Putative 60S ribosomal protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7H6_LEIBR

TriTrypDb:

LbrM.14.0150 , LBRM2903_140006400

Length:

181

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	16
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	16
GO:0043228	non-membrane-bounded organelle	3	16
GO:0043229	intracellular organelle	3	16
GO:0043232	intracellular non-membrane-bounded organelle	4	16
GO:0110165	cellular anatomical entity	1	16
GO:1990904	ribonucleoprotein complex	2	15

Expansion

Sequence features

A4H7H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7H6

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	16
GO:0006518	peptide metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009058	biosynthetic process	2	16
GO:0009059	macromolecule biosynthetic process	4	16
GO:0009987	cellular process	1	16
GO:0019538	protein metabolic process	3	16
GO:0034641	cellular nitrogen compound metabolic process	3	16
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	16
GO:0043043	peptide biosynthetic process	5	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043603	amide metabolic process	3	16
GO:0043604	amide biosynthetic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044260	obsolete cellular macromolecule metabolic process	3	16
GO:0044271	cellular nitrogen compound biosynthetic process	4	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16
GO:1901566	organonitrogen compound biosynthetic process	4	16
GO:1901576	organic substance biosynthetic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	16
GO:0005198	structural molecule activity	1	16
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.328
CLV_NRD_NRD_1	2	4	PF00675	0.537
CLV_PCSK_KEX2_1	2	4	PF00082	0.551
CLV_PCSK_SKI1_1	128	132	PF00082	0.326
CLV_PCSK_SKI1_1	134	138	PF00082	0.283
CLV_PCSK_SKI1_1	2	6	PF00082	0.577
CLV_PCSK_SKI1_1	52	56	PF00082	0.450
CLV_PCSK_SKI1_1	67	71	PF00082	0.500
DEG_Nend_UBRbox_1	1	4	PF02207	0.526
DOC_CYCLIN_RxL_1	64	74	PF00134	0.356
DOC_MAPK_gen_1	106	118	PF00069	0.509
DOC_MAPK_gen_1	131	141	PF00069	0.283
DOC_MAPK_MEF2A_6	120	129	PF00069	0.297
DOC_MAPK_RevD_3	42	57	PF00069	0.456
DOC_PP1_RVXF_1	50	56	PF00149	0.456
DOC_PP2B_PxIxI_1	122	128	PF00149	0.314
DOC_USP7_UBL2_3	103	107	PF12436	0.549
DOC_USP7_UBL2_3	146	150	PF12436	0.424
DOC_USP7_UBL2_3	173	177	PF12436	0.424
LIG_14-3-3_CanoR_1	19	25	PF00244	0.621
LIG_BRCT_BRCA1_1	60	64	PF00533	0.509
LIG_FHA_1	111	117	PF00498	0.319
LIG_FHA_2	158	164	PF00498	0.327
LIG_FHA_2	41	47	PF00498	0.433
LIG_PDZ_Class_3	176	181	PF00595	0.292
LIG_SH2_CRK	39	43	PF00017	0.437
LIG_SH2_STAP1	114	118	PF00017	0.358
LIG_SH2_STAP1	65	69	PF00017	0.453
MOD_CK1_1	40	46	PF00069	0.448
MOD_CK1_1	8	14	PF00069	0.679
MOD_CK2_1	40	46	PF00069	0.451
MOD_GlcNHglycan	13	16	PF01048	0.613
MOD_GlcNHglycan	73	76	PF01048	0.481
MOD_GSK3_1	5	12	PF00069	0.635
MOD_N-GLC_1	137	142	PF02516	0.398
MOD_N-GLC_1	157	162	PF02516	0.376
MOD_NEK2_1	154	159	PF00069	0.302
MOD_NEK2_1	5	10	PF00069	0.647
MOD_PIKK_1	37	43	PF00454	0.446
MOD_PKA_2	18	24	PF00069	0.692
MOD_Plk_1	137	143	PF00069	0.398
MOD_Plk_2-3	110	116	PF00069	0.510
MOD_Plk_4	5	11	PF00069	0.666
MOD_SUMO_for_1	102	105	PF00179	0.613
MOD_SUMO_for_1	116	119	PF00179	0.358
MOD_SUMO_for_1	176	179	PF00179	0.424
MOD_SUMO_rev_2	100	109	PF00179	0.584
MOD_SUMO_rev_2	110	118	PF00179	0.338
MOD_SUMO_rev_2	119	127	PF00179	0.260
MOD_SUMO_rev_2	140	147	PF00179	0.321
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.548
TRG_ENDOCYTIC_2	171	174	PF00928	0.424
TRG_ENDOCYTIC_2	39	42	PF00928	0.408
TRG_ER_diArg_1	1	3	PF00400	0.555
TRG_NES_CRM1_1	132	143	PF08389	0.272
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q4	Leptomonas seymouri	78%	100%
A0A0S4IRA5	Bodo saltans	59%	79%
A0A0S4JKH3	Bodo saltans	43%	75%
A0A1X0NIA7	Trypanosomatidae	43%	92%
A0A1X0NNT1	Trypanosomatidae	70%	98%
A0A3S5H6Q7	Leishmania donovani	87%	100%
A0A422NF54	Trypanosoma rangeli	38%	91%
A0A422NX95	Trypanosoma rangeli	62%	92%
A4HVV7	Leishmania infantum	86%	100%
B3EER1	Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)	34%	100%
C9ZMG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	85%
C9ZT69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	99%
E9APK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
P52815	Homo sapiens	33%	91%
P52827	Cricetus cricetus	34%	89%
Q160X6	Roseobacter denitrificans (strain ATCC 33942 / OCh 114)	36%	100%
Q1ACG9	Chara vulgaris	28%	100%
Q4QFX0	Leishmania major	86%	100%
Q7YR75	Bos taurus	32%	91%
Q9DB15	Mus musculus	36%	90%
Q9ZE21	Rickettsia prowazekii (strain Madrid E)	32%	100%
V5BHT7	Trypanosoma cruzi	65%	98%