Leucine_Rich_repeat_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4H7C5_LEIBR

TriTrypDb:

LbrM.13.1200 , LBRM2903_130018500

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

A4H7C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7C5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.612
CLV_C14_Caspase3-7	313	317	PF00656	0.515
CLV_NRD_NRD_1	336	338	PF00675	0.505
CLV_NRD_NRD_1	407	409	PF00675	0.522
CLV_NRD_NRD_1	520	522	PF00675	0.490
CLV_NRD_NRD_1	558	560	PF00675	0.654
CLV_PCSK_FUR_1	518	522	PF00082	0.576
CLV_PCSK_KEX2_1	336	338	PF00082	0.512
CLV_PCSK_KEX2_1	407	409	PF00082	0.522
CLV_PCSK_KEX2_1	518	520	PF00082	0.478
CLV_PCSK_SKI1_1	119	123	PF00082	0.723
CLV_PCSK_SKI1_1	162	166	PF00082	0.465
CLV_PCSK_SKI1_1	389	393	PF00082	0.444
DEG_APCC_DBOX_1	238	246	PF00400	0.412
DEG_ODPH_VHL_1	211	223	PF01847	0.210
DEG_SCF_FBW7_1	120	126	PF00400	0.506
DEG_SPOP_SBC_1	47	51	PF00917	0.719
DEG_SPOP_SBC_1	593	597	PF00917	0.640
DOC_CKS1_1	120	125	PF01111	0.508
DOC_CYCLIN_RxL_1	245	254	PF00134	0.297
DOC_CYCLIN_RxL_1	477	487	PF00134	0.364
DOC_MAPK_DCC_7	239	247	PF00069	0.332
DOC_MAPK_MEF2A_6	239	247	PF00069	0.333
DOC_PP1_RVXF_1	478	485	PF00149	0.369
DOC_PP4_FxxP_1	115	118	PF00568	0.664
DOC_USP7_MATH_1	123	127	PF00917	0.625
DOC_USP7_MATH_1	185	189	PF00917	0.301
DOC_USP7_MATH_1	325	329	PF00917	0.602
DOC_USP7_MATH_1	363	367	PF00917	0.579
DOC_USP7_MATH_1	463	467	PF00917	0.545
DOC_USP7_MATH_1	47	51	PF00917	0.690
DOC_USP7_MATH_1	594	598	PF00917	0.627
DOC_WW_Pin1_4	119	124	PF00397	0.530
DOC_WW_Pin1_4	359	364	PF00397	0.725
DOC_WW_Pin1_4	423	428	PF00397	0.787
DOC_WW_Pin1_4	453	458	PF00397	0.574
DOC_WW_Pin1_4	527	532	PF00397	0.453
DOC_WW_Pin1_4	559	564	PF00397	0.514
DOC_WW_Pin1_4	582	587	PF00397	0.681
LIG_14-3-3_CanoR_1	107	116	PF00244	0.545
LIG_14-3-3_CanoR_1	162	168	PF00244	0.490
LIG_14-3-3_CanoR_1	320	327	PF00244	0.673
LIG_14-3-3_CanoR_1	346	351	PF00244	0.734
LIG_14-3-3_CanoR_1	506	514	PF00244	0.522
LIG_Actin_WH2_2	335	353	PF00022	0.466
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_BIR_III_2	411	415	PF00653	0.471
LIG_BRCT_BRCA1_1	594	598	PF00533	0.535
LIG_BRCT_BRCA1_1	96	100	PF00533	0.564
LIG_CaM_IQ_9	511	527	PF13499	0.572
LIG_Clathr_ClatBox_1	220	224	PF01394	0.264
LIG_deltaCOP1_diTrp_1	589	598	PF00928	0.515
LIG_DLG_GKlike_1	346	354	PF00625	0.483
LIG_FHA_1	130	136	PF00498	0.514
LIG_FHA_1	152	158	PF00498	0.432
LIG_FHA_1	321	327	PF00498	0.549
LIG_FHA_1	460	466	PF00498	0.560
LIG_FHA_1	473	479	PF00498	0.511
LIG_FHA_1	483	489	PF00498	0.489
LIG_FHA_1	532	538	PF00498	0.547
LIG_FHA_1	599	605	PF00498	0.526
LIG_FHA_2	185	191	PF00498	0.442
LIG_FHA_2	308	314	PF00498	0.564
LIG_FHA_2	32	38	PF00498	0.500
LIG_FHA_2	5	11	PF00498	0.487
LIG_FHA_2	536	542	PF00498	0.504
LIG_LIR_Gen_1	154	164	PF02991	0.508
LIG_LIR_Nem_3	154	159	PF02991	0.506
LIG_NRP_CendR_1	627	628	PF00754	0.710
LIG_PTB_Apo_2	216	223	PF02174	0.210
LIG_PTB_Apo_2	478	485	PF02174	0.465
LIG_PTB_Phospho_1	216	222	PF10480	0.210
LIG_SH2_CRK	14	18	PF00017	0.665
LIG_SH2_CRK	479	483	PF00017	0.546
LIG_SH2_NCK_1	460	464	PF00017	0.450
LIG_SH2_PTP2	156	159	PF00017	0.317
LIG_SH2_SRC	222	225	PF00017	0.385
LIG_SH2_STAP1	533	537	PF00017	0.481
LIG_SH2_STAT3	277	280	PF00017	0.487
LIG_SH2_STAT5	156	159	PF00017	0.408
LIG_SH2_STAT5	180	183	PF00017	0.404
LIG_SH2_STAT5	222	225	PF00017	0.385
LIG_SH2_STAT5	277	280	PF00017	0.529
LIG_SH2_STAT5	533	536	PF00017	0.576
LIG_SH3_2	622	627	PF14604	0.689
LIG_SH3_3	117	123	PF00018	0.510
LIG_SH3_3	154	160	PF00018	0.481
LIG_SH3_3	324	330	PF00018	0.600
LIG_SH3_3	452	458	PF00018	0.518
LIG_SH3_3	570	576	PF00018	0.734
LIG_SH3_3	618	624	PF00018	0.601
LIG_SH3_CIN85_PxpxPR_1	622	627	PF14604	0.689
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.435
LIG_SUMO_SIM_anti_2	231	238	PF11976	0.367
LIG_SUMO_SIM_anti_2	534	541	PF11976	0.416
LIG_TRAF2_1	34	37	PF00917	0.506
LIG_TRAF2_1	7	10	PF00917	0.571
LIG_TRAF2_2	213	218	PF00917	0.210
LIG_TYR_ITIM	220	225	PF00017	0.385
LIG_WW_1	457	460	PF00397	0.494
LIG_WW_3	624	628	PF00397	0.692
LIG_WW_3	83	87	PF00397	0.485
MOD_CK1_1	166	172	PF00069	0.399
MOD_CK1_1	306	312	PF00069	0.677
MOD_CK1_1	362	368	PF00069	0.608
MOD_CK1_1	378	384	PF00069	0.654
MOD_CK1_1	49	55	PF00069	0.591
MOD_CK1_1	597	603	PF00069	0.659
MOD_CK1_1	615	621	PF00069	0.541
MOD_CK2_1	184	190	PF00069	0.594
MOD_CK2_1	305	311	PF00069	0.590
MOD_CK2_1	31	37	PF00069	0.569
MOD_CK2_1	4	10	PF00069	0.522
MOD_CK2_1	535	541	PF00069	0.401
MOD_CK2_1	613	619	PF00069	0.542
MOD_CK2_1	75	81	PF00069	0.652
MOD_GlcNHglycan	110	113	PF01048	0.673
MOD_GlcNHglycan	371	374	PF01048	0.653
MOD_GlcNHglycan	382	385	PF01048	0.543
MOD_GlcNHglycan	54	57	PF01048	0.806
MOD_GlcNHglycan	554	557	PF01048	0.488
MOD_GlcNHglycan	615	618	PF01048	0.660
MOD_GSK3_1	119	126	PF00069	0.641
MOD_GSK3_1	162	169	PF00069	0.405
MOD_GSK3_1	246	253	PF00069	0.492
MOD_GSK3_1	303	310	PF00069	0.728
MOD_GSK3_1	325	332	PF00069	0.522
MOD_GSK3_1	346	353	PF00069	0.653
MOD_GSK3_1	359	366	PF00069	0.538
MOD_GSK3_1	419	426	PF00069	0.689
MOD_GSK3_1	42	49	PF00069	0.776
MOD_GSK3_1	459	466	PF00069	0.564
MOD_GSK3_1	482	489	PF00069	0.624
MOD_GSK3_1	527	534	PF00069	0.578
MOD_GSK3_1	59	66	PF00069	0.585
MOD_GSK3_1	592	599	PF00069	0.661
MOD_GSK3_1	604	611	PF00069	0.544
MOD_GSK3_1	95	102	PF00069	0.553
MOD_N-GLC_1	124	129	PF02516	0.482
MOD_N-GLC_1	174	179	PF02516	0.363
MOD_N-GLC_1	228	233	PF02516	0.367
MOD_N-GLC_1	250	255	PF02516	0.431
MOD_N-GLC_1	430	435	PF02516	0.682
MOD_N-GLC_1	58	63	PF02516	0.500
MOD_N-GLC_1	582	587	PF02516	0.537
MOD_NEK2_1	100	105	PF00069	0.560
MOD_NEK2_1	174	179	PF00069	0.398
MOD_NEK2_1	223	228	PF00069	0.295
MOD_NEK2_1	31	36	PF00069	0.489
MOD_NEK2_1	350	355	PF00069	0.610
MOD_NEK2_1	369	374	PF00069	0.476
MOD_NEK2_1	430	435	PF00069	0.571
MOD_NEK2_1	598	603	PF00069	0.548
MOD_NEK2_1	63	68	PF00069	0.564
MOD_NEK2_2	375	380	PF00069	0.520
MOD_PIKK_1	129	135	PF00454	0.567
MOD_PIKK_1	193	199	PF00454	0.466
MOD_PIKK_1	31	37	PF00454	0.493
MOD_PIKK_1	378	384	PF00454	0.698
MOD_PIKK_1	437	443	PF00454	0.547
MOD_PIKK_1	482	488	PF00454	0.528
MOD_PK_1	329	335	PF00069	0.563
MOD_PKA_1	612	618	PF00069	0.541
MOD_PKA_2	263	269	PF00069	0.646
MOD_PKA_2	319	325	PF00069	0.643
MOD_PKA_2	350	356	PF00069	0.652
MOD_PKA_2	42	48	PF00069	0.615
MOD_PKA_2	431	437	PF00069	0.634
MOD_PKA_2	552	558	PF00069	0.632
MOD_Plk_1	124	130	PF00069	0.519
MOD_Plk_1	174	180	PF00069	0.378
MOD_Plk_1	375	381	PF00069	0.517
MOD_Plk_1	502	508	PF00069	0.514
MOD_Plk_2-3	307	313	PF00069	0.591
MOD_Plk_2-3	535	541	PF00069	0.401
MOD_Plk_4	535	541	PF00069	0.543
MOD_Plk_4	59	65	PF00069	0.600
MOD_ProDKin_1	119	125	PF00069	0.531
MOD_ProDKin_1	359	365	PF00069	0.727
MOD_ProDKin_1	423	429	PF00069	0.789
MOD_ProDKin_1	453	459	PF00069	0.570
MOD_ProDKin_1	527	533	PF00069	0.449
MOD_ProDKin_1	559	565	PF00069	0.516
MOD_ProDKin_1	582	588	PF00069	0.680
MOD_SUMO_rev_2	111	121	PF00179	0.497
MOD_SUMO_rev_2	448	456	PF00179	0.687
MOD_SUMO_rev_2	585	593	PF00179	0.514
TRG_DiLeu_BaEn_1	136	141	PF01217	0.552
TRG_DiLeu_BaEn_1	190	195	PF01217	0.497
TRG_DiLeu_BaEn_1	396	401	PF01217	0.576
TRG_DiLeu_BaEn_1	535	540	PF01217	0.412
TRG_DiLeu_BaEn_2	25	31	PF01217	0.455
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.501
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.357
TRG_ENDOCYTIC_2	14	17	PF00928	0.573
TRG_ENDOCYTIC_2	156	159	PF00928	0.408
TRG_ENDOCYTIC_2	222	225	PF00928	0.385
TRG_ENDOCYTIC_2	479	482	PF00928	0.452
TRG_ER_diArg_1	335	337	PF00400	0.599
TRG_ER_diArg_1	406	408	PF00400	0.530
TRG_ER_diArg_1	518	521	PF00400	0.496
TRG_ER_diArg_1	626	628	PF00400	0.703
TRG_NES_CRM1_1	193	207	PF08389	0.502
TRG_Pf-PMV_PEXEL_1	492	496	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P881	Leptomonas seymouri	40%	100%
A0A3S7WSM9	Leishmania donovani	65%	100%
A0A422P4A5	Trypanosoma rangeli	30%	100%
A4HVS1	Leishmania infantum	65%	100%
D0A6G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9APG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	99%
Q4QG11	Leishmania major	65%	99%