Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7H3_LEIBR

TriTrypDb:

LbrM.14.0120 , LBRM2903_140006100

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7H3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	208	210	PF00675	0.510
CLV_NRD_NRD_1	258	260	PF00675	0.593
CLV_NRD_NRD_1	274	276	PF00675	0.463
CLV_NRD_NRD_1	282	284	PF00675	0.603
CLV_NRD_NRD_1	290	292	PF00675	0.635
CLV_NRD_NRD_1	314	316	PF00675	0.762
CLV_NRD_NRD_1	323	325	PF00675	0.688
CLV_PCSK_FUR_1	290	294	PF00082	0.750
CLV_PCSK_KEX2_1	208	210	PF00082	0.511
CLV_PCSK_KEX2_1	274	276	PF00082	0.592
CLV_PCSK_KEX2_1	282	284	PF00082	0.633
CLV_PCSK_KEX2_1	290	292	PF00082	0.668
CLV_PCSK_KEX2_1	314	316	PF00082	0.694
CLV_PCSK_KEX2_1	323	325	PF00082	0.610
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.721
DEG_ODPH_VHL_1	56	69	PF01847	0.518
DEG_SCF_FBW7_1	69	75	PF00400	0.512
DOC_CDC14_PxL_1	56	64	PF14671	0.515
DOC_CKS1_1	69	74	PF01111	0.508
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.651
DOC_PP2B_LxvP_1	31	34	PF13499	0.563
DOC_PP2B_LxvP_1	48	51	PF13499	0.720
DOC_PP2B_LxvP_1	5	8	PF13499	0.526
DOC_USP7_MATH_1	15	19	PF00917	0.630
DOC_WW_Pin1_4	235	240	PF00397	0.538
DOC_WW_Pin1_4	248	253	PF00397	0.630
DOC_WW_Pin1_4	275	280	PF00397	0.664
DOC_WW_Pin1_4	283	288	PF00397	0.792
DOC_WW_Pin1_4	68	73	PF00397	0.598
LIG_14-3-3_CanoR_1	182	191	PF00244	0.380
LIG_14-3-3_CanoR_1	201	206	PF00244	0.450
LIG_14-3-3_CanoR_1	259	267	PF00244	0.520
LIG_14-3-3_CanoR_1	282	287	PF00244	0.550
LIG_14-3-3_CanoR_1	315	321	PF00244	0.662
LIG_14-3-3_CanoR_1	323	332	PF00244	0.682
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_BRCT_BRCA1_1	185	189	PF00533	0.522
LIG_EH1_1	156	164	PF00400	0.470
LIG_eIF4E_1	157	163	PF01652	0.511
LIG_eIF4E_1	307	313	PF01652	0.747
LIG_EVH1_1	31	35	PF00568	0.560
LIG_FHA_1	133	139	PF00498	0.598
LIG_FHA_1	159	165	PF00498	0.539
LIG_FHA_1	69	75	PF00498	0.696
LIG_FHA_1	90	96	PF00498	0.774
LIG_FHA_2	122	128	PF00498	0.417
LIG_FHA_2	201	207	PF00498	0.646
LIG_LIR_Gen_1	135	144	PF02991	0.491
LIG_LIR_Gen_1	227	237	PF02991	0.650
LIG_LIR_Gen_1	261	271	PF02991	0.489
LIG_LIR_Nem_3	116	121	PF02991	0.611
LIG_LIR_Nem_3	135	140	PF02991	0.509
LIG_LIR_Nem_3	227	233	PF02991	0.641
LIG_LIR_Nem_3	261	266	PF02991	0.490
LIG_LIR_Nem_3	327	332	PF02991	0.630
LIG_MYND_1	43	47	PF01753	0.510
LIG_RPA_C_Fungi	204	216	PF08784	0.608
LIG_SH2_CRK	332	336	PF00017	0.688
LIG_SH2_STAP1	263	267	PF00017	0.519
LIG_SH2_STAT3	197	200	PF00017	0.458
LIG_SH2_STAT5	137	140	PF00017	0.531
LIG_SH2_STAT5	311	314	PF00017	0.615
LIG_SH3_3	1	7	PF00018	0.594
LIG_SH3_3	106	112	PF00018	0.589
LIG_SH3_3	18	24	PF00018	0.668
LIG_SH3_3	240	246	PF00018	0.699
LIG_SH3_3	26	32	PF00018	0.557
LIG_SH3_3	37	43	PF00018	0.691
LIG_SH3_3	57	63	PF00018	0.633
LIG_SH3_3	64	70	PF00018	0.662
LIG_SH3_3	75	81	PF00018	0.705
LIG_SH3_3	85	91	PF00018	0.788
LIG_SH3_3	9	15	PF00018	0.590
LIG_SH3_3	92	98	PF00018	0.733
LIG_SUMO_SIM_par_1	111	116	PF11976	0.681
LIG_SUMO_SIM_par_1	245	251	PF11976	0.491
LIG_TRAF2_1	139	142	PF00917	0.622
LIG_TRAF2_1	204	207	PF00917	0.424
LIG_TRFH_1	332	336	PF08558	0.489
LIG_TYR_ITSM	133	140	PF00017	0.597
MOD_CDK_SPxxK_3	275	282	PF00069	0.672
MOD_CDK_SPxxK_3	283	290	PF00069	0.781
MOD_CK2_1	121	127	PF00069	0.416
MOD_CK2_1	200	206	PF00069	0.651
MOD_CK2_1	221	227	PF00069	0.602
MOD_CK2_1	258	264	PF00069	0.513
MOD_CK2_1	282	288	PF00069	0.725
MOD_Cter_Amidation	288	291	PF01082	0.674
MOD_GlcNHglycan	15	18	PF01048	0.731
MOD_GlcNHglycan	260	263	PF01048	0.569
MOD_GlcNHglycan	74	77	PF01048	0.789
MOD_GSK3_1	117	124	PF00069	0.561
MOD_GSK3_1	183	190	PF00069	0.488
MOD_GSK3_1	303	310	PF00069	0.655
MOD_GSK3_1	68	75	PF00069	0.513
MOD_N-GLC_1	201	206	PF02516	0.450
MOD_N-GLC_1	219	224	PF02516	0.415
MOD_N-GLC_1	307	312	PF02516	0.652
MOD_NEK2_1	121	126	PF00069	0.641
MOD_NEK2_1	132	137	PF00069	0.575
MOD_NEK2_1	189	194	PF00069	0.575
MOD_NEK2_1	258	263	PF00069	0.599
MOD_PIKK_1	189	195	PF00454	0.577
MOD_PK_1	201	207	PF00069	0.447
MOD_PKA_1	282	288	PF00069	0.524
MOD_PKA_2	200	206	PF00069	0.549
MOD_PKA_2	258	264	PF00069	0.563
MOD_PKA_2	282	288	PF00069	0.557
MOD_PKB_1	199	207	PF00069	0.455
MOD_Plk_1	132	138	PF00069	0.448
MOD_Plk_1	201	207	PF00069	0.447
MOD_Plk_4	158	164	PF00069	0.412
MOD_Plk_4	307	313	PF00069	0.671
MOD_Plk_4	90	96	PF00069	0.619
MOD_ProDKin_1	235	241	PF00069	0.542
MOD_ProDKin_1	248	254	PF00069	0.630
MOD_ProDKin_1	275	281	PF00069	0.666
MOD_ProDKin_1	283	289	PF00069	0.792
MOD_ProDKin_1	68	74	PF00069	0.602
TRG_ENDOCYTIC_2	137	140	PF00928	0.531
TRG_ENDOCYTIC_2	263	266	PF00928	0.484
TRG_ENDOCYTIC_2	331	334	PF00928	0.692
TRG_ER_diArg_1	282	284	PF00400	0.769
TRG_ER_diArg_1	290	293	PF00400	0.772
TRG_ER_diArg_1	313	315	PF00400	0.731
TRG_ER_diArg_1	322	324	PF00400	0.638
TRG_NLS_Bipartite_1	274	295	PF00514	0.509
TRG_NLS_MonoExtN_4	290	295	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCY4	Leptomonas seymouri	65%	92%
A0A1X0NPB8	Trypanosomatidae	36%	70%
A0A3Q8I9R2	Leishmania donovani	75%	95%
A4HVV4	Leishmania infantum	74%	95%
C9ZT73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	67%
E9APK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	96%
Q4QFX3	Leishmania major	76%	100%