Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7H8_LEIBR

TriTrypDb:

LbrM.14.0170 , LBRM2903_140006600

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7H8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7H8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.404
CLV_NRD_NRD_1	417	419	PF00675	0.588
CLV_NRD_NRD_1	442	444	PF00675	0.627
CLV_PCSK_KEX2_1	145	147	PF00082	0.404
CLV_PCSK_KEX2_1	417	419	PF00082	0.588
CLV_PCSK_KEX2_1	442	444	PF00082	0.628
CLV_PCSK_SKI1_1	101	105	PF00082	0.515
CLV_PCSK_SKI1_1	150	154	PF00082	0.455
CLV_PCSK_SKI1_1	87	91	PF00082	0.543
CLV_Separin_Metazoa	385	389	PF03568	0.504
DEG_APCC_DBOX_1	195	203	PF00400	0.441
DEG_APCC_DBOX_1	86	94	PF00400	0.521
DEG_SPOP_SBC_1	340	344	PF00917	0.555
DOC_ANK_TNKS_1	257	264	PF00023	0.389
DOC_CKS1_1	44	49	PF01111	0.617
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.359
DOC_MAPK_gen_1	207	216	PF00069	0.409
DOC_MAPK_gen_1	29	37	PF00069	0.482
DOC_MAPK_gen_1	395	402	PF00069	0.430
DOC_MAPK_MEF2A_6	196	203	PF00069	0.438
DOC_MAPK_MEF2A_6	29	37	PF00069	0.482
DOC_MAPK_NFAT4_5	196	204	PF00069	0.434
DOC_PP1_RVXF_1	304	310	PF00149	0.459
DOC_PP2B_LxvP_1	49	52	PF13499	0.646
DOC_USP7_MATH_1	340	344	PF00917	0.493
DOC_USP7_MATH_1	4	8	PF00917	0.705
DOC_USP7_MATH_1	462	466	PF00917	0.645
DOC_WW_Pin1_4	108	113	PF00397	0.556
DOC_WW_Pin1_4	17	22	PF00397	0.561
DOC_WW_Pin1_4	227	232	PF00397	0.458
DOC_WW_Pin1_4	43	48	PF00397	0.771
DOC_WW_Pin1_4	51	56	PF00397	0.625
DOC_WW_Pin1_4	82	87	PF00397	0.723
LIG_14-3-3_CanoR_1	154	160	PF00244	0.335
LIG_14-3-3_CanoR_1	207	212	PF00244	0.427
LIG_14-3-3_CanoR_1	29	34	PF00244	0.637
LIG_14-3-3_CanoR_1	338	346	PF00244	0.673
LIG_14-3-3_CanoR_1	388	394	PF00244	0.625
LIG_14-3-3_CanoR_1	395	401	PF00244	0.587
LIG_14-3-3_CanoR_1	408	413	PF00244	0.464
LIG_14-3-3_CanoR_1	417	423	PF00244	0.518
LIG_14-3-3_CanoR_1	6	11	PF00244	0.581
LIG_Actin_WH2_2	163	181	PF00022	0.319
LIG_Actin_WH2_2	199	214	PF00022	0.269
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_BRCT_BRCA1_1	342	346	PF00533	0.511
LIG_FHA_1	119	125	PF00498	0.447
LIG_FHA_1	273	279	PF00498	0.432
LIG_FHA_1	397	403	PF00498	0.510
LIG_FHA_1	418	424	PF00498	0.486
LIG_FHA_1	44	50	PF00498	0.692
LIG_FHA_2	131	137	PF00498	0.364
LIG_FHA_2	83	89	PF00498	0.594
LIG_FXI_DFP_1	191	195	PF00024	0.522
LIG_LIR_Gen_1	197	206	PF02991	0.368
LIG_LIR_Gen_1	347	356	PF02991	0.443
LIG_LIR_Nem_3	197	201	PF02991	0.378
LIG_LIR_Nem_3	334	339	PF02991	0.636
LIG_LIR_Nem_3	343	349	PF02991	0.396
LIG_MYND_1	47	51	PF01753	0.661
LIG_NRBOX	198	204	PF00104	0.400
LIG_NRBOX	351	357	PF00104	0.347
LIG_PDZ_Class_3	463	468	PF00595	0.561
LIG_Pex14_2	194	198	PF04695	0.398
LIG_Rb_LxCxE_1	68	85	PF01857	0.414
LIG_SH2_CRK	349	353	PF00017	0.488
LIG_SH2_STAP1	349	353	PF00017	0.488
LIG_SH2_STAT5	172	175	PF00017	0.361
LIG_SH2_STAT5	286	289	PF00017	0.425
LIG_SH2_STAT5	391	394	PF00017	0.608
LIG_SH3_1	438	444	PF00018	0.574
LIG_SH3_2	383	388	PF14604	0.503
LIG_SH3_3	18	24	PF00018	0.739
LIG_SH3_3	189	195	PF00018	0.377
LIG_SH3_3	380	386	PF00018	0.583
LIG_SH3_3	428	434	PF00018	0.503
LIG_SH3_3	438	444	PF00018	0.557
LIG_SH3_3	45	51	PF00018	0.629
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.433
LIG_SUMO_SIM_par_1	398	403	PF11976	0.400
LIG_TRAF2_1	133	136	PF00917	0.367
MOD_CDK_SPK_2	82	87	PF00069	0.520
MOD_CDK_SPxxK_3	43	50	PF00069	0.539
MOD_CK1_1	108	114	PF00069	0.474
MOD_CK1_1	2	8	PF00069	0.678
MOD_CK1_1	344	350	PF00069	0.501
MOD_CK2_1	122	128	PF00069	0.430
MOD_CK2_1	130	136	PF00069	0.443
MOD_CK2_1	251	257	PF00069	0.402
MOD_CK2_1	276	282	PF00069	0.369
MOD_CK2_1	457	463	PF00069	0.543
MOD_CK2_1	82	88	PF00069	0.538
MOD_GlcNHglycan	1	4	PF01048	0.543
MOD_GlcNHglycan	107	110	PF01048	0.480
MOD_GlcNHglycan	113	116	PF01048	0.446
MOD_GlcNHglycan	343	346	PF01048	0.504
MOD_GlcNHglycan	358	361	PF01048	0.530
MOD_GlcNHglycan	451	454	PF01048	0.515
MOD_GlcNHglycan	6	9	PF01048	0.609
MOD_GlcNHglycan	80	83	PF01048	0.440
MOD_GSK3_1	118	125	PF00069	0.462
MOD_GSK3_1	2	9	PF00069	0.677
MOD_GSK3_1	272	279	PF00069	0.544
MOD_GSK3_1	309	316	PF00069	0.370
MOD_GSK3_1	340	347	PF00069	0.569
MOD_GSK3_1	391	398	PF00069	0.588
MOD_GSK3_1	78	85	PF00069	0.518
MOD_N-GLC_1	289	294	PF02516	0.410
MOD_NEK2_1	153	158	PF00069	0.479
MOD_NEK2_1	202	207	PF00069	0.351
MOD_NEK2_1	269	274	PF00069	0.418
MOD_NEK2_1	309	314	PF00069	0.592
MOD_NEK2_1	341	346	PF00069	0.632
MOD_NEK2_1	389	394	PF00069	0.661
MOD_NEK2_1	396	401	PF00069	0.570
MOD_NEK2_1	416	421	PF00069	0.609
MOD_NEK2_1	78	83	PF00069	0.432
MOD_NEK2_2	251	256	PF00069	0.306
MOD_PIKK_1	309	315	PF00454	0.361
MOD_PIKK_1	6	12	PF00454	0.695
MOD_PKA_1	417	423	PF00069	0.433
MOD_PKA_2	153	159	PF00069	0.347
MOD_PKA_2	356	362	PF00069	0.498
MOD_PKA_2	396	402	PF00069	0.420
MOD_PKA_2	416	422	PF00069	0.544
MOD_Plk_1	289	295	PF00069	0.320
MOD_Plk_4	122	128	PF00069	0.430
MOD_Plk_4	173	179	PF00069	0.467
MOD_Plk_4	243	249	PF00069	0.305
MOD_Plk_4	269	275	PF00069	0.518
MOD_Plk_4	408	414	PF00069	0.543
MOD_Plk_4	432	438	PF00069	0.464
MOD_ProDKin_1	108	114	PF00069	0.553
MOD_ProDKin_1	17	23	PF00069	0.559
MOD_ProDKin_1	227	233	PF00069	0.453
MOD_ProDKin_1	43	49	PF00069	0.771
MOD_ProDKin_1	51	57	PF00069	0.626
MOD_ProDKin_1	82	88	PF00069	0.723
TRG_DiLeu_BaEn_1	348	353	PF01217	0.440
TRG_DiLeu_BaEn_4	384	390	PF01217	0.504
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.344
TRG_ENDOCYTIC_2	349	352	PF00928	0.426
TRG_ER_diArg_1	206	209	PF00400	0.354
TRG_ER_diArg_1	306	309	PF00400	0.395
TRG_ER_diArg_1	416	418	PF00400	0.579
TRG_ER_diArg_1	441	443	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B4	Leptomonas seymouri	43%	69%
A0A3Q8I8P4	Leishmania donovani	78%	68%
A4HVV9	Leishmania infantum	78%	68%
E9APL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	68%
Q4QFW8	Leishmania major	77%	100%