Fuz_longin_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Trafficking protein Mon1, putative

Species:

Leishmania braziliensis

UniProt:

A4H7E1_LEIBR

TriTrypDb:

LbrM.13.1370 , LBRM2903_200005300

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H7E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7E1

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	10
GO:0006623	protein targeting to vacuole	5	10
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0007034	vacuolar transport	4	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016192	vesicle-mediated transport	4	10
GO:0033036	macromolecule localization	2	10
GO:0033365	protein localization to organelle	5	10
GO:0045184	establishment of protein localization	3	10
GO:0046907	intracellular transport	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0072594	establishment of protein localization to organelle	4	10
GO:0072665	protein localization to vacuole	6	10
GO:0072666	establishment of protein localization to vacuole	5	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.660
CLV_NRD_NRD_1	244	246	PF00675	0.482
CLV_NRD_NRD_1	407	409	PF00675	0.399
CLV_NRD_NRD_1	666	668	PF00675	0.628
CLV_PCSK_KEX2_1	243	245	PF00082	0.501
CLV_PCSK_KEX2_1	407	409	PF00082	0.399
CLV_PCSK_KEX2_1	499	501	PF00082	0.515
CLV_PCSK_KEX2_1	666	668	PF00082	0.607
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.598
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.515
CLV_PCSK_SKI1_1	213	217	PF00082	0.573
CLV_PCSK_SKI1_1	31	35	PF00082	0.435
CLV_PCSK_SKI1_1	407	411	PF00082	0.233
CLV_PCSK_SKI1_1	41	45	PF00082	0.468
CLV_PCSK_SKI1_1	486	490	PF00082	0.714
CLV_PCSK_SKI1_1	510	514	PF00082	0.709
CLV_PCSK_SKI1_1	533	537	PF00082	0.450
DEG_APCC_DBOX_1	212	220	PF00400	0.613
DOC_CKS1_1	570	575	PF01111	0.614
DOC_MAPK_gen_1	364	374	PF00069	0.288
DOC_PP1_RVXF_1	444	450	PF00149	0.487
DOC_PP1_RVXF_1	508	514	PF00149	0.674
DOC_PP2B_LxvP_1	187	190	PF13499	0.593
DOC_PP2B_LxvP_1	413	416	PF13499	0.552
DOC_PP4_FxxP_1	583	586	PF00568	0.681
DOC_PP4_FxxP_1	590	593	PF00568	0.649
DOC_SPAK_OSR1_1	669	673	PF12202	0.556
DOC_USP7_MATH_1	143	147	PF00917	0.428
DOC_USP7_MATH_1	169	173	PF00917	0.610
DOC_USP7_MATH_1	505	509	PF00917	0.702
DOC_USP7_MATH_1	615	619	PF00917	0.715
DOC_WW_Pin1_4	108	113	PF00397	0.471
DOC_WW_Pin1_4	147	152	PF00397	0.513
DOC_WW_Pin1_4	196	201	PF00397	0.641
DOC_WW_Pin1_4	431	436	PF00397	0.627
DOC_WW_Pin1_4	51	56	PF00397	0.596
DOC_WW_Pin1_4	515	520	PF00397	0.603
DOC_WW_Pin1_4	569	574	PF00397	0.613
DOC_WW_Pin1_4	582	587	PF00397	0.556
DOC_WW_Pin1_4	644	649	PF00397	0.572
LIG_14-3-3_CanoR_1	253	263	PF00244	0.471
LIG_14-3-3_CanoR_1	324	330	PF00244	0.429
LIG_14-3-3_CanoR_1	345	353	PF00244	0.444
LIG_14-3-3_CanoR_1	407	416	PF00244	0.413
LIG_14-3-3_CanoR_1	446	455	PF00244	0.663
LIG_14-3-3_CanoR_1	77	83	PF00244	0.819
LIG_Actin_WH2_2	528	546	PF00022	0.664
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_BRCT_BRCA1_1	580	584	PF00533	0.679
LIG_BRCT_BRCA1_1	622	626	PF00533	0.443
LIG_CSL_BTD_1	337	340	PF09270	0.485
LIG_EABR_CEP55_1	282	291	PF12180	0.621
LIG_EH_1	587	591	PF12763	0.722
LIG_EH1_1	653	661	PF00400	0.601
LIG_EH1_1	669	677	PF00400	0.673
LIG_eIF4E_1	133	139	PF01652	0.464
LIG_eIF4E_1	275	281	PF01652	0.576
LIG_eIF4E_1	654	660	PF01652	0.495
LIG_FHA_1	226	232	PF00498	0.544
LIG_FHA_1	234	240	PF00498	0.537
LIG_FHA_1	287	293	PF00498	0.473
LIG_FHA_1	317	323	PF00498	0.316
LIG_FHA_1	347	353	PF00498	0.344
LIG_FHA_1	4	10	PF00498	0.500
LIG_FHA_1	408	414	PF00498	0.373
LIG_FHA_1	437	443	PF00498	0.672
LIG_FHA_1	459	465	PF00498	0.699
LIG_FHA_2	16	22	PF00498	0.484
LIG_FHA_2	189	195	PF00498	0.625
LIG_FHA_2	207	213	PF00498	0.585
LIG_FHA_2	522	528	PF00498	0.565
LIG_LIR_Apic_2	581	586	PF02991	0.676
LIG_LIR_Gen_1	272	281	PF02991	0.483
LIG_LIR_Gen_1	406	417	PF02991	0.482
LIG_LIR_Gen_1	518	526	PF02991	0.647
LIG_LIR_Nem_3	129	134	PF02991	0.415
LIG_LIR_Nem_3	272	276	PF02991	0.430
LIG_LIR_Nem_3	336	341	PF02991	0.344
LIG_LIR_Nem_3	373	378	PF02991	0.446
LIG_LIR_Nem_3	397	402	PF02991	0.369
LIG_LIR_Nem_3	406	412	PF02991	0.369
LIG_LIR_Nem_3	420	426	PF02991	0.494
LIG_LIR_Nem_3	518	523	PF02991	0.682
LIG_LIR_Nem_3	531	535	PF02991	0.625
LIG_MLH1_MIPbox_1	580	584	PF16413	0.430
LIG_NRBOX	384	390	PF00104	0.233
LIG_NRBOX	59	65	PF00104	0.593
LIG_NRP_CendR_1	679	680	PF00754	0.637
LIG_REV1ctd_RIR_1	420	429	PF16727	0.333
LIG_SH2_CRK	468	472	PF00017	0.682
LIG_SH2_NCK_1	208	212	PF00017	0.639
LIG_SH2_NCK_1	487	491	PF00017	0.499
LIG_SH2_SRC	414	417	PF00017	0.530
LIG_SH2_STAP1	325	329	PF00017	0.444
LIG_SH2_STAP1	355	359	PF00017	0.444
LIG_SH2_STAP1	362	366	PF00017	0.444
LIG_SH2_STAP1	624	628	PF00017	0.626
LIG_SH2_STAT3	539	542	PF00017	0.614
LIG_SH2_STAT5	133	136	PF00017	0.429
LIG_SH2_STAT5	140	143	PF00017	0.405
LIG_SH2_STAT5	173	176	PF00017	0.538
LIG_SH2_STAT5	208	211	PF00017	0.597
LIG_SH2_STAT5	275	278	PF00017	0.541
LIG_SH2_STAT5	279	282	PF00017	0.531
LIG_SH2_STAT5	290	293	PF00017	0.665
LIG_SH2_STAT5	351	354	PF00017	0.344
LIG_SH3_3	260	266	PF00018	0.679
LIG_SH3_3	281	287	PF00018	0.570
LIG_SH3_3	295	301	PF00018	0.726
LIG_SH3_3	338	344	PF00018	0.401
LIG_SH3_3	583	589	PF00018	0.628
LIG_SUMO_SIM_anti_2	384	389	PF11976	0.398
LIG_SUMO_SIM_anti_2	637	643	PF11976	0.544
LIG_SUMO_SIM_par_1	185	191	PF11976	0.578
LIG_SUMO_SIM_par_1	235	240	PF11976	0.579
LIG_SUMO_SIM_par_1	439	445	PF11976	0.601
LIG_TYR_ITIM	466	471	PF00017	0.685
LIG_UBA3_1	270	277	PF00899	0.554
LIG_WRC_WIRS_1	270	275	PF05994	0.433
MOD_CDK_SPK_2	582	587	PF00069	0.685
MOD_CK1_1	108	114	PF00069	0.632
MOD_CK1_1	146	152	PF00069	0.555
MOD_CK1_1	222	228	PF00069	0.596
MOD_CK1_1	328	334	PF00069	0.369
MOD_CK1_1	403	409	PF00069	0.406
MOD_CK1_1	445	451	PF00069	0.600
MOD_CK1_1	458	464	PF00069	0.702
MOD_CK1_1	515	521	PF00069	0.564
MOD_CK2_1	521	527	PF00069	0.477
MOD_Cter_Amidation	677	680	PF01082	0.584
MOD_GlcNHglycan	120	124	PF01048	0.660
MOD_GlcNHglycan	13	16	PF01048	0.727
MOD_GlcNHglycan	151	154	PF01048	0.599
MOD_GlcNHglycan	209	212	PF01048	0.564
MOD_GlcNHglycan	297	301	PF01048	0.705
MOD_GlcNHglycan	333	336	PF01048	0.233
MOD_GlcNHglycan	392	395	PF01048	0.444
MOD_GlcNHglycan	456	460	PF01048	0.592
MOD_GlcNHglycan	505	508	PF01048	0.681
MOD_GSK3_1	143	150	PF00069	0.577
MOD_GSK3_1	152	159	PF00069	0.658
MOD_GSK3_1	233	240	PF00069	0.565
MOD_GSK3_1	4	11	PF00069	0.510
MOD_GSK3_1	403	410	PF00069	0.364
MOD_GSK3_1	436	443	PF00069	0.572
MOD_GSK3_1	447	454	PF00069	0.603
MOD_GSK3_1	489	496	PF00069	0.711
MOD_GSK3_1	578	585	PF00069	0.478
MOD_N-GLC_1	3	8	PF02516	0.497
MOD_N-GLC_1	346	351	PF02516	0.344
MOD_N-GLC_1	357	362	PF02516	0.344
MOD_NEK2_1	219	224	PF00069	0.545
MOD_NEK2_1	34	39	PF00069	0.478
MOD_NEK2_1	346	351	PF00069	0.425
MOD_NEK2_1	390	395	PF00069	0.444
MOD_NEK2_1	402	407	PF00069	0.444
MOD_NEK2_1	442	447	PF00069	0.678
MOD_NEK2_1	512	517	PF00069	0.599
MOD_NEK2_1	521	526	PF00069	0.529
MOD_NEK2_1	92	97	PF00069	0.720
MOD_NEK2_2	505	510	PF00069	0.706
MOD_PIKK_1	392	398	PF00454	0.369
MOD_PIKK_1	407	413	PF00454	0.446
MOD_PIKK_1	42	48	PF00454	0.613
MOD_PIKK_1	512	518	PF00454	0.660
MOD_PIKK_1	78	84	PF00454	0.810
MOD_PKA_1	407	413	PF00069	0.309
MOD_PKA_2	331	337	PF00069	0.233
MOD_PKA_2	403	409	PF00069	0.444
MOD_PKA_2	445	451	PF00069	0.487
MOD_PKA_2	78	84	PF00069	0.557
MOD_Plk_1	225	231	PF00069	0.610
MOD_Plk_1	316	322	PF00069	0.233
MOD_Plk_1	357	363	PF00069	0.369
MOD_Plk_1	397	403	PF00069	0.401
MOD_Plk_1	521	527	PF00069	0.567
MOD_Plk_2-3	288	294	PF00069	0.601
MOD_Plk_2-3	522	528	PF00069	0.459
MOD_Plk_4	126	132	PF00069	0.458
MOD_Plk_4	316	322	PF00069	0.233
MOD_Plk_4	370	376	PF00069	0.370
MOD_Plk_4	622	628	PF00069	0.677
MOD_ProDKin_1	108	114	PF00069	0.477
MOD_ProDKin_1	147	153	PF00069	0.519
MOD_ProDKin_1	196	202	PF00069	0.639
MOD_ProDKin_1	431	437	PF00069	0.629
MOD_ProDKin_1	51	57	PF00069	0.588
MOD_ProDKin_1	515	521	PF00069	0.599
MOD_ProDKin_1	569	575	PF00069	0.612
MOD_ProDKin_1	582	588	PF00069	0.560
MOD_ProDKin_1	644	650	PF00069	0.574
MOD_SUMO_for_1	96	99	PF00179	0.586
MOD_SUMO_rev_2	159	168	PF00179	0.511
MOD_SUMO_rev_2	522	532	PF00179	0.498
TRG_DiLeu_BaEn_1	30	35	PF01217	0.567
TRG_DiLeu_BaEn_1	384	389	PF01217	0.284
TRG_DiLeu_BaEn_1	531	536	PF01217	0.552
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.681
TRG_ENDOCYTIC_2	468	471	PF00928	0.686
TRG_ER_diArg_1	244	246	PF00400	0.510
TRG_ER_diArg_1	407	409	PF00400	0.367
TRG_ER_diArg_1	666	669	PF00400	0.595
TRG_ER_diArg_1	77	80	PF00400	0.679
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKG6	Leptomonas seymouri	55%	96%
A0A1X0P9E4	Trypanosomatidae	28%	94%
A0A3S7X7E3	Leishmania donovani	78%	100%
A0A422N7B5	Trypanosoma rangeli	24%	96%
A4I9J9	Leishmania infantum	78%	100%
E9B4J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q3H9	Leishmania major	77%	100%
V5BM77	Trypanosoma cruzi	25%	93%