Cilia- and flagella-associated protein 36

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 18 protein

Species:

Leishmania braziliensis

UniProt:

A4H7I0_LEIBR

TriTrypDb:

LbrM.14.0200 , LBRM2903_140007100

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	6
GO:0034464	BBSome	2	6
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7I0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022607	cellular component assembly	4	6
GO:0030030	cell projection organization	4	6
GO:0030031	cell projection assembly	5	6
GO:0044782	cilium organization	5	6
GO:0060271	cilium assembly	6	6
GO:0070925	organelle assembly	5	6
GO:0071840	cellular component organization or biogenesis	2	6
GO:0120031	plasma membrane bounded cell projection assembly	6	6
GO:0120036	plasma membrane bounded cell projection organization	5	6
GO:0008104	protein localization	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0061512	protein localization to cilium	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1
GO:0097499	protein localization to non-motile cilium	7	1
GO:0097500	receptor localization to non-motile cilium	6	1
GO:1903441	protein localization to ciliary membrane	5	1
GO:1990778	protein localization to cell periphery	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	66	68	PF00082	0.530
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.530
CLV_PCSK_SKI1_1	61	65	PF00082	0.375
DEG_Nend_UBRbox_2	1	3	PF02207	0.825
DEG_SPOP_SBC_1	165	169	PF00917	0.684
DOC_CKS1_1	102	107	PF01111	0.581
DOC_MAPK_JIP1_4	38	44	PF00069	0.530
DOC_USP7_MATH_1	129	133	PF00917	0.827
DOC_USP7_MATH_1	165	169	PF00917	0.801
DOC_USP7_MATH_1	43	47	PF00917	0.530
DOC_USP7_UBL2_3	54	58	PF12436	0.384
DOC_WW_Pin1_4	101	106	PF00397	0.752
DOC_WW_Pin1_4	111	116	PF00397	0.616
DOC_WW_Pin1_4	119	124	PF00397	0.578
DOC_WW_Pin1_4	180	185	PF00397	0.737
DOC_WW_Pin1_4	79	84	PF00397	0.608
LIG_14-3-3_CanoR_1	137	145	PF00244	0.829
LIG_14-3-3_CanoR_1	174	184	PF00244	0.699
LIG_FHA_2	150	156	PF00498	0.812
LIG_FHA_2	79	85	PF00498	0.731
LIG_IRF3_LxIS_1	20	27	PF10401	0.277
LIG_MYND_1	39	43	PF01753	0.530
LIG_SH3_3	181	187	PF00018	0.562
LIG_SH3_3	94	100	PF00018	0.734
LIG_TRAF2_1	152	155	PF00917	0.758
LIG_TRAF2_1	87	90	PF00917	0.544
LIG_UBA3_1	41	45	PF00899	0.316
MOD_CDC14_SPxK_1	114	117	PF00782	0.570
MOD_CDK_SPxK_1	111	117	PF00069	0.710
MOD_CK1_1	125	131	PF00069	0.742
MOD_CK1_1	132	138	PF00069	0.796
MOD_CK1_1	141	147	PF00069	0.662
MOD_CK1_1	178	184	PF00069	0.725
MOD_CK2_1	144	150	PF00069	0.689
MOD_CK2_1	160	166	PF00069	0.679
MOD_CK2_1	83	89	PF00069	0.734
MOD_GlcNHglycan	124	127	PF01048	0.733
MOD_GlcNHglycan	132	135	PF01048	0.741
MOD_GlcNHglycan	162	165	PF01048	0.738
MOD_GSK3_1	125	132	PF00069	0.829
MOD_GSK3_1	160	167	PF00069	0.773
MOD_GSK3_1	172	179	PF00069	0.698
MOD_GSK3_1	79	86	PF00069	0.735
MOD_N-GLC_1	175	180	PF02516	0.578
MOD_NEK2_1	172	177	PF00069	0.581
MOD_NEK2_1	78	83	PF00069	0.715
MOD_PIKK_1	138	144	PF00454	0.726
MOD_PKA_2	4	10	PF00069	0.535
MOD_ProDKin_1	101	107	PF00069	0.750
MOD_ProDKin_1	111	117	PF00069	0.617
MOD_ProDKin_1	119	125	PF00069	0.580
MOD_ProDKin_1	180	186	PF00069	0.734
MOD_ProDKin_1	79	85	PF00069	0.614
MOD_SUMO_rev_2	27	32	PF00179	0.491
MOD_SUMO_rev_2	50	60	PF00179	0.530
MOD_SUMO_rev_2	84	94	PF00179	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II74	Leishmania donovani	67%	100%
A4HVW2	Leishmania infantum	68%	100%
E9APL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QFW5	Leishmania major	71%	100%