LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Serine/threonine-protein phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase
Gene product:
phosphoprotein phosphatase, putative
Species:
Leishmania braziliensis
UniProt:
A4H7D2_LEIBR
TriTrypDb:
LbrM.13.1270 , LBRM2903_130019200 *
Length:
546

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005634 nucleus 5 4
GO:0043226 organelle 2 4
GO:0043227 membrane-bounded organelle 3 4
GO:0043229 intracellular organelle 3 4
GO:0043231 intracellular membrane-bounded organelle 4 4
GO:0005829 cytosol 2 1

Expansion

Sequence features

A4H7D2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7D2

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 4
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0006807 nitrogen compound metabolic process 2 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 6
GO:0016311 dephosphorylation 5 4
GO:0019538 protein metabolic process 3 4
GO:0036211 protein modification process 4 4
GO:0043170 macromolecule metabolic process 3 5
GO:0043412 macromolecule modification 4 4
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0071704 organic substance metabolic process 2 5
GO:1901564 organonitrogen compound metabolic process 3 4
GO:0007165 signal transduction 2 1
GO:0019722 calcium-mediated signaling 5 1
GO:0019932 second-messenger-mediated signaling 4 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:0097720 calcineurin-mediated signaling 6 1
GO:0000724 double-strand break repair via homologous recombination 7 1
GO:0000725 recombinational repair 6 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006281 DNA repair 5 1
GO:0006302 double-strand break repair 6 1
GO:0006310 DNA recombination 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006950 response to stress 2 1
GO:0006974 DNA damage response 4 1
GO:0033554 cellular response to stress 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 26
GO:0004721 phosphoprotein phosphatase activity 3 24
GO:0004722 protein serine/threonine phosphatase activity 4 24
GO:0016787 hydrolase activity 2 26
GO:0016788 hydrolase activity, acting on ester bonds 3 24
GO:0016791 phosphatase activity 5 24
GO:0017018 myosin phosphatase activity 5 24
GO:0042578 phosphoric ester hydrolase activity 4 24
GO:0140096 catalytic activity, acting on a protein 2 24
GO:0005488 binding 1 5
GO:0043167 ion binding 2 5
GO:0043169 cation binding 3 5
GO:0046872 metal ion binding 4 5
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 5 1
GO:0033192 calmodulin-dependent protein phosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 34 38 PF00656 0.489
CLV_NRD_NRD_1 205 207 PF00675 0.280
CLV_NRD_NRD_1 298 300 PF00675 0.284
CLV_NRD_NRD_1 411 413 PF00675 0.284
CLV_NRD_NRD_1 534 536 PF00675 0.421
CLV_NRD_NRD_1 79 81 PF00675 0.674
CLV_PCSK_FUR_1 296 300 PF00082 0.189
CLV_PCSK_KEX2_1 205 207 PF00082 0.280
CLV_PCSK_KEX2_1 298 300 PF00082 0.232
CLV_PCSK_KEX2_1 411 413 PF00082 0.284
CLV_PCSK_KEX2_1 79 81 PF00082 0.674
CLV_PCSK_SKI1_1 100 104 PF00082 0.585
CLV_PCSK_SKI1_1 298 302 PF00082 0.298
CLV_PCSK_SKI1_1 371 375 PF00082 0.418
CLV_PCSK_SKI1_1 517 521 PF00082 0.272
DEG_Nend_UBRbox_3 1 3 PF02207 0.415
DEG_SCF_FBW7_1 118 124 PF00400 0.475
DEG_SPOP_SBC_1 126 130 PF00917 0.466
DEG_SPOP_SBC_1 136 140 PF00917 0.472
DOC_CKS1_1 118 123 PF01111 0.476
DOC_CYCLIN_yCln2_LP_2 374 380 PF00134 0.265
DOC_MAPK_gen_1 503 511 PF00069 0.428
DOC_MAPK_HePTP_8 246 258 PF00069 0.329
DOC_MAPK_MEF2A_6 249 258 PF00069 0.341
DOC_MAPK_MEF2A_6 309 318 PF00069 0.302
DOC_MAPK_MEF2A_6 371 378 PF00069 0.322
DOC_MAPK_NFAT4_5 371 379 PF00069 0.322
DOC_PP2B_LxvP_1 374 377 PF13499 0.265
DOC_PP4_FxxP_1 493 496 PF00568 0.342
DOC_SPAK_OSR1_1 388 392 PF12202 0.322
DOC_USP7_MATH_1 126 130 PF00917 0.672
DOC_USP7_MATH_1 136 140 PF00917 0.675
DOC_USP7_MATH_1 19 23 PF00917 0.563
DOC_USP7_MATH_1 215 219 PF00917 0.652
DOC_USP7_MATH_1 42 46 PF00917 0.553
DOC_WW_Pin1_4 107 112 PF00397 0.527
DOC_WW_Pin1_4 117 122 PF00397 0.481
DOC_WW_Pin1_4 127 132 PF00397 0.510
DOC_WW_Pin1_4 187 192 PF00397 0.383
DOC_WW_Pin1_4 394 399 PF00397 0.292
DOC_WW_Pin1_4 73 78 PF00397 0.730
LIG_14-3-3_CanoR_1 127 131 PF00244 0.665
LIG_14-3-3_CanoR_1 309 315 PF00244 0.296
LIG_14-3-3_CanoR_1 388 398 PF00244 0.322
LIG_14-3-3_CanoR_1 411 419 PF00244 0.322
LIG_14-3-3_CanoR_1 79 88 PF00244 0.466
LIG_BRCT_BRCA1_1 153 157 PF00533 0.453
LIG_BRCT_BRCA1_1 192 196 PF00533 0.283
LIG_BRCT_BRCA1_1 457 461 PF00533 0.339
LIG_FHA_1 118 124 PF00498 0.777
LIG_FHA_1 242 248 PF00498 0.324
LIG_FHA_1 261 267 PF00498 0.348
LIG_FHA_1 277 283 PF00498 0.265
LIG_FHA_1 341 347 PF00498 0.237
LIG_FHA_1 352 358 PF00498 0.237
LIG_FHA_1 426 432 PF00498 0.301
LIG_FHA_1 434 440 PF00498 0.349
LIG_FHA_1 52 58 PF00498 0.718
LIG_FHA_1 64 70 PF00498 0.529
LIG_FHA_2 41 47 PF00498 0.498
LIG_FHA_2 418 424 PF00498 0.412
LIG_FHA_2 438 444 PF00498 0.238
LIG_Integrin_RGD_1 209 211 PF01839 0.352
LIG_LIR_Apic_2 130 136 PF02991 0.471
LIG_LIR_Apic_2 491 496 PF02991 0.339
LIG_LIR_Gen_1 276 286 PF02991 0.322
LIG_LIR_Gen_1 297 307 PF02991 0.360
LIG_LIR_Gen_1 384 391 PF02991 0.362
LIG_LIR_Gen_1 464 473 PF02991 0.208
LIG_LIR_Gen_1 479 489 PF02991 0.300
LIG_LIR_Gen_1 538 546 PF02991 0.409
LIG_LIR_LC3C_4 262 266 PF02991 0.326
LIG_LIR_Nem_3 154 160 PF02991 0.468
LIG_LIR_Nem_3 183 189 PF02991 0.463
LIG_LIR_Nem_3 193 199 PF02991 0.427
LIG_LIR_Nem_3 276 281 PF02991 0.267
LIG_LIR_Nem_3 326 330 PF02991 0.276
LIG_LIR_Nem_3 344 350 PF02991 0.217
LIG_LIR_Nem_3 384 389 PF02991 0.337
LIG_LIR_Nem_3 464 470 PF02991 0.208
LIG_LYPXL_yS_3 327 330 PF13949 0.265
LIG_PCNA_yPIPBox_3 472 482 PF02747 0.324
LIG_Pex14_1 516 520 PF04695 0.249
LIG_Pex14_1 97 101 PF04695 0.459
LIG_Pex14_2 541 545 PF04695 0.475
LIG_REV1ctd_RIR_1 184 190 PF16727 0.285
LIG_SH2_CRK 133 137 PF00017 0.482
LIG_SH2_CRK 278 282 PF00017 0.426
LIG_SH2_CRK 347 351 PF00017 0.249
LIG_SH2_CRK 498 502 PF00017 0.344
LIG_SH2_NCK_1 523 527 PF00017 0.366
LIG_SH2_STAP1 278 282 PF00017 0.322
LIG_SH2_STAP1 459 463 PF00017 0.405
LIG_SH2_STAT5 235 238 PF00017 0.428
LIG_SH2_STAT5 278 281 PF00017 0.327
LIG_SH2_STAT5 306 309 PF00017 0.327
LIG_SH2_STAT5 332 335 PF00017 0.322
LIG_SH2_STAT5 459 462 PF00017 0.310
LIG_SH2_STAT5 498 501 PF00017 0.437
LIG_SH3_1 90 96 PF00018 0.426
LIG_SH3_2 74 79 PF14604 0.498
LIG_SH3_2 93 98 PF14604 0.425
LIG_SH3_3 209 215 PF00018 0.380
LIG_SH3_3 27 33 PF00018 0.574
LIG_SH3_3 322 328 PF00018 0.289
LIG_SH3_3 71 77 PF00018 0.564
LIG_SH3_3 90 96 PF00018 0.520
LIG_SUMO_SIM_anti_2 255 260 PF11976 0.369
LIG_SUMO_SIM_anti_2 262 269 PF11976 0.251
LIG_SUMO_SIM_par_1 252 257 PF11976 0.390
LIG_SUMO_SIM_par_1 262 269 PF11976 0.306
LIG_SUMO_SIM_par_1 488 494 PF11976 0.342
LIG_TRAF2_1 217 220 PF00917 0.737
LIG_TYR_ITIM 325 330 PF00017 0.265
LIG_UBA3_1 318 324 PF00899 0.305
LIG_WW_3 76 80 PF00397 0.498
MOD_CDC14_SPxK_1 76 79 PF00782 0.496
MOD_CDK_SPK_2 187 192 PF00069 0.286
MOD_CDK_SPxK_1 73 79 PF00069 0.497
MOD_CDK_SPxxK_3 73 80 PF00069 0.498
MOD_CK1_1 105 111 PF00069 0.504
MOD_CK1_1 135 141 PF00069 0.713
MOD_CK1_1 149 155 PF00069 0.776
MOD_CK1_1 165 171 PF00069 0.439
MOD_CK1_1 22 28 PF00069 0.463
MOD_CK1_1 35 41 PF00069 0.605
MOD_CK1_1 433 439 PF00069 0.322
MOD_CK1_1 51 57 PF00069 0.577
MOD_CK1_1 9 15 PF00069 0.435
MOD_CK2_1 135 141 PF00069 0.575
MOD_CK2_1 40 46 PF00069 0.660
MOD_CK2_1 417 423 PF00069 0.393
MOD_CK2_1 61 67 PF00069 0.489
MOD_DYRK1A_RPxSP_1 127 131 PF00069 0.464
MOD_GlcNHglycan 104 107 PF01048 0.598
MOD_GlcNHglycan 192 195 PF01048 0.495
MOD_GlcNHglycan 366 369 PF01048 0.328
MOD_GlcNHglycan 37 40 PF01048 0.498
MOD_GlcNHglycan 455 458 PF01048 0.436
MOD_GlcNHglycan 493 496 PF01048 0.382
MOD_GlcNHglycan 51 54 PF01048 0.486
MOD_GlcNHglycan 63 66 PF01048 0.553
MOD_GSK3_1 101 108 PF00069 0.492
MOD_GSK3_1 113 120 PF00069 0.619
MOD_GSK3_1 121 128 PF00069 0.579
MOD_GSK3_1 132 139 PF00069 0.703
MOD_GSK3_1 145 152 PF00069 0.785
MOD_GSK3_1 161 168 PF00069 0.594
MOD_GSK3_1 22 29 PF00069 0.473
MOD_GSK3_1 31 38 PF00069 0.594
MOD_GSK3_1 348 355 PF00069 0.331
MOD_GSK3_1 433 440 PF00069 0.194
MOD_GSK3_1 453 460 PF00069 0.307
MOD_GSK3_1 59 66 PF00069 0.667
MOD_N-GLC_1 412 417 PF02516 0.208
MOD_N-GLC_1 9 14 PF02516 0.432
MOD_N-GLC_2 497 499 PF02516 0.408
MOD_NEK2_1 101 106 PF00069 0.596
MOD_NEK2_1 14 19 PF00069 0.459
MOD_NEK2_1 277 282 PF00069 0.248
MOD_NEK2_1 389 394 PF00069 0.238
MOD_NEK2_1 452 457 PF00069 0.170
MOD_PIKK_1 105 111 PF00454 0.522
MOD_PIKK_1 169 175 PF00454 0.438
MOD_PIKK_1 215 221 PF00454 0.470
MOD_PIKK_1 22 28 PF00454 0.472
MOD_PIKK_1 223 229 PF00454 0.559
MOD_PKA_1 79 85 PF00069 0.478
MOD_PKA_2 126 132 PF00069 0.611
MOD_PKA_2 341 347 PF00069 0.211
MOD_PKA_2 59 65 PF00069 0.667
MOD_PKA_2 79 85 PF00069 0.478
MOD_Plk_1 162 168 PF00069 0.601
MOD_Plk_1 404 410 PF00069 0.363
MOD_Plk_1 437 443 PF00069 0.198
MOD_Plk_1 9 15 PF00069 0.435
MOD_Plk_4 260 266 PF00069 0.354
MOD_Plk_4 277 283 PF00069 0.233
MOD_Plk_4 326 332 PF00069 0.403
MOD_Plk_4 381 387 PF00069 0.481
MOD_Plk_4 437 443 PF00069 0.337
MOD_Plk_4 488 494 PF00069 0.314
MOD_Plk_4 9 15 PF00069 0.711
MOD_ProDKin_1 107 113 PF00069 0.526
MOD_ProDKin_1 117 123 PF00069 0.480
MOD_ProDKin_1 127 133 PF00069 0.512
MOD_ProDKin_1 187 193 PF00069 0.382
MOD_ProDKin_1 394 400 PF00069 0.292
MOD_ProDKin_1 73 79 PF00069 0.732
MOD_SUMO_for_1 323 326 PF00179 0.220
MOD_SUMO_rev_2 174 183 PF00179 0.425
MOD_SUMO_rev_2 458 467 PF00179 0.170
MOD_SUMO_rev_2 524 533 PF00179 0.423
TRG_DiLeu_BaEn_1 260 265 PF01217 0.269
TRG_DiLeu_BaEn_1 326 331 PF01217 0.309
TRG_DiLeu_BaLyEn_6 53 58 PF01217 0.487
TRG_DiLeu_LyEn_5 195 200 PF01217 0.255
TRG_ENDOCYTIC_2 278 281 PF00928 0.444
TRG_ENDOCYTIC_2 327 330 PF00928 0.314
TRG_ENDOCYTIC_2 347 350 PF00928 0.256
TRG_ENDOCYTIC_2 386 389 PF00928 0.199
TRG_ENDOCYTIC_2 481 484 PF00928 0.297
TRG_ENDOCYTIC_2 498 501 PF00928 0.342
TRG_ER_diArg_1 204 206 PF00400 0.282
TRG_ER_diArg_1 298 300 PF00400 0.343
TRG_ER_diArg_1 78 80 PF00400 0.683

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDS9 Leptomonas seymouri 59% 76%
A0A1X0NJI7 Trypanosomatidae 46% 98%
A0A1X0P9R6 Trypanosomatidae 39% 100%
A0A3Q8I8M6 Leishmania donovani 74% 100%
A0A3S5H6T9 Leishmania donovani 33% 100%
A0A3S5H7Q6 Leishmania donovani 34% 100%
A0A3S7WUR2 Leishmania donovani 34% 100%
A0A3S7XAY3 Leishmania donovani 31% 100%
A0A422N1U7 Trypanosoma rangeli 32% 91%
A4H7Z3 Leishmania braziliensis 33% 100%
A4HJQ1 Leishmania braziliensis 35% 100%
A4HP65 Leishmania braziliensis 32% 100%
A4HVT0 Leishmania infantum 74% 100%
A4HWC1 Leishmania infantum 33% 100%
A4HXP1 Leishmania infantum 34% 100%
A4I768 Leishmania infantum 34% 100%
A4IDH0 Leishmania infantum 31% 100%
C9ZM48 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
D0A019 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
D0A366 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 86%
E9APH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
E9AQ21 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9ARF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9ASX3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B262 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
O14829 Homo sapiens 24% 84%
O42773 Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) 31% 85%
Q4Q1M5 Leishmania major 31% 100%
Q4Q5Z8 Leishmania major 34% 100%
Q4QE27 Leishmania major 34% 100%
Q4QFG0 Leishmania major 32% 100%
Q4QG03 Leishmania major 73% 100%
V5BBS3 Trypanosoma cruzi 30% 91%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS