Cut12 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spindle assembly abnormal 4

Species:

Leishmania braziliensis

UniProt:

A4H7E9_LEIBR

TriTrypDb:

LbrM.13.1450 , LBRM2903_130020700

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005813	centrosome	3	1
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7E9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7E9

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0061511	centriole elongation	3	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.592
CLV_C14_Caspase3-7	319	323	PF00656	0.465
CLV_C14_Caspase3-7	54	58	PF00656	0.605
CLV_NRD_NRD_1	120	122	PF00675	0.655
CLV_NRD_NRD_1	180	182	PF00675	0.655
CLV_NRD_NRD_1	195	197	PF00675	0.562
CLV_NRD_NRD_1	22	24	PF00675	0.620
CLV_NRD_NRD_1	234	236	PF00675	0.658
CLV_NRD_NRD_1	315	317	PF00675	0.538
CLV_NRD_NRD_1	348	350	PF00675	0.507
CLV_NRD_NRD_1	383	385	PF00675	0.444
CLV_NRD_NRD_1	391	393	PF00675	0.445
CLV_NRD_NRD_1	501	503	PF00675	0.544
CLV_NRD_NRD_1	512	514	PF00675	0.535
CLV_NRD_NRD_1	537	539	PF00675	0.497
CLV_NRD_NRD_1	545	547	PF00675	0.578
CLV_NRD_NRD_1	55	57	PF00675	0.604
CLV_NRD_NRD_1	558	560	PF00675	0.540
CLV_NRD_NRD_1	580	582	PF00675	0.757
CLV_NRD_NRD_1	86	88	PF00675	0.661
CLV_PCSK_FUR_1	381	385	PF00082	0.444
CLV_PCSK_FUR_1	53	57	PF00082	0.626
CLV_PCSK_KEX2_1	120	122	PF00082	0.655
CLV_PCSK_KEX2_1	180	182	PF00082	0.655
CLV_PCSK_KEX2_1	195	197	PF00082	0.562
CLV_PCSK_KEX2_1	22	24	PF00082	0.643
CLV_PCSK_KEX2_1	234	236	PF00082	0.658
CLV_PCSK_KEX2_1	315	317	PF00082	0.538
CLV_PCSK_KEX2_1	348	350	PF00082	0.507
CLV_PCSK_KEX2_1	383	385	PF00082	0.444
CLV_PCSK_KEX2_1	391	393	PF00082	0.445
CLV_PCSK_KEX2_1	483	485	PF00082	0.507
CLV_PCSK_KEX2_1	503	505	PF00082	0.538
CLV_PCSK_KEX2_1	514	516	PF00082	0.548
CLV_PCSK_KEX2_1	537	539	PF00082	0.584
CLV_PCSK_KEX2_1	55	57	PF00082	0.604
CLV_PCSK_KEX2_1	579	581	PF00082	0.657
CLV_PCSK_KEX2_1	594	596	PF00082	0.481
CLV_PCSK_KEX2_1	633	635	PF00082	0.405
CLV_PCSK_KEX2_1	642	644	PF00082	0.266
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.531
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.521
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.483
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.668
CLV_PCSK_PC1ET2_1	594	596	PF00082	0.570
CLV_PCSK_PC1ET2_1	633	635	PF00082	0.405
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.266
CLV_PCSK_PC7_1	230	236	PF00082	0.656
CLV_PCSK_PC7_1	344	350	PF00082	0.499
CLV_PCSK_SKI1_1	348	352	PF00082	0.394
CLV_PCSK_SKI1_1	435	439	PF00082	0.514
CLV_PCSK_SKI1_1	634	638	PF00082	0.465
CLV_PCSK_SKI1_1	653	657	PF00082	0.183
CLV_PCSK_SKI1_1	70	74	PF00082	0.598
CLV_PCSK_SKI1_1	717	721	PF00082	0.263
DEG_APCC_DBOX_1	357	365	PF00400	0.447
DOC_CKS1_1	566	571	PF01111	0.626
DOC_MAPK_gen_1	332	341	PF00069	0.430
DOC_PP4_FxxP_1	233	236	PF00568	0.591
DOC_USP7_MATH_1	103	107	PF00917	0.531
DOC_USP7_MATH_1	222	226	PF00917	0.634
DOC_USP7_MATH_1	249	253	PF00917	0.625
DOC_USP7_MATH_1	377	381	PF00917	0.377
DOC_USP7_MATH_1	437	441	PF00917	0.518
DOC_USP7_MATH_1	731	735	PF00917	0.601
DOC_USP7_UBL2_3	11	15	PF12436	0.567
DOC_WW_Pin1_4	138	143	PF00397	0.656
DOC_WW_Pin1_4	198	203	PF00397	0.634
DOC_WW_Pin1_4	245	250	PF00397	0.643
DOC_WW_Pin1_4	34	39	PF00397	0.611
DOC_WW_Pin1_4	411	416	PF00397	0.631
DOC_WW_Pin1_4	459	464	PF00397	0.678
DOC_WW_Pin1_4	467	472	PF00397	0.634
DOC_WW_Pin1_4	565	570	PF00397	0.594
LIG_14-3-3_CanoR_1	27	31	PF00244	0.590
LIG_14-3-3_CanoR_1	277	283	PF00244	0.374
LIG_14-3-3_CanoR_1	298	305	PF00244	0.391
LIG_14-3-3_CanoR_1	3	7	PF00244	0.599
LIG_14-3-3_CanoR_1	348	357	PF00244	0.579
LIG_14-3-3_CanoR_1	420	427	PF00244	0.650
LIG_14-3-3_CanoR_1	580	589	PF00244	0.619
LIG_14-3-3_CanoR_1	70	78	PF00244	0.578
LIG_14-3-3_CanoR_1	94	99	PF00244	0.666
LIG_APCC_ABBAyCdc20_2	717	723	PF00400	0.457
LIG_BIR_II_1	1	5	PF00653	0.744
LIG_BRCT_BRCA1_1	16	20	PF00533	0.655
LIG_CaM_IQ_9	368	383	PF13499	0.367
LIG_DLG_GKlike_1	293	301	PF00625	0.366
LIG_FHA_1	122	128	PF00498	0.513
LIG_FHA_1	369	375	PF00498	0.375
LIG_FHA_1	566	572	PF00498	0.547
LIG_FHA_1	649	655	PF00498	0.518
LIG_FHA_1	714	720	PF00498	0.411
LIG_FHA_2	146	152	PF00498	0.653
LIG_FHA_2	598	604	PF00498	0.442
LIG_FHA_2	664	670	PF00498	0.477
LIG_FXI_DFP_1	608	612	PF00024	0.426
LIG_LIR_Apic_2	133	137	PF02991	0.663
LIG_LIR_Apic_2	161	167	PF02991	0.585
LIG_LIR_Nem_3	16	21	PF02991	0.654
LIG_LIR_Nem_3	723	729	PF02991	0.457
LIG_SH2_CRK	197	201	PF00017	0.649
LIG_SH2_CRK	212	216	PF00017	0.468
LIG_SH2_CRK	726	730	PF00017	0.457
LIG_SH2_GRB2like	647	650	PF00017	0.492
LIG_SH2_NCK_1	164	168	PF00017	0.525
LIG_SH2_NCK_1	212	216	PF00017	0.556
LIG_SH2_NCK_1	30	34	PF00017	0.667
LIG_SH2_NCK_1	683	687	PF00017	0.398
LIG_SH2_SRC	217	220	PF00017	0.618
LIG_SH2_SRC	441	444	PF00017	0.609
LIG_SH2_STAT3	282	285	PF00017	0.545
LIG_SH2_STAT3	299	302	PF00017	0.331
LIG_SH2_STAT5	193	196	PF00017	0.520
LIG_SH2_STAT5	232	235	PF00017	0.667
LIG_SH2_STAT5	280	283	PF00017	0.370
LIG_SH2_STAT5	647	650	PF00017	0.443
LIG_SH3_3	126	132	PF00018	0.700
LIG_SH3_3	136	142	PF00018	0.607
LIG_SH3_3	233	239	PF00018	0.560
LIG_SH3_3	563	569	PF00018	0.605
LIG_SH3_3	651	657	PF00018	0.533
LIG_SH3_3	80	86	PF00018	0.623
LIG_SH3_3	97	103	PF00018	0.548
LIG_SH3_4	11	18	PF00018	0.637
LIG_TRAF2_1	256	259	PF00917	0.515
LIG_TRAF2_1	272	275	PF00917	0.361
LIG_TRAF2_1	494	497	PF00917	0.508
LIG_TRAF2_1	498	501	PF00917	0.536
LIG_TRAF2_1	600	603	PF00917	0.437
LIG_UBA3_1	262	271	PF00899	0.517
LIG_UBA3_1	396	401	PF00899	0.500
LIG_WRC_WIRS_1	697	702	PF05994	0.352
MOD_CDC14_SPxK_1	37	40	PF00782	0.659
MOD_CDK_SPK_2	198	203	PF00069	0.634
MOD_CDK_SPK_2	467	472	PF00069	0.642
MOD_CDK_SPK_2	565	570	PF00069	0.594
MOD_CDK_SPxK_1	34	40	PF00069	0.664
MOD_CK1_1	106	112	PF00069	0.690
MOD_CK1_1	14	20	PF00069	0.726
MOD_CK1_1	147	153	PF00069	0.536
MOD_CK1_1	184	190	PF00069	0.751
MOD_CK1_1	2	8	PF00069	0.667
MOD_CK1_1	278	284	PF00069	0.374
MOD_CK1_1	29	35	PF00069	0.671
MOD_CK1_1	414	420	PF00069	0.742
MOD_CK1_1	423	429	PF00069	0.616
MOD_CK1_1	459	465	PF00069	0.563
MOD_CK1_1	658	664	PF00069	0.500
MOD_CK1_1	734	740	PF00069	0.500
MOD_CK2_1	104	110	PF00069	0.668
MOD_CK2_1	145	151	PF00069	0.665
MOD_CK2_1	253	259	PF00069	0.554
MOD_CK2_1	441	447	PF00069	0.562
MOD_CK2_1	48	54	PF00069	0.541
MOD_CK2_1	57	63	PF00069	0.427
MOD_CK2_1	597	603	PF00069	0.428
MOD_Cter_Amidation	640	643	PF01082	0.257
MOD_GlcNHglycan	106	109	PF01048	0.720
MOD_GlcNHglycan	168	171	PF01048	0.661
MOD_GlcNHglycan	172	175	PF01048	0.626
MOD_GlcNHglycan	203	206	PF01048	0.650
MOD_GlcNHglycan	218	223	PF01048	0.488
MOD_GlcNHglycan	225	228	PF01048	0.588
MOD_GlcNHglycan	245	248	PF01048	0.475
MOD_GlcNHglycan	251	254	PF01048	0.535
MOD_GlcNHglycan	336	339	PF01048	0.493
MOD_GlcNHglycan	411	414	PF01048	0.626
MOD_GlcNHglycan	430	434	PF01048	0.652
MOD_GlcNHglycan	561	564	PF01048	0.601
MOD_GlcNHglycan	572	575	PF01048	0.611
MOD_GlcNHglycan	582	585	PF01048	0.574
MOD_GlcNHglycan	639	642	PF01048	0.292
MOD_GlcNHglycan	657	660	PF01048	0.257
MOD_GlcNHglycan	96	99	PF01048	0.677
MOD_GSK3_1	162	169	PF00069	0.639
MOD_GSK3_1	170	177	PF00069	0.576
MOD_GSK3_1	218	225	PF00069	0.635
MOD_GSK3_1	245	252	PF00069	0.665
MOD_GSK3_1	293	300	PF00069	0.369
MOD_GSK3_1	34	41	PF00069	0.608
MOD_GSK3_1	364	371	PF00069	0.391
MOD_GSK3_1	414	421	PF00069	0.618
MOD_GSK3_1	425	432	PF00069	0.643
MOD_GSK3_1	437	444	PF00069	0.512
MOD_GSK3_1	570	577	PF00069	0.678
MOD_GSK3_1	655	662	PF00069	0.494
MOD_GSK3_1	701	708	PF00069	0.468
MOD_N-GLC_1	334	339	PF02516	0.642
MOD_N-GLC_1	353	358	PF02516	0.341
MOD_N-GLC_1	43	48	PF02516	0.595
MOD_N-GLC_1	648	653	PF02516	0.264
MOD_NEK2_1	160	165	PF00069	0.646
MOD_NEK2_1	28	33	PF00069	0.596
MOD_NEK2_1	364	369	PF00069	0.450
MOD_NEK2_1	589	594	PF00069	0.564
MOD_NEK2_1	637	642	PF00069	0.426
MOD_NEK2_1	663	668	PF00069	0.457
MOD_NEK2_1	702	707	PF00069	0.421
MOD_NEK2_2	574	579	PF00069	0.649
MOD_NEK2_2	659	664	PF00069	0.515
MOD_PIKK_1	298	304	PF00454	0.390
MOD_PIKK_1	348	354	PF00454	0.449
MOD_PIKK_1	368	374	PF00454	0.328
MOD_PIKK_1	414	420	PF00454	0.523
MOD_PIKK_1	620	626	PF00454	0.476
MOD_PKA_1	348	354	PF00069	0.449
MOD_PKA_1	55	61	PF00069	0.538
MOD_PKA_1	559	565	PF00069	0.602
MOD_PKA_1	579	585	PF00069	0.473
MOD_PKA_2	184	190	PF00069	0.751
MOD_PKA_2	2	8	PF00069	0.598
MOD_PKA_2	26	32	PF00069	0.640
MOD_PKA_2	297	303	PF00069	0.597
MOD_PKA_2	314	320	PF00069	0.518
MOD_PKA_2	326	332	PF00069	0.500
MOD_PKA_2	343	349	PF00069	0.354
MOD_PKA_2	368	374	PF00069	0.398
MOD_PKA_2	419	425	PF00069	0.815
MOD_PKA_2	55	61	PF00069	0.538
MOD_PKA_2	579	585	PF00069	0.631
MOD_PKA_2	702	708	PF00069	0.508
MOD_PKB_1	53	61	PF00069	0.606
MOD_Plk_1	160	166	PF00069	0.636
MOD_Plk_1	275	281	PF00069	0.442
MOD_Plk_1	334	340	PF00069	0.638
MOD_Plk_1	353	359	PF00069	0.375
MOD_Plk_1	377	383	PF00069	0.378
MOD_Plk_1	734	740	PF00069	0.457
MOD_Plk_2-3	326	332	PF00069	0.374
MOD_Plk_2-3	57	63	PF00069	0.474
MOD_Plk_4	2	8	PF00069	0.647
MOD_Plk_4	622	628	PF00069	0.444
MOD_Plk_4	677	683	PF00069	0.373
MOD_Plk_4	734	740	PF00069	0.457
MOD_ProDKin_1	138	144	PF00069	0.653
MOD_ProDKin_1	198	204	PF00069	0.635
MOD_ProDKin_1	245	251	PF00069	0.640
MOD_ProDKin_1	34	40	PF00069	0.609
MOD_ProDKin_1	411	417	PF00069	0.635
MOD_ProDKin_1	459	465	PF00069	0.676
MOD_ProDKin_1	467	473	PF00069	0.632
MOD_ProDKin_1	565	571	PF00069	0.594
MOD_SUMO_rev_2	265	273	PF00179	0.512
MOD_SUMO_rev_2	51	61	PF00179	0.614
MOD_SUMO_rev_2	557	562	PF00179	0.634
TRG_DiLeu_BaEn_1	258	263	PF01217	0.475
TRG_DiLeu_BaEn_2	15	21	PF01217	0.652
TRG_ENDOCYTIC_2	197	200	PF00928	0.730
TRG_ENDOCYTIC_2	726	729	PF00928	0.457
TRG_ER_diArg_1	120	122	PF00400	0.545
TRG_ER_diArg_1	179	181	PF00400	0.727
TRG_ER_diArg_1	194	196	PF00400	0.556
TRG_ER_diArg_1	21	23	PF00400	0.649
TRG_ER_diArg_1	233	235	PF00400	0.665
TRG_ER_diArg_1	315	318	PF00400	0.539
TRG_ER_diArg_1	348	350	PF00400	0.507
TRG_ER_diArg_1	381	384	PF00400	0.447
TRG_ER_diArg_1	537	540	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW13	Leptomonas seymouri	55%	97%
A0A3Q8I9S9	Leishmania donovani	79%	99%
A4HVT7	Leishmania infantum	79%	99%
E9API3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
Q4QFZ5	Leishmania major	76%	100%
V5B213	Trypanosoma cruzi	46%	98%