Cysteine-leucine rich protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cysteine leucine rich protein

Species:

Leishmania braziliensis

UniProt:

A4H7D3_LEIBR

TriTrypDb:

LbrM.13.1290 , LBRM2903_200011500

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0000151	ubiquitin ligase complex	3	1
GO:0005634	nucleus	5	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4H7D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7D3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	573	575	PF00675	0.485
CLV_PCSK_KEX2_1	502	504	PF00082	0.440
CLV_PCSK_KEX2_1	575	577	PF00082	0.347
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.440
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.347
CLV_PCSK_SKI1_1	26	30	PF00082	0.584
CLV_PCSK_SKI1_1	287	291	PF00082	0.413
CLV_PCSK_SKI1_1	502	506	PF00082	0.420
CLV_PCSK_SKI1_1	553	557	PF00082	0.379
DEG_APCC_DBOX_1	575	583	PF00400	0.335
DEG_SCF_FBW7_1	84	89	PF00400	0.551
DOC_CDC14_PxL_1	545	553	PF14671	0.389
DOC_CKS1_1	63	68	PF01111	0.523
DOC_CYCLIN_RxL_1	434	442	PF00134	0.380
DOC_CYCLIN_yClb5_NLxxxL_5	351	360	PF00134	0.259
DOC_CYCLIN_yCln2_LP_2	63	69	PF00134	0.505
DOC_MAPK_gen_1	502	509	PF00069	0.388
DOC_MAPK_gen_1	574	583	PF00069	0.417
DOC_MAPK_MEF2A_6	574	583	PF00069	0.330
DOC_PP1_RVXF_1	460	467	PF00149	0.441
DOC_PP2B_LxvP_1	468	471	PF13499	0.469
DOC_PP4_FxxP_1	583	586	PF00568	0.377
DOC_USP7_MATH_1	111	115	PF00917	0.569
DOC_USP7_MATH_1	181	185	PF00917	0.532
DOC_USP7_MATH_1	189	193	PF00917	0.545
DOC_USP7_MATH_1	246	250	PF00917	0.664
DOC_USP7_MATH_1	261	265	PF00917	0.389
DOC_USP7_MATH_1	380	384	PF00917	0.331
DOC_USP7_MATH_1	79	83	PF00917	0.735
DOC_WW_Pin1_4	100	105	PF00397	0.620
DOC_WW_Pin1_4	145	150	PF00397	0.632
DOC_WW_Pin1_4	165	170	PF00397	0.608
DOC_WW_Pin1_4	213	218	PF00397	0.622
DOC_WW_Pin1_4	307	312	PF00397	0.543
DOC_WW_Pin1_4	599	604	PF00397	0.631
DOC_WW_Pin1_4	612	617	PF00397	0.593
DOC_WW_Pin1_4	62	67	PF00397	0.588
DOC_WW_Pin1_4	75	80	PF00397	0.660
DOC_WW_Pin1_4	82	87	PF00397	0.634
LIG_14-3-3_CanoR_1	319	328	PF00244	0.553
LIG_14-3-3_CanoR_1	338	345	PF00244	0.312
LIG_14-3-3_CanoR_1	405	412	PF00244	0.367
LIG_14-3-3_CanoR_1	503	508	PF00244	0.408
LIG_14-3-3_CanoR_1	521	525	PF00244	0.379
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BIR_III_1	1	5	PF00653	0.647
LIG_BIR_III_2	341	345	PF00653	0.336
LIG_BIR_III_3	1	5	PF00653	0.647
LIG_BRCT_BRCA1_1	191	195	PF00533	0.538
LIG_BRCT_BRCA1_1	348	352	PF00533	0.392
LIG_FHA_1	155	161	PF00498	0.691
LIG_FHA_1	168	174	PF00498	0.576
LIG_FHA_1	23	29	PF00498	0.604
LIG_FHA_1	264	270	PF00498	0.368
LIG_FHA_1	361	367	PF00498	0.520
LIG_FHA_1	426	432	PF00498	0.346
LIG_FHA_1	504	510	PF00498	0.411
LIG_FHA_1	528	534	PF00498	0.261
LIG_FHA_1	550	556	PF00498	0.499
LIG_FHA_1	79	85	PF00498	0.670
LIG_FHA_2	145	151	PF00498	0.688
LIG_FHA_2	538	544	PF00498	0.376
LIG_FHA_2	616	622	PF00498	0.672
LIG_LIR_Apic_2	580	586	PF02991	0.375
LIG_LIR_Nem_3	174	179	PF02991	0.676
LIG_LIR_Nem_3	65	70	PF02991	0.604
LIG_LYPXL_yS_3	70	73	PF13949	0.598
LIG_NRBOX	463	469	PF00104	0.440
LIG_Rb_pABgroove_1	346	354	PF01858	0.361
LIG_SH2_STAP1	406	410	PF00017	0.365
LIG_SH2_STAT3	99	102	PF00017	0.689
LIG_SH2_STAT5	403	406	PF00017	0.348
LIG_SH3_1	101	107	PF00018	0.681
LIG_SH3_1	606	612	PF00018	0.668
LIG_SH3_3	101	107	PF00018	0.677
LIG_SH3_3	180	186	PF00018	0.577
LIG_SH3_3	188	194	PF00018	0.738
LIG_SH3_3	207	213	PF00018	0.644
LIG_SH3_3	606	612	PF00018	0.668
LIG_SH3_3	85	91	PF00018	0.818
LIG_SUMO_SIM_par_1	481	486	PF11976	0.341
LIG_UBA3_1	467	475	PF00899	0.332
LIG_WRC_WIRS_1	491	496	PF05994	0.424
MOD_CDC14_SPxK_1	216	219	PF00782	0.522
MOD_CDK_SPxK_1	213	219	PF00069	0.524
MOD_CDK_SPxxK_3	599	606	PF00069	0.644
MOD_CK1_1	120	126	PF00069	0.588
MOD_CK1_1	168	174	PF00069	0.601
MOD_CK1_1	215	221	PF00069	0.594
MOD_CK1_1	232	238	PF00069	0.641
MOD_CK1_1	388	394	PF00069	0.329
MOD_CK1_1	490	496	PF00069	0.374
MOD_CK1_1	610	616	PF00069	0.648
MOD_CK1_1	78	84	PF00069	0.707
MOD_CK2_1	144	150	PF00069	0.685
MOD_CK2_1	261	267	PF00069	0.456
MOD_CK2_1	537	543	PF00069	0.339
MOD_CK2_1	615	621	PF00069	0.672
MOD_GlcNHglycan	114	117	PF01048	0.663
MOD_GlcNHglycan	170	173	PF01048	0.669
MOD_GlcNHglycan	244	247	PF01048	0.489
MOD_GlcNHglycan	314	318	PF01048	0.396
MOD_GlcNHglycan	356	359	PF01048	0.338
MOD_GlcNHglycan	525	528	PF01048	0.362
MOD_GlcNHglycan	54	57	PF01048	0.545
MOD_GlcNHglycan	593	596	PF01048	0.706
MOD_GSK3_1	156	163	PF00069	0.615
MOD_GSK3_1	167	174	PF00069	0.637
MOD_GSK3_1	200	207	PF00069	0.615
MOD_GSK3_1	242	249	PF00069	0.570
MOD_GSK3_1	251	258	PF00069	0.482
MOD_GSK3_1	261	268	PF00069	0.508
MOD_GSK3_1	269	276	PF00069	0.408
MOD_GSK3_1	356	363	PF00069	0.377
MOD_GSK3_1	385	392	PF00069	0.336
MOD_GSK3_1	493	500	PF00069	0.348
MOD_GSK3_1	503	510	PF00069	0.427
MOD_GSK3_1	523	530	PF00069	0.300
MOD_GSK3_1	58	65	PF00069	0.530
MOD_GSK3_1	597	604	PF00069	0.626
MOD_GSK3_1	71	78	PF00069	0.728
MOD_GSK3_1	82	89	PF00069	0.603
MOD_N-GLC_1	112	117	PF02516	0.555
MOD_N-GLC_1	145	150	PF02516	0.529
MOD_N-GLC_1	246	251	PF02516	0.614
MOD_N-GLC_1	33	38	PF02516	0.655
MOD_N-GLC_1	354	359	PF02516	0.330
MOD_N-GLC_1	394	399	PF02516	0.473
MOD_N-GLC_1	82	87	PF02516	0.710
MOD_N-GLC_2	332	334	PF02516	0.423
MOD_N-GLC_2	382	384	PF02516	0.336
MOD_NEK2_1	160	165	PF00069	0.569
MOD_NEK2_1	22	27	PF00069	0.501
MOD_NEK2_1	231	236	PF00069	0.588
MOD_NEK2_1	251	256	PF00069	0.493
MOD_NEK2_1	269	274	PF00069	0.413
MOD_NEK2_1	320	325	PF00069	0.368
MOD_NEK2_1	354	359	PF00069	0.363
MOD_NEK2_1	360	365	PF00069	0.496
MOD_NEK2_1	439	444	PF00069	0.510
MOD_NEK2_1	507	512	PF00069	0.338
MOD_NEK2_1	59	64	PF00069	0.531
MOD_NEK2_2	527	532	PF00069	0.267
MOD_PIKK_1	456	462	PF00454	0.370
MOD_PKA_2	326	332	PF00069	0.397
MOD_PKA_2	337	343	PF00069	0.396
MOD_PKA_2	404	410	PF00069	0.358
MOD_PKA_2	507	513	PF00069	0.374
MOD_PKA_2	520	526	PF00069	0.387
MOD_Plk_1	112	118	PF00069	0.551
MOD_Plk_1	200	206	PF00069	0.574
MOD_Plk_1	232	238	PF00069	0.548
MOD_Plk_1	246	252	PF00069	0.554
MOD_Plk_1	313	319	PF00069	0.311
MOD_Plk_1	33	39	PF00069	0.657
MOD_Plk_1	388	394	PF00069	0.368
MOD_Plk_1	439	445	PF00069	0.350
MOD_Plk_1	456	462	PF00069	0.370
MOD_Plk_4	156	162	PF00069	0.734
MOD_Plk_4	204	210	PF00069	0.674
MOD_Plk_4	346	352	PF00069	0.396
MOD_Plk_4	356	362	PF00069	0.478
MOD_Plk_4	414	420	PF00069	0.377
MOD_Plk_4	487	493	PF00069	0.325
MOD_Plk_4	94	100	PF00069	0.525
MOD_ProDKin_1	100	106	PF00069	0.620
MOD_ProDKin_1	145	151	PF00069	0.634
MOD_ProDKin_1	165	171	PF00069	0.608
MOD_ProDKin_1	213	219	PF00069	0.622
MOD_ProDKin_1	307	313	PF00069	0.538
MOD_ProDKin_1	599	605	PF00069	0.630
MOD_ProDKin_1	612	618	PF00069	0.596
MOD_ProDKin_1	62	68	PF00069	0.591
MOD_ProDKin_1	75	81	PF00069	0.663
MOD_ProDKin_1	82	88	PF00069	0.632
MOD_SUMO_rev_2	114	123	PF00179	0.662
MOD_SUMO_rev_2	392	402	PF00179	0.355
TRG_ENDOCYTIC_2	70	73	PF00928	0.598
TRG_ER_diArg_1	573	576	PF00400	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N0	Leptomonas seymouri	63%	100%
A0A3S7X7J0	Leishmania donovani	82%	100%
A4I9M5	Leishmania infantum	82%	100%
E9B4M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q3F2	Leishmania major	82%	100%