Putative inosine-guanine nucleoside hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inosine-guanine nucleoside hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7H4_LEIBR

TriTrypDb:

LbrM.14.0130 , LBRM2903_140006200

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H7H4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7H4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006152	purine nucleoside catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	8
GO:0009056	catabolic process	2	1
GO:0009058	biosynthetic process	2	2
GO:0009116	nucleoside metabolic process	4	2
GO:0009164	nucleoside catabolic process	5	1
GO:0009987	cellular process	1	6
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034656	nucleobase-containing small molecule catabolic process	4	1
GO:0042278	purine nucleoside metabolic process	5	2
GO:0043094	cellular metabolic compound salvage	3	2
GO:0043101	purine-containing compound salvage	4	2
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044248	cellular catabolic process	3	1
GO:0044249	cellular biosynthetic process	3	2
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	1
GO:0046483	heterocycle metabolic process	3	6
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	6
GO:0072521	purine-containing compound metabolic process	4	2
GO:0072522	purine-containing compound biosynthetic process	5	2
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901575	organic substance catabolic process	3	1
GO:1901576	organic substance biosynthetic process	3	2
GO:1901657	glycosyl compound metabolic process	4	2
GO:1901658	glycosyl compound catabolic process	5	1
GO:0006166	purine ribonucleoside salvage	5	1
GO:0006179	guanosine salvage	6	1
GO:0008617	guanosine metabolic process	8	1
GO:0009119	ribonucleoside metabolic process	5	1
GO:0009163	nucleoside biosynthetic process	5	1
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	1
GO:0042451	purine nucleoside biosynthetic process	6	1
GO:0042455	ribonucleoside biosynthetic process	6	1
GO:0043174	nucleoside salvage	4	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046114	guanosine biosynthetic process	9	1
GO:0046128	purine ribonucleoside metabolic process	6	1
GO:0046129	purine ribonucleoside biosynthetic process	7	1
GO:1901068	guanosine-containing compound metabolic process	7	1
GO:1901070	guanosine-containing compound biosynthetic process	8	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901659	glycosyl compound biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0016787	hydrolase activity	2	17
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	17
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	17
GO:0008477	purine nucleosidase activity	5	6
GO:0045437	uridine nucleosidase activity	6	5
GO:0047724	inosine nucleosidase activity	6	2
GO:0050263	ribosylpyrimidine nucleosidase activity	5	5
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.422
CLV_C14_Caspase3-7	333	337	PF00656	0.519
CLV_NRD_NRD_1	4	6	PF00675	0.432
CLV_PCSK_KEX2_1	3	5	PF00082	0.361
CLV_PCSK_KEX2_1	322	324	PF00082	0.306
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.306
CLV_PCSK_SKI1_1	116	120	PF00082	0.341
CLV_PCSK_SKI1_1	291	295	PF00082	0.379
CLV_Separin_Metazoa	113	117	PF03568	0.543
DOC_ANK_TNKS_1	249	256	PF00023	0.543
DOC_MAPK_MEF2A_6	229	238	PF00069	0.497
DOC_PP1_RVXF_1	198	205	PF00149	0.571
DOC_PP2B_PxIxI_1	156	162	PF00149	0.543
DOC_PP4_FxxP_1	248	251	PF00568	0.487
DOC_USP7_MATH_1	100	104	PF00917	0.421
DOC_USP7_MATH_1	70	74	PF00917	0.506
DOC_USP7_UBL2_3	225	229	PF12436	0.415
DOC_WW_Pin1_4	66	71	PF00397	0.497
LIG_14-3-3_CanoR_1	200	205	PF00244	0.549
LIG_14-3-3_CanoR_1	291	300	PF00244	0.579
LIG_14-3-3_CanoR_1	306	314	PF00244	0.473
LIG_APCC_ABBA_1	178	183	PF00400	0.603
LIG_APCC_ABBA_1	234	239	PF00400	0.579
LIG_APCC_ABBAyCdc20_2	233	239	PF00400	0.579
LIG_BIR_III_4	16	20	PF00653	0.487
LIG_FHA_1	110	116	PF00498	0.528
LIG_FHA_1	247	253	PF00498	0.623
LIG_FHA_1	268	274	PF00498	0.487
LIG_FHA_1	27	33	PF00498	0.600
LIG_FHA_1	295	301	PF00498	0.534
LIG_FHA_1	67	73	PF00498	0.488
LIG_FHA_2	213	219	PF00498	0.506
LIG_FHA_2	254	260	PF00498	0.450
LIG_FHA_2	307	313	PF00498	0.518
LIG_FHA_2	331	337	PF00498	0.519
LIG_LIR_Apic_2	246	251	PF02991	0.487
LIG_LIR_Gen_1	123	134	PF02991	0.476
LIG_LIR_Gen_1	185	196	PF02991	0.530
LIG_LIR_Gen_1	213	221	PF02991	0.415
LIG_LIR_Gen_1	239	248	PF02991	0.507
LIG_LIR_Nem_3	123	129	PF02991	0.476
LIG_LIR_Nem_3	185	191	PF02991	0.530
LIG_LIR_Nem_3	213	217	PF02991	0.436
LIG_LIR_Nem_3	239	245	PF02991	0.516
LIG_LIR_Nem_3	35	41	PF02991	0.519
LIG_LIR_Nem_3	77	83	PF02991	0.476
LIG_NRBOX	49	55	PF00104	0.458
LIG_Pex14_2	216	220	PF04695	0.487
LIG_PTB_Apo_2	334	341	PF02174	0.519
LIG_SH2_CRK	126	130	PF00017	0.476
LIG_SH2_STAT5	188	191	PF00017	0.506
LIG_SH3_3	69	75	PF00018	0.604
LIG_TYR_ITSM	122	129	PF00017	0.567
LIG_ULM_U2AF65_1	322	327	PF00076	0.487
MOD_CK1_1	172	178	PF00069	0.545
MOD_CK2_1	150	156	PF00069	0.526
MOD_CK2_1	70	76	PF00069	0.579
MOD_GSK3_1	200	207	PF00069	0.543
MOD_GSK3_1	263	270	PF00069	0.497
MOD_GSK3_1	302	309	PF00069	0.519
MOD_GSK3_1	66	73	PF00069	0.584
MOD_N-GLC_1	170	175	PF02516	0.367
MOD_N-GLC_2	269	271	PF02516	0.306
MOD_NEK2_1	114	119	PF00069	0.438
MOD_NEK2_1	212	217	PF00069	0.579
MOD_PIKK_1	263	269	PF00454	0.481
MOD_PKA_2	302	308	PF00069	0.487
MOD_Plk_1	170	176	PF00069	0.497
MOD_Plk_1	204	210	PF00069	0.492
MOD_Plk_1	267	273	PF00069	0.476
MOD_Plk_1	316	322	PF00069	0.416
MOD_Plk_4	121	127	PF00069	0.567
MOD_Plk_4	284	290	PF00069	0.541
MOD_Plk_4	32	38	PF00069	0.527
MOD_ProDKin_1	66	72	PF00069	0.497
MOD_SUMO_for_1	118	121	PF00179	0.415
TRG_ENDOCYTIC_2	126	129	PF00928	0.476
TRG_ENDOCYTIC_2	188	191	PF00928	0.506
TRG_ER_diArg_1	2	5	PF00400	0.363
TRG_ER_diArg_1	323	326	PF00400	0.579
TRG_NES_CRM1_1	45	60	PF08389	0.487
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKH5	Leptomonas seymouri	80%	100%
A0A0S4ITJ9	Bodo saltans	61%	98%
A0A1X0NNR9	Trypanosomatidae	66%	98%
A0A3R7KUP9	Trypanosoma rangeli	65%	99%
A0A3S7X2U5	Leishmania donovani	26%	100%
A4H9Q9	Leishmania braziliensis	32%	100%
A4I4Y9	Leishmania infantum	26%	100%
A4W829	Enterobacter sp. (strain 638)	29%	100%
A6T9S2	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	27%	100%
A7ZXS0	Escherichia coli O9:H4 (strain HS)	28%	100%
B5XWV7	Klebsiella pneumoniae (strain 342)	27%	100%
C9ZT72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	99%
E9AEE2	Leishmania major	25%	100%
E9APK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9ARU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q04179	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q0T6R1	Shigella flexneri serotype 5b (strain 8401)	28%	100%
Q10314	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q18L05	Leishmania infantum	88%	100%
Q18L65	Leishmania donovani	88%	100%
Q2PDC5	Leishmania infantum	33%	100%
Q4QDN1	Leishmania major	33%	100%
Q4QFX2	Leishmania major	86%	100%
Q7KWM9	Dictyostelium discoideum	27%	100%
Q83LY1	Shigella flexneri	28%	100%
Q8WQX2	Leishmania donovani	33%	100%
Q9P6J4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
V5DDY4	Trypanosoma cruzi	66%	99%