P-loop containing nucleoside triphosphate hydrolase protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7G7_LEIBR

TriTrypDb:

LbrM.14.0060 , LBRM2903_140005500

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7G7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0003924	GTPase activity	7	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	81	83	PF00675	0.516
CLV_PCSK_SKI1_1	116	120	PF00082	0.483
CLV_PCSK_SKI1_1	150	154	PF00082	0.472
CLV_PCSK_SKI1_1	82	86	PF00082	0.393
DEG_Nend_Nbox_1	1	3	PF02207	0.356
DOC_PP4_FxxP_1	187	190	PF00568	0.525
DOC_USP7_MATH_1	109	113	PF00917	0.384
DOC_WW_Pin1_4	36	41	PF00397	0.543
DOC_WW_Pin1_4	50	55	PF00397	0.364
LIG_14-3-3_CanoR_1	116	125	PF00244	0.496
LIG_BRCT_BRCA1_1	111	115	PF00533	0.378
LIG_BRCT_BRCA1_1	90	94	PF00533	0.276
LIG_FHA_1	15	21	PF00498	0.343
LIG_FHA_1	4	10	PF00498	0.303
LIG_FHA_1	59	65	PF00498	0.441
LIG_FHA_1	90	96	PF00498	0.450
LIG_FHA_2	143	149	PF00498	0.340
LIG_LIR_Apic_2	184	190	PF02991	0.401
LIG_LIR_Gen_1	91	100	PF02991	0.448
LIG_LIR_Nem_3	112	118	PF02991	0.423
LIG_LIR_Nem_3	169	174	PF02991	0.371
LIG_LIR_Nem_3	91	97	PF02991	0.458
LIG_SH2_STAT3	117	120	PF00017	0.425
LIG_SH2_STAT3	25	28	PF00017	0.388
LIG_SH2_STAT5	117	120	PF00017	0.560
LIG_SH2_STAT5	25	28	PF00017	0.412
LIG_SH2_STAT5	7	10	PF00017	0.346
LIG_SH2_STAT5	98	101	PF00017	0.427
LIG_SUMO_SIM_anti_2	161	167	PF11976	0.287
LIG_SUMO_SIM_anti_2	45	50	PF11976	0.413
LIG_SUMO_SIM_par_1	164	170	PF11976	0.421
LIG_SUMO_SIM_par_1	47	53	PF11976	0.409
LIG_SUMO_SIM_par_1	60	66	PF11976	0.409
LIG_TRAF2_1	145	148	PF00917	0.425
MOD_CK1_1	158	164	PF00069	0.477
MOD_CK1_1	3	9	PF00069	0.255
MOD_CK2_1	142	148	PF00069	0.353
MOD_CK2_1	74	80	PF00069	0.414
MOD_GSK3_1	10	17	PF00069	0.356
MOD_GSK3_1	30	37	PF00069	0.341
MOD_GSK3_1	74	81	PF00069	0.397
MOD_NEK2_1	1	6	PF00069	0.339
MOD_NEK2_1	110	115	PF00069	0.497
MOD_NEK2_1	67	72	PF00069	0.427
MOD_NEK2_1	78	83	PF00069	0.333
MOD_PIKK_1	116	122	PF00454	0.446
MOD_PIKK_1	156	162	PF00454	0.479
MOD_PIKK_1	24	30	PF00454	0.474
MOD_PK_1	137	143	PF00069	0.492
MOD_Plk_1	44	50	PF00069	0.487
MOD_Plk_4	110	116	PF00069	0.308
MOD_Plk_4	128	134	PF00069	0.388
MOD_Plk_4	3	9	PF00069	0.252
MOD_Plk_4	44	50	PF00069	0.352
MOD_Plk_4	67	73	PF00069	0.390
MOD_Plk_4	74	80	PF00069	0.371
MOD_ProDKin_1	36	42	PF00069	0.546
MOD_ProDKin_1	50	56	PF00069	0.374
MOD_SUMO_rev_2	53	61	PF00179	0.361
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE8	Leptomonas seymouri	63%	78%
A0A1X0NNU1	Trypanosomatidae	36%	100%
A0A3R7LA27	Trypanosoma rangeli	44%	100%
A0A3S7WSS1	Leishmania donovani	87%	100%
A4HVU8	Leishmania infantum	87%	100%
C9ZT78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9APK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QFX9	Leishmania major	84%	100%
V5DE15	Trypanosoma cruzi	43%	100%