Programmed cell death 6 protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

programmed cell death 6 protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4H7C7_LEIBR

TriTrypDb:

LbrM.13.1220 , LBRM2903_130018700

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7C7

PDB structure(s): 1y1x_A , 1y1x_B

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0005509	calcium ion binding	5	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.392
CLV_NRD_NRD_1	178	180	PF00675	0.388
CLV_NRD_NRD_1	185	187	PF00675	0.355
CLV_PCSK_FUR_1	183	187	PF00082	0.354
CLV_PCSK_KEX2_1	185	187	PF00082	0.346
CLV_PCSK_SKI1_1	159	163	PF00082	0.373
CLV_PCSK_SKI1_1	205	209	PF00082	0.479
DEG_COP1_1	84	92	PF00400	0.239
DEG_SPOP_SBC_1	50	54	PF00917	0.750
DOC_CKS1_1	33	38	PF01111	0.689
DOC_MAPK_gen_1	183	191	PF00069	0.355
DOC_MAPK_gen_1	213	221	PF00069	0.560
DOC_USP7_MATH_1	95	99	PF00917	0.459
DOC_WW_Pin1_4	32	37	PF00397	0.667
LIG_14-3-3_CanoR_1	159	169	PF00244	0.270
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_BRCT_BRCA1_1	187	191	PF00533	0.380
LIG_FHA_1	106	112	PF00498	0.368
LIG_FHA_1	214	220	PF00498	0.559
LIG_FHA_1	32	38	PF00498	0.793
LIG_FHA_1	84	90	PF00498	0.368
LIG_LIR_Gen_1	122	131	PF02991	0.389
LIG_LIR_Gen_1	171	181	PF02991	0.368
LIG_LIR_Gen_1	192	201	PF02991	0.368
LIG_LIR_Gen_1	220	231	PF02991	0.484
LIG_LIR_Nem_3	122	128	PF02991	0.389
LIG_LIR_Nem_3	171	177	PF02991	0.404
LIG_LIR_Nem_3	188	194	PF02991	0.281
LIG_LIR_Nem_3	220	226	PF02991	0.426
LIG_LIR_Nem_3	56	62	PF02991	0.676
LIG_LIR_Nem_3	74	79	PF02991	0.474
LIG_PCNA_yPIPBox_3	69	77	PF02747	0.461
LIG_PDZ_Class_1	229	234	PF00595	0.454
LIG_PTB_Apo_2	5	12	PF02174	0.601
LIG_PTB_Phospho_1	5	11	PF10480	0.598
LIG_Rb_pABgroove_1	109	117	PF01858	0.353
LIG_SH2_CRK	11	15	PF00017	0.763
LIG_SH2_CRK	28	32	PF00017	0.612
LIG_SH2_CRK	59	63	PF00017	0.654
LIG_SH2_NCK_1	11	15	PF00017	0.712
LIG_SH2_NCK_1	28	32	PF00017	0.524
LIG_SH2_NCK_1	59	63	PF00017	0.650
LIG_SH2_PTP2	194	197	PF00017	0.384
LIG_SH2_SRC	59	62	PF00017	0.759
LIG_SH2_STAT3	39	42	PF00017	0.761
LIG_SH2_STAT5	194	197	PF00017	0.382
LIG_SH2_STAT5	3	6	PF00017	0.498
LIG_SH3_3	30	36	PF00018	0.733
LIG_SH3_3	45	51	PF00018	0.696
LIG_SH3_3	55	61	PF00018	0.662
LIG_SUMO_SIM_par_1	84	91	PF11976	0.239
LIG_UBA3_1	111	117	PF00899	0.472
LIG_UBA3_1	135	139	PF00899	0.497
LIG_WRC_WIRS_1	223	228	PF05994	0.539
MOD_CK1_1	104	110	PF00069	0.380
MOD_CK1_1	170	176	PF00069	0.431
MOD_CK1_1	52	58	PF00069	0.739
MOD_CK2_1	121	127	PF00069	0.452
MOD_CK2_1	85	91	PF00069	0.421
MOD_GlcNHglycan	118	122	PF01048	0.484
MOD_GlcNHglycan	146	150	PF01048	0.379
MOD_GlcNHglycan	164	167	PF01048	0.258
MOD_GlcNHglycan	82	86	PF01048	0.386
MOD_GlcNHglycan	97	100	PF01048	0.337
MOD_GSK3_1	101	108	PF00069	0.366
MOD_GSK3_1	117	124	PF00069	0.368
MOD_GSK3_1	195	202	PF00069	0.423
MOD_GSK3_1	213	220	PF00069	0.536
MOD_GSK3_1	49	56	PF00069	0.532
MOD_GSK3_1	81	88	PF00069	0.499
MOD_GSK3_1	90	97	PF00069	0.371
MOD_NEK2_1	162	167	PF00069	0.402
MOD_PIKK_1	16	22	PF00454	0.786
MOD_PIKK_1	26	32	PF00454	0.489
MOD_PKA_1	185	191	PF00069	0.355
MOD_PKA_2	144	150	PF00069	0.365
MOD_PKA_2	167	173	PF00069	0.470
MOD_PKA_2	185	191	PF00069	0.370
MOD_PKB_1	143	151	PF00069	0.382
MOD_PKB_1	183	191	PF00069	0.429
MOD_Plk_1	195	201	PF00069	0.395
MOD_Plk_4	195	201	PF00069	0.424
MOD_Plk_4	222	228	PF00069	0.509
MOD_ProDKin_1	32	38	PF00069	0.668
TRG_DiLeu_BaEn_2	129	135	PF01217	0.319
TRG_DiLeu_BaEn_2	195	201	PF01217	0.409
TRG_ENDOCYTIC_2	194	197	PF00928	0.368
TRG_ENDOCYTIC_2	59	62	PF00928	0.667
TRG_ER_diArg_1	142	145	PF00400	0.379
TRG_ER_diArg_1	183	186	PF00400	0.359
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.239

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P882	Leptomonas seymouri	75%	100%
A0A0N0P8K6	Leptomonas seymouri	45%	100%
A0A0S4JBG2	Bodo saltans	61%	82%
A0A1X0NJH7	Trypanosomatidae	50%	96%
A0A3Q8I9P0	Leishmania donovani	80%	100%
A0A3Q8IW81	Leishmania donovani	29%	100%
A0A422P491	Trypanosoma rangeli	42%	96%
A4HPN5	Leishmania braziliensis	29%	100%
A4HVS3	Leishmania infantum	80%	100%
A4ID29	Leishmania infantum	29%	100%
E9APG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9APH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
G3V7W1	Rattus norvegicus	33%	100%
O75340	Homo sapiens	34%	100%
P06815	Oryctolagus cuniculus	24%	77%
P09485	Lytechinus pictus	20%	73%
P12815	Mus musculus	34%	100%
P25070	Arabidopsis thaliana	24%	100%
P25071	Arabidopsis thaliana	27%	72%
P53238	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	70%
P53441	Naegleria gruberi	25%	100%
P81660	Anguilla anguilla	30%	100%
Q12798	Homo sapiens	26%	100%
Q24956	Giardia intestinalis	27%	100%
Q2QY10	Oryza sativa subsp. japonica	30%	80%
Q40642	Oryza sativa subsp. indica	25%	100%
Q4Q148	Leishmania major	29%	100%
Q4QG08	Leishmania major	77%	100%
Q4QG09	Leishmania major	53%	100%
Q5PQ53	Xenopus laevis	30%	83%
Q641Z8	Rattus norvegicus	31%	83%
Q6DC93	Danio rerio	30%	87%
Q8BFY6	Mus musculus	31%	85%
Q8VC88	Mus musculus	30%	100%
Q8W4L0	Arabidopsis thaliana	28%	70%
Q94743	Schistosoma japonicum	35%	100%
Q95YL5	Dictyostelium discoideum	34%	100%
Q9FYE4	Arabidopsis thaliana	28%	66%
Q9UBV8	Homo sapiens	31%	82%
Q9ZQH1	Arabidopsis thaliana	25%	100%
V5BM44	Trypanosoma cruzi	51%	100%