Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone acetyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7H5_LEIBR

TriTrypDb:

LbrM.14.0140 , LBRM2903_140006300

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7H5

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045944	positive regulation of transcription by RNA polymerase II	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004402	histone acetyltransferase activity	4	12
GO:0008080	N-acetyltransferase activity	6	12
GO:0016407	acetyltransferase activity	5	12
GO:0016410	N-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0034212	peptide N-acetyltransferase activity	7	12
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0003712	transcription coregulator activity	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.597
CLV_NRD_NRD_1	229	231	PF00675	0.562
CLV_NRD_NRD_1	286	288	PF00675	0.357
CLV_NRD_NRD_1	383	385	PF00675	0.296
CLV_NRD_NRD_1	89	91	PF00675	0.782
CLV_PCSK_FUR_1	136	140	PF00082	0.719
CLV_PCSK_FUR_1	470	474	PF00082	0.353
CLV_PCSK_KEX2_1	138	140	PF00082	0.675
CLV_PCSK_KEX2_1	229	231	PF00082	0.562
CLV_PCSK_KEX2_1	286	288	PF00082	0.357
CLV_PCSK_KEX2_1	383	385	PF00082	0.286
CLV_PCSK_KEX2_1	469	471	PF00082	0.468
CLV_PCSK_KEX2_1	472	474	PF00082	0.453
CLV_PCSK_KEX2_1	89	91	PF00082	0.782
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.524
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.512
CLV_PCSK_PC7_1	282	288	PF00082	0.382
CLV_PCSK_PC7_1	465	471	PF00082	0.475
CLV_PCSK_SKI1_1	310	314	PF00082	0.293
CLV_PCSK_SKI1_1	469	473	PF00082	0.586
CLV_PCSK_SKI1_1	475	479	PF00082	0.582
DEG_SPOP_SBC_1	110	114	PF00917	0.536
DEG_SPOP_SBC_1	195	199	PF00917	0.778
DOC_CDC14_PxL_1	487	495	PF14671	0.394
DOC_CKS1_1	388	393	PF01111	0.582
DOC_MAPK_gen_1	286	293	PF00069	0.557
DOC_MAPK_MEF2A_6	286	293	PF00069	0.516
DOC_PP2B_LxvP_1	360	363	PF13499	0.496
DOC_SPAK_OSR1_1	372	376	PF12202	0.496
DOC_USP7_MATH_1	241	245	PF00917	0.530
DOC_WW_Pin1_4	163	168	PF00397	0.445
DOC_WW_Pin1_4	320	325	PF00397	0.496
DOC_WW_Pin1_4	347	352	PF00397	0.496
DOC_WW_Pin1_4	387	392	PF00397	0.496
DOC_WW_Pin1_4	79	84	PF00397	0.774
LIG_14-3-3_CanoR_1	243	248	PF00244	0.509
LIG_14-3-3_CanoR_1	513	519	PF00244	0.498
LIG_Actin_WH2_2	242	257	PF00022	0.310
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BRCT_BRCA1_1	140	144	PF00533	0.597
LIG_BRCT_BRCA1_1	196	200	PF00533	0.528
LIG_BRCT_BRCA1_1	308	312	PF00533	0.496
LIG_BRCT_BRCA1_1	478	482	PF00533	0.537
LIG_Clathr_ClatBox_1	288	292	PF01394	0.509
LIG_deltaCOP1_diTrp_1	161	165	PF00928	0.454
LIG_FHA_1	1	7	PF00498	0.475
LIG_FHA_1	145	151	PF00498	0.604
LIG_FHA_1	202	208	PF00498	0.759
LIG_FHA_1	321	327	PF00498	0.507
LIG_FHA_1	333	339	PF00498	0.507
LIG_FHA_1	410	416	PF00498	0.582
LIG_FHA_1	432	438	PF00498	0.601
LIG_FHA_1	482	488	PF00498	0.552
LIG_FHA_2	110	116	PF00498	0.541
LIG_FHA_2	298	304	PF00498	0.570
LIG_FHA_2	455	461	PF00498	0.620
LIG_GBD_Chelix_1	289	297	PF00786	0.382
LIG_LIR_Apic_2	161	167	PF02991	0.523
LIG_LIR_Apic_2	279	284	PF02991	0.496
LIG_LIR_Gen_1	481	491	PF02991	0.534
LIG_LIR_Nem_3	323	328	PF02991	0.495
LIG_LIR_Nem_3	400	406	PF02991	0.496
LIG_LIR_Nem_3	478	483	PF02991	0.536
LIG_MLH1_MIPbox_1	140	144	PF16413	0.597
LIG_PTB_Apo_2	17	24	PF02174	0.582
LIG_REV1ctd_RIR_1	141	150	PF16727	0.538
LIG_SH2_CRK	16	20	PF00017	0.507
LIG_SH2_STAP1	151	155	PF00017	0.547
LIG_SH2_STAP1	158	162	PF00017	0.425
LIG_SH2_STAP1	467	471	PF00017	0.501
LIG_SH2_STAP1	483	487	PF00017	0.448
LIG_SH2_STAT3	429	432	PF00017	0.507
LIG_SH2_STAT3	46	49	PF00017	0.507
LIG_SH2_STAT5	164	167	PF00017	0.450
LIG_SH2_STAT5	252	255	PF00017	0.493
LIG_SH2_STAT5	328	331	PF00017	0.495
LIG_SH2_STAT5	343	346	PF00017	0.496
LIG_SH2_STAT5	403	406	PF00017	0.496
LIG_SH2_STAT5	429	432	PF00017	0.504
LIG_SH2_STAT5	43	46	PF00017	0.501
LIG_SH2_STAT5	480	483	PF00017	0.351
LIG_SH3_1	498	504	PF00018	0.685
LIG_SH3_3	385	391	PF00018	0.503
LIG_SH3_3	498	504	PF00018	0.626
LIG_SUMO_SIM_anti_2	101	106	PF11976	0.550
LIG_SUMO_SIM_anti_2	303	309	PF11976	0.507
LIG_SUMO_SIM_anti_2	357	363	PF11976	0.507
LIG_SUMO_SIM_par_1	27	34	PF11976	0.582
LIG_SUMO_SIM_par_1	287	292	PF11976	0.500
LIG_SUMO_SIM_par_1	373	378	PF11976	0.496
LIG_TRAF2_1	418	421	PF00917	0.507
LIG_TRAF2_1	8	11	PF00917	0.577
LIG_TRFH_1	252	256	PF08558	0.407
LIG_UBA3_1	307	316	PF00899	0.506
MOD_CDK_SPxK_1	387	393	PF00069	0.496
MOD_CK1_1	201	207	PF00069	0.721
MOD_CK1_1	221	227	PF00069	0.712
MOD_CK1_1	332	338	PF00069	0.601
MOD_CK1_1	92	98	PF00069	0.732
MOD_CK2_1	109	115	PF00069	0.754
MOD_CK2_1	297	303	PF00069	0.570
MOD_CK2_1	379	385	PF00069	0.496
MOD_CK2_1	454	460	PF00069	0.605
MOD_GlcNHglycan	115	119	PF01048	0.650
MOD_GlcNHglycan	140	143	PF01048	0.709
MOD_GlcNHglycan	204	207	PF01048	0.732
MOD_GlcNHglycan	3	6	PF01048	0.699
MOD_GlcNHglycan	451	454	PF01048	0.361
MOD_GlcNHglycan	83	86	PF01048	0.708
MOD_GlcNHglycan	98	101	PF01048	0.627
MOD_GSK3_1	110	117	PF00069	0.580
MOD_GSK3_1	138	145	PF00069	0.614
MOD_GSK3_1	180	187	PF00069	0.721
MOD_GSK3_1	194	201	PF00069	0.478
MOD_GSK3_1	202	209	PF00069	0.658
MOD_GSK3_1	214	221	PF00069	0.597
MOD_GSK3_1	237	244	PF00069	0.607
MOD_GSK3_1	293	300	PF00069	0.581
MOD_GSK3_1	375	382	PF00069	0.496
MOD_GSK3_1	481	488	PF00069	0.489
MOD_GSK3_1	81	88	PF00069	0.687
MOD_GSK3_1	92	99	PF00069	0.638
MOD_LATS_1	447	453	PF00433	0.517
MOD_N-GLC_1	19	24	PF02516	0.382
MOD_N-GLC_1	218	223	PF02516	0.794
MOD_N-GLC_1	354	359	PF02516	0.296
MOD_N-GLC_1	73	78	PF02516	0.736
MOD_NEK2_1	1	6	PF00069	0.739
MOD_NEK2_1	144	149	PF00069	0.602
MOD_NEK2_1	19	24	PF00069	0.394
MOD_NEK2_1	194	199	PF00069	0.751
MOD_NEK2_1	200	205	PF00069	0.718
MOD_PIKK_1	180	186	PF00454	0.649
MOD_PIKK_1	232	238	PF00454	0.541
MOD_PIKK_1	512	518	PF00454	0.607
MOD_PKA_1	138	144	PF00069	0.582
MOD_PKA_1	89	95	PF00069	0.781
MOD_PKA_2	138	144	PF00069	0.702
MOD_PKA_2	225	231	PF00069	0.751
MOD_PKA_2	254	260	PF00069	0.434
MOD_PKA_2	512	518	PF00069	0.494
MOD_PKA_2	89	95	PF00069	0.781
MOD_PKB_1	136	144	PF00069	0.587
MOD_PKB_1	473	481	PF00069	0.337
MOD_Plk_1	100	106	PF00069	0.684
MOD_Plk_1	218	224	PF00069	0.638
MOD_Plk_1	354	360	PF00069	0.496
MOD_Plk_1	375	381	PF00069	0.496
MOD_Plk_1	475	481	PF00069	0.565
MOD_Plk_2-3	218	224	PF00069	0.561
MOD_Plk_4	478	484	PF00069	0.522
MOD_Plk_4	502	508	PF00069	0.680
MOD_ProDKin_1	163	169	PF00069	0.454
MOD_ProDKin_1	320	326	PF00069	0.496
MOD_ProDKin_1	347	353	PF00069	0.496
MOD_ProDKin_1	387	393	PF00069	0.496
MOD_ProDKin_1	79	85	PF00069	0.774
MOD_SUMO_for_1	471	474	PF00179	0.486
MOD_SUMO_rev_2	309	318	PF00179	0.506
MOD_SUMO_rev_2	380	388	PF00179	0.507
TRG_DiLeu_BaEn_1	303	308	PF01217	0.507
TRG_ENDOCYTIC_2	16	19	PF00928	0.507
TRG_ENDOCYTIC_2	483	486	PF00928	0.440
TRG_ENDOCYTIC_2	494	497	PF00928	0.545
TRG_ER_diArg_1	135	138	PF00400	0.710
TRG_ER_diArg_1	285	287	PF00400	0.558
TRG_NES_CRM1_1	303	314	PF08389	0.537
TRG_NLS_MonoExtC_3	468	473	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	443	448	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B0	Leptomonas seymouri	79%	100%
A0A0S4IZ19	Bodo saltans	40%	100%
A0A1X0NNT9	Trypanosomatidae	58%	100%
A0A3R7M6T2	Trypanosoma rangeli	59%	100%
A4HVV6	Leishmania infantum	87%	100%
C9ZT70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D7RTH9	Leishmania donovani	87%	100%
E9APK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B048	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	68%
O94446	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q2UMQ5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	100%
Q4QFX1	Leishmania major	88%	100%
Q4WHG1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	32%	100%
V5BHR3	Trypanosoma cruzi	59%	100%