START domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7D8_LEIBR

TriTrypDb:

LbrM.13.1340 , LBRM2903_200005000

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7D8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0008289	lipid binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.356
CLV_C14_Caspase3-7	7	11	PF00656	0.626
CLV_C14_Caspase3-7	73	77	PF00656	0.563
CLV_NRD_NRD_1	284	286	PF00675	0.388
CLV_NRD_NRD_1	324	326	PF00675	0.713
CLV_NRD_NRD_1	346	348	PF00675	0.675
CLV_NRD_NRD_1	79	81	PF00675	0.432
CLV_PCSK_KEX2_1	201	203	PF00082	0.460
CLV_PCSK_KEX2_1	284	286	PF00082	0.388
CLV_PCSK_KEX2_1	346	348	PF00082	0.734
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.460
CLV_PCSK_SKI1_1	122	126	PF00082	0.419
CLV_PCSK_SKI1_1	202	206	PF00082	0.258
CLV_PCSK_SKI1_1	284	288	PF00082	0.374
CLV_PCSK_SKI1_1	302	306	PF00082	0.589
CLV_PCSK_SKI1_1	347	351	PF00082	0.662
CLV_PCSK_SKI1_1	80	84	PF00082	0.412
CLV_PCSK_SKI1_1	96	100	PF00082	0.398
DEG_Nend_Nbox_1	1	3	PF02207	0.539
DOC_MAPK_gen_1	346	357	PF00069	0.627
DOC_MAPK_gen_1	78	88	PF00069	0.474
DOC_PIKK_1	161	169	PF02985	0.474
DOC_PP1_RVXF_1	120	127	PF00149	0.439
DOC_PP1_RVXF_1	82	89	PF00149	0.549
DOC_PP4_FxxP_1	98	101	PF00568	0.368
DOC_USP7_MATH_1	22	26	PF00917	0.650
DOC_USP7_MATH_1	330	334	PF00917	0.530
DOC_USP7_UBL2_3	14	18	PF12436	0.650
DOC_WW_Pin1_4	116	121	PF00397	0.365
DOC_WW_Pin1_4	256	261	PF00397	0.420
LIG_14-3-3_CanoR_1	110	116	PF00244	0.479
LIG_14-3-3_CanoR_1	135	145	PF00244	0.342
LIG_14-3-3_CanoR_1	183	187	PF00244	0.524
LIG_APCC_ABBAyCdc20_2	284	290	PF00400	0.416
LIG_FHA_1	110	116	PF00498	0.438
LIG_FHA_1	264	270	PF00498	0.496
LIG_FHA_1	46	52	PF00498	0.448
LIG_FHA_2	213	219	PF00498	0.456
LIG_FHA_2	71	77	PF00498	0.535
LIG_LIR_Gen_1	194	203	PF02991	0.328
LIG_LIR_Gen_1	54	63	PF02991	0.476
LIG_LIR_Nem_3	180	184	PF02991	0.430
LIG_LIR_Nem_3	194	198	PF02991	0.251
LIG_LIR_Nem_3	248	254	PF02991	0.383
LIG_LIR_Nem_3	54	59	PF02991	0.483
LIG_OCRL_FandH_1	87	99	PF00620	0.313
LIG_Pex14_1	177	181	PF04695	0.454
LIG_Pex14_1	263	267	PF04695	0.445
LIG_Pex14_2	239	243	PF04695	0.378
LIG_Pex14_2	267	271	PF04695	0.468
LIG_PTB_Apo_2	50	57	PF02174	0.455
LIG_PTB_Phospho_1	50	56	PF10480	0.498
LIG_SH2_CRK	145	149	PF00017	0.488
LIG_SH2_CRK	184	188	PF00017	0.539
LIG_SH2_NCK_1	145	149	PF00017	0.488
LIG_SH2_NCK_1	184	188	PF00017	0.539
LIG_SH2_PTP2	56	59	PF00017	0.301
LIG_SH2_SRC	211	214	PF00017	0.305
LIG_SH2_SRC	288	291	PF00017	0.598
LIG_SH2_STAP1	138	142	PF00017	0.382
LIG_SH2_STAP1	145	149	PF00017	0.363
LIG_SH2_STAT5	158	161	PF00017	0.510
LIG_SH2_STAT5	203	206	PF00017	0.346
LIG_SH2_STAT5	211	214	PF00017	0.266
LIG_SH2_STAT5	251	254	PF00017	0.341
LIG_SH2_STAT5	56	59	PF00017	0.301
LIG_SH3_3	149	155	PF00018	0.501
LIG_SH3_3	25	31	PF00018	0.411
LIG_SH3_3	288	294	PF00018	0.526
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.225
LIG_SUMO_SIM_par_1	194	200	PF11976	0.225
LIG_TYR_ITIM	286	291	PF00017	0.603
LIG_WRC_WIRS_1	123	128	PF05994	0.561
MOD_CDC14_SPxK_1	119	122	PF00782	0.434
MOD_CDK_SPxK_1	116	122	PF00069	0.491
MOD_CK1_1	136	142	PF00069	0.375
MOD_CK1_1	256	262	PF00069	0.492
MOD_CK1_1	42	48	PF00069	0.424
MOD_GlcNHglycan	184	187	PF01048	0.477
MOD_GlcNHglycan	190	193	PF01048	0.381
MOD_GlcNHglycan	332	335	PF01048	0.682
MOD_GSK3_1	220	227	PF00069	0.589
MOD_GSK3_1	263	270	PF00069	0.542
MOD_GSK3_1	307	314	PF00069	0.698
MOD_N-GLC_1	116	121	PF02516	0.360
MOD_N-GLC_1	311	316	PF02516	0.673
MOD_N-GLC_1	52	57	PF02516	0.499
MOD_N-GLC_1	70	75	PF02516	0.520
MOD_N-GLC_2	141	143	PF02516	0.464
MOD_NEK2_1	267	272	PF00069	0.503
MOD_NEK2_1	315	320	PF00069	0.614
MOD_NEK2_1	337	342	PF00069	0.529
MOD_NEK2_1	4	9	PF00069	0.628
MOD_NEK2_1	52	57	PF00069	0.473
MOD_NEK2_1	69	74	PF00069	0.508
MOD_OFUCOSY	252	257	PF10250	0.455
MOD_PKA_2	109	115	PF00069	0.475
MOD_PKA_2	136	142	PF00069	0.479
MOD_PKA_2	182	188	PF00069	0.525
MOD_Plk_1	133	139	PF00069	0.392
MOD_Plk_1	311	317	PF00069	0.752
MOD_Plk_1	52	58	PF00069	0.492
MOD_Plk_1	70	76	PF00069	0.524
MOD_Plk_2-3	61	67	PF00069	0.482
MOD_Plk_4	122	128	PF00069	0.428
MOD_Plk_4	250	256	PF00069	0.331
MOD_Plk_4	263	269	PF00069	0.408
MOD_Plk_4	52	58	PF00069	0.540
MOD_ProDKin_1	116	122	PF00069	0.366
MOD_ProDKin_1	256	262	PF00069	0.432
MOD_SUMO_for_1	349	352	PF00179	0.701
MOD_SUMO_rev_2	72	79	PF00179	0.347
TRG_DiLeu_BaEn_4	344	350	PF01217	0.776
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.304
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.512
TRG_ENDOCYTIC_2	145	148	PF00928	0.493
TRG_ENDOCYTIC_2	288	291	PF00928	0.617
TRG_ENDOCYTIC_2	56	59	PF00928	0.483
TRG_ER_diArg_1	135	138	PF00400	0.506
TRG_ER_diArg_1	284	286	PF00400	0.388
TRG_NES_CRM1_1	164	176	PF08389	0.504
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	347	352	PF00026	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4J3	Leptomonas seymouri	65%	100%
A0A0S4KHG7	Bodo saltans	39%	100%
A0A1X0P8H6	Trypanosomatidae	40%	100%
A0A3R7MF23	Trypanosoma rangeli	39%	100%
A0A3S7X7C6	Leishmania donovani	77%	100%
A4I9K2	Leishmania infantum	77%	100%
D0A1W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B4K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q3H6	Leishmania major	76%	100%
V5DIM4	Trypanosoma cruzi	40%	100%