Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7C2_LEIBR

TriTrypDb:

LbrM.13.1170 , LBRM2903_130018200

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7C2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.490
CLV_C14_Caspase3-7	577	581	PF00656	0.452
CLV_NRD_NRD_1	185	187	PF00675	0.417
CLV_NRD_NRD_1	402	404	PF00675	0.517
CLV_NRD_NRD_1	5	7	PF00675	0.431
CLV_NRD_NRD_1	572	574	PF00675	0.484
CLV_NRD_NRD_1	658	660	PF00675	0.525
CLV_PCSK_KEX2_1	185	187	PF00082	0.418
CLV_PCSK_KEX2_1	4	6	PF00082	0.442
CLV_PCSK_KEX2_1	402	404	PF00082	0.517
CLV_PCSK_KEX2_1	571	573	PF00082	0.449
CLV_PCSK_KEX2_1	658	660	PF00082	0.525
CLV_PCSK_SKI1_1	185	189	PF00082	0.453
CLV_PCSK_SKI1_1	240	244	PF00082	0.302
CLV_PCSK_SKI1_1	36	40	PF00082	0.391
CLV_PCSK_SKI1_1	487	491	PF00082	0.538
CLV_PCSK_SKI1_1	5	9	PF00082	0.380
CLV_PCSK_SKI1_1	573	577	PF00082	0.356
CLV_PCSK_SKI1_1	658	662	PF00082	0.564
CLV_PCSK_SKI1_1	92	96	PF00082	0.433
CLV_Separin_Metazoa	753	757	PF03568	0.628
DEG_APCC_DBOX_1	176	184	PF00400	0.564
DEG_APCC_DBOX_1	538	546	PF00400	0.530
DEG_Nend_Nbox_1	1	3	PF02207	0.380
DEG_SCF_FBW7_1	662	667	PF00400	0.597
DEG_SPOP_SBC_1	423	427	PF00917	0.670
DOC_CDC14_PxL_1	55	63	PF14671	0.450
DOC_CKS1_1	14	19	PF01111	0.552
DOC_CKS1_1	22	27	PF01111	0.427
DOC_CKS1_1	327	332	PF01111	0.508
DOC_CKS1_1	555	560	PF01111	0.493
DOC_CKS1_1	625	630	PF01111	0.573
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.356
DOC_CYCLIN_yCln2_LP_2	126	129	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.279
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.364
DOC_MAPK_gen_1	190	199	PF00069	0.505
DOC_MAPK_gen_1	4	13	PF00069	0.484
DOC_MAPK_MEF2A_6	4	13	PF00069	0.465
DOC_MAPK_MEF2A_6	535	542	PF00069	0.564
DOC_PP2B_LxvP_1	11	14	PF13499	0.457
DOC_PP2B_LxvP_1	126	129	PF13499	0.418
DOC_PP2B_LxvP_1	538	541	PF13499	0.494
DOC_PP4_FxxP_1	122	125	PF00568	0.321
DOC_USP7_MATH_1	161	165	PF00917	0.622
DOC_USP7_MATH_1	234	238	PF00917	0.498
DOC_USP7_MATH_1	252	256	PF00917	0.522
DOC_USP7_MATH_1	305	309	PF00917	0.319
DOC_USP7_MATH_1	418	422	PF00917	0.755
DOC_USP7_MATH_1	428	432	PF00917	0.717
DOC_USP7_MATH_1	508	512	PF00917	0.601
DOC_USP7_MATH_1	664	668	PF00917	0.589
DOC_USP7_MATH_1	736	740	PF00917	0.547
DOC_USP7_MATH_1	82	86	PF00917	0.529
DOC_USP7_UBL2_3	480	484	PF12436	0.433
DOC_WW_Pin1_4	13	18	PF00397	0.429
DOC_WW_Pin1_4	21	26	PF00397	0.320
DOC_WW_Pin1_4	323	328	PF00397	0.520
DOC_WW_Pin1_4	413	418	PF00397	0.634
DOC_WW_Pin1_4	424	429	PF00397	0.597
DOC_WW_Pin1_4	554	559	PF00397	0.483
DOC_WW_Pin1_4	624	629	PF00397	0.459
DOC_WW_Pin1_4	660	665	PF00397	0.549
LIG_14-3-3_CanoR_1	36	41	PF00244	0.394
LIG_14-3-3_CanoR_1	403	413	PF00244	0.377
LIG_14-3-3_CanoR_1	519	527	PF00244	0.523
LIG_14-3-3_CanoR_1	539	548	PF00244	0.530
LIG_14-3-3_CanoR_1	573	583	PF00244	0.484
LIG_14-3-3_CanoR_1	658	663	PF00244	0.497
LIG_14-3-3_CanoR_1	767	773	PF00244	0.637
LIG_BIR_III_2	375	379	PF00653	0.462
LIG_CaM_NSCaTE_8	274	281	PF13499	0.362
LIG_eIF4E_1	441	447	PF01652	0.326
LIG_FHA_1	320	326	PF00498	0.576
LIG_FHA_1	37	43	PF00498	0.596
LIG_FHA_1	499	505	PF00498	0.562
LIG_FHA_1	607	613	PF00498	0.627
LIG_FHA_1	625	631	PF00498	0.510
LIG_FHA_1	741	747	PF00498	0.460
LIG_FHA_1	763	769	PF00498	0.518
LIG_FHA_1	8	14	PF00498	0.481
LIG_FHA_2	105	111	PF00498	0.433
LIG_FHA_2	141	147	PF00498	0.510
LIG_FHA_2	196	202	PF00498	0.521
LIG_FHA_2	431	437	PF00498	0.569
LIG_FHA_2	609	615	PF00498	0.639
LIG_LIR_Apic_2	71	75	PF02991	0.350
LIG_LIR_Gen_1	44	55	PF02991	0.365
LIG_LIR_Gen_1	774	781	PF02991	0.687
LIG_LIR_Nem_3	110	114	PF02991	0.438
LIG_LIR_Nem_3	221	226	PF02991	0.439
LIG_LIR_Nem_3	290	296	PF02991	0.460
LIG_LIR_Nem_3	44	50	PF02991	0.382
LIG_LIR_Nem_3	643	647	PF02991	0.400
LIG_LIR_Nem_3	774	780	PF02991	0.650
LIG_MYND_1	125	129	PF01753	0.489
LIG_Pex14_1	481	485	PF04695	0.351
LIG_Pex14_2	728	732	PF04695	0.412
LIG_SH2_CRK	293	297	PF00017	0.279
LIG_SH2_CRK	485	489	PF00017	0.382
LIG_SH2_CRK	55	59	PF00017	0.334
LIG_SH2_CRK	760	764	PF00017	0.507
LIG_SH2_NCK_1	55	59	PF00017	0.326
LIG_SH2_NCK_1	647	651	PF00017	0.480
LIG_SH2_SRC	636	639	PF00017	0.467
LIG_SH2_SRC	647	650	PF00017	0.437
LIG_SH2_STAP1	419	423	PF00017	0.704
LIG_SH2_STAP1	636	640	PF00017	0.320
LIG_SH2_STAT3	263	266	PF00017	0.469
LIG_SH2_STAT3	27	30	PF00017	0.383
LIG_SH2_STAT3	309	312	PF00017	0.504
LIG_SH2_STAT3	603	606	PF00017	0.550
LIG_SH2_STAT5	111	114	PF00017	0.293
LIG_SH2_STAT5	149	152	PF00017	0.336
LIG_SH2_STAT5	287	290	PF00017	0.351
LIG_SH2_STAT5	309	312	PF00017	0.429
LIG_SH2_STAT5	370	373	PF00017	0.445
LIG_SH2_STAT5	55	58	PF00017	0.368
LIG_SH2_STAT5	603	606	PF00017	0.450
LIG_SH2_STAT5	758	761	PF00017	0.516
LIG_SH3_3	11	17	PF00018	0.450
LIG_SH3_3	122	128	PF00018	0.289
LIG_SH3_3	324	330	PF00018	0.614
LIG_SH3_3	545	551	PF00018	0.419
LIG_SH3_3	763	769	PF00018	0.579
LIG_Sin3_3	66	73	PF02671	0.344
LIG_SUMO_SIM_anti_2	194	201	PF11976	0.543
LIG_SUMO_SIM_par_1	194	201	PF11976	0.574
LIG_TRAF2_1	192	195	PF00917	0.586
LIG_TRAF2_1	259	262	PF00917	0.721
LIG_TRAF2_1	611	614	PF00917	0.634
LIG_TRFH_1	55	59	PF08558	0.326
LIG_TRFH_1	660	664	PF08558	0.579
LIG_TYR_ITIM	109	114	PF00017	0.260
LIG_TYR_ITIM	53	58	PF00017	0.333
LIG_WRC_WIRS_1	37	42	PF05994	0.391
LIG_WW_3	753	757	PF00397	0.628
MOD_CDK_SPxxK_3	326	333	PF00069	0.673
MOD_CK1_1	164	170	PF00069	0.492
MOD_CK1_1	248	254	PF00069	0.616
MOD_CK1_1	255	261	PF00069	0.600
MOD_CK1_1	326	332	PF00069	0.645
MOD_CK1_1	432	438	PF00069	0.663
MOD_CK1_1	470	476	PF00069	0.529
MOD_CK1_1	667	673	PF00069	0.633
MOD_CK2_1	104	110	PF00069	0.387
MOD_CK2_1	140	146	PF00069	0.559
MOD_CK2_1	255	261	PF00069	0.539
MOD_CK2_1	430	436	PF00069	0.537
MOD_CK2_1	608	614	PF00069	0.641
MOD_CK2_1	742	748	PF00069	0.515
MOD_CK2_1	768	774	PF00069	0.635
MOD_Cter_Amidation	183	186	PF01082	0.478
MOD_Cter_Amidation	569	572	PF01082	0.377
MOD_GlcNHglycan	165	169	PF01048	0.389
MOD_GlcNHglycan	208	211	PF01048	0.427
MOD_GlcNHglycan	236	239	PF01048	0.564
MOD_GlcNHglycan	246	250	PF01048	0.538
MOD_GlcNHglycan	258	261	PF01048	0.768
MOD_GlcNHglycan	317	320	PF01048	0.493
MOD_GlcNHglycan	385	388	PF01048	0.666
MOD_GlcNHglycan	468	472	PF01048	0.503
MOD_GlcNHglycan	473	476	PF01048	0.671
MOD_GlcNHglycan	504	507	PF01048	0.573
MOD_GlcNHglycan	510	513	PF01048	0.620
MOD_GlcNHglycan	595	598	PF01048	0.603
MOD_GlcNHglycan	668	672	PF01048	0.593
MOD_GlcNHglycan	738	741	PF01048	0.405
MOD_GlcNHglycan	84	87	PF01048	0.498
MOD_GSK3_1	202	209	PF00069	0.489
MOD_GSK3_1	214	221	PF00069	0.400
MOD_GSK3_1	234	241	PF00069	0.524
MOD_GSK3_1	248	255	PF00069	0.540
MOD_GSK3_1	315	322	PF00069	0.573
MOD_GSK3_1	418	425	PF00069	0.692
MOD_GSK3_1	426	433	PF00069	0.660
MOD_GSK3_1	454	461	PF00069	0.551
MOD_GSK3_1	467	474	PF00069	0.660
MOD_GSK3_1	498	505	PF00069	0.561
MOD_GSK3_1	508	515	PF00069	0.532
MOD_GSK3_1	660	667	PF00069	0.487
MOD_GSK3_1	736	743	PF00069	0.456
MOD_GSK3_1	744	751	PF00069	0.527
MOD_GSK3_1	88	95	PF00069	0.505
MOD_LATS_1	590	596	PF00433	0.442
MOD_N-GLC_1	319	324	PF02516	0.624
MOD_NEK2_1	206	211	PF00069	0.449
MOD_NEK2_1	250	255	PF00069	0.531
MOD_NEK2_1	315	320	PF00069	0.454
MOD_NEK2_1	467	472	PF00069	0.544
MOD_NEK2_1	520	525	PF00069	0.449
MOD_NEK2_1	53	58	PF00069	0.302
MOD_NEK2_1	574	579	PF00069	0.516
MOD_NEK2_1	607	612	PF00069	0.529
MOD_NEK2_1	702	707	PF00069	0.692
MOD_NEK2_1	88	93	PF00069	0.403
MOD_NEK2_2	238	243	PF00069	0.346
MOD_NEK2_2	345	350	PF00069	0.371
MOD_NEK2_2	762	767	PF00069	0.520
MOD_PIKK_1	104	110	PF00454	0.387
MOD_PIKK_1	262	268	PF00454	0.469
MOD_PKA_1	658	664	PF00069	0.500
MOD_PKA_2	441	447	PF00069	0.579
MOD_PKA_2	518	524	PF00069	0.505
MOD_PKA_2	658	664	PF00069	0.500
MOD_PKA_2	88	94	PF00069	0.399
MOD_PKB_1	571	579	PF00069	0.282
MOD_Plk_1	140	146	PF00069	0.556
MOD_Plk_1	214	220	PF00069	0.550
MOD_Plk_1	345	351	PF00069	0.363
MOD_Plk_1	702	708	PF00069	0.536
MOD_Plk_2-3	195	201	PF00069	0.546
MOD_Plk_4	195	201	PF00069	0.528
MOD_Plk_4	202	208	PF00069	0.495
MOD_Plk_4	218	224	PF00069	0.256
MOD_Plk_4	53	59	PF00069	0.396
MOD_Plk_4	599	605	PF00069	0.591
MOD_ProDKin_1	13	19	PF00069	0.433
MOD_ProDKin_1	21	27	PF00069	0.317
MOD_ProDKin_1	323	329	PF00069	0.529
MOD_ProDKin_1	413	419	PF00069	0.647
MOD_ProDKin_1	424	430	PF00069	0.595
MOD_ProDKin_1	554	560	PF00069	0.491
MOD_ProDKin_1	624	630	PF00069	0.452
MOD_ProDKin_1	660	666	PF00069	0.560
MOD_SUMO_rev_2	577	583	PF00179	0.335
TRG_DiLeu_BaEn_1	649	654	PF01217	0.492
TRG_DiLeu_BaEn_1	65	70	PF01217	0.440
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.358
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.462
TRG_ENDOCYTIC_2	111	114	PF00928	0.475
TRG_ENDOCYTIC_2	293	296	PF00928	0.466
TRG_ENDOCYTIC_2	485	488	PF00928	0.392
TRG_ENDOCYTIC_2	55	58	PF00928	0.319
TRG_ENDOCYTIC_2	725	728	PF00928	0.511
TRG_ENDOCYTIC_2	760	763	PF00928	0.473
TRG_ENDOCYTIC_2	777	780	PF00928	0.617
TRG_ER_diArg_1	185	187	PF00400	0.418
TRG_ER_diArg_1	4	6	PF00400	0.420
TRG_ER_diArg_1	571	573	PF00400	0.517
TRG_ER_diArg_1	658	660	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM77	Leptomonas seymouri	57%	96%
A0A1X0NK49	Trypanosomatidae	34%	100%
A0A3Q8II43	Leishmania donovani	81%	100%
A4HVR8	Leishmania infantum	81%	100%
D0A6H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9APG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QG14	Leishmania major	81%	100%
V5BHJ9	Trypanosoma cruzi	34%	100%