J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7H2_LEIBR

TriTrypDb:

LbrM.14.0110 , LBRM2903_140006000

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H7H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7H2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.517
CLV_NRD_NRD_1	13	15	PF00675	0.516
CLV_NRD_NRD_1	223	225	PF00675	0.344
CLV_NRD_NRD_1	227	229	PF00675	0.361
CLV_NRD_NRD_1	238	240	PF00675	0.351
CLV_NRD_NRD_1	303	305	PF00675	0.463
CLV_NRD_NRD_1	33	35	PF00675	0.395
CLV_NRD_NRD_1	354	356	PF00675	0.371
CLV_NRD_NRD_1	398	400	PF00675	0.348
CLV_NRD_NRD_1	433	435	PF00675	0.447
CLV_PCSK_FUR_1	11	15	PF00082	0.416
CLV_PCSK_FUR_1	303	307	PF00082	0.452
CLV_PCSK_KEX2_1	13	15	PF00082	0.516
CLV_PCSK_KEX2_1	223	225	PF00082	0.336
CLV_PCSK_KEX2_1	227	229	PF00082	0.344
CLV_PCSK_KEX2_1	303	305	PF00082	0.401
CLV_PCSK_KEX2_1	33	35	PF00082	0.395
CLV_PCSK_KEX2_1	398	400	PF00082	0.360
CLV_PCSK_KEX2_1	432	434	PF00082	0.461
CLV_PCSK_KEX2_1	488	490	PF00082	0.384
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.382
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.395
CLV_PCSK_PC7_1	223	229	PF00082	0.425
CLV_PCSK_PC7_1	394	400	PF00082	0.353
CLV_PCSK_SKI1_1	177	181	PF00082	0.386
CLV_PCSK_SKI1_1	263	267	PF00082	0.288
CLV_PCSK_SKI1_1	404	408	PF00082	0.435
CLV_PCSK_SKI1_1	461	465	PF00082	0.300
DEG_APCC_DBOX_1	168	176	PF00400	0.599
DEG_APCC_DBOX_1	433	441	PF00400	0.618
DEG_Kelch_Keap1_1	509	514	PF01344	0.656
DEG_Nend_Nbox_1	1	3	PF02207	0.724
DEG_SCF_TRCP1_1	511	516	PF00400	0.696
DEG_SPOP_SBC_1	4	8	PF00917	0.571
DOC_CYCLIN_RxL_1	300	312	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.478
DOC_MAPK_DCC_7	263	272	PF00069	0.404
DOC_MAPK_FxFP_2	151	154	PF00069	0.508
DOC_MAPK_gen_1	303	311	PF00069	0.465
DOC_MAPK_gen_1	465	473	PF00069	0.511
DOC_MAPK_gen_1	74	81	PF00069	0.527
DOC_MAPK_JIP1_4	263	269	PF00069	0.464
DOC_MAPK_MEF2A_6	263	272	PF00069	0.420
DOC_MAPK_MEF2A_6	293	301	PF00069	0.533
DOC_MAPK_MEF2A_6	303	311	PF00069	0.464
DOC_MAPK_NFAT4_5	304	312	PF00069	0.384
DOC_PP2B_LxvP_1	108	111	PF13499	0.420
DOC_PP4_FxxP_1	151	154	PF00568	0.508
DOC_USP7_MATH_1	258	262	PF00917	0.509
DOC_USP7_MATH_1	337	341	PF00917	0.208
DOC_USP7_MATH_1	4	8	PF00917	0.571
DOC_USP7_UBL2_3	461	465	PF12436	0.543
DOC_WW_Pin1_4	27	32	PF00397	0.703
DOC_WW_Pin1_4	278	283	PF00397	0.567
DOC_WW_Pin1_4	379	384	PF00397	0.569
LIG_14-3-3_CanoR_1	132	138	PF00244	0.635
LIG_14-3-3_CanoR_1	33	39	PF00244	0.638
LIG_14-3-3_CanoR_1	432	440	PF00244	0.656
LIG_Actin_WH2_2	157	175	PF00022	0.447
LIG_BRCT_BRCA1_1	339	343	PF00533	0.443
LIG_BRCT_BRCA1_1	35	39	PF00533	0.704
LIG_EH1_1	102	110	PF00400	0.418
LIG_FHA_1	289	295	PF00498	0.513
LIG_FHA_1	4	10	PF00498	0.778
LIG_FHA_1	458	464	PF00498	0.496
LIG_FHA_2	380	386	PF00498	0.607
LIG_FHA_2	457	463	PF00498	0.444
LIG_FHA_2	96	102	PF00498	0.582
LIG_LIR_Apic_2	165	171	PF02991	0.493
LIG_LIR_Gen_1	190	198	PF02991	0.524
LIG_LIR_Nem_3	190	195	PF02991	0.523
LIG_LIR_Nem_3	496	501	PF02991	0.483
LIG_PDZ_Class_1	520	525	PF00595	0.595
LIG_Pex14_2	151	155	PF04695	0.533
LIG_Pex14_2	241	245	PF04695	0.543
LIG_Pex14_2	35	39	PF04695	0.704
LIG_SH2_CRK	498	502	PF00017	0.457
LIG_SH3_3	262	268	PF00018	0.388
LIG_SH3_3	291	297	PF00018	0.506
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.519
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.464
LIG_SxIP_EBH_1	204	214	PF03271	0.498
LIG_TRAF2_1	382	385	PF00917	0.597
LIG_UBA3_1	448	454	PF00899	0.485
MOD_CDC14_SPxK_1	30	33	PF00782	0.626
MOD_CDK_SPxK_1	27	33	PF00069	0.731
MOD_CDK_SPxxK_3	27	34	PF00069	0.630
MOD_CK1_1	213	219	PF00069	0.495
MOD_CK1_1	248	254	PF00069	0.531
MOD_CK1_1	27	33	PF00069	0.699
MOD_CK1_1	278	284	PF00069	0.552
MOD_CK1_1	457	463	PF00069	0.460
MOD_CK1_1	5	11	PF00069	0.640
MOD_CK1_1	509	515	PF00069	0.681
MOD_CK1_1	516	522	PF00069	0.764
MOD_CK2_1	164	170	PF00069	0.528
MOD_CK2_1	187	193	PF00069	0.527
MOD_CK2_1	216	222	PF00069	0.587
MOD_CK2_1	34	40	PF00069	0.734
MOD_CK2_1	379	385	PF00069	0.608
MOD_CK2_1	477	483	PF00069	0.592
MOD_CK2_1	81	87	PF00069	0.575
MOD_CK2_1	95	101	PF00069	0.576
MOD_GlcNHglycan	164	167	PF01048	0.279
MOD_GlcNHglycan	311	314	PF01048	0.262
MOD_GlcNHglycan	340	343	PF01048	0.433
MOD_GlcNHglycan	375	378	PF01048	0.378
MOD_GlcNHglycan	455	459	PF01048	0.280
MOD_GlcNHglycan	511	514	PF01048	0.429
MOD_GlcNHglycan	515	518	PF01048	0.461
MOD_GSK3_1	179	186	PF00069	0.499
MOD_GSK3_1	20	27	PF00069	0.713
MOD_GSK3_1	241	248	PF00069	0.566
MOD_GSK3_1	273	280	PF00069	0.538
MOD_GSK3_1	457	464	PF00069	0.458
MOD_GSK3_1	509	516	PF00069	0.656
MOD_N-GLC_1	133	138	PF02516	0.489
MOD_N-GLC_1	2	7	PF02516	0.372
MOD_N-GLC_1	248	253	PF02516	0.343
MOD_N-GLC_2	91	93	PF02516	0.398
MOD_NEK2_1	114	119	PF00069	0.504
MOD_NEK2_1	179	184	PF00069	0.561
MOD_NEK2_1	187	192	PF00069	0.534
MOD_NEK2_1	210	215	PF00069	0.518
MOD_NEK2_1	241	246	PF00069	0.568
MOD_NEK2_1	257	262	PF00069	0.532
MOD_NEK2_1	270	275	PF00069	0.491
MOD_NEK2_1	309	314	PF00069	0.345
MOD_NEK2_1	65	70	PF00069	0.601
MOD_NEK2_2	119	124	PF00069	0.506
MOD_NEK2_2	258	263	PF00069	0.403
MOD_PIKK_1	133	139	PF00454	0.574
MOD_PKA_1	223	229	PF00069	0.455
MOD_PKA_1	33	39	PF00069	0.595
MOD_PKA_1	432	438	PF00069	0.642
MOD_PKA_2	203	209	PF00069	0.516
MOD_PKA_2	223	229	PF00069	0.434
MOD_PKA_2	33	39	PF00069	0.686
MOD_PKA_2	432	438	PF00069	0.641
MOD_Plk_1	248	254	PF00069	0.569
MOD_Plk_2-3	101	107	PF00069	0.504
MOD_Plk_2-3	477	483	PF00069	0.373
MOD_Plk_4	183	189	PF00069	0.482
MOD_Plk_4	203	209	PF00069	0.608
MOD_Plk_4	216	222	PF00069	0.530
MOD_Plk_4	241	247	PF00069	0.544
MOD_Plk_4	248	254	PF00069	0.536
MOD_Plk_4	314	320	PF00069	0.322
MOD_Plk_4	34	40	PF00069	0.750
MOD_Plk_4	67	73	PF00069	0.600
MOD_ProDKin_1	27	33	PF00069	0.705
MOD_ProDKin_1	278	284	PF00069	0.563
MOD_ProDKin_1	379	385	PF00069	0.570
MOD_SUMO_for_1	411	414	PF00179	0.559
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.448
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.472
TRG_ENDOCYTIC_2	158	161	PF00928	0.530
TRG_ENDOCYTIC_2	445	448	PF00928	0.442
TRG_ENDOCYTIC_2	498	501	PF00928	0.457
TRG_ER_diArg_1	11	14	PF00400	0.685
TRG_ER_diArg_1	223	225	PF00400	0.534
TRG_ER_diArg_1	227	229	PF00400	0.543
TRG_ER_diArg_1	303	306	PF00400	0.655
TRG_ER_diArg_1	33	35	PF00400	0.743
TRG_ER_diArg_1	397	399	PF00400	0.530
TRG_ER_diArg_1	432	434	PF00400	0.657
TRG_NES_CRM1_1	363	375	PF08389	0.515
TRG_NLS_MonoExtN_4	303	308	PF00514	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK13	Leptomonas seymouri	75%	100%
A0A0S4ITI3	Bodo saltans	45%	100%
A0A1X0NQB1	Trypanosomatidae	56%	100%
A0A1X0NVK2	Trypanosomatidae	24%	100%
A0A3S7WSV3	Leishmania donovani	86%	100%
A0A3S7WYG6	Leishmania donovani	24%	100%
A0A422N8L2	Trypanosoma rangeli	23%	100%
A4HDG4	Leishmania braziliensis	23%	100%
A4HVV3	Leishmania infantum	86%	100%
A4I0U5	Leishmania infantum	23%	100%
C9ZT74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
D0A774	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9APK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AWU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4QAM5	Leishmania major	23%	100%
Q4QFX4	Leishmania major	86%	100%
V5BD52	Trypanosoma cruzi	57%	100%
V5DSF1	Trypanosoma cruzi	23%	100%