Gamma-soluble NSF attachment protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein, gamma), putative

Species:

Leishmania braziliensis

UniProt:

A4H7D4_LEIBR

TriTrypDb:

LbrM.13.1300 , LBRM2903_200011400

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4H7D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7D4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005483	soluble NSF attachment protein activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.463
CLV_NRD_NRD_1	187	189	PF00675	0.613
CLV_NRD_NRD_1	202	204	PF00675	0.604
CLV_PCSK_KEX2_1	187	189	PF00082	0.613
CLV_PCSK_KEX2_1	207	209	PF00082	0.404
CLV_PCSK_KEX2_1	218	220	PF00082	0.451
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.404
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.451
CLV_PCSK_PC7_1	203	209	PF00082	0.404
CLV_PCSK_SKI1_1	318	322	PF00082	0.428
CLV_PCSK_SKI1_1	366	370	PF00082	0.417
CLV_PCSK_SKI1_1	44	48	PF00082	0.426
CLV_PCSK_SKI1_1	52	56	PF00082	0.454
DOC_CKS1_1	181	186	PF01111	0.363
DOC_MAPK_DCC_7	204	214	PF00069	0.287
DOC_MAPK_gen_1	203	214	PF00069	0.397
DOC_MAPK_MEF2A_6	207	216	PF00069	0.554
DOC_MAPK_MEF2A_6	289	296	PF00069	0.339
DOC_USP7_MATH_1	104	108	PF00917	0.448
DOC_USP7_MATH_1	121	125	PF00917	0.469
DOC_USP7_MATH_1	362	366	PF00917	0.540
DOC_USP7_MATH_1	397	401	PF00917	0.696
DOC_USP7_MATH_1	93	97	PF00917	0.484
DOC_USP7_UBL2_3	44	48	PF12436	0.416
DOC_WW_Pin1_4	180	185	PF00397	0.474
DOC_WW_Pin1_4	262	267	PF00397	0.644
LIG_14-3-3_CanoR_1	403	407	PF00244	0.521
LIG_eIF4E_1	235	241	PF01652	0.412
LIG_FHA_1	133	139	PF00498	0.679
LIG_FHA_1	197	203	PF00498	0.478
LIG_FHA_2	193	199	PF00498	0.649
LIG_FHA_2	268	274	PF00498	0.579
LIG_FHA_2	288	294	PF00498	0.366
LIG_FHA_2	299	305	PF00498	0.550
LIG_FHA_2	409	415	PF00498	0.735
LIG_LIR_Apic_2	226	232	PF02991	0.539
LIG_LIR_Gen_1	237	243	PF02991	0.415
LIG_LIR_Gen_1	308	317	PF02991	0.514
LIG_LIR_Gen_1	355	364	PF02991	0.431
LIG_LIR_Nem_3	109	114	PF02991	0.517
LIG_LIR_Nem_3	205	209	PF02991	0.507
LIG_LIR_Nem_3	233	238	PF02991	0.397
LIG_LIR_Nem_3	308	312	PF02991	0.509
LIG_LIR_Nem_3	355	360	PF02991	0.439
LIG_SH2_CRK	13	17	PF00017	0.498
LIG_SH2_CRK	206	210	PF00017	0.470
LIG_SH2_CRK	75	79	PF00017	0.550
LIG_SH2_GRB2like	75	78	PF00017	0.540
LIG_SH2_NCK_1	150	154	PF00017	0.502
LIG_SH2_NCK_1	229	233	PF00017	0.314
LIG_SH2_SRC	150	153	PF00017	0.503
LIG_SH2_SRC	271	274	PF00017	0.569
LIG_SH2_STAT5	201	204	PF00017	0.459
LIG_SH2_STAT5	307	310	PF00017	0.518
LIG_SH3_3	379	385	PF00018	0.678
LIG_SUMO_SIM_anti_2	290	296	PF11976	0.362
LIG_SUMO_SIM_par_1	210	215	PF11976	0.396
LIG_TRAF2_1	149	152	PF00917	0.502
LIG_TRAF2_1	326	329	PF00917	0.420
LIG_UBA3_1	209	218	PF00899	0.282
MOD_CDK_SPxxK_3	180	187	PF00069	0.364
MOD_CK1_1	124	130	PF00069	0.631
MOD_CK1_1	180	186	PF00069	0.574
MOD_CK1_1	31	37	PF00069	0.402
MOD_CK1_1	402	408	PF00069	0.560
MOD_CK2_1	287	293	PF00069	0.366
MOD_CK2_1	323	329	PF00069	0.388
MOD_CK2_1	406	412	PF00069	0.701
MOD_GlcNHglycan	127	130	PF01048	0.606
MOD_GlcNHglycan	244	247	PF01048	0.466
MOD_GlcNHglycan	394	397	PF01048	0.694
MOD_GlcNHglycan	44	47	PF01048	0.587
MOD_GSK3_1	121	128	PF00069	0.601
MOD_GSK3_1	132	139	PF00069	0.564
MOD_GSK3_1	187	194	PF00069	0.638
MOD_GSK3_1	398	405	PF00069	0.716
MOD_GSK3_1	406	413	PF00069	0.810
MOD_N-GLC_1	129	134	PF02516	0.613
MOD_N-GLC_1	161	166	PF02516	0.579
MOD_N-GLC_1	324	329	PF02516	0.395
MOD_N-GLC_2	354	356	PF02516	0.444
MOD_NEK2_1	16	21	PF00069	0.476
MOD_NEK2_1	177	182	PF00069	0.539
MOD_NEK2_1	186	191	PF00069	0.462
MOD_NEK2_1	297	302	PF00069	0.382
MOD_NEK2_1	3	8	PF00069	0.515
MOD_PIKK_1	113	119	PF00454	0.523
MOD_PIKK_1	251	257	PF00454	0.291
MOD_PIKK_1	28	34	PF00454	0.490
MOD_PIKK_1	86	92	PF00454	0.458
MOD_PKA_1	187	193	PF00069	0.463
MOD_PKA_1	369	375	PF00069	0.529
MOD_PKA_2	186	192	PF00069	0.568
MOD_PKA_2	402	408	PF00069	0.517
MOD_Plk_1	362	368	PF00069	0.399
MOD_Plk_2-3	410	416	PF00069	0.725
MOD_Plk_4	121	127	PF00069	0.461
MOD_ProDKin_1	180	186	PF00069	0.477
MOD_ProDKin_1	262	268	PF00069	0.641
MOD_SUMO_rev_2	45	55	PF00179	0.652
TRG_DiLeu_BaEn_4	151	157	PF01217	0.513
TRG_ENDOCYTIC_2	13	16	PF00928	0.629
TRG_ENDOCYTIC_2	206	209	PF00928	0.506
TRG_ENDOCYTIC_2	238	241	PF00928	0.417
TRG_ENDOCYTIC_2	75	78	PF00928	0.454
TRG_ER_diArg_1	186	188	PF00400	0.574
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I337	Leptomonas seymouri	61%	100%
A0A0S4J5L6	Bodo saltans	28%	100%
A0A1X0P9K4	Trypanosomatidae	37%	100%
A0A3Q8IKP9	Leishmania donovani	78%	100%
A0A422MZB1	Trypanosoma rangeli	38%	100%
A4I9M4	Leishmania infantum	78%	100%
D0A1Z0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B4M3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q3F3	Leishmania major	76%	100%
V5BRU6	Trypanosoma cruzi	35%	100%