Major facilitator superfamily domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein associated with differentiation 8, putative

Species:

Leishmania braziliensis

UniProt:

A4H7F9_LEIBR

TriTrypDb:

LbrM.13.1550 , LBRM2903_130021700

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A4H7F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7F9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0022857	transmembrane transporter activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.574
CLV_NRD_NRD_1	301	303	PF00675	0.548
CLV_NRD_NRD_1	331	333	PF00675	0.352
CLV_PCSK_KEX2_1	199	201	PF00082	0.355
CLV_PCSK_KEX2_1	331	333	PF00082	0.371
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.403
CLV_PCSK_PC7_1	195	201	PF00082	0.355
CLV_PCSK_SKI1_1	167	171	PF00082	0.243
CLV_PCSK_SKI1_1	226	230	PF00082	0.563
CLV_PCSK_SKI1_1	35	39	PF00082	0.236
DEG_APCC_DBOX_1	166	174	PF00400	0.164
DEG_Nend_Nbox_1	1	3	PF02207	0.435
DEG_SPOP_SBC_1	82	86	PF00917	0.574
DOC_CKS1_1	305	310	PF01111	0.300
DOC_CYCLIN_RxL_1	88	99	PF00134	0.558
DOC_CYCLIN_yCln2_LP_2	229	235	PF00134	0.236
DOC_MAPK_gen_1	199	207	PF00069	0.462
DOC_MAPK_MEF2A_6	199	207	PF00069	0.475
DOC_MAPK_MEF2A_6	303	312	PF00069	0.341
DOC_PP1_RVXF_1	33	39	PF00149	0.272
DOC_PP2B_LxvP_1	207	210	PF13499	0.269
DOC_PP2B_LxvP_1	222	225	PF13499	0.426
DOC_PP2B_LxvP_1	229	232	PF13499	0.294
DOC_USP7_MATH_1	210	214	PF00917	0.395
DOC_USP7_MATH_1	271	275	PF00917	0.285
DOC_USP7_MATH_1	319	323	PF00917	0.273
DOC_USP7_MATH_1	82	86	PF00917	0.722
DOC_USP7_UBL2_3	257	261	PF12436	0.528
DOC_WW_Pin1_4	304	309	PF00397	0.294
DOC_WW_Pin1_4	78	83	PF00397	0.577
LIG_14-3-3_CanoR_1	167	173	PF00244	0.304
LIG_14-3-3_CanoR_1	182	188	PF00244	0.426
LIG_14-3-3_CanoR_1	331	338	PF00244	0.584
LIG_14-3-3_CanoR_1	80	89	PF00244	0.697
LIG_BRCT_BRCA1_1	150	154	PF00533	0.413
LIG_eIF4E_1	5	11	PF01652	0.225
LIG_FHA_1	116	122	PF00498	0.586
LIG_FHA_1	164	170	PF00498	0.313
LIG_FHA_1	19	25	PF00498	0.432
LIG_FHA_1	202	208	PF00498	0.329
LIG_FHA_1	209	215	PF00498	0.379
LIG_FHA_1	244	250	PF00498	0.381
LIG_FHA_1	305	311	PF00498	0.313
LIG_FHA_1	350	356	PF00498	0.682
LIG_FHA_1	40	46	PF00498	0.245
LIG_FHA_1	90	96	PF00498	0.673
LIG_FHA_2	105	111	PF00498	0.669
LIG_FHA_2	69	75	PF00498	0.662
LIG_FHA_2	97	103	PF00498	0.709
LIG_GBD_Chelix_1	216	224	PF00786	0.236
LIG_LIR_Apic_2	108	114	PF02991	0.624
LIG_LIR_Gen_1	103	114	PF02991	0.483
LIG_LIR_Gen_1	135	142	PF02991	0.380
LIG_LIR_Gen_1	189	197	PF02991	0.433
LIG_LIR_Gen_1	46	56	PF02991	0.455
LIG_LIR_Gen_1	71	79	PF02991	0.566
LIG_LIR_Nem_3	103	109	PF02991	0.510
LIG_LIR_Nem_3	135	140	PF02991	0.389
LIG_LIR_Nem_3	151	157	PF02991	0.300
LIG_LIR_Nem_3	284	288	PF02991	0.301
LIG_LIR_Nem_3	329	333	PF02991	0.597
LIG_LIR_Nem_3	46	52	PF02991	0.326
LIG_LIR_Nem_3	71	75	PF02991	0.559
LIG_NRBOX	120	126	PF00104	0.555
LIG_PCNA_PIPBox_1	11	20	PF02747	0.326
LIG_Pex14_1	133	137	PF04695	0.407
LIG_Pex14_1	2	6	PF04695	0.472
LIG_Pex14_2	4	8	PF04695	0.326
LIG_PTB_Apo_2	146	153	PF02174	0.267
LIG_PTB_Phospho_1	146	152	PF10480	0.427
LIG_SH2_CRK	6	10	PF00017	0.271
LIG_SH2_NCK_1	106	110	PF00017	0.493
LIG_SH2_PTP2	111	114	PF00017	0.608
LIG_SH2_SRC	233	236	PF00017	0.236
LIG_SH2_STAP1	286	290	PF00017	0.242
LIG_SH2_STAP1	333	337	PF00017	0.478
LIG_SH2_STAT3	286	289	PF00017	0.259
LIG_SH2_STAT5	106	109	PF00017	0.503
LIG_SH2_STAT5	111	114	PF00017	0.604
LIG_SH2_STAT5	152	155	PF00017	0.283
LIG_SH2_STAT5	187	190	PF00017	0.578
LIG_SH2_STAT5	233	236	PF00017	0.197
LIG_SH2_STAT5	286	289	PF00017	0.211
LIG_SH3_3	302	308	PF00018	0.341
LIG_SUMO_SIM_anti_2	168	174	PF11976	0.267
LIG_SUMO_SIM_anti_2	307	313	PF11976	0.164
LIG_SUMO_SIM_par_1	168	174	PF11976	0.326
LIG_SUMO_SIM_par_1	246	251	PF11976	0.430
LIG_UBA3_1	153	161	PF00899	0.410
LIG_UBA3_1	220	226	PF00899	0.263
LIG_UBA3_1	249	257	PF00899	0.224
MOD_CDK_SPK_2	78	83	PF00069	0.577
MOD_CK1_1	104	110	PF00069	0.593
MOD_CK1_1	163	169	PF00069	0.352
MOD_CK1_1	346	352	PF00069	0.667
MOD_CK1_1	68	74	PF00069	0.638
MOD_CK1_1	85	91	PF00069	0.767
MOD_CK2_1	183	189	PF00069	0.453
MOD_CK2_1	96	102	PF00069	0.602
MOD_CMANNOS	130	133	PF00535	0.267
MOD_GlcNHglycan	173	176	PF01048	0.196
MOD_GlcNHglycan	177	180	PF01048	0.309
MOD_GlcNHglycan	317	320	PF01048	0.273
MOD_GlcNHglycan	46	49	PF01048	0.174
MOD_GlcNHglycan	67	70	PF01048	0.494
MOD_GSK3_1	159	166	PF00069	0.341
MOD_GSK3_1	171	178	PF00069	0.381
MOD_GSK3_1	244	251	PF00069	0.362
MOD_GSK3_1	266	273	PF00069	0.202
MOD_GSK3_1	293	300	PF00069	0.455
MOD_GSK3_1	315	322	PF00069	0.433
MOD_GSK3_1	39	46	PF00069	0.395
MOD_GSK3_1	60	67	PF00069	0.652
MOD_GSK3_1	78	85	PF00069	0.576
MOD_N-GLC_1	148	153	PF02516	0.549
MOD_N-GLC_1	64	69	PF02516	0.486
MOD_NEK2_1	101	106	PF00069	0.523
MOD_NEK2_1	183	188	PF00069	0.423
MOD_NEK2_1	243	248	PF00069	0.398
MOD_NEK2_1	267	272	PF00069	0.223
MOD_NEK2_1	293	298	PF00069	0.427
MOD_NEK2_1	315	320	PF00069	0.385
MOD_PIKK_1	189	195	PF00454	0.595
MOD_PIKK_1	346	352	PF00454	0.510
MOD_PKA_1	331	337	PF00069	0.427
MOD_PKA_2	331	337	PF00069	0.570
MOD_PKA_2	82	88	PF00069	0.787
MOD_PKB_1	341	349	PF00069	0.480
MOD_Plk_1	101	107	PF00069	0.611
MOD_Plk_1	148	154	PF00069	0.293
MOD_Plk_1	293	299	PF00069	0.308
MOD_Plk_2-3	96	102	PF00069	0.688
MOD_Plk_4	116	122	PF00069	0.528
MOD_Plk_4	148	154	PF00069	0.276
MOD_Plk_4	168	174	PF00069	0.377
MOD_Plk_4	183	189	PF00069	0.415
MOD_Plk_4	210	216	PF00069	0.391
MOD_Plk_4	244	250	PF00069	0.358
MOD_Plk_4	293	299	PF00069	0.458
MOD_Plk_4	40	46	PF00069	0.263
MOD_Plk_4	96	102	PF00069	0.637
MOD_ProDKin_1	304	310	PF00069	0.298
MOD_ProDKin_1	78	84	PF00069	0.577
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.267
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.374
TRG_ENDOCYTIC_2	106	109	PF00928	0.503
TRG_ENDOCYTIC_2	5	8	PF00928	0.390
TRG_ER_diArg_1	330	332	PF00400	0.548
TRG_ER_diArg_1	341	344	PF00400	0.577
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX2	Leptomonas seymouri	22%	86%
A0A3Q8I7Y9	Leishmania donovani	43%	71%
A0A3R7JPZ0	Trypanosoma rangeli	30%	89%
A0A3R7LYU0	Trypanosoma rangeli	33%	100%
A0A3R7MH63	Trypanosoma rangeli	35%	100%
A0A3R7R6N6	Trypanosoma rangeli	28%	89%
A0A422MSE4	Trypanosoma rangeli	44%	72%
A0A422MSP6	Trypanosoma rangeli	30%	69%
A0A422MU68	Trypanosoma rangeli	30%	78%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	66%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	66%
Q4QH10	Leishmania major	43%	67%
Q4QH11	Leishmania major	43%	66%
Q4QH12	Leishmania major	43%	66%
Q4QH13	Leishmania major	43%	66%