DUF4201 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4201), putative

Species:

Leishmania braziliensis

UniProt:

A4H7I1_LEIBR

TriTrypDb:

LbrM.14.0210 , LBRM2903_140007200

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005856	cytoskeleton	5	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4H7I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7I1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.595
CLV_C14_Caspase3-7	274	278	PF00656	0.752
CLV_C14_Caspase3-7	61	65	PF00656	0.712
CLV_C14_Caspase3-7	67	71	PF00656	0.475
CLV_NRD_NRD_1	107	109	PF00675	0.401
CLV_NRD_NRD_1	131	133	PF00675	0.487
CLV_NRD_NRD_1	200	202	PF00675	0.480
CLV_NRD_NRD_1	24	26	PF00675	0.479
CLV_NRD_NRD_1	253	255	PF00675	0.509
CLV_NRD_NRD_1	369	371	PF00675	0.245
CLV_NRD_NRD_1	398	400	PF00675	0.219
CLV_NRD_NRD_1	41	43	PF00675	0.445
CLV_NRD_NRD_1	9	11	PF00675	0.588
CLV_PCSK_FUR_1	251	255	PF00082	0.564
CLV_PCSK_KEX2_1	107	109	PF00082	0.406
CLV_PCSK_KEX2_1	130	132	PF00082	0.598
CLV_PCSK_KEX2_1	24	26	PF00082	0.493
CLV_PCSK_KEX2_1	253	255	PF00082	0.575
CLV_PCSK_KEX2_1	367	369	PF00082	0.219
CLV_PCSK_KEX2_1	398	400	PF00082	0.245
CLV_PCSK_KEX2_1	41	43	PF00082	0.430
CLV_PCSK_KEX2_1	9	11	PF00082	0.587
CLV_PCSK_KEX2_1	93	95	PF00082	0.544
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.428
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.219
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.286
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.603
CLV_PCSK_SKI1_1	102	106	PF00082	0.457
CLV_PCSK_SKI1_1	108	112	PF00082	0.444
CLV_PCSK_SKI1_1	254	258	PF00082	0.549
CLV_PCSK_SKI1_1	390	394	PF00082	0.233
CLV_PCSK_SKI1_1	418	422	PF00082	0.245
CLV_PCSK_SKI1_1	42	46	PF00082	0.571
DEG_APCC_DBOX_1	331	339	PF00400	0.518
DEG_APCC_DBOX_1	406	414	PF00400	0.502
DEG_Nend_Nbox_1	1	3	PF02207	0.572
DEG_SCF_FBW7_2	141	147	PF00400	0.542
DOC_CKS1_1	141	146	PF01111	0.550
DOC_CYCLIN_RxL_1	106	113	PF00134	0.530
DOC_MAPK_gen_1	199	209	PF00069	0.404
DOC_MAPK_gen_1	318	327	PF00069	0.419
DOC_MAPK_gen_1	379	386	PF00069	0.518
DOC_PP2B_LxvP_1	51	54	PF13499	0.442
DOC_USP7_MATH_1	165	169	PF00917	0.498
DOC_USP7_MATH_1	17	21	PF00917	0.480
DOC_USP7_MATH_1	230	234	PF00917	0.383
DOC_USP7_MATH_1	261	265	PF00917	0.726
DOC_USP7_MATH_1	40	44	PF00917	0.457
DOC_USP7_MATH_1	84	88	PF00917	0.577
DOC_USP7_UBL2_3	316	320	PF12436	0.431
DOC_WW_Pin1_4	140	145	PF00397	0.546
DOC_WW_Pin1_4	259	264	PF00397	0.454
DOC_WW_Pin1_4	70	75	PF00397	0.668
LIG_14-3-3_CanoR_1	208	217	PF00244	0.420
LIG_14-3-3_CanoR_1	41	45	PF00244	0.612
LIG_BRCT_BRCA1_1	205	209	PF00533	0.507
LIG_CaM_IQ_9	19	35	PF13499	0.427
LIG_CaM_IQ_9	240	256	PF13499	0.530
LIG_Clathr_ClatBox_1	290	294	PF01394	0.419
LIG_FHA_1	216	222	PF00498	0.403
LIG_FHA_1	320	326	PF00498	0.419
LIG_FHA_1	406	412	PF00498	0.518
LIG_FHA_1	419	425	PF00498	0.498
LIG_FHA_2	140	146	PF00498	0.594
LIG_FHA_2	272	278	PF00498	0.666
LIG_FHA_2	300	306	PF00498	0.357
LIG_FHA_2	350	356	PF00498	0.428
LIG_LIR_Gen_1	292	298	PF02991	0.419
LIG_LIR_Nem_3	147	153	PF02991	0.490
LIG_LIR_Nem_3	292	296	PF02991	0.419
LIG_LIR_Nem_3	99	104	PF02991	0.397
LIG_PCNA_PIPBox_1	119	128	PF02747	0.441
LIG_Pex14_2	289	293	PF04695	0.518
LIG_PTB_Apo_2	74	81	PF02174	0.682
LIG_SH2_CRK	101	105	PF00017	0.416
LIG_SH2_CRK	118	122	PF00017	0.385
LIG_SH2_NCK_1	2	6	PF00017	0.627
LIG_SH2_SRC	182	185	PF00017	0.516
LIG_SH2_SRC	2	5	PF00017	0.602
LIG_SH2_STAT3	126	129	PF00017	0.559
LIG_SH2_STAT5	224	227	PF00017	0.520
LIG_SH2_STAT5	242	245	PF00017	0.320
LIG_SUMO_SIM_anti_2	46	53	PF11976	0.662
LIG_TRAF2_1	190	193	PF00917	0.452
LIG_TRAF2_1	352	355	PF00917	0.447
LIG_TYR_ITIM	116	121	PF00017	0.483
LIG_TYR_ITIM	240	245	PF00017	0.430
LIG_UBA3_1	249	257	PF00899	0.526
MOD_CK1_1	262	268	PF00069	0.697
MOD_CK1_1	319	325	PF00069	0.357
MOD_CK1_1	43	49	PF00069	0.573
MOD_CK1_1	73	79	PF00069	0.738
MOD_CK2_1	299	305	PF00069	0.493
MOD_CK2_1	348	354	PF00069	0.429
MOD_GlcNHglycan	167	170	PF01048	0.455
MOD_GlcNHglycan	232	235	PF01048	0.443
MOD_GlcNHglycan	266	269	PF01048	0.724
MOD_GlcNHglycan	46	49	PF01048	0.508
MOD_GSK3_1	136	143	PF00069	0.673
MOD_GSK3_1	267	274	PF00069	0.726
MOD_GSK3_1	40	47	PF00069	0.597
MOD_GSK3_1	426	433	PF00069	0.561
MOD_LATS_1	373	379	PF00433	0.518
MOD_N-GLC_1	299	304	PF02516	0.293
MOD_NEK2_1	203	208	PF00069	0.440
MOD_NEK2_1	209	214	PF00069	0.414
MOD_NEK2_1	363	368	PF00069	0.429
MOD_NEK2_1	44	49	PF00069	0.660
MOD_NEK2_1	83	88	PF00069	0.631
MOD_NEK2_2	40	45	PF00069	0.535
MOD_PIKK_1	136	142	PF00454	0.500
MOD_PIKK_1	84	90	PF00454	0.548
MOD_PKA_2	210	216	PF00069	0.371
MOD_PKA_2	235	241	PF00069	0.454
MOD_PKA_2	40	46	PF00069	0.529
MOD_Plk_1	136	142	PF00069	0.535
MOD_Plk_1	298	304	PF00069	0.493
MOD_Plk_1	427	433	PF00069	0.577
MOD_Plk_1	436	442	PF00069	0.560
MOD_Plk_2-3	299	305	PF00069	0.522
MOD_Plk_2-3	308	314	PF00069	0.491
MOD_Plk_4	17	23	PF00069	0.526
MOD_Plk_4	427	433	PF00069	0.552
MOD_ProDKin_1	140	146	PF00069	0.536
MOD_ProDKin_1	259	265	PF00069	0.455
MOD_ProDKin_1	70	76	PF00069	0.666
MOD_SUMO_for_1	296	299	PF00179	0.419
TRG_DiLeu_BaEn_1	100	105	PF01217	0.397
TRG_DiLeu_BaEn_4	312	318	PF01217	0.518
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.558
TRG_ENDOCYTIC_2	101	104	PF00928	0.394
TRG_ENDOCYTIC_2	118	121	PF00928	0.404
TRG_ENDOCYTIC_2	150	153	PF00928	0.523
TRG_ENDOCYTIC_2	182	185	PF00928	0.516
TRG_ENDOCYTIC_2	242	245	PF00928	0.330
TRG_ER_diArg_1	130	132	PF00400	0.559
TRG_ER_diArg_1	161	164	PF00400	0.482
TRG_ER_diArg_1	179	182	PF00400	0.487
TRG_ER_diArg_1	239	242	PF00400	0.482
TRG_ER_diArg_1	24	26	PF00400	0.561
TRG_ER_diArg_1	250	253	PF00400	0.532
TRG_ER_diArg_1	368	370	PF00400	0.437
TRG_ER_diArg_1	406	409	PF00400	0.518
TRG_NLS_Bipartite_1	92	111	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	390	395	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.241

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC16	Leptomonas seymouri	67%	100%
A0A0S4IZV5	Bodo saltans	34%	100%
A0A1X0NPB4	Trypanosomatidae	38%	100%
A0A3S5H6Q9	Leishmania donovani	80%	100%
A0A422NXD4	Trypanosoma rangeli	38%	100%
A4HVW3	Leishmania infantum	81%	100%
C9ZT63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9APL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q2M329	Homo sapiens	30%	80%
Q4QFW4	Leishmania major	81%	100%
Q95LS7	Macaca fascicularis	29%	79%
V5BHR7	Trypanosoma cruzi	37%	100%