DNA repair metallo-beta-lactamase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7D0_LEIBR

TriTrypDb:

LbrM.13.1250 , LBRM2903_130019000

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7D0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7D0

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006303	double-strand break repair via nonhomologous end joining	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0031848	protection from non-homologous end joining at telomere	6	1
GO:0032200	telomere organization	6	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0036297	interstrand cross-link repair	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043247	telomere maintenance in response to DNA damage	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051276	chromosome organization	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003684	damaged DNA binding	5	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0005488	binding	1	1
GO:0008409	5'-3' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0035312	5'-3' DNA exonuclease activity	7	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.601
CLV_C14_Caspase3-7	415	419	PF00656	0.509
CLV_C14_Caspase3-7	618	622	PF00656	0.657
CLV_C14_Caspase3-7	741	745	PF00656	0.645
CLV_C14_Caspase3-7	776	780	PF00656	0.543
CLV_NRD_NRD_1	260	262	PF00675	0.450
CLV_NRD_NRD_1	52	54	PF00675	0.591
CLV_NRD_NRD_1	628	630	PF00675	0.611
CLV_NRD_NRD_1	724	726	PF00675	0.514
CLV_PCSK_FUR_1	722	726	PF00082	0.448
CLV_PCSK_KEX2_1	260	262	PF00082	0.450
CLV_PCSK_KEX2_1	51	53	PF00082	0.588
CLV_PCSK_KEX2_1	628	630	PF00082	0.611
CLV_PCSK_KEX2_1	724	726	PF00082	0.622
CLV_PCSK_KEX2_1	739	741	PF00082	0.640
CLV_PCSK_PC1ET2_1	739	741	PF00082	0.655
CLV_PCSK_SKI1_1	190	194	PF00082	0.381
CLV_PCSK_SKI1_1	319	323	PF00082	0.363
CLV_PCSK_SKI1_1	343	347	PF00082	0.359
CLV_PCSK_SKI1_1	724	728	PF00082	0.488
CLV_PCSK_SKI1_1	98	102	PF00082	0.334
DEG_Nend_UBRbox_3	1	3	PF02207	0.497
DEG_SPOP_SBC_1	130	134	PF00917	0.487
DEG_SPOP_SBC_1	558	562	PF00917	0.522
DEG_SPOP_SBC_1	666	670	PF00917	0.534
DOC_ANK_TNKS_1	739	746	PF00023	0.570
DOC_CKS1_1	163	168	PF01111	0.442
DOC_CYCLIN_RxL_1	793	802	PF00134	0.504
DOC_CYCLIN_RxL_1	95	106	PF00134	0.351
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.317
DOC_CYCLIN_yCln2_LP_2	515	521	PF00134	0.370
DOC_MAPK_DCC_7	438	447	PF00069	0.506
DOC_MAPK_gen_1	109	117	PF00069	0.355
DOC_MAPK_gen_1	7	16	PF00069	0.481
DOC_MAPK_HePTP_8	534	546	PF00069	0.483
DOC_MAPK_MEF2A_6	109	117	PF00069	0.420
DOC_MAPK_MEF2A_6	304	313	PF00069	0.372
DOC_MAPK_MEF2A_6	33	41	PF00069	0.480
DOC_MAPK_MEF2A_6	438	447	PF00069	0.512
DOC_MAPK_MEF2A_6	537	546	PF00069	0.485
DOC_MAPK_MEF2A_6	7	16	PF00069	0.481
DOC_PP2B_LxvP_1	113	116	PF13499	0.401
DOC_PP2B_LxvP_1	14	17	PF13499	0.479
DOC_PP2B_LxvP_1	542	545	PF13499	0.511
DOC_PP2B_LxvP_1	712	715	PF13499	0.511
DOC_PP2B_PxIxI_1	442	448	PF00149	0.395
DOC_PP4_FxxP_1	153	156	PF00568	0.320
DOC_PP4_FxxP_1	163	166	PF00568	0.359
DOC_PP4_FxxP_1	604	607	PF00568	0.479
DOC_PP4_FxxP_1	672	675	PF00568	0.632
DOC_PP4_MxPP_1	733	736	PF00568	0.534
DOC_USP7_MATH_1	18	22	PF00917	0.478
DOC_USP7_MATH_1	226	230	PF00917	0.507
DOC_USP7_MATH_1	412	416	PF00917	0.519
DOC_USP7_MATH_1	432	436	PF00917	0.565
DOC_USP7_MATH_1	639	643	PF00917	0.632
DOC_USP7_MATH_1	699	703	PF00917	0.711
DOC_USP7_MATH_1	785	789	PF00917	0.531
DOC_WW_Pin1_4	118	123	PF00397	0.322
DOC_WW_Pin1_4	162	167	PF00397	0.428
DOC_WW_Pin1_4	184	189	PF00397	0.351
DOC_WW_Pin1_4	222	227	PF00397	0.641
DOC_WW_Pin1_4	362	367	PF00397	0.558
DOC_WW_Pin1_4	466	471	PF00397	0.506
DOC_WW_Pin1_4	502	507	PF00397	0.380
DOC_WW_Pin1_4	519	524	PF00397	0.381
DOC_WW_Pin1_4	637	642	PF00397	0.528
LIG_14-3-3_CanoR_1	22	30	PF00244	0.483
LIG_14-3-3_CanoR_1	343	348	PF00244	0.358
LIG_14-3-3_CanoR_1	51	59	PF00244	0.515
LIG_14-3-3_CanoR_1	517	526	PF00244	0.390
LIG_14-3-3_CanoR_1	7	13	PF00244	0.481
LIG_14-3-3_CanoR_1	724	733	PF00244	0.548
LIG_14-3-3_CanoR_1	759	765	PF00244	0.676
LIG_14-3-3_CanoR_1	796	801	PF00244	0.519
LIG_BRCT_BRCA1_1	157	161	PF00533	0.239
LIG_BRCT_BRCA1_1	600	604	PF00533	0.460
LIG_BRCT_BRCA1_1	669	673	PF00533	0.561
LIG_FHA_1	119	125	PF00498	0.361
LIG_FHA_1	137	143	PF00498	0.480
LIG_FHA_1	178	184	PF00498	0.301
LIG_FHA_1	330	336	PF00498	0.374
LIG_FHA_1	580	586	PF00498	0.401
LIG_FHA_1	598	604	PF00498	0.550
LIG_FHA_1	792	798	PF00498	0.662
LIG_FHA_1	85	91	PF00498	0.429
LIG_FHA_1	95	101	PF00498	0.297
LIG_FHA_2	344	350	PF00498	0.366
LIG_FHA_2	503	509	PF00498	0.371
LIG_FHA_2	550	556	PF00498	0.517
LIG_FHA_2	774	780	PF00498	0.560
LIG_GBD_Chelix_1	322	330	PF00786	0.306
LIG_HCF-1_HBM_1	199	202	PF13415	0.341
LIG_Integrin_RGD_1	530	532	PF01839	0.357
LIG_KLC1_Yacidic_2	199	204	PF13176	0.337
LIG_LIR_Apic_2	437	443	PF02991	0.429
LIG_LIR_Apic_2	601	607	PF02991	0.469
LIG_LIR_Apic_2	669	675	PF02991	0.549
LIG_LIR_Gen_1	143	153	PF02991	0.253
LIG_LIR_Gen_1	204	215	PF02991	0.404
LIG_LIR_Gen_1	338	348	PF02991	0.364
LIG_LIR_Gen_1	727	736	PF02991	0.509
LIG_LIR_Nem_3	103	108	PF02991	0.297
LIG_LIR_Nem_3	143	149	PF02991	0.264
LIG_LIR_Nem_3	204	210	PF02991	0.351
LIG_LIR_Nem_3	338	344	PF02991	0.365
LIG_LIR_Nem_3	42	47	PF02991	0.430
LIG_LIR_Nem_3	469	475	PF02991	0.388
LIG_LIR_Nem_3	477	482	PF02991	0.490
LIG_MLH1_MIPbox_1	669	673	PF16413	0.561
LIG_MYND_1	715	719	PF01753	0.454
LIG_NRBOX	241	247	PF00104	0.451
LIG_PDZ_Class_2	804	809	PF00595	0.632
LIG_Pex14_2	70	74	PF04695	0.396
LIG_SH2_CRK	341	345	PF00017	0.364
LIG_SH2_CRK	472	476	PF00017	0.359
LIG_SH2_GRB2like	730	733	PF00017	0.507
LIG_SH2_PTP2	146	149	PF00017	0.305
LIG_SH2_SRC	440	443	PF00017	0.383
LIG_SH2_STAP1	179	183	PF00017	0.452
LIG_SH2_STAP1	24	28	PF00017	0.482
LIG_SH2_STAP1	341	345	PF00017	0.364
LIG_SH2_STAT5	146	149	PF00017	0.311
LIG_SH2_STAT5	171	174	PF00017	0.346
LIG_SH2_STAT5	179	182	PF00017	0.436
LIG_SH2_STAT5	202	205	PF00017	0.335
LIG_SH2_STAT5	312	315	PF00017	0.391
LIG_SH2_STAT5	541	544	PF00017	0.420
LIG_SH2_STAT5	579	582	PF00017	0.497
LIG_SH2_STAT5	671	674	PF00017	0.631
LIG_SH2_STAT5	730	733	PF00017	0.576
LIG_SH3_1	575	581	PF00018	0.467
LIG_SH3_3	32	38	PF00018	0.445
LIG_SH3_3	575	581	PF00018	0.554
LIG_SUMO_SIM_anti_2	139	146	PF11976	0.357
LIG_SUMO_SIM_par_1	343	350	PF11976	0.430
LIG_SUMO_SIM_par_1	36	43	PF11976	0.453
LIG_SUMO_SIM_par_1	374	380	PF11976	0.370
LIG_SUMO_SIM_par_1	443	450	PF11976	0.368
LIG_SUMO_SIM_par_1	794	802	PF11976	0.580
LIG_TRAF2_1	350	353	PF00917	0.395
LIG_TRAF2_1	377	380	PF00917	0.414
LIG_TRAF2_1	505	508	PF00917	0.384
LIG_TRAF2_1	622	625	PF00917	0.646
LIG_TYR_ITIM	144	149	PF00017	0.346
LIG_TYR_ITIM	339	344	PF00017	0.296
LIG_TYR_ITSM	467	474	PF00017	0.450
LIG_WRC_WIRS_1	189	194	PF05994	0.373
LIG_WRC_WIRS_1	400	405	PF05994	0.377
MOD_CDC14_SPxK_1	187	190	PF00782	0.333
MOD_CDC14_SPxK_1	365	368	PF00782	0.556
MOD_CDK_SPxK_1	184	190	PF00069	0.354
MOD_CDK_SPxK_1	362	368	PF00069	0.537
MOD_CDK_SPxxK_3	637	644	PF00069	0.528
MOD_CK1_1	134	140	PF00069	0.494
MOD_CK1_1	167	173	PF00069	0.362
MOD_CK1_1	291	297	PF00069	0.605
MOD_CK1_1	450	456	PF00069	0.481
MOD_CK1_1	489	495	PF00069	0.427
MOD_CK1_1	54	60	PF00069	0.517
MOD_CK1_1	591	597	PF00069	0.513
MOD_CK1_1	640	646	PF00069	0.528
MOD_CK1_1	702	708	PF00069	0.752
MOD_CK1_1	751	757	PF00069	0.553
MOD_CK1_1	788	794	PF00069	0.626
MOD_CK1_1	8	14	PF00069	0.481
MOD_CK1_1	84	90	PF00069	0.390
MOD_CK2_1	100	106	PF00069	0.279
MOD_CK2_1	343	349	PF00069	0.366
MOD_CK2_1	374	380	PF00069	0.447
MOD_CK2_1	383	389	PF00069	0.385
MOD_CK2_1	502	508	PF00069	0.378
MOD_CK2_1	619	625	PF00069	0.530
MOD_Cter_Amidation	258	261	PF01082	0.445
MOD_Cter_Amidation	737	740	PF01082	0.699
MOD_GlcNHglycan	124	127	PF01048	0.488
MOD_GlcNHglycan	135	139	PF01048	0.559
MOD_GlcNHglycan	157	160	PF01048	0.316
MOD_GlcNHglycan	166	169	PF01048	0.400
MOD_GlcNHglycan	236	239	PF01048	0.534
MOD_GlcNHglycan	24	27	PF01048	0.458
MOD_GlcNHglycan	294	297	PF01048	0.656
MOD_GlcNHglycan	385	388	PF01048	0.366
MOD_GlcNHglycan	430	433	PF01048	0.600
MOD_GlcNHglycan	462	465	PF01048	0.536
MOD_GlcNHglycan	476	479	PF01048	0.396
MOD_GlcNHglycan	488	491	PF01048	0.613
MOD_GlcNHglycan	519	522	PF01048	0.303
MOD_GlcNHglycan	563	566	PF01048	0.511
MOD_GlcNHglycan	60	63	PF01048	0.569
MOD_GlcNHglycan	600	603	PF01048	0.567
MOD_GlcNHglycan	683	686	PF01048	0.547
MOD_GlcNHglycan	7	10	PF01048	0.482
MOD_GlcNHglycan	705	708	PF01048	0.573
MOD_GlcNHglycan	768	771	PF01048	0.724
MOD_GlcNHglycan	791	794	PF01048	0.640
MOD_GSK3_1	118	125	PF00069	0.356
MOD_GSK3_1	126	133	PF00069	0.528
MOD_GSK3_1	136	143	PF00069	0.429
MOD_GSK3_1	167	174	PF00069	0.359
MOD_GSK3_1	18	25	PF00069	0.481
MOD_GSK3_1	184	191	PF00069	0.381
MOD_GSK3_1	222	229	PF00069	0.514
MOD_GSK3_1	287	294	PF00069	0.619
MOD_GSK3_1	325	332	PF00069	0.322
MOD_GSK3_1	343	350	PF00069	0.314
MOD_GSK3_1	428	435	PF00069	0.624
MOD_GSK3_1	446	453	PF00069	0.331
MOD_GSK3_1	497	504	PF00069	0.396
MOD_GSK3_1	54	61	PF00069	0.688
MOD_GSK3_1	549	556	PF00069	0.585
MOD_GSK3_1	557	564	PF00069	0.606
MOD_GSK3_1	662	669	PF00069	0.553
MOD_GSK3_1	673	680	PF00069	0.556
MOD_GSK3_1	69	76	PF00069	0.272
MOD_GSK3_1	698	705	PF00069	0.808
MOD_GSK3_1	713	720	PF00069	0.472
MOD_GSK3_1	744	751	PF00069	0.570
MOD_GSK3_1	760	767	PF00069	0.591
MOD_GSK3_1	773	780	PF00069	0.571
MOD_GSK3_1	785	792	PF00069	0.624
MOD_GSK3_1	80	87	PF00069	0.398
MOD_GSK3_1	90	97	PF00069	0.301
MOD_LATS_1	78	84	PF00433	0.443
MOD_N-GLC_1	281	286	PF02516	0.643
MOD_N-GLC_1	432	437	PF02516	0.527
MOD_N-GLC_1	84	89	PF02516	0.345
MOD_N-GLC_2	690	692	PF02516	0.533
MOD_NEK2_1	100	105	PF00069	0.295
MOD_NEK2_1	192	197	PF00069	0.378
MOD_NEK2_1	203	208	PF00069	0.341
MOD_NEK2_1	288	293	PF00069	0.522
MOD_NEK2_1	369	374	PF00069	0.461
MOD_NEK2_1	428	433	PF00069	0.619
MOD_NEK2_1	5	10	PF00069	0.479
MOD_NEK2_1	598	603	PF00069	0.491
MOD_NEK2_1	69	74	PF00069	0.332
MOD_NEK2_1	726	731	PF00069	0.524
MOD_NEK2_1	789	794	PF00069	0.768
MOD_NEK2_2	188	193	PF00069	0.373
MOD_PIKK_1	401	407	PF00454	0.383
MOD_PIKK_1	481	487	PF00454	0.572
MOD_PIKK_1	591	597	PF00454	0.591
MOD_PIKK_1	724	730	PF00454	0.614
MOD_PKA_1	51	57	PF00069	0.513
MOD_PKA_1	724	730	PF00069	0.472
MOD_PKA_2	288	294	PF00069	0.517
MOD_PKA_2	383	389	PF00069	0.385
MOD_PKA_2	450	456	PF00069	0.541
MOD_PKA_2	51	57	PF00069	0.536
MOD_PKA_2	526	532	PF00069	0.457
MOD_PKA_2	591	597	PF00069	0.503
MOD_PKA_2	724	730	PF00069	0.529
MOD_PKA_2	758	764	PF00069	0.554
MOD_PKB_1	51	59	PF00069	0.513
MOD_PKB_1	722	730	PF00069	0.465
MOD_Plk_1	203	209	PF00069	0.345
MOD_Plk_1	213	219	PF00069	0.530
MOD_Plk_1	432	438	PF00069	0.625
MOD_Plk_4	140	146	PF00069	0.405
MOD_Plk_4	167	173	PF00069	0.362
MOD_Plk_4	203	209	PF00069	0.345
MOD_Plk_4	343	349	PF00069	0.431
MOD_Plk_4	662	668	PF00069	0.541
MOD_Plk_4	713	719	PF00069	0.614
MOD_Plk_4	726	732	PF00069	0.507
MOD_Plk_4	803	809	PF00069	0.486
MOD_ProDKin_1	118	124	PF00069	0.321
MOD_ProDKin_1	162	168	PF00069	0.433
MOD_ProDKin_1	184	190	PF00069	0.354
MOD_ProDKin_1	222	228	PF00069	0.641
MOD_ProDKin_1	362	368	PF00069	0.563
MOD_ProDKin_1	466	472	PF00069	0.501
MOD_ProDKin_1	502	508	PF00069	0.378
MOD_ProDKin_1	519	525	PF00069	0.389
MOD_ProDKin_1	637	643	PF00069	0.527
MOD_SUMO_for_1	765	768	PF00179	0.628
MOD_SUMO_rev_2	618	627	PF00179	0.646
TRG_DiLeu_BaEn_2	507	513	PF01217	0.435
TRG_DiLeu_BaEn_4	353	359	PF01217	0.420
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.360
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.436
TRG_DiLeu_BaLyEn_6	793	798	PF01217	0.520
TRG_ENDOCYTIC_2	146	149	PF00928	0.305
TRG_ENDOCYTIC_2	341	344	PF00928	0.359
TRG_ENDOCYTIC_2	471	474	PF00928	0.360
TRG_ENDOCYTIC_2	541	544	PF00928	0.485
TRG_ENDOCYTIC_2	730	733	PF00928	0.507
TRG_ER_diArg_1	108	111	PF00400	0.381
TRG_ER_diArg_1	260	262	PF00400	0.450
TRG_ER_diArg_1	330	333	PF00400	0.401
TRG_ER_diArg_1	51	53	PF00400	0.509
TRG_ER_diArg_1	627	629	PF00400	0.656
TRG_ER_diArg_1	721	724	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	724	728	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAX7	Leptomonas seymouri	50%	100%
A0A3S5H6Q1	Leishmania donovani	74%	100%
A4HVS7	Leishmania infantum	74%	100%
E9APH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QG05	Leishmania major	73%	99%