Putative chaperonin TCP20

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperonin TCP20, putative

Species:

Leishmania braziliensis

UniProt:

A4H7F6_LEIBR

TriTrypDb:

LbrM.13.1520 , LBRM2903_130021400

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005832	chaperonin-containing T-complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0101031	protein folding chaperone complex	3	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

A4H7F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7F6

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0044183	protein folding chaperone	1	12
GO:0051082	unfolded protein binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:0140662	ATP-dependent protein folding chaperone	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.483
CLV_NRD_NRD_1	146	148	PF00675	0.415
CLV_NRD_NRD_1	265	267	PF00675	0.358
CLV_NRD_NRD_1	317	319	PF00675	0.358
CLV_NRD_NRD_1	321	323	PF00675	0.358
CLV_NRD_NRD_1	476	478	PF00675	0.447
CLV_NRD_NRD_1	532	534	PF00675	0.560
CLV_PCSK_FUR_1	318	322	PF00082	0.374
CLV_PCSK_KEX2_1	146	148	PF00082	0.374
CLV_PCSK_KEX2_1	317	319	PF00082	0.358
CLV_PCSK_KEX2_1	320	322	PF00082	0.358
CLV_PCSK_KEX2_1	507	509	PF00082	0.445
CLV_PCSK_KEX2_1	532	534	PF00082	0.560
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.359
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.479
CLV_PCSK_PC7_1	317	323	PF00082	0.358
CLV_PCSK_SKI1_1	117	121	PF00082	0.351
CLV_PCSK_SKI1_1	155	159	PF00082	0.389
CLV_PCSK_SKI1_1	317	321	PF00082	0.358
CLV_PCSK_SKI1_1	326	330	PF00082	0.355
CLV_PCSK_SKI1_1	399	403	PF00082	0.358
CLV_PCSK_SKI1_1	508	512	PF00082	0.387
CLV_PCSK_SKI1_1	79	83	PF00082	0.358
CLV_Separin_Metazoa	101	105	PF03568	0.358
DEG_APCC_DBOX_1	146	154	PF00400	0.358
DEG_APCC_DBOX_1	394	402	PF00400	0.358
DEG_APCC_KENBOX_2	285	289	PF00400	0.374
DEG_APCC_KENBOX_2	309	313	PF00400	0.479
DOC_CKS1_1	448	453	PF01111	0.363
DOC_CYCLIN_RxL_1	505	514	PF00134	0.479
DOC_MAPK_gen_1	12	22	PF00069	0.493
DOC_MAPK_gen_1	272	279	PF00069	0.374
DOC_MAPK_gen_1	320	329	PF00069	0.358
DOC_MAPK_gen_1	371	379	PF00069	0.418
DOC_MAPK_gen_1	477	487	PF00069	0.479
DOC_MAPK_HePTP_8	295	307	PF00069	0.358
DOC_MAPK_MEF2A_6	15	24	PF00069	0.474
DOC_MAPK_MEF2A_6	298	307	PF00069	0.358
DOC_MAPK_RevD_3	303	318	PF00069	0.358
DOC_USP7_MATH_1	335	339	PF00917	0.398
DOC_USP7_MATH_1	455	459	PF00917	0.358
DOC_USP7_MATH_1	476	480	PF00917	0.253
DOC_USP7_UBL2_3	12	16	PF12436	0.563
DOC_WW_Pin1_4	340	345	PF00397	0.392
DOC_WW_Pin1_4	447	452	PF00397	0.363
LIG_14-3-3_CanoR_1	104	110	PF00244	0.429
LIG_14-3-3_CanoR_1	117	125	PF00244	0.270
LIG_14-3-3_CanoR_1	15	24	PF00244	0.483
LIG_14-3-3_CanoR_1	155	164	PF00244	0.350
LIG_14-3-3_CanoR_1	199	209	PF00244	0.366
LIG_14-3-3_CanoR_1	266	273	PF00244	0.363
LIG_14-3-3_CanoR_1	79	87	PF00244	0.358
LIG_Actin_WH2_2	301	319	PF00022	0.358
LIG_Actin_WH2_2	383	401	PF00022	0.358
LIG_BIR_II_1	1	5	PF00653	0.534
LIG_Clathr_ClatBox_1	521	525	PF01394	0.358
LIG_eIF4E_1	443	449	PF01652	0.374
LIG_FHA_1	204	210	PF00498	0.373
LIG_FHA_1	232	238	PF00498	0.380
LIG_FHA_1	289	295	PF00498	0.415
LIG_FHA_1	337	343	PF00498	0.361
LIG_FHA_1	374	380	PF00498	0.358
LIG_FHA_1	512	518	PF00498	0.374
LIG_FHA_1	71	77	PF00498	0.374
LIG_FHA_1	91	97	PF00498	0.365
LIG_FHA_2	116	122	PF00498	0.505
LIG_FHA_2	355	361	PF00498	0.364
LIG_FHA_2	362	368	PF00498	0.351
LIG_FHA_2	451	457	PF00498	0.356
LIG_FHA_2	466	472	PF00498	0.358
LIG_FHA_2	80	86	PF00498	0.358
LIG_FHA_2	96	102	PF00498	0.358
LIG_GBD_Chelix_1	95	103	PF00786	0.479
LIG_Integrin_isoDGR_2	288	290	PF01839	0.479
LIG_LIR_Gen_1	291	300	PF02991	0.358
LIG_LIR_Gen_1	360	369	PF02991	0.358
LIG_LIR_Nem_3	291	295	PF02991	0.358
LIG_LIR_Nem_3	360	366	PF02991	0.358
LIG_LIR_Nem_3	479	485	PF02991	0.290
LIG_SH2_GRB2like	6	9	PF00017	0.557
LIG_SH2_NCK_1	179	183	PF00017	0.479
LIG_SH2_PTP2	6	9	PF00017	0.557
LIG_SH2_SRC	179	182	PF00017	0.505
LIG_SH2_SRC	443	446	PF00017	0.370
LIG_SH2_SRC	6	9	PF00017	0.557
LIG_SH2_STAP1	443	447	PF00017	0.378
LIG_SH2_STAT5	109	112	PF00017	0.358
LIG_SH2_STAT5	149	152	PF00017	0.415
LIG_SH2_STAT5	226	229	PF00017	0.381
LIG_SH2_STAT5	231	234	PF00017	0.309
LIG_SH2_STAT5	356	359	PF00017	0.360
LIG_SH2_STAT5	363	366	PF00017	0.328
LIG_SH2_STAT5	6	9	PF00017	0.557
LIG_SH3_3	376	382	PF00018	0.374
LIG_SH3_3	489	495	PF00018	0.415
LIG_Sin3_3	407	414	PF02671	0.478
LIG_SUMO_SIM_par_1	137	145	PF11976	0.388
LIG_SUMO_SIM_par_1	301	306	PF11976	0.415
LIG_SUMO_SIM_par_1	464	471	PF11976	0.363
LIG_SUMO_SIM_par_1	520	526	PF11976	0.359
LIG_SUMO_SIM_par_1	92	101	PF11976	0.352
LIG_TRAF2_1	126	129	PF00917	0.328
LIG_TRAF2_1	468	471	PF00917	0.348
LIG_UBA3_1	276	281	PF00899	0.347
LIG_UBA3_1	313	320	PF00899	0.345
LIG_UBA3_1	53	58	PF00899	0.393
MOD_CDK_SPK_2	447	452	PF00069	0.363
MOD_CK1_1	137	143	PF00069	0.342
MOD_CK1_1	203	209	PF00069	0.374
MOD_CK2_1	115	121	PF00069	0.505
MOD_CK2_1	361	367	PF00069	0.358
MOD_CK2_1	450	456	PF00069	0.358
MOD_CK2_1	465	471	PF00069	0.358
MOD_CK2_1	506	512	PF00069	0.374
MOD_CK2_1	95	101	PF00069	0.505
MOD_Cter_Amidation	530	533	PF01082	0.541
MOD_GlcNHglycan	17	20	PF01048	0.487
MOD_GlcNHglycan	432	435	PF01048	0.418
MOD_GlcNHglycan	456	460	PF01048	0.358
MOD_GlcNHglycan	478	481	PF01048	0.253
MOD_GlcNHglycan	48	51	PF01048	0.350
MOD_GSK3_1	137	144	PF00069	0.413
MOD_GSK3_1	153	160	PF00069	0.340
MOD_GSK3_1	231	238	PF00069	0.377
MOD_GSK3_1	241	248	PF00069	0.397
MOD_GSK3_1	336	343	PF00069	0.373
MOD_GSK3_1	367	374	PF00069	0.423
MOD_GSK3_1	472	479	PF00069	0.494
MOD_GSK3_1	506	513	PF00069	0.378
MOD_GSK3_1	85	92	PF00069	0.394
MOD_LATS_1	115	121	PF00433	0.358
MOD_N-GLC_1	235	240	PF02516	0.356
MOD_N-GLC_1	336	341	PF02516	0.360
MOD_N-GLC_1	367	372	PF02516	0.505
MOD_N-GLC_1	430	435	PF02516	0.460
MOD_NEK2_1	134	139	PF00069	0.273
MOD_NEK2_1	46	51	PF00069	0.350
MOD_NEK2_1	510	515	PF00069	0.458
MOD_NEK2_2	40	45	PF00069	0.358
MOD_PKA_1	15	21	PF00069	0.505
MOD_PKA_1	266	272	PF00069	0.358
MOD_PKA_2	103	109	PF00069	0.479
MOD_PKA_2	200	206	PF00069	0.374
MOD_PKA_2	40	46	PF00069	0.374
MOD_PKA_2	476	482	PF00069	0.253
MOD_PKB_1	199	207	PF00069	0.443
MOD_Plk_1	134	140	PF00069	0.259
MOD_Plk_1	235	241	PF00069	0.349
MOD_Plk_1	354	360	PF00069	0.374
MOD_Plk_1	383	389	PF00069	0.358
MOD_Plk_2-3	301	307	PF00069	0.505
MOD_Plk_2-3	361	367	PF00069	0.358
MOD_Plk_4	134	140	PF00069	0.363
MOD_Plk_4	361	367	PF00069	0.350
MOD_Plk_4	373	379	PF00069	0.333
MOD_Plk_4	59	65	PF00069	0.374
MOD_Plk_4	91	97	PF00069	0.331
MOD_ProDKin_1	340	346	PF00069	0.392
MOD_ProDKin_1	447	453	PF00069	0.363
MOD_SUMO_rev_2	263	269	PF00179	0.458
MOD_SUMO_rev_2	355	364	PF00179	0.358
TRG_DiLeu_BaEn_3	128	134	PF01217	0.328
TRG_ENDOCYTIC_2	363	366	PF00928	0.358
TRG_ER_diArg_1	198	201	PF00400	0.443
TRG_ER_diArg_1	316	318	PF00400	0.358
TRG_NLS_MonoExtC_3	319	325	PF00514	0.358
TRG_NLS_MonoExtN_4	317	324	PF00514	0.358
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	508	512	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U4	Leptomonas seymouri	27%	98%
A0A0N1HUM6	Leptomonas seymouri	27%	100%
A0A0N1HUW6	Leptomonas seymouri	26%	98%
A0A0N1HXN1	Leptomonas seymouri	91%	100%
A0A0N1I104	Leptomonas seymouri	28%	94%
A0A0N1I2L2	Leptomonas seymouri	30%	100%
A0A0N1II94	Leptomonas seymouri	27%	98%
A0A0N1IM41	Leptomonas seymouri	27%	100%
A0A0S4IN05	Bodo saltans	22%	91%
A0A0S4IWM5	Bodo saltans	25%	98%
A0A0S4J048	Bodo saltans	28%	94%
A0A0S4J2A3	Bodo saltans	28%	93%
A0A0S4JDP9	Bodo saltans	26%	98%
A0A0S4JFF0	Bodo saltans	28%	94%
A0A0S4KI45	Bodo saltans	27%	100%
A0A0S4KIR9	Bodo saltans	29%	100%
A0A0S4KJ28	Bodo saltans	26%	100%
A0A0S4KQ13	Bodo saltans	75%	99%
A0A1X0NJG5	Trypanosomatidae	81%	99%
A0A1X0NL95	Trypanosomatidae	26%	100%
A0A1X0NSG8	Trypanosomatidae	28%	99%
A0A1X0NUN9	Trypanosomatidae	29%	100%
A0A1X0NWR4	Trypanosomatidae	27%	97%
A0A1X0NXT3	Trypanosomatidae	29%	100%
A0A1X0P4G0	Trypanosomatidae	27%	100%
A0A1X0P560	Trypanosomatidae	27%	95%
A0A3Q8IFF2	Leishmania donovani	28%	94%
A0A3Q8II90	Leishmania donovani	26%	100%
A0A3Q8IJL9	Leishmania donovani	27%	99%
A0A3R7KZ57	Trypanosoma rangeli	27%	100%
A0A3R7N205	Trypanosoma rangeli	30%	100%
A0A3R7NPP8	Trypanosoma rangeli	25%	100%
A0A3R7NRL8	Trypanosoma rangeli	28%	98%
A0A3R7RBS2	Trypanosoma rangeli	28%	95%
A0A3R7RTF6	Trypanosoma rangeli	82%	99%
A0A3S5H7C3	Leishmania donovani	26%	98%
A0A3S7WSR3	Leishmania donovani	94%	100%
A0A3S7WWK8	Leishmania donovani	28%	98%
A0A3S7X0N9	Leishmania donovani	27%	100%
A0A3S7X5D6	Leishmania donovani	30%	100%
A0A422NW95	Trypanosoma rangeli	29%	100%
A0A422NY11	Trypanosoma rangeli	25%	97%
A0AKH5	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	21%	99%
A0AXY5	Burkholderia cenocepacia (strain HI2424)	21%	99%
A0K536	Burkholderia cenocepacia (strain HI2424)	23%	99%
A1V1Z9	Burkholderia mallei (strain SAVP1)	24%	98%
A1WZJ2	Halorhodospira halophila (strain DSM 244 / SL1)	22%	98%
A2S9S5	Burkholderia mallei (strain NCTC 10229)	24%	98%
A3MMB4	Burkholderia mallei (strain NCTC 10247)	24%	98%
A3NCQ8	Burkholderia pseudomallei (strain 668)	24%	99%
A3NYH0	Burkholderia pseudomallei (strain 1106a)	24%	99%
A4G837	Herminiimonas arsenicoxydans	23%	99%
A4HCZ3	Leishmania braziliensis	25%	100%
A4HFQ1	Leishmania braziliensis	27%	99%
A4HK82	Leishmania braziliensis	31%	100%
A4HKX2	Leishmania braziliensis	27%	100%
A4HN57	Leishmania braziliensis	28%	100%
A4HQL2	Leishmania braziliensis	27%	100%
A4I0H8	Leishmania infantum	26%	98%
A4I2S6	Leishmania infantum	27%	100%
A4I7R7	Leishmania infantum	30%	100%
A4I8F2	Leishmania infantum	27%	99%
A4IBS4	Leishmania infantum	28%	94%
A4ICD2	Leishmania infantum	26%	100%
A4JC03	Burkholderia vietnamiensis (strain G4 / LMG 22486)	22%	99%
A5G9I2	Geotalea uraniireducens (strain Rf4)	23%	98%
A5I723	Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)	22%	99%
A5IJR6	Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)	21%	100%
A6LJ30	Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)	21%	100%
A6NM43	Homo sapiens	24%	97%
A6QBP8	Sulfurovum sp. (strain NBC37-1)	21%	99%
A6T1E5	Janthinobacterium sp. (strain Marseille)	23%	98%
A6TLJ1	Alkaliphilus metalliredigens (strain QYMF)	23%	98%
A6U901	Sinorhizobium medicae (strain WSM419)	22%	99%
A7FYP3	Clostridium botulinum (strain ATCC 19397 / Type A)	22%	99%
A7GIN3	Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)	22%	99%
A7GZ43	Campylobacter curvus (strain 525.92)	21%	99%
A7ZCV2	Campylobacter concisus (strain 13826)	22%	99%
A8LJP9	Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)	22%	98%
A8MJJ7	Alkaliphilus oremlandii (strain OhILAs)	21%	99%
A8X6I9	Caenorhabditis briggsae	24%	98%
A9BHK4	Petrotoga mobilis (strain DSM 10674 / SJ95)	20%	100%
A9HK37	Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5)	21%	98%
A9VQG8	Bacillus mycoides (strain KBAB4)	21%	99%
B0K3P6	Thermoanaerobacter sp. (strain X514)	20%	99%
B0KBR3	Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E)	20%	99%
B1IFD4	Clostridium botulinum (strain Okra / Type B1)	22%	99%
B1L8Y8	Thermotoga sp. (strain RQ2)	21%	100%
B2T0I0	Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)	24%	99%
B4U8T6	Hydrogenobaculum sp. (strain Y04AAS1)	21%	99%
B5Y894	Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / OCM 4 / BT)	22%	100%
B5Z6D1	Helicobacter pylori (strain G27)	23%	99%
B6IU98	Rhodospirillum centenum (strain ATCC 51521 / SW)	24%	99%
B6JPA7	Helicobacter pylori (strain P12)	23%	99%
B8DH59	Listeria monocytogenes serotype 4a (strain HCC23)	21%	99%
B8FNT7	Desulfitobacterium hafniense (strain DSM 10664 / DCB-2)	23%	99%
B9L698	Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)	22%	99%
B9LZ35	Geotalea daltonii (strain DSM 22248 / JCM 15807 / FRC-32)	23%	98%
C1FLV5	Clostridium botulinum (strain Kyoto / Type A2)	22%	99%
C1KX21	Listeria monocytogenes serotype 4b (strain CLIP80459)	21%	99%
C3KUC8	Clostridium botulinum (strain 657 / Type Ba4)	22%	99%
C4ZD46	Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / VPI 0990)	21%	99%
C9ZVA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
C9ZYU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	95%
D0A1B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A3R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A5Y5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A6E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	99%
D0A9X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0AAR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
E9ADA4	Leishmania major	27%	99%
E9AFL0	Leishmania major	28%	100%
E9AGK2	Leishmania infantum	94%	100%
E9AGX7	Leishmania infantum	28%	98%
E9AIQ3	Leishmania braziliensis	27%	100%
E9APJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AUC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AV93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	98%
E9AWE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	98%
E9AZ29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B2M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B3B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	99%
E9B6R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	94%
O00782	Oxytricha granulifera	28%	96%
O04450	Arabidopsis thaliana	29%	100%
O15891	Tetrahymena pyriformis	27%	98%
O24730	Thermococcus sp. (strain JCM 11816 / KS-1)	33%	99%
O24731	Thermococcus sp. (strain KS-8)	33%	98%
O24732	Thermococcus sp. (strain KS-8)	33%	99%
O24734	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	32%	96%
O24735	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	35%	97%
O26320	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	34%	99%
O26885	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	33%	100%
O28045	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	33%	99%
O28821	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	34%	99%
O30560	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	32%	97%
O30561	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	33%	96%
O57762	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	34%	98%
O74341	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O77323	Plasmodium falciparum (isolate 3D7)	27%	100%
O77622	Oryctolagus cuniculus	56%	100%
O85754	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	22%	98%
O93624	Methanothermococcus thermolithotrophicus	33%	99%
O94501	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	97%
O94515	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	100%
P11983	Mus musculus	27%	97%
P12612	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	96%
P12613	Drosophila melanogaster	26%	97%
P17987	Homo sapiens	28%	97%
P18279	Cricetulus griseus	28%	97%
P28480	Rattus norvegicus	28%	97%
P28488	Saccharolobus shibatae	36%	97%
P28769	Arabidopsis thaliana	26%	99%
P37578	Mycobacterium leprae (strain TN)	21%	100%
P39076	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P39077	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P39078	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P39079	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	99%
P40227	Homo sapiens	56%	100%
P40412	Avena sativa	28%	100%
P40413	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	96%
P41988	Caenorhabditis elegans	26%	98%
P42383	Helicobacter pylori (strain ATCC 700392 / 26695)	22%	99%
P42932	Mus musculus	24%	98%
P42943	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	98%
P46219	Saccharolobus shibatae	31%	96%
P46550	Caenorhabditis elegans	54%	100%
P47079	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	95%
P47207	Caenorhabditis elegans	26%	100%
P47208	Caenorhabditis elegans	28%	100%
P47209	Caenorhabditis elegans	30%	99%
P47828	Candida albicans	25%	100%
P48212	Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)	22%	99%
P48424	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	36%	99%
P48425	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	30%	99%
P48605	Drosophila melanogaster	27%	99%
P48643	Homo sapiens	27%	99%
P49368	Homo sapiens	27%	99%
P50016	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	35%	99%
P50143	Xenopus laevis	28%	98%
P50990	Homo sapiens	25%	98%
P50991	Homo sapiens	29%	100%
P50999	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P53451	Takifugu rubripes	29%	100%
P54408	Tetrahymena pyriformis	25%	96%
P54409	Tetrahymena pyriformis	28%	96%
P54411	Avena sativa	29%	100%
P58723	Burkholderia thailandensis	24%	99%
P61111	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	33%	98%
P61112	Thermococcus sp. (strain JCM 11816 / KS-1)	33%	98%
P61438	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	21%	99%
P61490	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	21%	99%
P77829	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	22%	100%
P78371	Homo sapiens	26%	100%
P78921	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	99%
P80313	Mus musculus	28%	99%
P80314	Mus musculus	26%	100%
P80315	Mus musculus	29%	100%
P80316	Mus musculus	28%	99%
P80317	Mus musculus	57%	100%
P80318	Mus musculus	27%	99%
P87153	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	96%
Q03VC3	Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y)	22%	100%
Q045Q8	Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / BCRC 14619 / CIP 102991 / JCM 1131 / KCTC 3163 / NCIMB 11718 / NCTC 13722 / AM63)	23%	99%
Q0B4V5	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	24%	99%
Q0BHT1	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	23%	99%
Q10147	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q119S1	Trichodesmium erythraeum (strain IMS101)	22%	96%
Q11LG4	Chelativorans sp. (strain BNC1)	20%	99%
Q13IM9	Paraburkholderia xenovorans (strain LB400)	24%	99%
Q13NE4	Paraburkholderia xenovorans (strain LB400)	24%	99%
Q144Q6	Paraburkholderia xenovorans (strain LB400)	24%	99%
Q162U5	Roseobacter denitrificans (strain ATCC 33942 / OCh 114)	22%	98%
Q1BYL5	Burkholderia cenocepacia (strain AU 1054)	23%	99%
Q1CVE5	Helicobacter pylori (strain HPAG1)	23%	99%
Q1GJ36	Ruegeria sp. (strain TM1040)	21%	98%
Q1GRD4	Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)	20%	100%
Q1QVJ7	Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)	23%	98%
Q1WSW0	Ligilactobacillus salivarius (strain UCC118)	21%	100%
Q24QE3	Desulfitobacterium hafniense (strain Y51)	23%	99%
Q2JXD4	Synechococcus sp. (strain JA-3-3Ab)	21%	99%
Q2NKZ1	Bos taurus	28%	99%
Q2RL13	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	22%	100%
Q2RWV4	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	24%	98%
Q2RY28	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	22%	99%
Q2SYJ5	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	24%	99%
Q2T3W7	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	22%	99%
Q2T9X2	Bos taurus	29%	99%
Q2WAW8	Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)	22%	97%
Q31IT1	Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2)	23%	99%
Q32L40	Bos taurus	28%	97%
Q38YR7	Latilactobacillus sakei subsp. sakei (strain 23K)	21%	99%
Q391Y9	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	21%	99%
Q39J12	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	23%	99%
Q39ZP5	Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)	23%	99%
Q3JPF6	Burkholderia pseudomallei (strain 1710b)	24%	99%
Q3M6L5	Trichormus variabilis (strain ATCC 29413 / PCC 7937)	21%	96%
Q3MHL7	Bos taurus	56%	100%
Q3SQS3	Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)	21%	99%
Q3T084	Bos taurus	55%	100%
Q3T0K2	Bos taurus	27%	99%
Q3ZBH0	Bos taurus	27%	100%
Q3ZCI9	Bos taurus	24%	98%
Q47IZ8	Dechloromonas aromatica (strain RCB)	22%	98%
Q4Q063	Leishmania major	26%	100%
Q4Q4U5	Leishmania major	27%	100%
Q4Q5I2	Leishmania major	30%	100%
Q4QB32	Leishmania major	25%	100%
Q4QC87	Leishmania major	27%	100%
Q4QFY8	Leishmania major	94%	100%
Q4R5G2	Macaca fascicularis	28%	97%
Q4R5J0	Macaca fascicularis	25%	98%
Q4R6F8	Macaca fascicularis	26%	100%
Q4R6V2	Macaca fascicularis	27%	99%
Q4R963	Macaca fascicularis	27%	99%
Q52500	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	33%	99%
Q53546	Desulfurococcus sp. (strain SY)	32%	99%
Q54CL2	Dictyostelium discoideum	27%	100%
Q54ER7	Dictyostelium discoideum	26%	97%
Q54ES9	Dictyostelium discoideum	27%	100%
Q54TD3	Dictyostelium discoideum	28%	100%
Q54TH8	Dictyostelium discoideum	26%	100%
Q552J0	Dictyostelium discoideum	24%	100%
Q55BM4	Dictyostelium discoideum	27%	98%
Q58405	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	36%	99%
Q5FPQ6	Gluconobacter oxydans (strain 621H)	21%	99%
Q5NVF9	Pongo abelii	27%	99%
Q5R5C8	Pongo abelii	28%	99%
Q5R637	Pongo abelii	29%	100%
Q5RAP1	Pongo abelii	25%	98%
Q5RCD2	Pongo abelii	55%	100%
Q5RF02	Pongo abelii	27%	99%
Q5SLM2	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	21%	99%
Q5XIM9	Rattus norvegicus	26%	100%
Q5ZJ54	Gallus gallus	56%	100%
Q5ZJK8	Gallus gallus	28%	97%
Q61390	Mus musculus	55%	100%
Q62I82	Burkholderia mallei (strain ATCC 23344)	24%	98%
Q67KB8	Symbiobacterium thermophilum (strain T / IAM 14863)	21%	100%
Q68FQ0	Rattus norvegicus	27%	99%
Q6BXF6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	100%
Q6C100	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	100%
Q6CL82	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	100%
Q6EE31	Gallus gallus	24%	98%
Q6FQT2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	100%
Q6MBZ5	Protochlamydia amoebophila (strain UWE25)	23%	100%
Q6P502	Rattus norvegicus	27%	99%
Q71XU6	Listeria monocytogenes serotype 4b (strain F2365)	21%	99%
Q747C7	Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)	23%	99%
Q75A36	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q76NU3	Dictyostelium discoideum	55%	100%
Q7TPB1	Rattus norvegicus	29%	100%
Q7UM97	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	22%	100%
Q84WV1	Arabidopsis thaliana	25%	97%
Q85G22	Cyanidioschyzon merolae (strain NIES-3377 / 10D)	21%	100%
Q88YM5	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	22%	99%
Q89DA6	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	21%	99%
Q8GBD2	Acetobacter pasteurianus (strain NBRC 105184 / IFO 3283-01)	21%	99%
Q8KJ24	Clostridium botulinum	21%	99%
Q8L7N0	Arabidopsis thaliana	57%	100%
Q8R5T7	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	21%	100%
Q8SQP2	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q8SR53	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q8SR76	Encephalitozoon cuniculi (strain GB-M1)	28%	100%
Q8SRP9	Encephalitozoon cuniculi (strain GB-M1)	29%	100%
Q8SS33	Encephalitozoon cuniculi (strain GB-M1)	22%	100%
Q8SSC9	Encephalitozoon cuniculi (strain GB-M1)	27%	100%
Q8SSH3	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q92526	Homo sapiens	55%	100%
Q929V0	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	21%	99%
Q93GW2	Campylobacter rectus	22%	98%
Q93N34	Buchnera aphidicola subsp. Rhopalosiphum padi	25%	98%
Q940P8	Arabidopsis thaliana	29%	100%
Q94757	Schistosoma mansoni	27%	99%
Q94K05	Arabidopsis thaliana	26%	98%
Q96SF2	Homo sapiens	23%	97%
Q99832	Homo sapiens	28%	99%
Q9AGE6	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	21%	99%
Q9EZV1	Thermotoga neapolitana	21%	100%
Q9F712	Burkholderia pseudomallei (strain K96243)	24%	99%
Q9HH21	Saccharolobus shibatae	29%	100%
Q9HHA2	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	30%	100%
Q9HN70	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	32%	96%
Q9HNI0	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	30%	97%
Q9KJ23	Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)	22%	99%
Q9LKI7	Thalassiosira weissflogii	26%	96%
Q9LV21	Arabidopsis thaliana	26%	100%
Q9M888	Arabidopsis thaliana	56%	100%
Q9N358	Caenorhabditis elegans	23%	98%
Q9N4J8	Caenorhabditis elegans	27%	99%
Q9NB32	Ochlerotatus triseriatus	28%	100%
Q9RWQ9	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	22%	98%
Q9SF16	Arabidopsis thaliana	26%	97%
Q9TLZ1	Cyanidium caldarium	20%	100%
Q9UTM4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	99%
Q9V2Q7	Pyrococcus abyssi (strain GE5 / Orsay)	34%	98%
Q9V2S9	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	31%	96%
Q9V2T3	Desulfurococcus mucosus	34%	100%
Q9V2T4	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	34%	97%
Q9V2T5	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	31%	96%
Q9V2T7	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	29%	100%
Q9V2T8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	36%	97%
Q9W790	Paleosuchus palpebrosus	27%	96%
Q9XT06	Monodelphis domestica	27%	97%
Q9YA66	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	31%	98%
Q9YDK6	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	36%	97%
Q9ZCT7	Rickettsia prowazekii (strain Madrid E)	22%	98%
Q9ZFD8	Burkholderia vietnamiensis	22%	99%
Q9ZFE0	Burkholderia cepacia	23%	99%
Q9ZN50	Helicobacter pylori (strain J99 / ATCC 700824)	23%	99%
V5AR01	Trypanosoma cruzi	29%	100%
V5B209	Trypanosoma cruzi	80%	100%
V5B5Q0	Trypanosoma cruzi	28%	98%
V5BD32	Trypanosoma cruzi	26%	100%
V5BL37	Trypanosoma cruzi	27%	100%
V5BNS0	Trypanosoma cruzi	26%	97%
V5C2S4	Trypanosoma cruzi	28%	95%
V5DHJ5	Trypanosoma cruzi	29%	100%