Tim44 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7G9_LEIBR

TriTrypDb:

LbrM.14.0080 , LBRM2903_140005700

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7G9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.425
CLV_NRD_NRD_1	160	162	PF00675	0.369
CLV_NRD_NRD_1	165	167	PF00675	0.368
CLV_NRD_NRD_1	171	173	PF00675	0.361
CLV_NRD_NRD_1	332	334	PF00675	0.536
CLV_NRD_NRD_1	75	77	PF00675	0.575
CLV_PCSK_KEX2_1	116	118	PF00082	0.511
CLV_PCSK_KEX2_1	160	162	PF00082	0.360
CLV_PCSK_KEX2_1	171	173	PF00082	0.382
CLV_PCSK_KEX2_1	75	77	PF00082	0.575
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.530
CLV_PCSK_SKI1_1	156	160	PF00082	0.393
CLV_PCSK_SKI1_1	161	165	PF00082	0.374
CLV_PCSK_SKI1_1	181	185	PF00082	0.391
CLV_PCSK_SKI1_1	213	217	PF00082	0.427
CLV_PCSK_SKI1_1	232	236	PF00082	0.353
CLV_PCSK_SKI1_1	62	66	PF00082	0.434
DOC_CKS1_1	301	306	PF01111	0.341
DOC_PP2B_PxIxI_1	307	313	PF00149	0.399
DOC_PP4_FxxP_1	70	73	PF00568	0.595
DOC_USP7_MATH_1	227	231	PF00917	0.559
DOC_USP7_MATH_1	4	8	PF00917	0.448
DOC_WW_Pin1_4	142	147	PF00397	0.377
DOC_WW_Pin1_4	192	197	PF00397	0.535
DOC_WW_Pin1_4	300	305	PF00397	0.395
LIG_14-3-3_CanoR_1	10	15	PF00244	0.565
LIG_14-3-3_CanoR_1	132	137	PF00244	0.437
LIG_14-3-3_CanoR_1	148	153	PF00244	0.507
LIG_14-3-3_CanoR_1	160	166	PF00244	0.366
LIG_14-3-3_CanoR_1	53	59	PF00244	0.658
LIG_14-3-3_CanoR_1	62	67	PF00244	0.642
LIG_BIR_II_1	1	5	PF00653	0.465
LIG_BRCT_BRCA1_1	32	36	PF00533	0.449
LIG_deltaCOP1_diTrp_1	125	133	PF00928	0.458
LIG_eIF4E_1	282	288	PF01652	0.280
LIG_FHA_1	240	246	PF00498	0.302
LIG_FHA_1	55	61	PF00498	0.564
LIG_FHA_2	102	108	PF00498	0.500
LIG_FHA_2	116	122	PF00498	0.469
LIG_FHA_2	205	211	PF00498	0.342
LIG_FHA_2	284	290	PF00498	0.475
LIG_LIR_Gen_1	182	192	PF02991	0.500
LIG_LIR_Gen_1	248	257	PF02991	0.333
LIG_LIR_Gen_1	263	270	PF02991	0.286
LIG_LIR_Gen_1	281	292	PF02991	0.348
LIG_LIR_Gen_1	306	315	PF02991	0.358
LIG_LIR_Gen_1	33	42	PF02991	0.445
LIG_LIR_Gen_1	8	19	PF02991	0.440
LIG_LIR_Nem_3	150	155	PF02991	0.427
LIG_LIR_Nem_3	182	187	PF02991	0.482
LIG_LIR_Nem_3	197	202	PF02991	0.479
LIG_LIR_Nem_3	230	234	PF02991	0.530
LIG_LIR_Nem_3	248	253	PF02991	0.338
LIG_LIR_Nem_3	263	268	PF02991	0.289
LIG_LIR_Nem_3	281	287	PF02991	0.377
LIG_LIR_Nem_3	289	293	PF02991	0.296
LIG_LIR_Nem_3	306	312	PF02991	0.432
LIG_LIR_Nem_3	33	39	PF02991	0.577
LIG_LIR_Nem_3	8	14	PF02991	0.440
LIG_Pex14_2	14	18	PF04695	0.441
LIG_SH2_STAP1	149	153	PF00017	0.387
LIG_SH2_STAP1	243	247	PF00017	0.428
LIG_SH2_STAT3	256	259	PF00017	0.348
LIG_SH2_STAT5	149	152	PF00017	0.404
LIG_SH3_3	298	304	PF00018	0.512
LIG_SH3_3	80	86	PF00018	0.690
LIG_WRC_WIRS_1	11	16	PF05994	0.441
LIG_WRC_WIRS_1	149	154	PF05994	0.298
LIG_WRC_WIRS_1	247	252	PF05994	0.343
MOD_CDK_SPxK_1	142	148	PF00069	0.382
MOD_CK1_1	101	107	PF00069	0.485
MOD_CK1_1	2	8	PF00069	0.454
MOD_CK1_1	230	236	PF00069	0.547
MOD_CK1_1	29	35	PF00069	0.602
MOD_CK2_1	101	107	PF00069	0.541
MOD_CK2_1	204	210	PF00069	0.353
MOD_CK2_1	238	244	PF00069	0.562
MOD_CK2_1	283	289	PF00069	0.385
MOD_GlcNHglycan	46	49	PF01048	0.622
MOD_GSK3_1	10	17	PF00069	0.570
MOD_GSK3_1	107	114	PF00069	0.541
MOD_GSK3_1	188	195	PF00069	0.382
MOD_GSK3_1	26	33	PF00069	0.635
MOD_GSK3_1	54	61	PF00069	0.722
MOD_N-GLC_1	5	10	PF02516	0.447
MOD_N-GLC_1	62	67	PF02516	0.434
MOD_N-GLC_1	98	103	PF02516	0.478
MOD_N-GLC_2	49	51	PF02516	0.465
MOD_NEK2_1	14	19	PF00069	0.582
MOD_NEK2_1	266	271	PF00069	0.322
MOD_NEK2_1	336	341	PF00069	0.451
MOD_NEK2_1	34	39	PF00069	0.686
MOD_NEK2_1	98	103	PF00069	0.585
MOD_PIKK_1	107	113	PF00454	0.600
MOD_PIKK_1	258	264	PF00454	0.474
MOD_PIKK_1	323	329	PF00454	0.469
MOD_PKA_2	147	153	PF00069	0.416
MOD_PKA_2	203	209	PF00069	0.358
MOD_PKA_2	52	58	PF00069	0.658
MOD_Plk_1	62	68	PF00069	0.434
MOD_Plk_1	98	104	PF00069	0.491
MOD_Plk_2-3	283	289	PF00069	0.404
MOD_Plk_4	14	20	PF00069	0.573
MOD_Plk_4	283	289	PF00069	0.409
MOD_Plk_4	62	68	PF00069	0.578
MOD_ProDKin_1	142	148	PF00069	0.382
MOD_ProDKin_1	192	198	PF00069	0.529
MOD_ProDKin_1	300	306	PF00069	0.395
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.446
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.567
TRG_ENDOCYTIC_2	11	14	PF00928	0.439
TRG_ENDOCYTIC_2	149	152	PF00928	0.389
TRG_ENDOCYTIC_2	290	293	PF00928	0.324
TRG_ER_diArg_1	159	161	PF00400	0.370
TRG_ER_diArg_1	171	173	PF00400	0.357
TRG_ER_diArg_1	218	221	PF00400	0.316
TRG_ER_diArg_1	274	277	PF00400	0.378
TRG_ER_diArg_1	74	76	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I365	Leptomonas seymouri	82%	100%
A0A0S4IUM2	Bodo saltans	60%	100%
A0A1X0NNS4	Trypanosomatidae	69%	100%
A0A3S5H6Q6	Leishmania donovani	90%	100%
A0A3S5IS70	Trypanosoma rangeli	66%	100%
A4HVV0	Leishmania infantum	90%	100%
C9ZT77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9APK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QFX7	Leishmania major	91%	100%
V5AXQ5	Trypanosoma cruzi	66%	100%