LeishMANIAdb
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Amastin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Amastin
Gene product:
amastin
Species:
Leishmania braziliensis
UniProt:
A4H7D7_LEIBR
TriTrypDb:
LbrM.13.1330 , LBRM2903_130019500 *
Length:
194

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 8
Silverman et al. no yes: 0
Pissara et al. no yes: 18
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 12, no: 212
NetGPI no yes: 0, no: 224
Cellular components
Term Name Level Count
GO:0016020 membrane 2 200
GO:0110165 cellular anatomical entity 1 200

Expansion

Sequence features

A4H7D7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7D7

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0016485 protein processing 5 1
GO:0016540 protein autoprocessing 6 1
GO:0019538 protein metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0051604 protein maturation 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004175 endopeptidase activity 4 1
GO:0004197 cysteine-type endopeptidase activity 5 1
GO:0008233 peptidase activity 3 1
GO:0008234 cysteine-type peptidase activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 73 75 PF00675 0.483
CLV_PCSK_KEX2_1 146 148 PF00082 0.398
CLV_PCSK_KEX2_1 73 75 PF00082 0.492
CLV_PCSK_PC1ET2_1 146 148 PF00082 0.397
DEG_Nend_UBRbox_1 1 4 PF02207 0.641
DOC_CDC14_PxL_1 166 174 PF14671 0.196
DOC_CKS1_1 23 28 PF01111 0.354
DOC_CYCLIN_yCln2_LP_2 167 173 PF00134 0.492
DOC_MAPK_gen_1 106 115 PF00069 0.514
DOC_MAPK_MEF2A_6 106 115 PF00069 0.445
DOC_MAPK_MEF2A_6 2 11 PF00069 0.532
DOC_PP1_RVXF_1 104 111 PF00149 0.454
DOC_PP2B_LxvP_1 167 170 PF13499 0.508
DOC_SPAK_OSR1_1 76 80 PF12202 0.205
DOC_USP7_MATH_1 84 88 PF00917 0.410
DOC_WW_Pin1_4 22 27 PF00397 0.351
LIG_14-3-3_CanoR_1 43 48 PF00244 0.360
LIG_Actin_WH2_2 93 111 PF00022 0.371
LIG_BRCT_BRCA1_1 57 61 PF00533 0.335
LIG_FHA_1 120 126 PF00498 0.366
LIG_FHA_2 23 29 PF00498 0.377
LIG_FHA_2 50 56 PF00498 0.328
LIG_LIR_Gen_1 56 66 PF02991 0.411
LIG_LIR_Gen_1 87 97 PF02991 0.265
LIG_LIR_Nem_3 56 62 PF02991 0.308
LIG_LIR_Nem_3 87 92 PF02991 0.272
LIG_NRBOX 159 165 PF00104 0.199
LIG_Pex14_2 57 61 PF04695 0.370
LIG_SH2_CRK 59 63 PF00017 0.201
LIG_SH2_PTP2 10 13 PF00017 0.521
LIG_SH2_STAT5 10 13 PF00017 0.452
LIG_SH2_STAT5 107 110 PF00017 0.524
LIG_SH2_STAT5 45 48 PF00017 0.300
LIG_SH2_STAT5 91 94 PF00017 0.402
LIG_SH3_3 20 26 PF00018 0.368
LIG_SUMO_SIM_anti_2 4 10 PF11976 0.275
LIG_TYR_ITIM 8 13 PF00017 0.463
LIG_Vh1_VBS_1 90 108 PF01044 0.406
LIG_WW_3 70 74 PF00397 0.198
MOD_CK1_1 34 40 PF00069 0.321
MOD_GlcNHglycan 178 181 PF01048 0.512
MOD_GSK3_1 185 192 PF00069 0.829
MOD_GSK3_1 49 56 PF00069 0.318
MOD_N-GLC_1 189 194 PF02516 0.421
MOD_NEK2_1 1 6 PF00069 0.616
MOD_NEK2_1 130 135 PF00069 0.441
MOD_NEK2_1 145 150 PF00069 0.298
MOD_NEK2_1 66 71 PF00069 0.231
MOD_NEK2_2 84 89 PF00069 0.455
MOD_PIKK_1 34 40 PF00454 0.333
MOD_PKA_2 34 40 PF00069 0.309
MOD_Plk_4 43 49 PF00069 0.312
MOD_Plk_4 84 90 PF00069 0.319
MOD_ProDKin_1 22 28 PF00069 0.351
MOD_SUMO_rev_2 183 192 PF00179 0.606
TRG_ENDOCYTIC_2 10 13 PF00928 0.429
TRG_ENDOCYTIC_2 59 62 PF00928 0.299
TRG_ER_diArg_1 30 33 PF00400 0.275
TRG_ER_diArg_1 72 74 PF00400 0.352

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2C4 Leptomonas seymouri 32% 100%
A0A0N0P547 Leptomonas seymouri 44% 100%
A0A0N0P6P9 Leptomonas seymouri 23% 84%
A0A0N0P993 Leptomonas seymouri 29% 87%
A0A0N1HWY5 Leptomonas seymouri 28% 99%
A0A0N1I295 Leptomonas seymouri 27% 100%
A0A0N1PAD5 Leptomonas seymouri 26% 77%
A0A0N1PDH0 Leptomonas seymouri 37% 96%
A0A0N1PFN2 Leptomonas seymouri 22% 100%
A0A1X0NQ58 Trypanosomatidae 33% 100%
A0A1X0NUH1 Trypanosomatidae 31% 85%
A0A1X0NVN5 Trypanosomatidae 26% 100%
A0A1X0NVT7 Trypanosomatidae 34% 100%
A0A1X0NX02 Trypanosomatidae 34% 100%
A0A1X0NX81 Trypanosomatidae 29% 100%
A0A1X0P2R3 Trypanosomatidae 30% 92%
A0A1X0P988 Trypanosomatidae 42% 100%
A0A381MTA7 Leishmania infantum 52% 100%
A0A381MTB8 Leishmania infantum 44% 100%
A0A381MTC7 Leishmania infantum 50% 95%
A0A381MTN2 Leishmania infantum 43% 99%
A0A381MVY0 Leishmania infantum 54% 100%
A0A3Q8ID16 Leishmania donovani 33% 100%
A0A3Q8IE85 Leishmania donovani 52% 100%
A0A3Q8IEC2 Leishmania donovani 47% 100%
A0A3Q8IEI1 Leishmania donovani 49% 100%
A0A3Q8IF65 Leishmania donovani 47% 98%
A0A3Q8IFB9 Leishmania donovani 37% 96%
A0A3Q8IFH7 Leishmania donovani 50% 95%
A0A3Q8IFI8 Leishmania donovani 21% 98%
A0A3Q8IH65 Leishmania donovani 44% 100%
A0A3Q8IHN2 Leishmania donovani 48% 100%
A0A3Q8IHW7 Leishmania donovani 51% 100%
A0A3Q8IHZ6 Leishmania donovani 50% 92%
A0A3Q8IIH1 Leishmania donovani 47% 100%
A0A3Q8IL03 Leishmania donovani 43% 100%
A0A3Q8IMR4 Leishmania donovani 27% 100%
A0A3Q8IUK8 Leishmania donovani 49% 100%
A0A3Q8IUR5 Leishmania donovani 43% 99%
A0A3S5H662 Leishmania donovani 48% 96%
A0A3S5H663 Leishmania donovani 48% 96%
A0A3S5H665 Leishmania donovani 49% 96%
A0A3S5H666 Leishmania donovani 46% 100%
A0A3S5H667 Leishmania donovani 49% 96%
A0A3S5H7D2 Leishmania donovani 35% 100%
A0A3S5H7L2 Leishmania donovani 47% 95%
A0A3S5H7V9 Leishmania donovani 43% 98%
A0A3S5H7W2 Leishmania donovani 31% 100%
A0A3S5H7W6 Leishmania donovani 50% 97%
A0A3S7WQA0 Leishmania donovani 49% 96%
A0A3S7WQA8 Leishmania donovani 51% 100%
A0A3S7WQC1 Leishmania donovani 43% 100%
A0A3S7X2E6 Leishmania donovani 44% 100%
A0A3S7X357 Leishmania donovani 27% 87%
A0A3S7X381 Leishmania donovani 21% 98%
A0A3S7X453 Leishmania donovani 47% 98%
A0A3S7X472 Leishmania donovani 46% 97%
A0A3S7X7E5 Leishmania donovani 53% 78%
A0A3S7X7M4 Leishmania donovani 51% 92%
A0A3S7X7U1 Leishmania donovani 49% 92%
A0A3S7X7U4 Leishmania donovani 51% 75%
A0A3S7X7W2 Leishmania donovani 39% 92%
A0A3S7X7Y0 Leishmania donovani 45% 100%
A4H595 Leishmania braziliensis 51% 100%
A4H596 Leishmania braziliensis 52% 100%
A4H597 Leishmania braziliensis 51% 100%
A4H5D1 Leishmania braziliensis 73% 99%
A4H5D2 Leishmania braziliensis 40% 100%
A4H5G0 Leishmania braziliensis 50% 99%
A4H5G4 Leishmania braziliensis 46% 100%
A4H5G6 Leishmania braziliensis 47% 100%
A4H5G7 Leishmania braziliensis 51% 100%
A4H5G9 Leishmania braziliensis 50% 100%
A4H5H0 Leishmania braziliensis 50% 100%
A4H5H1 Leishmania braziliensis 46% 99%
A4H5H2 Leishmania braziliensis 49% 99%
A4H5H3 Leishmania braziliensis 45% 100%
A4H6C8 Leishmania braziliensis 42% 100%
A4H9E8 Leishmania braziliensis 58% 93%
A4H9E9 Leishmania braziliensis 53% 99%
A4HAJ4 Leishmania braziliensis 53% 92%
A4HAJ5 Leishmania braziliensis 50% 87%
A4HAJ6 Leishmania braziliensis 51% 84%
A4HAL1 Leishmania braziliensis 56% 100%
A4HAL2 Leishmania braziliensis 30% 100%
A4HAM2 Leishmania braziliensis 50% 100%
A4HAM4 Leishmania braziliensis 50% 100%
A4HAR1 Leishmania braziliensis 46% 100%
A4HAZ8 Leishmania braziliensis 48% 100%
A4HB00 Leishmania braziliensis 45% 100%
A4HB02 Leishmania braziliensis 49% 100%
A4HB47 Leishmania braziliensis 34% 96%
A4HBJ0 Leishmania braziliensis 51% 100%
A4HBJ1 Leishmania braziliensis 50% 100%
A4HBJ2 Leishmania braziliensis 50% 93%
A4HDI2 Leishmania braziliensis 30% 100%
A4HDI3 Leishmania braziliensis 33% 80%
A4HDI4 Leishmania braziliensis 31% 100%
A4HDL3 Leishmania braziliensis 33% 100%
A4HDL4 Leishmania braziliensis 32% 100%
A4HI41 Leishmania braziliensis 28% 98%
A4HI43 Leishmania braziliensis 29% 92%
A4HTM3 Leishmania infantum 42% 100%
A4HTM4 Leishmania infantum 51% 100%
A4HTM5 Leishmania infantum 47% 100%
A4I0W3 Leishmania infantum 27% 100%
A4I0W4 Leishmania infantum 34% 100%
A4I0W5 Leishmania infantum 33% 100%
A4I4J2 Leishmania infantum 48% 95%
A4I4J3 Leishmania infantum 46% 75%
A4I5B8 Leishmania infantum 22% 98%
A4I5B9 Leishmania infantum 27% 87%
A4I6E5 Leishmania infantum 45% 97%
A4I9Q4 Leishmania infantum 48% 100%
A4I9R4 Leishmania infantum 31% 100%
A4I9R5 Leishmania infantum 37% 96%
A4I9R7 Leishmania infantum 53% 98%
A4I9W8 Leishmania infantum 51% 75%
A4I9X0 Leishmania infantum 38% 92%
A4IA59 Leishmania infantum 43% 75%
A4IAL7 Leishmania infantum 51% 100%
A4IAM1 Leishmania infantum 46% 100%
A4IAM2 Leishmania infantum 48% 100%
C6K3X9 Leptomonas seymouri 30% 100%
E8NHC3 Leishmania infantum 48% 97%
E8NHD3 Leishmania infantum 47% 95%
E8NHD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E8NHD9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E8NHE0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 93%
E8NHF4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 93%
E8NHF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E8NHF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E8NHG2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 92%
E8NHH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 92%
E8NHH9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E8NHI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 99%
E8NHI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E8NHK7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 92%
E8NHK9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E8NHL7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E8NHL9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 100%
E8NHM0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E8NHM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 99%
E8NHM3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 92%
E8NHM5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 92%
E8NHM6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E8NHM7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E8NHP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 94%
E8NHQ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 93%
E8NHQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 99%
E8NHR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E8NHR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E8NHS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 92%
E9AG81 Leishmania infantum 47% 95%
E9AG82 Leishmania infantum 47% 95%
E9AG83 Leishmania infantum 44% 97%
E9AG85 Leishmania infantum 49% 96%
E9AHI9 Leishmania infantum 44% 100%
E9AHT2 Leishmania infantum 53% 92%
E9AME9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9AMF0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AMF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 93%
E9AMF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 99%
E9AMF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 99%
E9AMF4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 75%
E9AMF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 93%
E9AMF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9AMF8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9AMF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9ASP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 93%
E9AWW7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AWW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9AWW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AWX0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B0L4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 98%
E9B0L5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 98%
E9B0L6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 87%
E9B1J3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 99%
E9B1J4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 93%
E9B1J5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 92%
E9B4L9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 98%
E9B4R7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 98%
E9B4R8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 99%
E9B4R9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 96%
E9B4S0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B4Y3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 94%
Q4Q1U9 Leishmania major 53% 98%
Q4Q305 Leishmania major 46% 98%
Q4Q309 Leishmania major 52% 100%
Q4Q313 Leishmania major 46% 98%
Q4Q317 Leishmania major 43% 100%
Q4Q325 Leishmania major 48% 100%
Q4Q327 Leishmania major 49% 98%
Q4Q329 Leishmania major 47% 98%
Q4Q333 Leishmania major 47% 98%
Q4Q335 Leishmania major 47% 98%
Q4Q337 Leishmania major 52% 98%
Q4Q339 Leishmania major 46% 98%
Q4Q341 Leishmania major 55% 98%
Q4Q397 Leishmania major 51% 100%
Q4Q3A7 Leishmania major 30% 100%
Q4Q3A8 Leishmania major 36% 100%
Q4Q3A9 Leishmania major 49% 100%
Q4Q3F7 Leishmania major 49% 100%
Q4Q6L8 Leishmania major 44% 100%
Q4Q7L6 Leishmania major 28% 100%
Q4Q7L7 Leishmania major 23% 100%
Q4Q7L8 Leishmania major 24% 100%
Q4QAK4 Leishmania major 28% 99%
Q4QAK5 Leishmania major 33% 100%
Q4QAK6 Leishmania major 36% 99%
Q4QAK7 Leishmania major 28% 99%
Q4QI84 Leishmania major 53% 100%
Q4QI85 Leishmania major 49% 99%
Q4QI86 Leishmania major 54% 100%
Q4QI87 Leishmania major 45% 99%
Q4QI88 Leishmania major 48% 99%
Q4QI92 Leishmania major 44% 100%
Q4QI93 Leishmania major 44% 100%
Q4QI95 Leishmania major 43% 100%
Q4QI97 Leishmania major 43% 100%
Q4QIA0 Leishmania major 43% 100%
Q4QIA1 Leishmania major 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS