Thioredoxin-like_fold domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thioredoxin-like, putative

Species:

Leishmania braziliensis

UniProt:

A4H7H9_LEIBR

TriTrypDb:

LbrM.14.0190 , LBRM2903_140007000

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7H9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.665
CLV_PCSK_SKI1_1	70	74	PF00082	0.305
DEG_APCC_DBOX_1	160	168	PF00400	0.427
DOC_CYCLIN_RxL_1	97	105	PF00134	0.496
DOC_CYCLIN_yClb5_NLxxxL_5	28	37	PF00134	0.287
DOC_MAPK_MEF2A_6	29	37	PF00069	0.287
DOC_PP1_RVXF_1	140	146	PF00149	0.517
DOC_PP1_RVXF_1	68	74	PF00149	0.386
DOC_PP2B_LxvP_1	104	107	PF13499	0.386
DOC_USP7_MATH_1	122	126	PF00917	0.498
DOC_USP7_UBL2_3	115	119	PF12436	0.442
DOC_USP7_UBL2_3	17	21	PF12436	0.406
DOC_USP7_UBL2_3	87	91	PF12436	0.442
DOC_WW_Pin1_4	102	107	PF00397	0.384
LIG_FHA_1	23	29	PF00498	0.494
LIG_FHA_1	32	38	PF00498	0.464
LIG_FHA_2	6	12	PF00498	0.369
LIG_FHA_2	76	82	PF00498	0.544
LIG_LIR_Gen_1	118	129	PF02991	0.477
LIG_LIR_Gen_1	58	67	PF02991	0.498
LIG_LIR_Nem_3	118	124	PF02991	0.477
LIG_LIR_Nem_3	38	44	PF02991	0.410
LIG_LIR_Nem_3	58	63	PF02991	0.350
LIG_PDZ_Class_1	194	199	PF00595	0.533
LIG_Pex14_1	145	149	PF04695	0.313
LIG_Pex14_2	45	49	PF04695	0.442
LIG_PTB_Apo_2	44	51	PF02174	0.442
LIG_PTB_Apo_2	54	61	PF02174	0.442
LIG_PTB_Phospho_1	44	50	PF10480	0.442
LIG_SH2_CRK	121	125	PF00017	0.451
LIG_SH2_NCK_1	121	125	PF00017	0.455
LIG_SH2_SRC	111	114	PF00017	0.498
LIG_SH2_STAP1	9	13	PF00017	0.446
LIG_SH2_STAT5	41	44	PF00017	0.444
LIG_SH2_STAT5	88	91	PF00017	0.455
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.498
LIG_SUMO_SIM_par_1	33	38	PF11976	0.273
LIG_TRAF2_1	169	172	PF00917	0.462
LIG_WRC_WIRS_1	46	51	PF05994	0.442
MOD_CK1_1	125	131	PF00069	0.472
MOD_GSK3_1	151	158	PF00069	0.385
MOD_GSK3_1	7	14	PF00069	0.461
MOD_N-GLC_1	125	130	PF02516	0.273
MOD_N-GLC_1	155	160	PF02516	0.428
MOD_N-GLC_1	31	36	PF02516	0.280
MOD_NEK2_1	45	50	PF00069	0.442
MOD_NEK2_2	194	199	PF00069	0.612
MOD_Plk_1	11	17	PF00069	0.431
MOD_Plk_1	125	131	PF00069	0.455
MOD_Plk_1	31	37	PF00069	0.233
MOD_Plk_1	58	64	PF00069	0.455
MOD_Plk_2-3	5	11	PF00069	0.376
MOD_Plk_4	125	131	PF00069	0.455
MOD_Plk_4	45	51	PF00069	0.442
MOD_ProDKin_1	102	108	PF00069	0.384
MOD_SUMO_for_1	180	183	PF00179	0.624
MOD_SUMO_for_1	83	86	PF00179	0.498
MOD_SUMO_rev_2	112	117	PF00179	0.432
MOD_SUMO_rev_2	3	8	PF00179	0.407
TRG_ENDOCYTIC_2	121	124	PF00928	0.450
TRG_NES_CRM1_1	65	79	PF08389	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXV8	Leptomonas seymouri	82%	100%
A0A0S4J513	Bodo saltans	54%	100%
A0A1X0NP28	Trypanosomatidae	69%	100%
A0A3R7MRI8	Trypanosoma rangeli	67%	100%
A0A3S5H6Q8	Leishmania donovani	85%	100%
A4HVW1	Leishmania infantum	85%	100%
C9ZT65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	99%
E9APL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QFW6	Leishmania major	84%	100%