VWFA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

von Willebrand factor type A domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7I6_LEIBR

TriTrypDb:

LbrM.14.0260 , LBRM2903_140007700

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7I6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	526	530	PF00656	0.409
CLV_C14_Caspase3-7	549	553	PF00656	0.523
CLV_C14_Caspase3-7	664	668	PF00656	0.592
CLV_MEL_PAP_1	582	588	PF00089	0.482
CLV_NRD_NRD_1	700	702	PF00675	0.587
CLV_PCSK_FUR_1	698	702	PF00082	0.630
CLV_PCSK_KEX2_1	700	702	PF00082	0.589
CLV_PCSK_SKI1_1	15	19	PF00082	0.501
CLV_PCSK_SKI1_1	184	188	PF00082	0.486
CLV_PCSK_SKI1_1	415	419	PF00082	0.480
CLV_PCSK_SKI1_1	471	475	PF00082	0.227
CLV_PCSK_SKI1_1	546	550	PF00082	0.608
CLV_Separin_Metazoa	267	271	PF03568	0.452
DEG_APCC_DBOX_1	179	187	PF00400	0.640
DEG_APCC_DBOX_1	470	478	PF00400	0.227
DEG_Nend_UBRbox_2	1	3	PF02207	0.769
DEG_SPOP_SBC_1	489	493	PF00917	0.564
DOC_CYCLIN_RxL_1	21	32	PF00134	0.548
DOC_MAPK_gen_1	456	465	PF00069	0.419
DOC_MAPK_MEF2A_6	249	258	PF00069	0.584
DOC_PP2B_LxvP_1	201	204	PF13499	0.549
DOC_PP2B_LxvP_1	277	280	PF13499	0.487
DOC_PP4_FxxP_1	153	156	PF00568	0.497
DOC_USP7_MATH_1	128	132	PF00917	0.481
DOC_USP7_MATH_1	282	286	PF00917	0.519
DOC_USP7_MATH_1	327	331	PF00917	0.451
DOC_USP7_MATH_1	334	338	PF00917	0.454
DOC_USP7_MATH_1	363	367	PF00917	0.426
DOC_USP7_MATH_1	373	377	PF00917	0.378
DOC_USP7_MATH_1	386	390	PF00917	0.447
DOC_USP7_MATH_1	481	485	PF00917	0.431
DOC_USP7_MATH_1	488	492	PF00917	0.637
DOC_USP7_MATH_1	506	510	PF00917	0.484
DOC_USP7_MATH_1	551	555	PF00917	0.405
DOC_USP7_MATH_1	6	10	PF00917	0.599
DOC_USP7_MATH_1	602	606	PF00917	0.560
DOC_USP7_MATH_1	712	716	PF00917	0.567
DOC_USP7_MATH_1	94	98	PF00917	0.623
DOC_WW_Pin1_4	285	290	PF00397	0.622
DOC_WW_Pin1_4	390	395	PF00397	0.440
DOC_WW_Pin1_4	398	403	PF00397	0.474
DOC_WW_Pin1_4	540	545	PF00397	0.672
DOC_WW_Pin1_4	598	603	PF00397	0.585
DOC_WW_Pin1_4	657	662	PF00397	0.462
LIG_14-3-3_CanoR_1	184	193	PF00244	0.325
LIG_14-3-3_CanoR_1	206	212	PF00244	0.565
LIG_14-3-3_CanoR_1	259	269	PF00244	0.575
LIG_14-3-3_CanoR_1	270	276	PF00244	0.580
LIG_14-3-3_CanoR_1	415	425	PF00244	0.454
LIG_14-3-3_CanoR_1	459	464	PF00244	0.383
LIG_14-3-3_CanoR_1	505	514	PF00244	0.519
LIG_14-3-3_CanoR_1	655	659	PF00244	0.460
LIG_14-3-3_CanoR_1	687	697	PF00244	0.498
LIG_14-3-3_CanoR_1	93	99	PF00244	0.662
LIG_APCC_ABBA_1	517	522	PF00400	0.332
LIG_BRCT_BRCA1_1	3	7	PF00533	0.709
LIG_Clathr_ClatBox_1	208	212	PF01394	0.564
LIG_eIF4E_1	561	567	PF01652	0.291
LIG_EVH1_1	64	68	PF00568	0.514
LIG_FHA_1	117	123	PF00498	0.528
LIG_FHA_1	146	152	PF00498	0.526
LIG_FHA_1	213	219	PF00498	0.535
LIG_FHA_1	272	278	PF00498	0.577
LIG_FHA_1	286	292	PF00498	0.581
LIG_FHA_1	339	345	PF00498	0.419
LIG_FHA_1	356	362	PF00498	0.150
LIG_FHA_1	416	422	PF00498	0.424
LIG_FHA_1	52	58	PF00498	0.535
LIG_FHA_1	561	567	PF00498	0.560
LIG_FHA_1	633	639	PF00498	0.586
LIG_FHA_2	185	191	PF00498	0.586
LIG_FHA_2	519	525	PF00498	0.497
LIG_FHA_2	547	553	PF00498	0.506
LIG_FHA_2	662	668	PF00498	0.590
LIG_FHA_2	689	695	PF00498	0.476
LIG_Integrin_RGD_1	243	245	PF01839	0.316
LIG_LIR_Apic_2	150	156	PF02991	0.491
LIG_LIR_Apic_2	653	659	PF02991	0.459
LIG_LIR_Gen_1	248	258	PF02991	0.582
LIG_LIR_Gen_1	4	11	PF02991	0.418
LIG_LIR_Gen_1	660	667	PF02991	0.471
LIG_LIR_Nem_3	22	26	PF02991	0.281
LIG_LIR_Nem_3	4	10	PF02991	0.670
LIG_LIR_Nem_3	660	665	PF02991	0.586
LIG_NRBOX	566	572	PF00104	0.531
LIG_SH2_CRK	23	27	PF00017	0.517
LIG_SH2_CRK	656	660	PF00017	0.520
LIG_SH2_CRK	662	666	PF00017	0.527
LIG_SH2_GRB2like	50	53	PF00017	0.391
LIG_SH2_NCK_1	449	453	PF00017	0.227
LIG_SH2_NCK_1	656	660	PF00017	0.329
LIG_SH2_SRC	27	30	PF00017	0.264
LIG_SH2_STAP1	40	44	PF00017	0.431
LIG_SH2_STAP1	593	597	PF00017	0.341
LIG_SH2_STAT3	40	43	PF00017	0.400
LIG_SH2_STAT3	561	564	PF00017	0.300
LIG_SH2_STAT3	70	73	PF00017	0.559
LIG_SH2_STAT5	121	124	PF00017	0.327
LIG_SH2_STAT5	173	176	PF00017	0.551
LIG_SH2_STAT5	27	30	PF00017	0.405
LIG_SH2_STAT5	425	428	PF00017	0.355
LIG_SH2_STAT5	50	53	PF00017	0.423
LIG_SH2_STAT5	593	596	PF00017	0.482
LIG_SH2_STAT5	633	636	PF00017	0.465
LIG_SH2_STAT5	656	659	PF00017	0.483
LIG_SH2_STAT5	662	665	PF00017	0.507
LIG_SH3_3	272	278	PF00018	0.651
LIG_SH3_3	281	287	PF00018	0.680
LIG_SH3_3	399	405	PF00018	0.438
LIG_SH3_3	536	542	PF00018	0.669
LIG_SH3_3	62	68	PF00018	0.505
LIG_SH3_3	679	685	PF00018	0.609
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.227
LIG_SUMO_SIM_par_1	207	212	PF11976	0.520
LIG_SUMO_SIM_par_1	314	321	PF11976	0.392
LIG_SUMO_SIM_par_1	428	434	PF11976	0.378
LIG_SUMO_SIM_par_1	44	49	PF11976	0.509
LIG_SUMO_SIM_par_1	515	522	PF11976	0.536
LIG_SxIP_EBH_1	153	165	PF03271	0.558
LIG_SxIP_EBH_1	414	427	PF03271	0.480
LIG_TRAF2_1	11	14	PF00917	0.612
LIG_TRAF2_1	187	190	PF00917	0.398
LIG_TYR_ITIM	566	571	PF00017	0.490
LIG_WW_1	67	70	PF00397	0.494
MOD_CDC14_SPxK_1	543	546	PF00782	0.615
MOD_CDK_SPK_2	390	395	PF00069	0.368
MOD_CDK_SPxK_1	540	546	PF00069	0.657
MOD_CK1_1	285	291	PF00069	0.671
MOD_CK1_1	330	336	PF00069	0.389
MOD_CK1_1	484	490	PF00069	0.607
MOD_CK1_1	605	611	PF00069	0.632
MOD_CK1_1	660	666	PF00069	0.476
MOD_CK1_1	85	91	PF00069	0.528
MOD_CK1_1	9	15	PF00069	0.623
MOD_CK2_1	184	190	PF00069	0.598
MOD_CK2_1	488	494	PF00069	0.496
MOD_CK2_1	518	524	PF00069	0.485
MOD_CK2_1	639	645	PF00069	0.503
MOD_CK2_1	688	694	PF00069	0.472
MOD_GlcNHglycan	101	104	PF01048	0.685
MOD_GlcNHglycan	114	117	PF01048	0.502
MOD_GlcNHglycan	142	145	PF01048	0.500
MOD_GlcNHglycan	2	6	PF01048	0.669
MOD_GlcNHglycan	332	335	PF01048	0.405
MOD_GlcNHglycan	369	372	PF01048	0.496
MOD_GlcNHglycan	37	40	PF01048	0.467
MOD_GlcNHglycan	390	393	PF01048	0.301
MOD_GlcNHglycan	486	489	PF01048	0.580
MOD_GlcNHglycan	497	500	PF01048	0.354
MOD_GlcNHglycan	508	511	PF01048	0.434
MOD_GlcNHglycan	534	537	PF01048	0.499
MOD_GlcNHglycan	572	575	PF01048	0.552
MOD_GlcNHglycan	595	598	PF01048	0.595
MOD_GlcNHglycan	641	644	PF01048	0.488
MOD_GlcNHglycan	669	672	PF01048	0.692
MOD_GlcNHglycan	83	87	PF01048	0.555
MOD_GSK3_1	1	8	PF00069	0.557
MOD_GSK3_1	112	119	PF00069	0.572
MOD_GSK3_1	138	145	PF00069	0.552
MOD_GSK3_1	151	158	PF00069	0.518
MOD_GSK3_1	295	302	PF00069	0.304
MOD_GSK3_1	330	337	PF00069	0.458
MOD_GSK3_1	363	370	PF00069	0.480
MOD_GSK3_1	386	393	PF00069	0.292
MOD_GSK3_1	430	437	PF00069	0.379
MOD_GSK3_1	484	491	PF00069	0.589
MOD_GSK3_1	598	605	PF00069	0.638
MOD_GSK3_1	617	624	PF00069	0.536
MOD_GSK3_1	650	657	PF00069	0.490
MOD_GSK3_1	663	670	PF00069	0.541
MOD_GSK3_1	85	92	PF00069	0.586
MOD_N-GLC_1	51	56	PF02516	0.396
MOD_NEK2_1	109	114	PF00069	0.639
MOD_NEK2_1	19	24	PF00069	0.558
MOD_NEK2_1	221	226	PF00069	0.652
MOD_NEK2_1	238	243	PF00069	0.306
MOD_NEK2_1	271	276	PF00069	0.371
MOD_NEK2_1	295	300	PF00069	0.447
MOD_NEK2_1	338	343	PF00069	0.474
MOD_NEK2_1	570	575	PF00069	0.528
MOD_NEK2_1	591	596	PF00069	0.553
MOD_NEK2_1	621	626	PF00069	0.469
MOD_NEK2_1	650	655	PF00069	0.466
MOD_NEK2_1	710	715	PF00069	0.466
MOD_NEK2_1	72	77	PF00069	0.373
MOD_PIKK_1	116	122	PF00454	0.475
MOD_PIKK_1	184	190	PF00454	0.519
MOD_PIKK_1	434	440	PF00454	0.421
MOD_PIKK_1	560	566	PF00454	0.442
MOD_PIKK_1	650	656	PF00454	0.339
MOD_PIKK_1	688	694	PF00454	0.472
MOD_PIKK_1	9	15	PF00454	0.610
MOD_PK_1	459	465	PF00069	0.227
MOD_PKA_2	654	660	PF00069	0.386
MOD_PKB_1	182	190	PF00069	0.356
MOD_Plk_1	693	699	PF00069	0.481
MOD_Plk_2-3	518	524	PF00069	0.344
MOD_Plk_4	128	134	PF00069	0.426
MOD_Plk_4	155	161	PF00069	0.495
MOD_Plk_4	327	333	PF00069	0.459
MOD_Plk_4	357	363	PF00069	0.453
MOD_Plk_4	373	379	PF00069	0.335
MOD_Plk_4	403	409	PF00069	0.441
MOD_Plk_4	617	623	PF00069	0.500
MOD_Plk_4	72	78	PF00069	0.357
MOD_ProDKin_1	285	291	PF00069	0.604
MOD_ProDKin_1	390	396	PF00069	0.440
MOD_ProDKin_1	398	404	PF00069	0.474
MOD_ProDKin_1	540	546	PF00069	0.662
MOD_ProDKin_1	598	604	PF00069	0.600
MOD_ProDKin_1	657	663	PF00069	0.462
MOD_SUMO_for_1	381	384	PF00179	0.480
MOD_SUMO_rev_2	606	615	PF00179	0.525
MOD_SUMO_rev_2	670	678	PF00179	0.720
TRG_DiLeu_BaEn_1	14	19	PF01217	0.543
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.539
TRG_ENDOCYTIC_2	173	176	PF00928	0.523
TRG_ENDOCYTIC_2	23	26	PF00928	0.525
TRG_ENDOCYTIC_2	251	254	PF00928	0.622
TRG_ENDOCYTIC_2	568	571	PF00928	0.490
TRG_ENDOCYTIC_2	662	665	PF00928	0.511
TRG_ER_diArg_1	180	183	PF00400	0.602
TRG_ER_diArg_1	697	700	PF00400	0.620
TRG_NES_CRM1_1	200	212	PF08389	0.446
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B7	Leptomonas seymouri	42%	97%
A0A1X0NPD4	Trypanosomatidae	27%	85%
A0A3S5H6R0	Leishmania donovani	77%	99%
A0A422NXB2	Trypanosoma rangeli	28%	86%
A4HVW8	Leishmania infantum	78%	99%
C9ZT55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	85%
E9APL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
Q4QFV9	Leishmania major	77%	100%
V5AXR7	Trypanosoma cruzi	28%	86%