LeishMANIAdb
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Mitogen-activated protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitogen-activated protein kinase
Gene product:
mitogen-activated protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4H7F4_LEIBR
TriTrypDb:
LbrM.13.1500 , LBRM2903_130021200 *
Length:
593

Annotations

LeishMANIAdb annotations

Acyltransferase involved in GPI anchor remodelling (homologue of yeast GUP1)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H7F4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7F4

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 8
GO:0006793 phosphorus metabolic process 3 8
GO:0006796 phosphate-containing compound metabolic process 4 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 8
GO:0009987 cellular process 1 8
GO:0016310 phosphorylation 5 8
GO:0019538 protein metabolic process 3 8
GO:0036211 protein modification process 4 8
GO:0043170 macromolecule metabolic process 3 8
GO:0043412 macromolecule modification 4 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0071704 organic substance metabolic process 2 8
GO:1901564 organonitrogen compound metabolic process 3 8
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 8
GO:0003824 catalytic activity 1 8
GO:0004672 protein kinase activity 3 8
GO:0004674 protein serine/threonine kinase activity 4 8
GO:0004707 MAP kinase activity 5 8
GO:0005488 binding 1 8
GO:0005524 ATP binding 5 8
GO:0016301 kinase activity 4 8
GO:0016740 transferase activity 2 8
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 8
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 8
GO:0017076 purine nucleotide binding 4 8
GO:0030554 adenyl nucleotide binding 5 8
GO:0032553 ribonucleotide binding 3 8
GO:0032555 purine ribonucleotide binding 4 8
GO:0032559 adenyl ribonucleotide binding 5 8
GO:0035639 purine ribonucleoside triphosphate binding 4 8
GO:0036094 small molecule binding 2 8
GO:0043167 ion binding 2 8
GO:0043168 anion binding 3 8
GO:0097159 organic cyclic compound binding 2 8
GO:0097367 carbohydrate derivative binding 2 8
GO:0140096 catalytic activity, acting on a protein 2 8
GO:1901265 nucleoside phosphate binding 3 8
GO:1901363 heterocyclic compound binding 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 168 172 PF00656 0.279
CLV_C14_Caspase3-7 512 516 PF00656 0.387
CLV_NRD_NRD_1 109 111 PF00675 0.613
CLV_NRD_NRD_1 145 147 PF00675 0.534
CLV_NRD_NRD_1 173 175 PF00675 0.342
CLV_NRD_NRD_1 383 385 PF00675 0.334
CLV_NRD_NRD_1 483 485 PF00675 0.351
CLV_PCSK_FUR_1 107 111 PF00082 0.596
CLV_PCSK_KEX2_1 107 109 PF00082 0.608
CLV_PCSK_KEX2_1 144 146 PF00082 0.552
CLV_PCSK_KEX2_1 173 175 PF00082 0.282
CLV_PCSK_KEX2_1 383 385 PF00082 0.334
CLV_PCSK_KEX2_1 485 487 PF00082 0.275
CLV_PCSK_PC1ET2_1 144 146 PF00082 0.542
CLV_PCSK_PC1ET2_1 485 487 PF00082 0.275
CLV_PCSK_PC7_1 103 109 PF00082 0.487
CLV_PCSK_SKI1_1 103 107 PF00082 0.752
CLV_PCSK_SKI1_1 121 125 PF00082 0.430
CLV_PCSK_SKI1_1 145 149 PF00082 0.507
CLV_PCSK_SKI1_1 161 165 PF00082 0.408
CLV_PCSK_SKI1_1 173 177 PF00082 0.315
CLV_PCSK_SKI1_1 180 184 PF00082 0.315
CLV_PCSK_SKI1_1 263 267 PF00082 0.275
CLV_PCSK_SKI1_1 384 388 PF00082 0.278
CLV_PCSK_SKI1_1 559 563 PF00082 0.361
CLV_Separin_Metazoa 507 511 PF03568 0.446
DEG_APCC_DBOX_1 172 180 PF00400 0.334
DEG_Nend_UBRbox_2 1 3 PF02207 0.444
DEG_SCF_FBW7_1 124 131 PF00400 0.430
DEG_SPOP_SBC_1 326 330 PF00917 0.444
DOC_CDC14_PxL_1 352 360 PF14671 0.351
DOC_CKS1_1 400 405 PF01111 0.310
DOC_CKS1_1 409 414 PF01111 0.281
DOC_CYCLIN_RxL_1 474 482 PF00134 0.324
DOC_CYCLIN_yClb1_LxF_4 238 244 PF00134 0.194
DOC_CYCLIN_yCln2_LP_2 382 388 PF00134 0.206
DOC_MAPK_gen_1 173 181 PF00069 0.275
DOC_MAPK_gen_1 263 272 PF00069 0.275
DOC_MAPK_gen_1 351 360 PF00069 0.275
DOC_MAPK_gen_1 530 538 PF00069 0.384
DOC_MAPK_HePTP_8 348 360 PF00069 0.275
DOC_MAPK_MEF2A_6 351 360 PF00069 0.298
DOC_MAPK_MEF2A_6 530 538 PF00069 0.555
DOC_PP1_RVXF_1 475 482 PF00149 0.324
DOC_PP2B_LxvP_1 583 586 PF13499 0.463
DOC_PP4_FxxP_1 497 500 PF00568 0.415
DOC_USP7_MATH_1 306 310 PF00917 0.621
DOC_USP7_MATH_1 325 329 PF00917 0.551
DOC_USP7_MATH_1 36 40 PF00917 0.470
DOC_USP7_MATH_1 513 517 PF00917 0.522
DOC_USP7_UBL2_3 160 164 PF12436 0.275
DOC_WW_Pin1_4 124 129 PF00397 0.609
DOC_WW_Pin1_4 151 156 PF00397 0.387
DOC_WW_Pin1_4 399 404 PF00397 0.299
DOC_WW_Pin1_4 408 413 PF00397 0.336
DOC_WW_Pin1_4 496 501 PF00397 0.403
LIG_14-3-3_CanoR_1 199 207 PF00244 0.243
LIG_14-3-3_CanoR_1 327 335 PF00244 0.611
LIG_14-3-3_CanoR_1 510 518 PF00244 0.536
LIG_14-3-3_CanoR_1 581 586 PF00244 0.609
LIG_Actin_WH2_2 162 179 PF00022 0.275
LIG_Actin_WH2_2 215 233 PF00022 0.334
LIG_Actin_WH2_2 392 408 PF00022 0.334
LIG_AP2alpha_2 495 497 PF02296 0.334
LIG_APCC_ABBA_1 58 63 PF00400 0.423
LIG_BRCT_BRCA1_1 139 143 PF00533 0.582
LIG_BRCT_BRCA1_1 208 212 PF00533 0.351
LIG_Clathr_ClatBox_1 478 482 PF01394 0.334
LIG_CtBP_PxDLS_1 468 472 PF00389 0.335
LIG_deltaCOP1_diTrp_1 314 321 PF00928 0.553
LIG_EH1_1 215 223 PF00400 0.275
LIG_EH1_1 426 434 PF00400 0.334
LIG_eIF4E_1 216 222 PF01652 0.275
LIG_eIF4E_1 353 359 PF01652 0.275
LIG_FHA_1 118 124 PF00498 0.605
LIG_FHA_1 343 349 PF00498 0.323
LIG_FHA_1 395 401 PF00498 0.293
LIG_FHA_1 70 76 PF00498 0.390
LIG_FHA_2 209 215 PF00498 0.221
LIG_FHA_2 415 421 PF00498 0.327
LIG_FHA_2 486 492 PF00498 0.346
LIG_FHA_2 510 516 PF00498 0.367
LIG_FHA_2 9 15 PF00498 0.530
LIG_FHA_2 95 101 PF00498 0.478
LIG_GBD_Chelix_1 244 252 PF00786 0.334
LIG_LIR_Apic_2 350 356 PF02991 0.275
LIG_LIR_Apic_2 495 500 PF02991 0.334
LIG_LIR_Gen_1 154 163 PF02991 0.277
LIG_LIR_Gen_1 209 218 PF02991 0.351
LIG_LIR_Nem_3 154 159 PF02991 0.301
LIG_LIR_Nem_3 209 215 PF02991 0.319
LIG_LIR_Nem_3 314 319 PF02991 0.530
LIG_LIR_Nem_3 495 501 PF02991 0.334
LIG_LIR_Nem_3 72 76 PF02991 0.483
LIG_NRBOX 225 231 PF00104 0.334
LIG_Pex14_2 544 548 PF04695 0.499
LIG_PTB_Apo_2 538 545 PF02174 0.363
LIG_Rb_LxCxE_1 6 25 PF01857 0.365
LIG_SH2_CRK 73 77 PF00017 0.354
LIG_SH2_GRB2like 90 93 PF00017 0.503
LIG_SH2_NCK_1 139 143 PF00017 0.566
LIG_SH2_SRC 254 257 PF00017 0.334
LIG_SH2_STAT3 392 395 PF00017 0.275
LIG_SH2_STAT5 117 120 PF00017 0.560
LIG_SH2_STAT5 184 187 PF00017 0.334
LIG_SH2_STAT5 216 219 PF00017 0.275
LIG_SH2_STAT5 254 257 PF00017 0.334
LIG_SH2_STAT5 347 350 PF00017 0.275
LIG_SH2_STAT5 392 395 PF00017 0.275
LIG_SH3_1 406 412 PF00018 0.334
LIG_SH3_3 130 136 PF00018 0.536
LIG_SH3_3 194 200 PF00018 0.334
LIG_SH3_3 406 412 PF00018 0.275
LIG_SH3_3 539 545 PF00018 0.368
LIG_SUMO_SIM_anti_2 357 362 PF11976 0.275
LIG_SUMO_SIM_anti_2 394 402 PF11976 0.334
LIG_SUMO_SIM_par_1 396 402 PF11976 0.194
LIG_TRAF2_1 232 235 PF00917 0.348
LIG_TRAF2_1 309 312 PF00917 0.530
LIG_TRAF2_1 519 522 PF00917 0.492
LIG_TRAF2_1 97 100 PF00917 0.471
LIG_WRC_WIRS_1 478 483 PF05994 0.334
LIG_WW_1 339 342 PF00397 0.351
MOD_CDC14_SPxK_1 131 134 PF00782 0.457
MOD_CDK_SPxK_1 128 134 PF00069 0.445
MOD_CDK_SPxxK_3 399 406 PF00069 0.334
MOD_CK1_1 208 214 PF00069 0.260
MOD_CK1_1 330 336 PF00069 0.543
MOD_CK1_1 39 45 PF00069 0.650
MOD_CK1_1 394 400 PF00069 0.274
MOD_CK1_1 557 563 PF00069 0.302
MOD_CK1_1 584 590 PF00069 0.521
MOD_CK2_1 15 21 PF00069 0.313
MOD_CK2_1 229 235 PF00069 0.351
MOD_CK2_1 305 311 PF00069 0.568
MOD_CK2_1 414 420 PF00069 0.338
MOD_CK2_1 485 491 PF00069 0.344
MOD_CK2_1 557 563 PF00069 0.418
MOD_CK2_1 8 14 PF00069 0.386
MOD_CK2_1 94 100 PF00069 0.456
MOD_Cter_Amidation 171 174 PF01082 0.275
MOD_GlcNHglycan 128 131 PF01048 0.502
MOD_GlcNHglycan 208 211 PF01048 0.403
MOD_GlcNHglycan 257 260 PF01048 0.275
MOD_GlcNHglycan 323 326 PF01048 0.578
MOD_GlcNHglycan 371 374 PF01048 0.369
MOD_GlcNHglycan 463 466 PF01048 0.268
MOD_GlcNHglycan 5 8 PF01048 0.691
MOD_GlcNHglycan 515 518 PF01048 0.446
MOD_GlcNHglycan 583 586 PF01048 0.502
MOD_GlcNHglycan 65 68 PF01048 0.506
MOD_GSK3_1 124 131 PF00069 0.674
MOD_GSK3_1 201 208 PF00069 0.362
MOD_GSK3_1 321 328 PF00069 0.532
MOD_GSK3_1 35 42 PF00069 0.530
MOD_GSK3_1 456 463 PF00069 0.442
MOD_GSK3_1 509 516 PF00069 0.532
MOD_GSK3_1 550 557 PF00069 0.430
MOD_N-GLC_1 8 13 PF02516 0.442
MOD_NEK2_1 22 27 PF00069 0.445
MOD_NEK2_1 229 234 PF00069 0.330
MOD_NEK2_1 28 33 PF00069 0.442
MOD_NEK2_1 283 288 PF00069 0.308
MOD_NEK2_1 294 299 PF00069 0.513
MOD_NEK2_1 319 324 PF00069 0.517
MOD_NEK2_1 434 439 PF00069 0.423
MOD_NEK2_1 455 460 PF00069 0.334
MOD_NEK2_1 8 13 PF00069 0.446
MOD_PIKK_1 230 236 PF00454 0.334
MOD_PIKK_1 391 397 PF00454 0.298
MOD_PIKK_1 449 455 PF00454 0.334
MOD_PKA_1 485 491 PF00069 0.275
MOD_PKA_2 326 332 PF00069 0.450
MOD_PKA_2 485 491 PF00069 0.275
MOD_PKA_2 509 515 PF00069 0.353
MOD_PKA_2 550 556 PF00069 0.470
MOD_Plk_1 295 301 PF00069 0.548
MOD_Plk_1 306 312 PF00069 0.445
MOD_Plk_4 15 21 PF00069 0.578
MOD_Plk_4 394 400 PF00069 0.221
MOD_Plk_4 414 420 PF00069 0.146
MOD_Plk_4 456 462 PF00069 0.445
MOD_Plk_4 587 593 PF00069 0.530
MOD_Plk_4 85 91 PF00069 0.484
MOD_ProDKin_1 124 130 PF00069 0.608
MOD_ProDKin_1 151 157 PF00069 0.376
MOD_ProDKin_1 399 405 PF00069 0.299
MOD_ProDKin_1 408 414 PF00069 0.336
MOD_ProDKin_1 496 502 PF00069 0.405
MOD_SUMO_rev_2 258 267 PF00179 0.275
MOD_SUMO_rev_2 420 428 PF00179 0.334
TRG_DiLeu_BaEn_2 151 157 PF01217 0.397
TRG_DiLeu_BaEn_3 423 429 PF01217 0.334
TRG_DiLeu_BaEn_3 99 105 PF01217 0.597
TRG_ENDOCYTIC_2 246 249 PF00928 0.330
TRG_ENDOCYTIC_2 73 76 PF00928 0.412
TRG_ER_diArg_1 107 110 PF00400 0.673
TRG_ER_diArg_1 118 121 PF00400 0.531
TRG_ER_diArg_1 145 147 PF00400 0.489
TRG_ER_diArg_1 173 175 PF00400 0.342
TRG_ER_diArg_1 382 384 PF00400 0.334
TRG_ER_diArg_1 483 486 PF00400 0.351
TRG_NLS_MonoExtN_4 142 148 PF00514 0.539
TRG_NLS_MonoExtN_4 483 488 PF00514 0.351
TRG_Pf-PMV_PEXEL_1 174 178 PF00026 0.295
TRG_Pf-PMV_PEXEL_1 444 449 PF00026 0.194
TRG_Pf-PMV_PEXEL_1 559 563 PF00026 0.409
TRG_Pf-PMV_PEXEL_1 96 100 PF00026 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I304 Leptomonas seymouri 65% 100%
A0A0S4J343 Bodo saltans 24% 100%
A0A0S4JCX8 Bodo saltans 24% 100%
A0A0S4JTP3 Bodo saltans 24% 73%
A0A0S4KIN4 Bodo saltans 39% 87%
A0A3Q8IB74 Leishmania donovani 25% 100%
A0A3Q8IH39 Leishmania donovani 32% 100%
A0A3Q8ITZ9 Leishmania donovani 32% 100%
A0A3Q8IVR8 Leishmania donovani 32% 100%
A0A3R7M0A0 Trypanosoma rangeli 31% 100%
A0A3R7MSS9 Trypanosoma rangeli 24% 100%
A0A3R7NBN7 Trypanosoma rangeli 27% 100%
A0A3S7WSP5 Leishmania donovani 82% 100%
A0A3S7X2Z6 Leishmania donovani 31% 100%
A0A3S7X9D1 Leishmania donovani 25% 100%
A0A3S7XA45 Leishmania donovani 31% 100%
A0A422N878 Trypanosoma rangeli 24% 100%
A2QN07 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 34% 100%
A4H601 Leishmania braziliensis 32% 100%
A4HFF3 Leishmania braziliensis 24% 100%
A4HLJ9 Leishmania braziliensis 33% 100%
A4HMK7 Leishmania braziliensis 26% 100%
A4HNT2 Leishmania braziliensis 32% 100%
A4HUC8 Leishmania infantum 32% 100%
A4HVU2 Leishmania infantum 82% 100%
A4I564 Leishmania infantum 31% 100%
A4I910 Leishmania infantum 32% 100%
A4IB86 Leishmania infantum 25% 100%
A4IC54 Leishmania infantum 31% 100%
A4ICR2 Leishmania infantum 32% 100%
B1H3E1 Xenopus tropicalis 30% 100%
E9AF07 Leishmania major 25% 100%
E9AFX4 Leishmania major 31% 100%
E9AGS0 Leishmania infantum 25% 100%
E9AN28 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9API8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
E9AQQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9ARW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B0G1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B3X5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B663 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B727 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
O04160 Brassica napus 28% 100%
O23145 Arabidopsis thaliana 28% 100%
P27704 Rattus norvegicus 29% 82%
P46551 Caenorhabditis elegans 29% 81%
Q0CQK1 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 27% 100%
Q16659 Homo sapiens 29% 82%
Q336M2 Oryza sativa subsp. japonica 26% 100%
Q4Q204 Leishmania major 32% 100%
Q4Q449 Leishmania major 31% 100%
Q4Q7S2 Leishmania major 31% 100%
Q4QDK3 Leishmania major 25% 100%
Q4QFZ0 Leishmania major 80% 100%
Q4QHJ8 Leishmania major 32% 100%
Q5F3W3 Gallus gallus 30% 82%
Q5R7U1 Pongo abelii 29% 82%
Q61532 Mus musculus 29% 82%
Q6FQ83 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 25% 89%
Q6P5G0 Mus musculus 29% 100%
Q8QGV6 Xenopus laevis 30% 100%
Q96287 Arabidopsis thaliana 28% 100%
Q96Q40 Homo sapiens 27% 100%
Q96WV9 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
V5BCX5 Trypanosoma cruzi 26% 100%
V5DIC3 Trypanosoma cruzi 25% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS