Squalene monooxygenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

squalene monooxygenase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H7F2_LEIBR

TriTrypDb:

LbrM.13.1480 , LBRM2903_130021000

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	12
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A4H7F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7F2

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006694	steroid biosynthetic process	5	12
GO:0008152	metabolic process	1	12
GO:0008202	steroid metabolic process	4	12
GO:0008610	lipid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0016125	sterol metabolic process	4	12
GO:0016126	sterol biosynthetic process	5	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004497	monooxygenase activity	3	12
GO:0004506	squalene monooxygenase activity	5	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	12
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.499
CLV_NRD_NRD_1	205	207	PF00675	0.479
CLV_NRD_NRD_1	563	565	PF00675	0.530
CLV_NRD_NRD_1	58	60	PF00675	0.303
CLV_PCSK_KEX2_1	205	207	PF00082	0.482
CLV_PCSK_KEX2_1	548	550	PF00082	0.407
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.407
CLV_PCSK_SKI1_1	149	153	PF00082	0.226
CLV_PCSK_SKI1_1	206	210	PF00082	0.310
CLV_PCSK_SKI1_1	284	288	PF00082	0.305

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K9	Leptomonas seymouri	79%	100%
A0A0S4IT90	Bodo saltans	54%	87%
A0A1X0NLC9	Trypanosomatidae	60%	100%
A0A3S7WSP8	Leishmania donovani	84%	100%
A0A422P4A3	Trypanosoma rangeli	61%	100%
A4HVU0	Leishmania infantum	84%	100%
B7TWW5	Panax ginseng	34%	100%
D0A6E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	98%
E9API6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9R5G2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	34%	100%

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