F-box/LRR-repeat protein 20

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H7G0_LEIBR

TriTrypDb:

LbrM.13.1560 , LBRM2903_130021800

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	20
GO:0042995	cell projection	2	20
GO:0043226	organelle	2	20
GO:0043227	membrane-bounded organelle	3	20
GO:0110165	cellular anatomical entity	1	20
GO:0120025	plasma membrane bounded cell projection	3	20
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

A4H7G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7G0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	241	243	PF00675	0.533
CLV_PCSK_KEX2_1	241	243	PF00082	0.276
CLV_PCSK_SKI1_1	123	127	PF00082	0.444
CLV_PCSK_SKI1_1	135	139	PF00082	0.390
CLV_PCSK_SKI1_1	370	374	PF00082	0.423
CLV_PCSK_SKI1_1	430	434	PF00082	0.451
CLV_PCSK_SKI1_1	78	82	PF00082	0.503
CLV_Separin_Metazoa	407	411	PF03568	0.281
DEG_APCC_DBOX_1	134	142	PF00400	0.275
DEG_APCC_DBOX_1	51	59	PF00400	0.539
DEG_Nend_UBRbox_2	1	3	PF02207	0.592
DOC_CDC14_PxL_1	199	207	PF14671	0.359
DOC_CDC14_PxL_1	333	341	PF14671	0.417
DOC_CDC14_PxL_1	378	386	PF14671	0.309
DOC_CDC14_PxL_1	423	431	PF14671	0.483
DOC_CYCLIN_RxL_1	278	286	PF00134	0.323
DOC_CYCLIN_yClb5_NLxxxL_5	46	55	PF00134	0.366
DOC_CYCLIN_yCln2_LP_2	442	448	PF00134	0.255
DOC_MAPK_DCC_7	198	207	PF00069	0.228
DOC_MAPK_gen_1	120	128	PF00069	0.445
DOC_MAPK_HePTP_8	69	81	PF00069	0.402
DOC_MAPK_MEF2A_6	112	119	PF00069	0.401
DOC_MAPK_MEF2A_6	139	147	PF00069	0.377
DOC_MAPK_MEF2A_6	198	207	PF00069	0.228
DOC_MAPK_MEF2A_6	72	81	PF00069	0.500
DOC_USP7_MATH_1	169	173	PF00917	0.405
DOC_USP7_MATH_1	457	461	PF00917	0.670
DOC_USP7_MATH_1	95	99	PF00917	0.567
DOC_WW_Pin1_4	373	378	PF00397	0.480
DOC_WW_Pin1_4	418	423	PF00397	0.429
DOC_WW_Pin1_4	56	61	PF00397	0.528
LIG_14-3-3_CanoR_1	139	144	PF00244	0.517
LIG_14-3-3_CanoR_1	198	206	PF00244	0.457
LIG_14-3-3_CanoR_1	22	27	PF00244	0.560
LIG_14-3-3_CanoR_1	241	249	PF00244	0.264
LIG_14-3-3_CanoR_1	281	286	PF00244	0.383
LIG_14-3-3_CanoR_1	370	378	PF00244	0.446
LIG_14-3-3_CanoR_1	52	56	PF00244	0.578
LIG_Actin_WH2_2	122	137	PF00022	0.264
LIG_Actin_WH2_2	326	342	PF00022	0.467
LIG_Actin_WH2_2	36	54	PF00022	0.543
LIG_APCC_ABBA_1	156	161	PF00400	0.244
LIG_APCC_ABBAyCdc20_2	61	67	PF00400	0.286
LIG_BRCT_BRCA1_1	173	177	PF00533	0.243
LIG_DLG_GKlike_1	139	146	PF00625	0.327
LIG_DLG_GKlike_1	281	288	PF00625	0.303
LIG_FHA_1	105	111	PF00498	0.535
LIG_FHA_1	11	17	PF00498	0.495
LIG_FHA_1	271	277	PF00498	0.415
LIG_FHA_1	294	300	PF00498	0.443
LIG_FHA_1	361	367	PF00498	0.297
LIG_FHA_2	261	267	PF00498	0.504
LIG_FHA_2	321	327	PF00498	0.369
LIG_Integrin_RGD_1	120	122	PF01839	0.349
LIG_LIR_Gen_1	168	177	PF02991	0.469
LIG_LIR_Gen_1	388	397	PF02991	0.464
LIG_LIR_Nem_3	168	173	PF02991	0.463
LIG_LIR_Nem_3	298	304	PF02991	0.506
LIG_LIR_Nem_3	388	394	PF02991	0.465
LIG_NRBOX	76	82	PF00104	0.338
LIG_SUMO_SIM_anti_2	124	132	PF11976	0.511
LIG_SUMO_SIM_anti_2	142	147	PF11976	0.567
LIG_SUMO_SIM_anti_2	257	263	PF11976	0.285
LIG_SUMO_SIM_anti_2	273	278	PF11976	0.530
LIG_SUMO_SIM_anti_2	405	410	PF11976	0.332
LIG_SUMO_SIM_par_1	204	209	PF11976	0.368
LIG_SUMO_SIM_par_1	281	286	PF11976	0.460
LIG_SUMO_SIM_par_1	295	300	PF11976	0.458
LIG_TRAF2_2	228	233	PF00917	0.437
LIG_UBA3_1	442	451	PF00899	0.412
MOD_CDK_SPK_2	56	61	PF00069	0.405
MOD_CDK_SPxxK_3	56	63	PF00069	0.517
MOD_CK1_1	209	215	PF00069	0.498
MOD_CK1_1	245	251	PF00069	0.448
MOD_CK1_1	257	263	PF00069	0.232
MOD_CK1_1	270	276	PF00069	0.350
MOD_CK1_1	320	326	PF00069	0.316
MOD_CK2_1	320	326	PF00069	0.335
MOD_GlcNHglycan	173	176	PF01048	0.337
MOD_GlcNHglycan	192	195	PF01048	0.509
MOD_GlcNHglycan	244	247	PF01048	0.513
MOD_GlcNHglycan	254	257	PF01048	0.247
MOD_GlcNHglycan	285	288	PF01048	0.380
MOD_GlcNHglycan	301	304	PF01048	0.350
MOD_GlcNHglycan	346	349	PF01048	0.419
MOD_GlcNHglycan	391	394	PF01048	0.346
MOD_GSK3_1	137	144	PF00069	0.358
MOD_GSK3_1	171	178	PF00069	0.323
MOD_GSK3_1	215	222	PF00069	0.653
MOD_GSK3_1	293	300	PF00069	0.434
MOD_GSK3_1	68	75	PF00069	0.480
MOD_N-GLC_1	175	180	PF02516	0.242
MOD_N-GLC_1	22	27	PF02516	0.351
MOD_NEK2_1	128	133	PF00069	0.515
MOD_NEK2_1	197	202	PF00069	0.346
MOD_NEK2_1	219	224	PF00069	0.549
MOD_NEK2_1	252	257	PF00069	0.450
MOD_NEK2_1	283	288	PF00069	0.542
MOD_NEK2_1	51	56	PF00069	0.606
MOD_NEK2_1	68	73	PF00069	0.574
MOD_NEK2_1	81	86	PF00069	0.623
MOD_NEK2_2	360	365	PF00069	0.449
MOD_OFUCOSY	92	99	PF10250	0.338
MOD_PIKK_1	175	181	PF00454	0.475
MOD_PIKK_1	197	203	PF00454	0.333
MOD_PK_1	295	301	PF00069	0.303
MOD_PKA_2	197	203	PF00069	0.478
MOD_PKA_2	21	27	PF00069	0.571
MOD_PKA_2	252	258	PF00069	0.431
MOD_PKA_2	317	323	PF00069	0.473
MOD_PKA_2	51	57	PF00069	0.648
MOD_Plk_1	121	127	PF00069	0.469
MOD_Plk_1	175	181	PF00069	0.464
MOD_Plk_1	22	28	PF00069	0.408
MOD_Plk_1	387	393	PF00069	0.435
MOD_Plk_1	81	87	PF00069	0.557
MOD_Plk_1	95	101	PF00069	0.346
MOD_Plk_2-3	317	323	PF00069	0.289
MOD_Plk_4	104	110	PF00069	0.547
MOD_Plk_4	141	147	PF00069	0.383
MOD_Plk_4	257	263	PF00069	0.470
MOD_Plk_4	272	278	PF00069	0.215
MOD_Plk_4	444	450	PF00069	0.376
MOD_Plk_4	82	88	PF00069	0.383
MOD_ProDKin_1	373	379	PF00069	0.485
MOD_ProDKin_1	418	424	PF00069	0.430
MOD_ProDKin_1	56	62	PF00069	0.522
TRG_DiLeu_BaEn_1	36	41	PF01217	0.331
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.570
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.527
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.459
TRG_ER_diArg_1	133	136	PF00400	0.488
TRG_ER_diArg_1	240	242	PF00400	0.276
TRG_ER_diArg_1	337	340	PF00400	0.311
TRG_ER_diArg_1	382	385	PF00400	0.313
TRG_NES_CRM1_1	201	211	PF08389	0.299
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F9	Leptomonas seymouri	33%	88%
A0A0N0P8N9	Leptomonas seymouri	32%	70%
A0A0N1HZK9	Leptomonas seymouri	31%	87%
A0A0N1I0W0	Leptomonas seymouri	30%	90%
A0A0N1I1E8	Leptomonas seymouri	26%	100%
A0A1X0NEN5	Trypanosomatidae	25%	79%
A0A1X0NG16	Trypanosomatidae	27%	79%
A0A1X0P4M6	Trypanosomatidae	25%	79%
A0A3Q8I8N4	Leishmania donovani	77%	100%
A0A3S5H5M6	Leishmania donovani	23%	86%
A4H3R1	Leishmania braziliensis	29%	67%
A4H4H0	Leishmania braziliensis	23%	100%
A4HSP5	Leishmania infantum	23%	86%
E9AGK6	Leishmania infantum	77%	100%
E9AKN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9APJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QFY4	Leishmania major	78%	100%
V5BMQ2	Trypanosoma cruzi	26%	82%