Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7C4_LEIBR

TriTrypDb:

LbrM.13.1190 , LBRM2903_130018400

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7C4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.442
CLV_PCSK_KEX2_1	112	114	PF00082	0.442
CLV_PCSK_KEX2_1	238	240	PF00082	0.696
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.696
CLV_PCSK_SKI1_1	164	168	PF00082	0.526
CLV_PCSK_SKI1_1	203	207	PF00082	0.372
CLV_PCSK_SKI1_1	216	220	PF00082	0.412
CLV_Separin_Metazoa	88	92	PF03568	0.327
DEG_SPOP_SBC_1	25	29	PF00917	0.544
DOC_MAPK_gen_1	175	183	PF00069	0.354
DOC_MAPK_gen_1	197	206	PF00069	0.424
DOC_MAPK_RevD_3	98	113	PF00069	0.409
DOC_USP7_MATH_1	133	137	PF00917	0.381
DOC_USP7_MATH_1	38	42	PF00917	0.716
DOC_USP7_UBL2_3	226	230	PF12436	0.503
DOC_WW_Pin1_4	135	140	PF00397	0.561
DOC_WW_Pin1_4	150	155	PF00397	0.568
DOC_WW_Pin1_4	26	31	PF00397	0.716
LIG_14-3-3_CanoR_1	147	152	PF00244	0.717
LIG_14-3-3_CanoR_1	20	30	PF00244	0.444
LIG_14-3-3_CanoR_1	216	223	PF00244	0.583
LIG_14-3-3_CanoR_1	54	58	PF00244	0.606
LIG_Actin_WH2_2	6	24	PF00022	0.525
LIG_BIR_II_1	1	5	PF00653	0.362
LIG_FHA_1	120	126	PF00498	0.477
LIG_FHA_1	151	157	PF00498	0.568
LIG_FHA_1	217	223	PF00498	0.351
LIG_FHA_1	69	75	PF00498	0.745
LIG_FHA_2	125	131	PF00498	0.491
LIG_FHA_2	44	50	PF00498	0.550
LIG_LIR_Gen_1	129	139	PF02991	0.442
LIG_LIR_Gen_1	47	57	PF02991	0.524
LIG_LIR_Nem_3	129	134	PF02991	0.419
LIG_LIR_Nem_3	47	53	PF02991	0.510
LIG_SH2_CRK	131	135	PF00017	0.351
LIG_SH2_STAP1	114	118	PF00017	0.499
LIG_SH2_STAT5	92	95	PF00017	0.537
LIG_SH3_1	58	64	PF00018	0.458
LIG_SH3_3	146	152	PF00018	0.606
LIG_SH3_3	58	64	PF00018	0.563
LIG_SUMO_SIM_anti_2	40	49	PF11976	0.505
LIG_SUMO_SIM_par_1	124	130	PF11976	0.410
LIG_SUMO_SIM_par_1	203	209	PF11976	0.464
LIG_TRAF2_1	168	171	PF00917	0.593
LIG_UBA3_1	5	12	PF00899	0.508
MOD_CK1_1	150	156	PF00069	0.632
MOD_CK1_1	43	49	PF00069	0.516
MOD_CK2_1	124	130	PF00069	0.486
MOD_GlcNHglycan	2	5	PF01048	0.578
MOD_GlcNHglycan	48	53	PF01048	0.517
MOD_GlcNHglycan	65	68	PF01048	0.504
MOD_GlcNHglycan	77	80	PF01048	0.677
MOD_GSK3_1	20	27	PF00069	0.613
MOD_GSK3_1	40	47	PF00069	0.621
MOD_GSK3_1	59	66	PF00069	0.407
MOD_NEK2_1	21	26	PF00069	0.644
MOD_PKA_2	21	27	PF00069	0.535
MOD_PKA_2	53	59	PF00069	0.606
MOD_PKB_1	18	26	PF00069	0.404
MOD_Plk_1	48	54	PF00069	0.552
MOD_Plk_2-3	124	130	PF00069	0.512
MOD_Plk_4	40	46	PF00069	0.538
MOD_ProDKin_1	135	141	PF00069	0.570
MOD_ProDKin_1	150	156	PF00069	0.561
MOD_ProDKin_1	26	32	PF00069	0.720
MOD_SUMO_for_1	11	14	PF00179	0.307
MOD_SUMO_rev_2	193	198	PF00179	0.500
TRG_DiLeu_BaEn_1	130	135	PF01217	0.535
TRG_ENDOCYTIC_2	114	117	PF00928	0.503
TRG_ENDOCYTIC_2	131	134	PF00928	0.417
TRG_ENDOCYTIC_2	92	95	PF00928	0.498
TRG_ER_diArg_1	112	114	PF00400	0.439
TRG_ER_diArg_1	17	20	PF00400	0.529
TRG_ER_diArg_1	178	181	PF00400	0.362
TRG_NLS_MonoCore_2	237	242	PF00514	0.743
TRG_NLS_MonoExtC_3	237	243	PF00514	0.698
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Q3	Leptomonas seymouri	52%	100%
A0A3S7WSS0	Leishmania donovani	76%	100%
A0A422P490	Trypanosoma rangeli	32%	100%
A4HVS9	Leishmania infantum	76%	100%
E9APG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QG12	Leishmania major	75%	98%
V5BHL0	Trypanosoma cruzi	34%	100%