HIT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HIT domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7I4_LEIBR

TriTrypDb:

LbrM.14.0240 , LBRM2903_140007500

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7I4

PDB structure(s): 3ksv_A

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	106	108	PF00082	0.247
CLV_PCSK_KEX2_1	132	134	PF00082	0.670
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.259
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.670
CLV_PCSK_SKI1_1	9	13	PF00082	0.636
DOC_PP1_RVXF_1	112	118	PF00149	0.641
DOC_PP2B_LxvP_1	41	44	PF13499	0.509
DOC_USP7_MATH_1	21	25	PF00917	0.612
DOC_USP7_MATH_1	67	71	PF00917	0.567
LIG_14-3-3_CanoR_1	133	141	PF00244	0.591

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q7	Leptomonas seymouri	73%	100%
A0A0S4JN40	Bodo saltans	34%	81%
A0A1X0NNT0	Trypanosomatidae	61%	100%
A0A3S5IS68	Trypanosoma rangeli	61%	100%
A0A3S7WSU6	Leishmania donovani	85%	100%
A4HVW6	Leishmania infantum	85%	100%
C4LYI2	Entamoeba histolytica	42%	100%
C9ZT59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9APL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
F4K1R2	Arabidopsis thaliana	34%	72%

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