Serine/threonine-protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoprotein phosphatase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H7E7_LEIBR

TriTrypDb:

LbrM.13.1430 , LBRM2903_130020500

Length:

585

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005955	calcineurin complex	3	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	3
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4H7E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7E7

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	5
GO:0009987	cellular process	1	7
GO:0019722	calcium-mediated signaling	5	5
GO:0019932	second-messenger-mediated signaling	4	5
GO:0035556	intracellular signal transduction	3	5
GO:0050789	regulation of biological process	2	5
GO:0050794	regulation of cellular process	3	5
GO:0065007	biological regulation	1	5
GO:0097720	calcineurin-mediated signaling	6	5
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004721	phosphoprotein phosphatase activity	3	16
GO:0004722	protein serine/threonine phosphatase activity	4	16
GO:0016787	hydrolase activity	2	16
GO:0016788	hydrolase activity, acting on ester bonds	3	16
GO:0016791	phosphatase activity	5	16
GO:0017018	myosin phosphatase activity	5	16
GO:0042578	phosphoric ester hydrolase activity	4	16
GO:0140096	catalytic activity, acting on a protein	2	16
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	5	5
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1
GO:0033192	calmodulin-dependent protein phosphatase activity	6	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	51	55	PF00656	0.619
CLV_NRD_NRD_1	163	165	PF00675	0.509
CLV_NRD_NRD_1	245	247	PF00675	0.429
CLV_NRD_NRD_1	338	340	PF00675	0.243
CLV_PCSK_FUR_1	336	340	PF00082	0.271
CLV_PCSK_KEX2_1	224	226	PF00082	0.501
CLV_PCSK_KEX2_1	245	247	PF00082	0.429
CLV_PCSK_KEX2_1	338	340	PF00082	0.238
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.501
CLV_PCSK_SKI1_1	164	168	PF00082	0.506
CLV_PCSK_SKI1_1	177	181	PF00082	0.509
CLV_PCSK_SKI1_1	224	228	PF00082	0.453
CLV_PCSK_SKI1_1	338	342	PF00082	0.462
CLV_PCSK_SKI1_1	411	415	PF00082	0.357
CLV_PCSK_SKI1_1	528	532	PF00082	0.323
CLV_PCSK_SKI1_1	557	561	PF00082	0.295
CLV_PCSK_SKI1_1	94	98	PF00082	0.584
DEG_Nend_UBRbox_1	1	4	PF02207	0.513
DEG_SPOP_SBC_1	101	105	PF00917	0.521
DEG_SPOP_SBC_1	31	35	PF00917	0.523
DOC_CYCLIN_RxL_1	174	184	PF00134	0.512
DOC_CYCLIN_yClb1_LxF_4	504	510	PF00134	0.266
DOC_CYCLIN_yCln2_LP_2	414	420	PF00134	0.304
DOC_MAPK_gen_1	208	214	PF00069	0.719
DOC_MAPK_gen_1	503	509	PF00069	0.221
DOC_MAPK_HePTP_8	286	298	PF00069	0.394
DOC_MAPK_MEF2A_6	289	298	PF00069	0.398
DOC_MAPK_MEF2A_6	349	358	PF00069	0.357
DOC_MAPK_MEF2A_6	411	418	PF00069	0.357
DOC_MAPK_MEF2A_6	569	578	PF00069	0.475
DOC_MAPK_NFAT4_5	411	419	PF00069	0.357
DOC_PP2B_LxvP_1	414	417	PF13499	0.304
DOC_PP4_FxxP_1	533	536	PF00568	0.373
DOC_SPAK_OSR1_1	428	432	PF12202	0.357
DOC_USP7_MATH_1	101	105	PF00917	0.600
DOC_USP7_MATH_1	110	114	PF00917	0.505
DOC_USP7_MATH_1	18	22	PF00917	0.540
DOC_USP7_MATH_1	255	259	PF00917	0.533
DOC_USP7_MATH_1	495	499	PF00917	0.357
DOC_USP7_MATH_1	84	88	PF00917	0.542
DOC_WW_Pin1_4	121	126	PF00397	0.610
DOC_WW_Pin1_4	154	159	PF00397	0.493
DOC_WW_Pin1_4	227	232	PF00397	0.465
DOC_WW_Pin1_4	434	439	PF00397	0.350
DOC_WW_Pin1_4	82	87	PF00397	0.599
LIG_14-3-3_CanoR_1	135	145	PF00244	0.566
LIG_14-3-3_CanoR_1	177	182	PF00244	0.555
LIG_14-3-3_CanoR_1	225	231	PF00244	0.337
LIG_14-3-3_CanoR_1	349	355	PF00244	0.314
LIG_14-3-3_CanoR_1	428	438	PF00244	0.385
LIG_14-3-3_CanoR_1	528	533	PF00244	0.308
LIG_14-3-3_CanoR_1	569	574	PF00244	0.537
LIG_BIR_III_2	56	60	PF00653	0.573
LIG_BRCT_BRCA1_1	232	236	PF00533	0.438
LIG_BRCT_BRCA1_1	497	501	PF00533	0.430
LIG_BRCT_BRCA1_1	555	559	PF00533	0.337
LIG_BRCT_BRCA1_1	580	584	PF00533	0.556
LIG_BRCT_BRCA1_2	497	503	PF00533	0.221
LIG_FHA_1	127	133	PF00498	0.619
LIG_FHA_1	282	288	PF00498	0.392
LIG_FHA_1	301	307	PF00498	0.283
LIG_FHA_1	31	37	PF00498	0.560
LIG_FHA_1	317	323	PF00498	0.234
LIG_FHA_1	381	387	PF00498	0.357
LIG_FHA_1	392	398	PF00498	0.267
LIG_FHA_1	454	460	PF00498	0.286
LIG_FHA_2	128	134	PF00498	0.547
LIG_FHA_2	178	184	PF00498	0.514
LIG_FHA_2	200	206	PF00498	0.584
LIG_FHA_2	218	224	PF00498	0.485
LIG_FHA_2	290	296	PF00498	0.342
LIG_FHA_2	40	46	PF00498	0.575
LIG_FHA_2	51	57	PF00498	0.606
LIG_FHA_2	522	528	PF00498	0.421
LIG_Integrin_RGD_1	249	251	PF01839	0.469
LIG_LIR_Apic_2	531	536	PF02991	0.370
LIG_LIR_Apic_2	568	574	PF02991	0.481
LIG_LIR_Gen_1	316	326	PF02991	0.363
LIG_LIR_Gen_1	337	347	PF02991	0.477
LIG_LIR_Gen_1	424	431	PF02991	0.413
LIG_LIR_LC3C_4	302	306	PF02991	0.357
LIG_LIR_Nem_3	103	109	PF02991	0.526
LIG_LIR_Nem_3	233	239	PF02991	0.413
LIG_LIR_Nem_3	316	321	PF02991	0.363
LIG_LIR_Nem_3	366	370	PF02991	0.509
LIG_LIR_Nem_3	384	390	PF02991	0.209
LIG_LIR_Nem_3	424	429	PF02991	0.413
LIG_LYPXL_yS_3	367	370	PF13949	0.357
LIG_MAD2	528	536	PF02301	0.324
LIG_MLH1_MIPbox_1	580	584	PF16413	0.478
LIG_PCNA_PIPBox_1	515	524	PF02747	0.394
LIG_PCNA_yPIPBox_3	512	522	PF02747	0.368
LIG_SH2_CRK	318	322	PF00017	0.436
LIG_SH2_CRK	387	391	PF00017	0.304
LIG_SH2_CRK	538	542	PF00017	0.391
LIG_SH2_NCK_1	571	575	PF00017	0.463
LIG_SH2_STAP1	318	322	PF00017	0.357
LIG_SH2_STAT5	275	278	PF00017	0.297
LIG_SH2_STAT5	318	321	PF00017	0.357
LIG_SH2_STAT5	346	349	PF00017	0.369
LIG_SH2_STAT5	372	375	PF00017	0.357
LIG_SH2_STAT5	521	524	PF00017	0.369
LIG_SH2_STAT5	538	541	PF00017	0.440
LIG_SH2_STAT5	72	75	PF00017	0.581
LIG_SH3_3	119	125	PF00018	0.582
LIG_SH3_3	249	255	PF00018	0.449
LIG_SH3_3	362	368	PF00018	0.478
LIG_SUMO_SIM_anti_2	295	300	PF11976	0.522
LIG_SUMO_SIM_anti_2	302	309	PF11976	0.421
LIG_SUMO_SIM_par_1	117	124	PF11976	0.549
LIG_SUMO_SIM_par_1	176	184	PF11976	0.567
LIG_SUMO_SIM_par_1	292	297	PF11976	0.411
LIG_SUMO_SIM_par_1	302	309	PF11976	0.347
LIG_SUMO_SIM_par_1	526	534	PF11976	0.446
LIG_TRAF2_1	114	117	PF00917	0.601
LIG_TRAF2_1	257	260	PF00917	0.445
LIG_TRAF2_2	126	131	PF00917	0.526
LIG_TYR_ITIM	365	370	PF00017	0.357
LIG_UBA3_1	358	364	PF00899	0.471
MOD_CDK_SPK_2	227	232	PF00069	0.416
MOD_CK1_1	140	146	PF00069	0.518
MOD_CK1_1	157	163	PF00069	0.555
MOD_CK1_1	197	203	PF00069	0.603
MOD_CK1_1	217	223	PF00069	0.503
MOD_CK1_1	34	40	PF00069	0.581
MOD_CK1_1	44	50	PF00069	0.587
MOD_CK2_1	102	108	PF00069	0.556
MOD_CK2_1	127	133	PF00069	0.551
MOD_CK2_1	217	223	PF00069	0.494
MOD_CK2_1	289	295	PF00069	0.352
MOD_CK2_1	39	45	PF00069	0.546
MOD_CK2_1	462	468	PF00069	0.239
MOD_GlcNHglycan	112	115	PF01048	0.550
MOD_GlcNHglycan	216	219	PF01048	0.562
MOD_GlcNHglycan	232	235	PF01048	0.504
MOD_GlcNHglycan	406	409	PF01048	0.426
MOD_GlcNHglycan	533	536	PF01048	0.378
MOD_GlcNHglycan	551	554	PF01048	0.444
MOD_GSK3_1	136	143	PF00069	0.524
MOD_GSK3_1	173	180	PF00069	0.742
MOD_GSK3_1	18	25	PF00069	0.555
MOD_GSK3_1	190	197	PF00069	0.558
MOD_GSK3_1	226	233	PF00069	0.371
MOD_GSK3_1	30	37	PF00069	0.575
MOD_GSK3_1	388	395	PF00069	0.373
MOD_GSK3_1	44	51	PF00069	0.564
MOD_GSK3_1	453	460	PF00069	0.314
MOD_GSK3_1	470	477	PF00069	0.269
MOD_GSK3_1	493	500	PF00069	0.304
MOD_GSK3_1	549	556	PF00069	0.296
MOD_GSK3_1	574	581	PF00069	0.542
MOD_GSK3_1	84	91	PF00069	0.581
MOD_N-GLC_1	136	141	PF02516	0.533
MOD_N-GLC_1	190	195	PF02516	0.526
MOD_N-GLC_1	569	574	PF02516	0.460
MOD_N-GLC_1	74	79	PF02516	0.477
MOD_N-GLC_2	537	539	PF02516	0.414
MOD_NEK2_1	1	6	PF00069	0.586
MOD_NEK2_1	136	141	PF00069	0.613
MOD_NEK2_1	173	178	PF00069	0.566
MOD_NEK2_1	181	186	PF00069	0.532
MOD_NEK2_1	214	219	PF00069	0.606
MOD_NEK2_1	226	231	PF00069	0.499
MOD_NEK2_1	317	322	PF00069	0.327
MOD_NEK2_1	429	434	PF00069	0.357
MOD_NEK2_1	578	583	PF00069	0.539
MOD_NEK2_1	7	12	PF00069	0.576
MOD_NEK2_1	73	78	PF00069	0.502
MOD_NEK2_1	89	94	PF00069	0.535
MOD_NEK2_2	574	579	PF00069	0.500
MOD_PIKK_1	255	261	PF00454	0.579
MOD_PIKK_1	263	269	PF00454	0.526
MOD_PKA_2	214	220	PF00069	0.516
MOD_PKA_2	381	387	PF00069	0.300
MOD_PKA_2	47	53	PF00069	0.596
MOD_PKB_1	46	54	PF00069	0.563
MOD_Plk_1	190	196	PF00069	0.526
MOD_Plk_1	31	37	PF00069	0.581
MOD_Plk_1	444	450	PF00069	0.332
MOD_Plk_1	574	580	PF00069	0.447
MOD_Plk_2-3	462	468	PF00069	0.221
MOD_Plk_4	289	295	PF00069	0.453
MOD_Plk_4	300	306	PF00069	0.524
MOD_Plk_4	317	323	PF00069	0.229
MOD_Plk_4	366	372	PF00069	0.472
MOD_Plk_4	421	427	PF00069	0.355
MOD_Plk_4	462	468	PF00069	0.221
MOD_Plk_4	528	534	PF00069	0.344
MOD_Plk_4	579	585	PF00069	0.586
MOD_Plk_4	84	90	PF00069	0.514
MOD_ProDKin_1	121	127	PF00069	0.610
MOD_ProDKin_1	154	160	PF00069	0.493
MOD_ProDKin_1	227	233	PF00069	0.464
MOD_ProDKin_1	434	440	PF00069	0.350
MOD_ProDKin_1	82	88	PF00069	0.601
MOD_SUMO_for_1	363	366	PF00179	0.357
MOD_SUMO_rev_2	217	226	PF00179	0.530
TRG_DiLeu_BaEn_1	300	305	PF01217	0.294
TRG_DiLeu_BaEn_1	366	371	PF01217	0.282
TRG_DiLeu_LyEn_5	235	240	PF01217	0.388
TRG_ENDOCYTIC_2	318	321	PF00928	0.454
TRG_ENDOCYTIC_2	367	370	PF00928	0.357
TRG_ENDOCYTIC_2	387	390	PF00928	0.193
TRG_ENDOCYTIC_2	426	429	PF00928	0.343
TRG_ENDOCYTIC_2	538	541	PF00928	0.408
TRG_ER_diArg_1	244	246	PF00400	0.428
TRG_ER_diArg_1	338	340	PF00400	0.241
TRG_Pf-PMV_PEXEL_1	177	182	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8M6	Leishmania donovani	72%	100%
A0A3Q8II54	Leishmania donovani	68%	100%
A0A3S7XAY3	Leishmania donovani	31%	100%
A0A422N1U7	Trypanosoma rangeli	32%	98%
A4HP65	Leishmania braziliensis	32%	100%
A4HVT0	Leishmania infantum	72%	100%
A4HVT6	Leishmania infantum	68%	100%
A4IDH0	Leishmania infantum	31%	100%
E9APH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9API1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	99%
E9ASX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q1M5	Leishmania major	30%	100%
Q4QFZ7	Leishmania major	67%	100%
Q4QG03	Leishmania major	72%	100%