Chromo domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7H7_LEIBR

TriTrypDb:

LbrM.14.0160 , LBRM2903_140006500

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7H7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.501
CLV_NRD_NRD_1	123	125	PF00675	0.479
CLV_NRD_NRD_1	168	170	PF00675	0.733
CLV_NRD_NRD_1	93	95	PF00675	0.740
CLV_PCSK_KEX2_1	12	14	PF00082	0.501
CLV_PCSK_KEX2_1	123	125	PF00082	0.649
CLV_PCSK_KEX2_1	168	170	PF00082	0.648
CLV_PCSK_KEX2_1	190	192	PF00082	0.706
CLV_PCSK_KEX2_1	235	237	PF00082	0.345
CLV_PCSK_KEX2_1	38	40	PF00082	0.623
CLV_PCSK_KEX2_1	78	80	PF00082	0.637
CLV_PCSK_KEX2_1	95	97	PF00082	0.578
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.681
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.690
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.345
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.623
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.658
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.578
CLV_PCSK_PC7_1	74	80	PF00082	0.495
CLV_PCSK_SKI1_1	227	231	PF00082	0.562
CLV_PCSK_SKI1_1	341	345	PF00082	0.555
DEG_SCF_FBW7_2	318	324	PF00400	0.639
DOC_CDC14_PxL_1	180	188	PF14671	0.684
DOC_CDC14_PxL_1	243	251	PF14671	0.634
DOC_CKS1_1	318	323	PF01111	0.638
DOC_MAPK_gen_1	235	242	PF00069	0.409
DOC_MAPK_HePTP_8	267	279	PF00069	0.532
DOC_MAPK_MEF2A_6	270	279	PF00069	0.526
DOC_MAPK_MEF2A_6	331	339	PF00069	0.482
DOC_MAPK_MEF2A_6	341	349	PF00069	0.400
DOC_PP1_RVXF_1	339	345	PF00149	0.564
DOC_PP2B_LxvP_1	119	122	PF13499	0.705
DOC_PP4_FxxP_1	257	260	PF00568	0.678
DOC_USP7_MATH_1	221	225	PF00917	0.616
DOC_USP7_MATH_1	234	238	PF00917	0.433
DOC_WW_Pin1_4	208	213	PF00397	0.537
DOC_WW_Pin1_4	280	285	PF00397	0.580
DOC_WW_Pin1_4	317	322	PF00397	0.652
DOC_WW_Pin1_4	98	103	PF00397	0.789
LIG_14-3-3_CanoR_1	123	130	PF00244	0.487
LIG_14-3-3_CanoR_1	227	233	PF00244	0.570
LIG_14-3-3_CanoR_1	236	243	PF00244	0.514
LIG_14-3-3_CanoR_1	276	280	PF00244	0.589
LIG_14-3-3_CanoR_1	331	336	PF00244	0.500
LIG_14-3-3_CanoR_1	96	101	PF00244	0.778
LIG_APCC_ABBA_1	294	299	PF00400	0.676
LIG_BIR_III_4	194	198	PF00653	0.442
LIG_BRCT_BRCA1_1	282	286	PF00533	0.676
LIG_deltaCOP1_diTrp_1	66	73	PF00928	0.708
LIG_FHA_1	320	326	PF00498	0.693
LIG_FHA_1	88	94	PF00498	0.530
LIG_FHA_2	133	139	PF00498	0.489
LIG_FHA_2	3	9	PF00498	0.618
LIG_FHA_2	312	318	PF00498	0.603
LIG_FHA_2	59	65	PF00498	0.615
LIG_LIR_Nem_3	211	217	PF02991	0.423
LIG_LIR_Nem_3	338	343	PF02991	0.510
LIG_LYPXL_S_1	213	217	PF13949	0.420
LIG_Pex14_2	213	217	PF04695	0.673
LIG_Pex14_2	340	344	PF04695	0.559
LIG_SH2_NCK_1	4	8	PF00017	0.361
LIG_SH2_PTP2	305	308	PF00017	0.576
LIG_SH2_SRC	305	308	PF00017	0.537
LIG_SH2_SRC	46	49	PF00017	0.603
LIG_SH2_STAP1	23	27	PF00017	0.448
LIG_SH2_STAP1	46	50	PF00017	0.357
LIG_SH2_STAT5	305	308	PF00017	0.450
LIG_SH2_STAT5	351	354	PF00017	0.540
LIG_SH2_STAT5	4	7	PF00017	0.579
LIG_SH3_3	209	215	PF00018	0.681
LIG_SH3_3	312	318	PF00018	0.623
LIG_SH3_3	339	345	PF00018	0.597
LIG_SUMO_SIM_par_1	142	148	PF11976	0.612
LIG_SUMO_SIM_par_1	259	264	PF11976	0.669
LIG_TRAF2_1	137	140	PF00917	0.728
LIG_TRAF2_1	289	292	PF00917	0.600
LIG_TRAF2_1	61	64	PF00917	0.624
LIG_UBA3_1	348	354	PF00899	0.320
LIG_WW_3	120	124	PF00397	0.633
MOD_CK2_1	132	138	PF00069	0.678
MOD_CK2_1	2	8	PF00069	0.612
MOD_CK2_1	42	48	PF00069	0.583
MOD_CK2_1	57	63	PF00069	0.619
MOD_DYRK1A_RPxSP_1	98	102	PF00069	0.749
MOD_GlcNHglycan	114	117	PF01048	0.482
MOD_GlcNHglycan	223	226	PF01048	0.539
MOD_GlcNHglycan	252	255	PF01048	0.541
MOD_GlcNHglycan	287	290	PF01048	0.662
MOD_GSK3_1	169	176	PF00069	0.733
MOD_GSK3_1	196	203	PF00069	0.552
MOD_GSK3_1	280	287	PF00069	0.569
MOD_GSK3_1	331	338	PF00069	0.482
MOD_GSK3_1	94	101	PF00069	0.750
MOD_LATS_1	239	245	PF00433	0.596
MOD_LATS_1	329	335	PF00433	0.603
MOD_N-GLC_1	159	164	PF02516	0.757
MOD_NEK2_1	159	164	PF00069	0.743
MOD_NEK2_1	250	255	PF00069	0.566
MOD_NEK2_1	275	280	PF00069	0.565
MOD_NEK2_1	285	290	PF00069	0.532
MOD_NEK2_1	353	358	PF00069	0.502
MOD_NEK2_1	42	47	PF00069	0.486
MOD_PK_1	206	212	PF00069	0.450
MOD_PK_1	241	247	PF00069	0.613
MOD_PK_1	96	102	PF00069	0.773
MOD_PKA_1	123	129	PF00069	0.484
MOD_PKA_1	169	175	PF00069	0.659
MOD_PKA_1	235	241	PF00069	0.342
MOD_PKA_1	94	100	PF00069	0.741
MOD_PKA_2	123	129	PF00069	0.615
MOD_PKA_2	235	241	PF00069	0.562
MOD_PKA_2	275	281	PF00069	0.600
MOD_PKB_1	94	102	PF00069	0.736
MOD_Plk_1	153	159	PF00069	0.638
MOD_Plk_1	32	38	PF00069	0.522
MOD_Plk_2-3	17	23	PF00069	0.428
MOD_Plk_4	139	145	PF00069	0.594
MOD_Plk_4	154	160	PF00069	0.608
MOD_Plk_4	196	202	PF00069	0.596
MOD_Plk_4	335	341	PF00069	0.453
MOD_Plk_4	353	359	PF00069	0.486
MOD_Plk_4	82	88	PF00069	0.521
MOD_ProDKin_1	208	214	PF00069	0.536
MOD_ProDKin_1	280	286	PF00069	0.583
MOD_ProDKin_1	317	323	PF00069	0.652
MOD_ProDKin_1	98	104	PF00069	0.787
MOD_SUMO_rev_2	70	80	PF00179	0.486
TRG_DiLeu_BaEn_1	140	145	PF01217	0.623
TRG_DiLeu_BaEn_1	82	87	PF01217	0.520
TRG_DiLeu_BaEn_3	138	144	PF01217	0.718
TRG_DiLeu_BaEn_3	153	159	PF01217	0.469
TRG_ENDOCYTIC_2	214	217	PF00928	0.432
TRG_ER_diArg_1	12	14	PF00400	0.501
TRG_ER_diArg_1	122	124	PF00400	0.481
TRG_ER_diArg_1	93	96	PF00400	0.741
TRG_NLS_Bipartite_1	78	99	PF00514	0.773
TRG_NLS_MonoCore_2	166	171	PF00514	0.631
TRG_NLS_MonoExtC_3	166	171	PF00514	0.742
TRG_NLS_MonoExtC_3	93	98	PF00514	0.740
TRG_NLS_MonoExtN_4	167	172	PF00514	0.667
TRG_NLS_MonoExtN_4	94	99	PF00514	0.766
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I624	Leptomonas seymouri	52%	92%
A0A1X0NPE6	Trypanosomatidae	30%	100%
A0A3Q8ID14	Leishmania donovani	82%	100%
A0A422NX90	Trypanosoma rangeli	31%	100%
A4HVV8	Leishmania infantum	82%	100%
C9ZT68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9APL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QFW9	Leishmania major	80%	98%
V5BM97	Trypanosoma cruzi	29%	100%