Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7G4_LEIBR

TriTrypDb:

LbrM.14.0030 , LBRM2903_140005200

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H7G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7G4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.520
CLV_NRD_NRD_1	109	111	PF00675	0.649
CLV_NRD_NRD_1	125	127	PF00675	0.688
CLV_NRD_NRD_1	130	132	PF00675	0.670
CLV_NRD_NRD_1	70	72	PF00675	0.537
CLV_NRD_NRD_1	78	80	PF00675	0.444
CLV_PCSK_KEX2_1	109	111	PF00082	0.694
CLV_PCSK_KEX2_1	129	131	PF00082	0.552
CLV_PCSK_KEX2_1	69	71	PF00082	0.487
CLV_PCSK_KEX2_1	78	80	PF00082	0.449
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.608
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.398
CLV_PCSK_PC7_1	126	132	PF00082	0.608
CLV_PCSK_SKI1_1	212	216	PF00082	0.709
CLV_PCSK_SKI1_1	246	250	PF00082	0.699
DOC_CYCLIN_yClb5_NLxxxL_5	86	95	PF00134	0.326
DOC_MAPK_gen_1	78	86	PF00069	0.531
DOC_USP7_MATH_1	180	184	PF00917	0.511
DOC_USP7_MATH_1	203	207	PF00917	0.496
DOC_USP7_MATH_1	41	45	PF00917	0.678
DOC_USP7_MATH_1	54	58	PF00917	0.727
DOC_USP7_UBL2_3	51	55	PF12436	0.578
DOC_WW_Pin1_4	116	121	PF00397	0.401
DOC_WW_Pin1_4	98	103	PF00397	0.602
LIG_14-3-3_CanoR_1	179	185	PF00244	0.532
LIG_14-3-3_CanoR_1	216	224	PF00244	0.507
LIG_14-3-3_CanoR_1	71	77	PF00244	0.573
LIG_BRCT_BRCA1_1	187	191	PF00533	0.508
LIG_FHA_1	192	198	PF00498	0.464
LIG_FHA_1	226	232	PF00498	0.532
LIG_FHA_1	239	245	PF00498	0.546
LIG_FHA_1	86	92	PF00498	0.341
LIG_FHA_2	149	155	PF00498	0.452
LIG_LIR_Gen_1	206	215	PF02991	0.531
LIG_LIR_Gen_1	43	54	PF02991	0.671
LIG_LIR_Nem_3	43	49	PF02991	0.659
LIG_PCNA_yPIPBox_3	8	17	PF02747	0.659
LIG_Pex14_2	226	230	PF04695	0.475
LIG_SH2_STAT5	114	117	PF00017	0.543
LIG_SH2_STAT5	14	17	PF00017	0.655
LIG_SH3_3	30	36	PF00018	0.652
LIG_TRAF2_1	59	62	PF00917	0.694
LIG_WRC_WIRS_1	83	88	PF05994	0.391
MOD_CK1_1	183	189	PF00069	0.532
MOD_CK1_1	218	224	PF00069	0.374
MOD_CK1_1	239	245	PF00069	0.524
MOD_CK1_1	252	258	PF00069	0.573
MOD_CK1_1	44	50	PF00069	0.655
MOD_CK1_1	57	63	PF00069	0.676
MOD_CK1_1	85	91	PF00069	0.364
MOD_CK2_1	166	172	PF00069	0.599
MOD_CK2_1	239	245	PF00069	0.483
MOD_CK2_1	56	62	PF00069	0.695
MOD_GlcNHglycan	120	123	PF01048	0.787
MOD_GlcNHglycan	219	223	PF01048	0.752
MOD_GlcNHglycan	251	254	PF01048	0.716
MOD_GlcNHglycan	43	46	PF01048	0.484
MOD_GlcNHglycan	56	59	PF01048	0.453
MOD_GSK3_1	168	175	PF00069	0.525
MOD_GSK3_1	180	187	PF00069	0.409
MOD_GSK3_1	214	221	PF00069	0.524
MOD_GSK3_1	235	242	PF00069	0.543
MOD_GSK3_1	247	254	PF00069	0.501
MOD_GSK3_1	56	63	PF00069	0.725
MOD_N-GLC_1	148	153	PF02516	0.758
MOD_N-GLC_1	72	77	PF02516	0.519
MOD_NEK2_1	104	109	PF00069	0.503
MOD_NEK2_1	191	196	PF00069	0.528
MOD_NEK2_1	226	231	PF00069	0.477
MOD_NEK2_1	249	254	PF00069	0.521
MOD_NEK2_2	148	153	PF00069	0.615
MOD_PKA_2	215	221	PF00069	0.414
MOD_PKA_2	25	31	PF00069	0.667
MOD_Plk_1	138	144	PF00069	0.500
MOD_Plk_1	148	154	PF00069	0.612
MOD_Plk_1	191	197	PF00069	0.589
MOD_Plk_1	226	232	PF00069	0.532
MOD_Plk_1	235	241	PF00069	0.532
MOD_Plk_1	60	66	PF00069	0.682
MOD_Plk_1	72	78	PF00069	0.711
MOD_Plk_4	138	144	PF00069	0.404
MOD_Plk_4	186	192	PF00069	0.544
MOD_Plk_4	226	232	PF00069	0.532
MOD_Plk_4	82	88	PF00069	0.417
MOD_ProDKin_1	116	122	PF00069	0.401
MOD_ProDKin_1	98	104	PF00069	0.603
TRG_DiLeu_BaEn_1	227	232	PF01217	0.391
TRG_ENDOCYTIC_2	46	49	PF00928	0.697
TRG_ER_diArg_1	108	110	PF00400	0.350
TRG_ER_diArg_1	68	71	PF00400	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXV2	Leptomonas seymouri	47%	96%
A0A1X0NNV6	Trypanosomatidae	23%	100%
A0A3S5H6Q5	Leishmania donovani	74%	96%
A0A422NXF3	Trypanosoma rangeli	25%	100%
A4HVU5	Leishmania infantum	74%	96%
E9APJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	96%
Q4QFY2	Leishmania major	71%	100%