2_1	122	125	PF00917	0.694
LIG_TRAF2_1	376	379	PF00917	0.505
LIG_TRAF2_1	912	915	PF00917	0.785
LIG_TRFH_1	406	410	PF08558	0.478
LIG_TYR_ITIM	136	141	PF00017	0.678
LIG_UBA3_1	162	169	PF00899	0.306
LIG_WRC_WIRS_1	716	721	PF05994	0.520
MOD_CK1_1	119	125	PF00069	0.608
MOD_CK1_1	316	322	PF00069	0.652
MOD_CK1_1	543	549	PF00069	0.682
MOD_CK1_1	641	647	PF00069	0.558
MOD_CK1_1	723	729	PF00069	0.503
MOD_CK1_1	79	85	PF00069	0.474
MOD_CK1_1	844	850	PF00069	0.622
MOD_CK1_1	892	898	PF00069	0.754
MOD_CK1_1	909	915	PF00069	0.749
MOD_CK2_1	119	125	PF00069	0.671
MOD_CK2_1	127	133	PF00069	0.689
MOD_CK2_1	260	266	PF00069	0.451
MOD_CK2_1	66	72	PF00069	0.595
MOD_CK2_1	667	673	PF00069	0.512
MOD_CK2_1	862	868	PF00069	0.660
MOD_CK2_1	909	915	PF00069	0.761
MOD_GlcNHglycan	130	133	PF01048	0.610
MOD_GlcNHglycan	150	153	PF01048	0.450
MOD_GlcNHglycan	18	21	PF01048	0.308
MOD_GlcNHglycan	288	291	PF01048	0.346
MOD_GlcNHglycan	3	6	PF01048	0.624
MOD_GlcNHglycan	317	321	PF01048	0.640
MOD_GlcNHglycan	344	347	PF01048	0.537
MOD_GlcNHglycan	546	549	PF01048	0.711
MOD_GlcNHglycan	60	63	PF01048	0.546
MOD_GSK3_1	115	122	PF00069	0.537
MOD_GSK3_1	169	176	PF00069	0.497
MOD_GSK3_1	18	25	PF00069	0.353
MOD_GSK3_1	294	301	PF00069	0.574
MOD_GSK3_1	316	323	PF00069	0.621
MOD_GSK3_1	338	345	PF00069	0.597
MOD_GSK3_1	484	491	PF00069	0.565
MOD_GSK3_1	540	547	PF00069	0.698
MOD_GSK3_1	58	65	PF00069	0.548
MOD_GSK3_1	663	670	PF00069	0.580
MOD_GSK3_1	751	758	PF00069	0.515
MOD_GSK3_1	837	844	PF00069	0.651
MOD_GSK3_1	846	853	PF00069	0.684
MOD_GSK3_1	905	912	PF00069	0.601
MOD_GSK3_1	922	929	PF00069	0.568
MOD_N-GLC_1	249	254	PF02516	0.632
MOD_N-GLC_1	622	627	PF02516	0.597
MOD_N-GLC_1	723	728	PF02516	0.546
MOD_N-GLC_2	513	515	PF02516	0.563
MOD_N-GLC_2	568	570	PF02516	0.562
MOD_NEK2_1	1	6	PF00069	0.640
MOD_NEK2_1	173	178	PF00069	0.412
MOD_NEK2_1	18	23	PF00069	0.384
MOD_NEK2_1	221	226	PF00069	0.503
MOD_NEK2_1	274	279	PF00069	0.533
MOD_NEK2_1	327	332	PF00069	0.648
MOD_NEK2_1	349	354	PF00069	0.559
MOD_NEK2_1	433	438	PF00069	0.566
MOD_NEK2_1	488	493	PF00069	0.621
MOD_NEK2_1	66	71	PF00069	0.626
MOD_NEK2_1	720	725	PF00069	0.543
MOD_NEK2_1	746	751	PF00069	0.402
MOD_NEK2_1	771	776	PF00069	0.506
MOD_NEK2_1	839	844	PF00069	0.691
MOD_NEK2_1	852	857	PF00069	0.602
MOD_NEK2_1	96	101	PF00069	0.424
MOD_NEK2_2	116	121	PF00069	0.590
MOD_NEK2_2	383	388	PF00069	0.441
MOD_NEK2_2	410	415	PF00069	0.525
MOD_NEK2_2	475	480	PF00069	0.585
MOD_PIKK_1	682	688	PF00454	0.561
MOD_PIKK_1	850	856	PF00454	0.652
MOD_PKA_1	540	546	PF00069	0.679
MOD_PKA_2	214	220	PF00069	0.449
MOD_PKA_2	221	227	PF00069	0.451
MOD_PKA_2	434	440	PF00069	0.649
MOD_PKA_2	540	546	PF00069	0.668
MOD_PKA_2	641	647	PF00069	0.507
MOD_PKA_2	682	688	PF00069	0.360
MOD_PKA_2	771	777	PF00069	0.544
MOD_PKA_2	96	102	PF00069	0.528
MOD_PKB_1	898	906	PF00069	0.533
MOD_Plk_1	23	29	PF00069	0.464
MOD_Plk_1	249	255	PF00069	0.644
MOD_Plk_1	316	322	PF00069	0.640
MOD_Plk_1	62	68	PF00069	0.646
MOD_Plk_1	831	837	PF00069	0.439
MOD_Plk_2-3	910	916	PF00069	0.543
MOD_Plk_2-3	940	946	PF00069	0.539
MOD_Plk_4	103	109	PF00069	0.508
MOD_Plk_4	142	148	PF00069	0.576
MOD_Plk_4	169	175	PF00069	0.515
MOD_Plk_4	214	220	PF00069	0.543
MOD_Plk_4	23	29	PF00069	0.416
MOD_Plk_4	240	246	PF00069	0.607
MOD_Plk_4	274	280	PF00069	0.391
MOD_Plk_4	338	344	PF00069	0.494
MOD_Plk_4	410	416	PF00069	0.566
MOD_Plk_4	475	481	PF00069	0.477
MOD_Plk_4	688	694	PF00069	0.328
MOD_Plk_4	715	721	PF00069	0.517
MOD_Plk_4	774	780	PF00069	0.420
MOD_Plk_4	799	805	PF00069	0.413
MOD_Plk_4	834	840	PF00069	0.628
MOD_ProDKin_1	311	317	PF00069	0.665
MOD_ProDKin_1	421	427	PF00069	0.577
MOD_ProDKin_1	846	852	PF00069	0.708
MOD_SUMO_for_1	261	264	PF00179	0.584
TRG_DiLeu_BaEn_1	442	447	PF01217	0.528
TRG_DiLeu_BaEn_4	502	508	PF01217	0.519
TRG_ENDOCYTIC_2	138	141	PF00928	0.589
TRG_ENDOCYTIC_2	170	173	PF00928	0.413
TRG_ENDOCYTIC_2	183	186	PF00928	0.396
TRG_ENDOCYTIC_2	377	380	PF00928	0.423
TRG_ENDOCYTIC_2	406	409	PF00928	0.488
TRG_ENDOCYTIC_2	497	500	PF00928	0.556
TRG_ENDOCYTIC_2	637	640	PF00928	0.542
TRG_ENDOCYTIC_2	788	791	PF00928	0.520
TRG_ENDOCYTIC_2	843	846	PF00928	0.734
TRG_ENDOCYTIC_2	957	960	PF00928	0.532
TRG_ER_diArg_1	219	222	PF00400	0.459
TRG_ER_diArg_1	438	440	PF00400	0.521
TRG_ER_diArg_1	457	460	PF00400	0.433
TRG_ER_diArg_1	465	468	PF00400	0.564
TRG_ER_diArg_1	539	541	PF00400	0.461
TRG_ER_diArg_1	562	564	PF00400	0.543
TRG_ER_diArg_1	614	616	PF00400	0.619
TRG_ER_diArg_1	661	663	PF00400	0.578
TRG_ER_diArg_1	771	773	PF00400	0.468
TRG_ER_diArg_1	821	824	PF00400	0.458
TRG_NLS_MonoCore_2	918	923	PF00514	0.791
TRG_NLS_MonoExtC_3	918	923	PF00514	0.787
TRG_NLS_MonoExtN_4	918	925	PF00514	0.785
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	638	643	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK9	Leptomonas seymouri	79%	100%
A0A0S4IYU3	Bodo saltans	27%	83%
A0A1X0NQD8	Trypanosomatidae	46%	91%
A0A3S7WST9	Leishmania donovani	90%	100%
A0A422NXF4	Trypanosoma rangeli	47%	95%
A4HVX0	Leishmania infantum	88%	100%
C9ZT54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	93%
E9APM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QFV7	Leishmania major	89%	99%
V5BHS0	Trypanosoma cruzi	48%	95%