Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H7E3_LEIBR

TriTrypDb:

LbrM.13.1390 , LBRM2903_130020400

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7E3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.765
CLV_NRD_NRD_1	346	348	PF00675	0.661
CLV_NRD_NRD_1	51	53	PF00675	0.766
CLV_PCSK_KEX2_1	346	348	PF00082	0.661
CLV_PCSK_KEX2_1	51	53	PF00082	0.709
CLV_PCSK_PC7_1	47	53	PF00082	0.701
CLV_PCSK_SKI1_1	257	261	PF00082	0.577
DEG_APCC_DBOX_1	236	244	PF00400	0.493
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.793
DOC_PP2B_LxvP_1	175	178	PF13499	0.801
DOC_PP2B_LxvP_1	415	418	PF13499	0.668
DOC_PP2B_LxvP_1	468	471	PF13499	0.637
DOC_PP4_FxxP_1	391	394	PF00568	0.579
DOC_USP7_MATH_1	111	115	PF00917	0.600
DOC_USP7_MATH_1	239	243	PF00917	0.491
DOC_USP7_MATH_1	281	285	PF00917	0.448
DOC_USP7_MATH_1	313	317	PF00917	0.457
DOC_USP7_MATH_1	382	386	PF00917	0.756
DOC_WW_Pin1_4	124	129	PF00397	0.647
DOC_WW_Pin1_4	220	225	PF00397	0.543
DOC_WW_Pin1_4	235	240	PF00397	0.576
DOC_WW_Pin1_4	389	394	PF00397	0.688
DOC_WW_Pin1_4	70	75	PF00397	0.793
LIG_14-3-3_CanoR_1	315	325	PF00244	0.470
LIG_14-3-3_CanoR_1	355	365	PF00244	0.565
LIG_14-3-3_CanoR_1	41	49	PF00244	0.634
LIG_14-3-3_CanoR_1	410	416	PF00244	0.585
LIG_14-3-3_CanoR_1	419	428	PF00244	0.457
LIG_14-3-3_CterR_2	485	488	PF00244	0.810
LIG_Actin_WH2_2	75	92	PF00022	0.516
LIG_APCC_ABBA_1	157	162	PF00400	0.705
LIG_APCC_ABBA_1	204	209	PF00400	0.616
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_Clathr_ClatBox_1	226	230	PF01394	0.446
LIG_FHA_1	251	257	PF00498	0.547
LIG_FHA_1	319	325	PF00498	0.587
LIG_FHA_1	412	418	PF00498	0.679
LIG_FHA_1	421	427	PF00498	0.444
LIG_FHA_2	10	16	PF00498	0.680
LIG_FHA_2	104	110	PF00498	0.502
LIG_FHA_2	250	256	PF00498	0.611
LIG_FHA_2	317	323	PF00498	0.517
LIG_FHA_2	52	58	PF00498	0.591
LIG_FHA_2	90	96	PF00498	0.691
LIG_GBD_Chelix_1	227	235	PF00786	0.550
LIG_KLC1_Yacidic_2	158	162	PF13176	0.710
LIG_LIR_Gen_1	151	161	PF02991	0.724
LIG_LIR_LC3C_4	223	228	PF02991	0.453
LIG_LIR_Nem_3	151	157	PF02991	0.665
LIG_MYND_1	87	91	PF01753	0.531
LIG_NRBOX	463	469	PF00104	0.639
LIG_PDZ_Class_1	483	488	PF00595	0.821
LIG_Pex14_2	265	269	PF04695	0.451
LIG_Rb_pABgroove_1	148	156	PF01858	0.712
LIG_SH2_CRK	21	25	PF00017	0.616
LIG_SH2_CRK	218	222	PF00017	0.744
LIG_SH2_SRC	160	163	PF00017	0.719
LIG_SH2_STAP1	218	222	PF00017	0.744
LIG_SH2_STAT3	338	341	PF00017	0.569
LIG_SH2_STAT5	160	163	PF00017	0.737
LIG_SH2_STAT5	317	320	PF00017	0.545
LIG_SH3_3	167	173	PF00018	0.553
LIG_SH3_3	218	224	PF00018	0.718
LIG_SH3_3	307	313	PF00018	0.562
LIG_SH3_3	322	328	PF00018	0.370
LIG_SH3_3	387	393	PF00018	0.759
LIG_SUMO_SIM_anti_2	223	230	PF11976	0.398
LIG_SUMO_SIM_anti_2	422	431	PF11976	0.521
LIG_SUMO_SIM_par_1	223	230	PF11976	0.478
LIG_SUMO_SIM_par_1	422	431	PF11976	0.521
LIG_TRAF2_1	68	71	PF00917	0.769
LIG_WRC_WIRS_1	266	271	PF05994	0.323
MOD_CK1_1	130	136	PF00069	0.666
MOD_CK1_1	316	322	PF00069	0.427
MOD_CK2_1	185	191	PF00069	0.719
MOD_CK2_1	249	255	PF00069	0.621
MOD_CK2_1	265	271	PF00069	0.294
MOD_CK2_1	281	287	PF00069	0.507
MOD_CK2_1	295	301	PF00069	0.514
MOD_CK2_1	444	450	PF00069	0.381
MOD_CK2_1	51	57	PF00069	0.723
MOD_CK2_1	70	76	PF00069	0.799
MOD_CK2_1	89	95	PF00069	0.688
MOD_CK2_1	9	15	PF00069	0.685
MOD_Cter_Amidation	49	52	PF01082	0.596
MOD_GlcNHglycan	1	4	PF01048	0.558
MOD_GlcNHglycan	109	112	PF01048	0.664
MOD_GlcNHglycan	144	147	PF01048	0.641
MOD_GlcNHglycan	213	216	PF01048	0.766
MOD_GlcNHglycan	453	456	PF01048	0.511
MOD_GlcNHglycan	478	481	PF01048	0.603
MOD_GlcNHglycan	482	485	PF01048	0.633
MOD_GSK3_1	1	8	PF00069	0.655
MOD_GSK3_1	103	110	PF00069	0.699
MOD_GSK3_1	130	137	PF00069	0.577
MOD_GSK3_1	162	169	PF00069	0.693
MOD_GSK3_1	231	238	PF00069	0.475
MOD_GSK3_1	265	272	PF00069	0.407
MOD_GSK3_1	291	298	PF00069	0.479
MOD_GSK3_1	313	320	PF00069	0.473
MOD_GSK3_1	444	451	PF00069	0.532
MOD_GSK3_1	476	483	PF00069	0.699
MOD_GSK3_1	51	58	PF00069	0.681
MOD_NEK2_1	1	6	PF00069	0.662
MOD_NEK2_1	161	166	PF00069	0.558
MOD_NEK2_1	231	236	PF00069	0.451
MOD_NEK2_1	265	270	PF00069	0.459
MOD_NEK2_1	29	34	PF00069	0.577
MOD_NEK2_1	356	361	PF00069	0.728
MOD_NEK2_1	395	400	PF00069	0.659
MOD_NEK2_1	453	458	PF00069	0.560
MOD_NEK2_2	103	108	PF00069	0.538
MOD_NEK2_2	382	387	PF00069	0.801
MOD_PIKK_1	185	191	PF00454	0.719
MOD_PIKK_1	356	362	PF00454	0.562
MOD_PIKK_1	437	443	PF00454	0.548
MOD_PIKK_1	80	86	PF00454	0.663
MOD_PKA_1	51	57	PF00069	0.594
MOD_PKA_2	107	113	PF00069	0.533
MOD_PKA_2	40	46	PF00069	0.632
MOD_PKA_2	51	57	PF00069	0.648
MOD_PKA_2	89	95	PF00069	0.702
MOD_Plk_1	161	167	PF00069	0.766
MOD_Plk_2-3	9	15	PF00069	0.506
MOD_Plk_4	217	223	PF00069	0.670
MOD_Plk_4	231	237	PF00069	0.269
MOD_Plk_4	411	417	PF00069	0.783
MOD_Plk_4	453	459	PF00069	0.494
MOD_Plk_4	9	15	PF00069	0.553
MOD_ProDKin_1	124	130	PF00069	0.646
MOD_ProDKin_1	220	226	PF00069	0.528
MOD_ProDKin_1	235	241	PF00069	0.579
MOD_ProDKin_1	389	395	PF00069	0.689
MOD_ProDKin_1	70	76	PF00069	0.789
TRG_DiLeu_BaEn_1	352	357	PF01217	0.531
TRG_DiLeu_BaEn_1	463	468	PF01217	0.633
TRG_DiLeu_BaEn_4	61	67	PF01217	0.603
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.756
TRG_DiLeu_LyEn_5	352	357	PF01217	0.531
TRG_ENDOCYTIC_2	21	24	PF00928	0.619
TRG_ENDOCYTIC_2	218	221	PF00928	0.727
TRG_ER_diArg_1	210	213	PF00400	0.756
TRG_ER_diArg_1	65	68	PF00400	0.601
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	355	360	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	419	424	PF00026	0.466
TRG_PTS1	485	488	PF00515	0.730

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K4	Leptomonas seymouri	48%	83%
A0A3S7WSN4	Leishmania donovani	75%	100%
A4HVT3	Leishmania infantum	75%	100%
E9APH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QG00	Leishmania major	74%	100%