Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7E0_LEIBR

TriTrypDb:

LbrM.13.1360 , LBRM2903_200005200

Length:

758

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H7E0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7E0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0030515	snoRNA binding	5	11
GO:0034511	U3 snoRNA binding	6	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.493
CLV_NRD_NRD_1	111	113	PF00675	0.602
CLV_NRD_NRD_1	141	143	PF00675	0.496
CLV_NRD_NRD_1	18	20	PF00675	0.523
CLV_NRD_NRD_1	204	206	PF00675	0.478
CLV_NRD_NRD_1	275	277	PF00675	0.282
CLV_NRD_NRD_1	327	329	PF00675	0.441
CLV_NRD_NRD_1	410	412	PF00675	0.409
CLV_NRD_NRD_1	465	467	PF00675	0.566
CLV_NRD_NRD_1	565	567	PF00675	0.513
CLV_NRD_NRD_1	57	59	PF00675	0.531
CLV_NRD_NRD_1	690	692	PF00675	0.674
CLV_PCSK_KEX2_1	111	113	PF00082	0.602
CLV_PCSK_KEX2_1	141	143	PF00082	0.496
CLV_PCSK_KEX2_1	18	20	PF00082	0.505
CLV_PCSK_KEX2_1	203	205	PF00082	0.568
CLV_PCSK_KEX2_1	410	412	PF00082	0.409
CLV_PCSK_KEX2_1	465	467	PF00082	0.566
CLV_PCSK_KEX2_1	509	511	PF00082	0.736
CLV_PCSK_KEX2_1	565	567	PF00082	0.480
CLV_PCSK_KEX2_1	57	59	PF00082	0.488
CLV_PCSK_KEX2_1	689	691	PF00082	0.658
CLV_PCSK_KEX2_1	737	739	PF00082	0.631
CLV_PCSK_KEX2_1	9	11	PF00082	0.483
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.675
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.488
CLV_PCSK_PC1ET2_1	689	691	PF00082	0.685
CLV_PCSK_PC1ET2_1	737	739	PF00082	0.626
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.532
CLV_PCSK_SKI1_1	205	209	PF00082	0.381
CLV_PCSK_SKI1_1	233	237	PF00082	0.544
CLV_PCSK_SKI1_1	269	273	PF00082	0.504
CLV_PCSK_SKI1_1	277	281	PF00082	0.339
CLV_PCSK_SKI1_1	364	368	PF00082	0.605
CLV_PCSK_SKI1_1	6	10	PF00082	0.592
CLV_PCSK_SKI1_1	61	65	PF00082	0.711
CLV_PCSK_SKI1_1	691	695	PF00082	0.557
CLV_PCSK_SKI1_1	721	725	PF00082	0.649
CLV_PCSK_SKI1_1	727	731	PF00082	0.636
CLV_PCSK_SKI1_1	751	755	PF00082	0.597
DEG_APCC_DBOX_1	410	418	PF00400	0.440
DEG_APCC_DBOX_1	588	596	PF00400	0.637
DEG_APCC_DBOX_1	60	68	PF00400	0.486
DEG_Nend_Nbox_1	1	3	PF02207	0.528
DEG_SPOP_SBC_1	45	49	PF00917	0.577
DOC_CYCLIN_RxL_1	203	210	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.419
DOC_MAPK_gen_1	141	152	PF00069	0.446
DOC_MAPK_gen_1	203	209	PF00069	0.522
DOC_MAPK_gen_1	276	284	PF00069	0.517
DOC_MAPK_gen_1	328	335	PF00069	0.312
DOC_MAPK_gen_1	410	417	PF00069	0.376
DOC_MAPK_gen_1	673	680	PF00069	0.670
DOC_MAPK_gen_1	702	712	PF00069	0.642
DOC_MAPK_MEF2A_6	410	417	PF00069	0.448
DOC_MAPK_MEF2A_6	576	584	PF00069	0.486
DOC_MAPK_MEF2A_6	705	712	PF00069	0.493
DOC_PP1_RVXF_1	267	274	PF00149	0.461
DOC_PP2B_LxvP_1	580	583	PF13499	0.480
DOC_USP7_MATH_1	212	216	PF00917	0.311
DOC_USP7_MATH_1	362	366	PF00917	0.622
DOC_USP7_MATH_1	370	374	PF00917	0.656
DOC_USP7_MATH_1	43	47	PF00917	0.653
DOC_USP7_MATH_1	453	457	PF00917	0.690
DOC_USP7_MATH_1	484	488	PF00917	0.470
DOC_USP7_MATH_1	520	524	PF00917	0.587
DOC_USP7_MATH_1	645	649	PF00917	0.620
DOC_USP7_MATH_1	713	717	PF00917	0.696
DOC_USP7_MATH_1	733	737	PF00917	0.697
DOC_USP7_UBL2_3	750	754	PF12436	0.604
DOC_WW_Pin1_4	371	376	PF00397	0.738
DOC_WW_Pin1_4	464	469	PF00397	0.419
LIG_14-3-3_CanoR_1	515	519	PF00244	0.785
LIG_14-3-3_CanoR_1	58	64	PF00244	0.631
LIG_14-3-3_CanoR_1	738	748	PF00244	0.575
LIG_Clathr_ClatBox_1	606	610	PF01394	0.659
LIG_FHA_1	186	192	PF00498	0.594
LIG_FHA_1	286	292	PF00498	0.525
LIG_FHA_1	297	303	PF00498	0.370
LIG_FHA_1	400	406	PF00498	0.357
LIG_FHA_1	702	708	PF00498	0.767
LIG_FHA_1	718	724	PF00498	0.451
LIG_FHA_2	229	235	PF00498	0.600
LIG_FHA_2	237	243	PF00498	0.594
LIG_FHA_2	26	32	PF00498	0.492
LIG_FHA_2	332	338	PF00498	0.330
LIG_FHA_2	428	434	PF00498	0.493
LIG_FHA_2	616	622	PF00498	0.480
LIG_LIR_Apic_2	355	359	PF02991	0.341
LIG_LIR_Gen_1	259	267	PF02991	0.458
LIG_LIR_Nem_3	259	264	PF02991	0.451
LIG_LIR_Nem_3	485	491	PF02991	0.461
LIG_MAD2	206	214	PF02301	0.505
LIG_MYND_1	530	534	PF01753	0.312
LIG_PCNA_PIPBox_1	308	317	PF02747	0.480
LIG_Rb_pABgroove_1	658	666	PF01858	0.614
LIG_SH2_CRK	356	360	PF00017	0.466
LIG_SH2_CRK	488	492	PF00017	0.497
LIG_SH2_SRC	356	359	PF00017	0.494
LIG_SH2_SRC	479	482	PF00017	0.541
LIG_SH2_STAP1	479	483	PF00017	0.453
LIG_SH2_STAT5	137	140	PF00017	0.491
LIG_SH2_STAT5	180	183	PF00017	0.407
LIG_SH2_STAT5	248	251	PF00017	0.306
LIG_SH3_1	356	362	PF00018	0.374
LIG_SH3_2	359	364	PF14604	0.424
LIG_SH3_3	208	214	PF00018	0.394
LIG_SH3_3	356	362	PF00018	0.501
LIG_SH3_3	369	375	PF00018	0.725
LIG_SH3_3	412	418	PF00018	0.443
LIG_SUMO_SIM_par_1	307	312	PF11976	0.436
LIG_SUMO_SIM_par_1	400	407	PF11976	0.310
LIG_SUMO_SIM_par_1	554	559	PF11976	0.266
LIG_SUMO_SIM_par_1	706	711	PF11976	0.494
LIG_SxIP_EBH_1	689	703	PF03271	0.492
LIG_TRAF2_1	611	614	PF00917	0.678
LIG_TRAF2_1	618	621	PF00917	0.691
LIG_TYR_ITIM	477	482	PF00017	0.471
LIG_UBA3_1	271	277	PF00899	0.499
LIG_UBA3_1	556	562	PF00899	0.272
LIG_ULM_U2AF65_1	565	570	PF00076	0.535
LIG_WW_3	357	361	PF00397	0.378
MOD_CK1_1	185	191	PF00069	0.569
MOD_CK1_1	223	229	PF00069	0.517
MOD_CK1_1	244	250	PF00069	0.373
MOD_CK1_1	457	463	PF00069	0.687
MOD_CK1_1	46	52	PF00069	0.647
MOD_CK1_1	648	654	PF00069	0.659
MOD_CK2_1	256	262	PF00069	0.442
MOD_CK2_1	290	296	PF00069	0.471
MOD_CK2_1	331	337	PF00069	0.341
MOD_CK2_1	427	433	PF00069	0.488
MOD_CK2_1	615	621	PF00069	0.589
MOD_CK2_1	63	69	PF00069	0.529
MOD_CK2_1	636	642	PF00069	0.621
MOD_Cter_Amidation	507	510	PF01082	0.646
MOD_GlcNHglycan	13	16	PF01048	0.530
MOD_GlcNHglycan	174	178	PF01048	0.360
MOD_GlcNHglycan	188	191	PF01048	0.511
MOD_GlcNHglycan	214	217	PF01048	0.441
MOD_GlcNHglycan	363	367	PF01048	0.592
MOD_GlcNHglycan	457	460	PF01048	0.775
MOD_GlcNHglycan	522	525	PF01048	0.725
MOD_GlcNHglycan	573	576	PF01048	0.451
MOD_GlcNHglycan	586	589	PF01048	0.432
MOD_GlcNHglycan	639	642	PF01048	0.652
MOD_GlcNHglycan	694	697	PF01048	0.707
MOD_GlcNHglycan	715	718	PF01048	0.741
MOD_GlcNHglycan	724	727	PF01048	0.729
MOD_GlcNHglycan	73	76	PF01048	0.554
MOD_GSK3_1	182	189	PF00069	0.499
MOD_GSK3_1	212	219	PF00069	0.369
MOD_GSK3_1	237	244	PF00069	0.501
MOD_GSK3_1	25	32	PF00069	0.581
MOD_GSK3_1	256	263	PF00069	0.390
MOD_GSK3_1	41	48	PF00069	0.556
MOD_GSK3_1	451	458	PF00069	0.687
MOD_GSK3_1	59	66	PF00069	0.663
MOD_GSK3_1	67	74	PF00069	0.631
MOD_GSK3_1	713	720	PF00069	0.674
MOD_GSK3_1	75	82	PF00069	0.448
MOD_LATS_1	275	281	PF00433	0.535
MOD_N-GLC_1	389	394	PF02516	0.404
MOD_N-GLC_1	637	642	PF02516	0.599
MOD_N-GLC_1	645	650	PF02516	0.551
MOD_NEK2_1	186	191	PF00069	0.540
MOD_NEK2_1	236	241	PF00069	0.519
MOD_NEK2_1	34	39	PF00069	0.623
MOD_NEK2_1	389	394	PF00069	0.404
MOD_NEK2_1	556	561	PF00069	0.364
MOD_NEK2_1	584	589	PF00069	0.480
MOD_NEK2_1	746	751	PF00069	0.581
MOD_OFUCOSY	156	161	PF10250	0.414
MOD_PIKK_1	29	35	PF00454	0.631
MOD_PIKK_1	347	353	PF00454	0.392
MOD_PKA_1	328	334	PF00069	0.474
MOD_PKA_1	57	63	PF00069	0.487
MOD_PKA_2	228	234	PF00069	0.493
MOD_PKA_2	514	520	PF00069	0.587
MOD_PKA_2	57	63	PF00069	0.513
MOD_PKA_2	701	707	PF00069	0.673
MOD_PKA_2	713	719	PF00069	0.625
MOD_PKB_1	283	291	PF00069	0.479
MOD_Plk_1	182	188	PF00069	0.470
MOD_Plk_1	236	242	PF00069	0.515
MOD_Plk_1	389	395	PF00069	0.400
MOD_Plk_1	708	714	PF00069	0.646
MOD_Plk_2-3	237	243	PF00069	0.548
MOD_Plk_4	244	250	PF00069	0.361
MOD_Plk_4	389	395	PF00069	0.410
MOD_Plk_4	399	405	PF00069	0.426
MOD_ProDKin_1	371	377	PF00069	0.735
MOD_ProDKin_1	464	470	PF00069	0.405
MOD_SUMO_rev_2	642	651	PF00179	0.506
TRG_ENDOCYTIC_2	479	482	PF00928	0.470
TRG_ENDOCYTIC_2	488	491	PF00928	0.443
TRG_ER_diArg_1	17	19	PF00400	0.619
TRG_ER_diArg_1	203	205	PF00400	0.568
TRG_ER_diArg_1	564	566	PF00400	0.502
TRG_ER_diArg_1	589	592	PF00400	0.517
TRG_ER_diLys_1	754	758	PF00400	0.598
TRG_NLS_MonoCore_2	55	60	PF00514	0.595
TRG_NLS_MonoCore_2	688	693	PF00514	0.596
TRG_NLS_MonoExtC_3	56	61	PF00514	0.582
TRG_NLS_MonoExtN_4	56	62	PF00514	0.592
TRG_NLS_MonoExtN_4	689	695	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A4	Leptomonas seymouri	66%	99%
A0A1X0P8I5	Trypanosomatidae	42%	100%
A0A3S5IQN4	Trypanosoma rangeli	41%	100%
A0A3S7X7G1	Leishmania donovani	79%	99%
A4I9K0	Leishmania infantum	80%	100%
D0A1V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B4J8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q3H8	Leishmania major	80%	99%
V5BRS0	Trypanosoma cruzi	40%	100%