Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7G8_LEIBR

TriTrypDb:

LbrM.14.0070 , LBRM2903_140005600

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H7G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7G8

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016409	palmitoyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	7
GO:0019707	protein-cysteine S-acyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.290
CLV_PCSK_KEX2_1	151	153	PF00082	0.244
CLV_PCSK_KEX2_1	176	178	PF00082	0.244
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.189
CLV_PCSK_SKI1_1	177	181	PF00082	0.244
CLV_PCSK_SKI1_1	212	216	PF00082	0.385
CLV_PCSK_SKI1_1	80	84	PF00082	0.454
DEG_APCC_DBOX_1	176	184	PF00400	0.444
DEG_MDM2_SWIB_1	62	69	PF02201	0.274
DOC_MAPK_DCC_7	80	90	PF00069	0.244
DOC_MAPK_gen_1	176	183	PF00069	0.444
DOC_MAPK_MEF2A_6	176	183	PF00069	0.389
DOC_MAPK_NFAT4_5	176	184	PF00069	0.389
DOC_MAPK_RevD_3	193	208	PF00069	0.201
DOC_PP1_RVXF_1	36	42	PF00149	0.524
DOC_PP2B_PxIxI_1	85	91	PF00149	0.343
DOC_PP4_FxxP_1	71	74	PF00568	0.262
DOC_USP7_MATH_1	43	47	PF00917	0.504
DOC_WW_Pin1_4	120	125	PF00397	0.544
DOC_WW_Pin1_4	39	44	PF00397	0.506
LIG_14-3-3_CanoR_1	212	220	PF00244	0.189
LIG_14-3-3_CanoR_1	259	265	PF00244	0.605
LIG_14-3-3_CanoR_1	70	74	PF00244	0.321
LIG_14-3-3_CanoR_1	80	89	PF00244	0.314
LIG_Actin_WH2_2	57	72	PF00022	0.340
LIG_BIR_II_1	1	5	PF00653	0.661
LIG_BRCT_BRCA1_1	67	71	PF00533	0.232
LIG_CSL_BTD_1	40	43	PF09270	0.506
LIG_EH1_1	46	54	PF00400	0.278
LIG_eIF4E_1	178	184	PF01652	0.278
LIG_FHA_1	136	142	PF00498	0.535
LIG_FHA_1	215	221	PF00498	0.352
LIG_FHA_1	229	235	PF00498	0.218
LIG_FHA_1	97	103	PF00498	0.302
LIG_GBD_Chelix_1	193	201	PF00786	0.201
LIG_LIR_Apic_2	68	74	PF02991	0.301
LIG_LIR_Gen_1	190	200	PF02991	0.201
LIG_LIR_Gen_1	2	11	PF02991	0.631
LIG_LIR_Gen_1	46	56	PF02991	0.368
LIG_LIR_Gen_1	59	69	PF02991	0.212
LIG_LIR_Nem_3	190	195	PF02991	0.220
LIG_LIR_Nem_3	2	7	PF02991	0.635
LIG_LIR_Nem_3	46	51	PF02991	0.368
LIG_LIR_Nem_3	59	65	PF02991	0.212
LIG_MYND_1	74	78	PF01753	0.268
LIG_NRBOX	60	66	PF00104	0.332
LIG_PDZ_Wminus1_1	277	279	PF00595	0.518
LIG_Pex14_2	62	66	PF04695	0.278
LIG_SH2_STAP1	189	193	PF00017	0.201
LIG_SH2_STAT5	129	132	PF00017	0.546
LIG_SH2_STAT5	135	138	PF00017	0.444
LIG_SH2_STAT5	178	181	PF00017	0.286
LIG_SH2_STAT5	199	202	PF00017	0.244
LIG_SH2_STAT5	233	236	PF00017	0.283
LIG_SH2_STAT5	250	253	PF00017	0.556
LIG_SH3_3	200	206	PF00018	0.286
LIG_SH3_3	268	274	PF00018	0.535
LIG_SUMO_SIM_anti_2	266	272	PF11976	0.429
LIG_SUMO_SIM_anti_2	87	93	PF11976	0.196
LIG_SUMO_SIM_par_1	222	227	PF11976	0.343
LIG_SUMO_SIM_par_1	48	54	PF11976	0.264
LIG_SUMO_SIM_par_1	98	105	PF11976	0.255
LIG_TYR_ITIM	197	202	PF00017	0.321
LIG_WRC_WIRS_1	225	230	PF05994	0.201
MOD_CDK_SPxxK_3	120	127	PF00069	0.509
MOD_CK1_1	123	129	PF00069	0.565
MOD_CK1_1	227	233	PF00069	0.201
MOD_CK1_1	260	266	PF00069	0.465
MOD_CK2_1	6	12	PF00069	0.641
MOD_GlcNHglycan	189	192	PF01048	0.469
MOD_GlcNHglycan	21	24	PF01048	0.414
MOD_GlcNHglycan	251	254	PF01048	0.267
MOD_GSK3_1	119	126	PF00069	0.583
MOD_GSK3_1	15	22	PF00069	0.677
MOD_GSK3_1	220	227	PF00069	0.343
MOD_GSK3_1	249	256	PF00069	0.482
MOD_GSK3_1	39	46	PF00069	0.504
MOD_GSK3_1	65	72	PF00069	0.321
MOD_N-GLC_1	257	262	PF02516	0.296
MOD_N-GLC_2	154	156	PF02516	0.270
MOD_NEK2_1	101	106	PF00069	0.278
MOD_NEK2_1	182	187	PF00069	0.329
MOD_NEK2_1	220	225	PF00069	0.343
MOD_NEK2_1	228	233	PF00069	0.257
MOD_NEK2_1	65	70	PF00069	0.323
MOD_NEK2_2	135	140	PF00069	0.490
MOD_PIKK_1	142	148	PF00454	0.495
MOD_PIKK_1	80	86	PF00454	0.245
MOD_PKA_2	142	148	PF00069	0.453
MOD_PKA_2	260	266	PF00069	0.504
MOD_PKA_2	69	75	PF00069	0.311
MOD_Plk_1	43	49	PF00069	0.587
MOD_Plk_4	220	226	PF00069	0.392
MOD_Plk_4	56	62	PF00069	0.340
MOD_Plk_4	96	102	PF00069	0.308
MOD_ProDKin_1	120	126	PF00069	0.540
MOD_ProDKin_1	39	45	PF00069	0.503
MOD_SUMO_for_1	274	277	PF00179	0.479
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.511
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.490
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.470
TRG_ENDOCYTIC_2	178	181	PF00928	0.278
TRG_ENDOCYTIC_2	189	192	PF00928	0.278
TRG_ENDOCYTIC_2	199	202	PF00928	0.310
TRG_ENDOCYTIC_2	28	31	PF00928	0.562
TRG_ER_diLys_1	275	279	PF00400	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B1	Leptomonas seymouri	59%	100%
A0A0N1I542	Leptomonas seymouri	29%	94%
A0A3S7WSS8	Leishmania donovani	81%	100%
A0A3S7WZD9	Leishmania donovani	25%	85%
A4HVU9	Leishmania infantum	81%	100%
A4I1S8	Leishmania infantum	25%	85%
E9AIR6	Leishmania braziliensis	28%	94%
E9APK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9AXW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	85%
F1QAM1	Danio rerio	28%	81%
F1R013	Danio rerio	27%	72%
O80685	Arabidopsis thaliana	28%	68%
P59268	Mus musculus	28%	77%
Q2TGJ1	Rattus norvegicus	29%	72%
Q4Q9K8	Leishmania major	25%	85%
Q4QB09	Leishmania major	23%	100%
Q4QFX8	Leishmania major	81%	100%
Q58DA8	Bos taurus	28%	77%
Q5PNZ1	Arabidopsis thaliana	30%	68%
Q5R5J8	Pongo abelii	25%	77%
Q5Y5T2	Mus musculus	29%	73%
Q750R7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	76%
Q7ZVN4	Danio rerio	32%	72%
Q8VYS8	Arabidopsis thaliana	29%	69%
Q9FLM3	Arabidopsis thaliana	26%	68%
Q9NUE0	Homo sapiens	28%	72%
Q9SB58	Arabidopsis thaliana	29%	69%
Q9Y397	Homo sapiens	28%	77%