Transmembrane 9 superfamily member

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endomembrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7C1_LEIBR

TriTrypDb:

LbrM.13.1150 , LBRM2903_130018000

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H7C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7C1

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	418	420	PF00675	0.216
CLV_NRD_NRD_1	423	425	PF00675	0.213
CLV_NRD_NRD_1	441	443	PF00675	0.303
CLV_PCSK_KEX2_1	418	420	PF00082	0.235
CLV_PCSK_KEX2_1	422	424	PF00082	0.260
CLV_PCSK_KEX2_1	441	443	PF00082	0.353
CLV_PCSK_PC7_1	414	420	PF00082	0.228
CLV_PCSK_SKI1_1	22	26	PF00082	0.474
CLV_PCSK_SKI1_1	389	393	PF00082	0.360
CLV_PCSK_SKI1_1	414	418	PF00082	0.224
CLV_PCSK_SKI1_1	441	445	PF00082	0.326
CLV_PCSK_SKI1_1	63	67	PF00082	0.486
DEG_MDM2_SWIB_1	469	477	PF02201	0.249
DOC_AGCK_PIF_1	462	467	PF00069	0.260
DOC_MAPK_gen_1	350	359	PF00069	0.437
DOC_MAPK_MEF2A_6	105	113	PF00069	0.160
DOC_MAPK_MEF2A_6	389	397	PF00069	0.312
DOC_PP1_RVXF_1	64	71	PF00149	0.160
DOC_PP2B_LxvP_1	343	346	PF13499	0.474
DOC_PP2B_LxvP_1	443	446	PF13499	0.490
DOC_PP2B_PxIxI_1	362	368	PF00149	0.227
DOC_PP2B_PxIxI_1	456	462	PF00149	0.383
DOC_PP4_FxxP_1	271	274	PF00568	0.510
DOC_PP4_FxxP_1	342	345	PF00568	0.471
DOC_PP4_FxxP_1	360	363	PF00568	0.252
DOC_USP7_MATH_1	346	350	PF00917	0.463
DOC_USP7_MATH_1	496	500	PF00917	0.379
DOC_USP7_MATH_1	523	527	PF00917	0.226
DOC_WW_Pin1_4	165	170	PF00397	0.310
LIG_14-3-3_CanoR_1	196	201	PF00244	0.324
LIG_14-3-3_CanoR_1	204	213	PF00244	0.307
LIG_14-3-3_CanoR_1	307	311	PF00244	0.271
LIG_14-3-3_CanoR_1	418	426	PF00244	0.488
LIG_APCC_ABBA_1	34	39	PF00400	0.273
LIG_APCC_ABBA_1	459	464	PF00400	0.383
LIG_BIR_II_1	1	5	PF00653	0.356
LIG_BIR_III_2	64	68	PF00653	0.160
LIG_BRCT_BRCA1_1	182	186	PF00533	0.215
LIG_BRCT_BRCA1_1	465	469	PF00533	0.265
LIG_BRCT_BRCA1_1	517	521	PF00533	0.286
LIG_EH1_1	225	233	PF00400	0.172
LIG_EH1_1	554	562	PF00400	0.172
LIG_eIF4E_1	387	393	PF01652	0.246
LIG_FHA_1	105	111	PF00498	0.319
LIG_FHA_1	147	153	PF00498	0.325
LIG_FHA_1	179	185	PF00498	0.233
LIG_FHA_1	201	207	PF00498	0.335
LIG_FHA_1	208	214	PF00498	0.277
LIG_FHA_1	286	292	PF00498	0.431
LIG_FHA_1	314	320	PF00498	0.344
LIG_FHA_1	323	329	PF00498	0.222
LIG_FHA_1	366	372	PF00498	0.291
LIG_FHA_1	373	379	PF00498	0.301
LIG_FHA_1	472	478	PF00498	0.182
LIG_FHA_1	485	491	PF00498	0.224
LIG_FHA_1	501	507	PF00498	0.250
LIG_FHA_1	92	98	PF00498	0.238
LIG_FHA_2	18	24	PF00498	0.462
LIG_FHA_2	197	203	PF00498	0.275
LIG_FHA_2	67	73	PF00498	0.307
LIG_GBD_Chelix_1	557	565	PF00786	0.172
LIG_IBAR_NPY_1	46	48	PF08397	0.232
LIG_Integrin_RGD_1	115	117	PF01839	0.360
LIG_LIR_Apic_2	269	274	PF02991	0.471
LIG_LIR_Apic_2	341	345	PF02991	0.365
LIG_LIR_Gen_1	117	128	PF02991	0.224
LIG_LIR_Gen_1	139	150	PF02991	0.174
LIG_LIR_Gen_1	179	188	PF02991	0.252
LIG_LIR_Gen_1	2	12	PF02991	0.613
LIG_LIR_Gen_1	210	220	PF02991	0.212
LIG_LIR_Gen_1	279	284	PF02991	0.338
LIG_LIR_Gen_1	316	324	PF02991	0.460
LIG_LIR_Gen_1	333	343	PF02991	0.228
LIG_LIR_Gen_1	460	469	PF02991	0.328
LIG_LIR_Gen_1	49	57	PF02991	0.226
LIG_LIR_Gen_1	503	510	PF02991	0.260
LIG_LIR_Gen_1	576	586	PF02991	0.502
LIG_LIR_Nem_3	117	123	PF02991	0.230
LIG_LIR_Nem_3	139	145	PF02991	0.323
LIG_LIR_Nem_3	179	185	PF02991	0.232
LIG_LIR_Nem_3	2	7	PF02991	0.627
LIG_LIR_Nem_3	210	215	PF02991	0.330
LIG_LIR_Nem_3	260	266	PF02991	0.422
LIG_LIR_Nem_3	279	283	PF02991	0.292
LIG_LIR_Nem_3	316	320	PF02991	0.347
LIG_LIR_Nem_3	333	338	PF02991	0.167
LIG_LIR_Nem_3	45	51	PF02991	0.291
LIG_LIR_Nem_3	460	465	PF02991	0.322
LIG_LIR_Nem_3	466	472	PF02991	0.292
LIG_LIR_Nem_3	474	478	PF02991	0.195
LIG_LIR_Nem_3	503	507	PF02991	0.257
LIG_LIR_Nem_3	576	581	PF02991	0.492
LIG_LIR_Nem_3	69	73	PF02991	0.256
LIG_PCNA_yPIPBox_3	211	224	PF02747	0.162
LIG_Pex14_1	263	267	PF04695	0.428
LIG_Pex14_1	351	355	PF04695	0.510
LIG_Pex14_2	320	324	PF04695	0.194
LIG_Pex14_2	355	359	PF04695	0.383
LIG_Pex14_2	458	462	PF04695	0.366
LIG_Pex14_2	465	469	PF04695	0.304
LIG_Pex14_2	535	539	PF04695	0.347
LIG_SH2_CRK	182	186	PF00017	0.271
LIG_SH2_CRK	335	339	PF00017	0.381
LIG_SH2_CRK	4	8	PF00017	0.338
LIG_SH2_CRK	481	485	PF00017	0.228
LIG_SH2_GRB2like	193	196	PF00017	0.310
LIG_SH2_NCK_1	182	186	PF00017	0.271
LIG_SH2_NCK_1	267	271	PF00017	0.510
LIG_SH2_PTP2	491	494	PF00017	0.326
LIG_SH2_SRC	267	270	PF00017	0.450
LIG_SH2_SRC	28	31	PF00017	0.222
LIG_SH2_SRC	51	54	PF00017	0.175
LIG_SH2_STAP1	120	124	PF00017	0.178
LIG_SH2_STAP1	178	182	PF00017	0.222
LIG_SH2_STAP1	193	197	PF00017	0.194
LIG_SH2_STAP1	267	271	PF00017	0.486
LIG_SH2_STAP1	532	536	PF00017	0.260
LIG_SH2_STAP1	553	557	PF00017	0.234
LIG_SH2_STAT5	14	17	PF00017	0.391
LIG_SH2_STAT5	178	181	PF00017	0.263
LIG_SH2_STAT5	205	208	PF00017	0.275
LIG_SH2_STAT5	28	31	PF00017	0.302
LIG_SH2_STAT5	317	320	PF00017	0.319
LIG_SH2_STAT5	322	325	PF00017	0.347
LIG_SH2_STAT5	331	334	PF00017	0.324
LIG_SH2_STAT5	366	369	PF00017	0.429
LIG_SH2_STAT5	387	390	PF00017	0.280
LIG_SH2_STAT5	415	418	PF00017	0.477
LIG_SH2_STAT5	491	494	PF00017	0.307
LIG_SH2_STAT5	53	56	PF00017	0.222
LIG_SH2_STAT5	537	540	PF00017	0.260
LIG_SH2_STAT5	555	558	PF00017	0.147
LIG_SH2_STAT5	572	575	PF00017	0.383
LIG_SH3_1	434	440	PF00018	0.415
LIG_SH3_2	437	442	PF14604	0.471
LIG_SH3_3	398	404	PF00018	0.263
LIG_SH3_3	434	440	PF00018	0.431
LIG_SUMO_SIM_anti_2	227	234	PF11976	0.446
LIG_SUMO_SIM_anti_2	288	294	PF11976	0.373
LIG_SUMO_SIM_anti_2	373	380	PF11976	0.172
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.323
LIG_SUMO_SIM_par_1	288	294	PF11976	0.313
LIG_SUMO_SIM_par_1	298	304	PF11976	0.222
LIG_SUMO_SIM_par_1	448	453	PF11976	0.330
LIG_TRFH_1	359	363	PF08558	0.314
LIG_TYR_ITIM	489	494	PF00017	0.412
LIG_WRC_WIRS_1	177	182	PF05994	0.260
LIG_WRC_WIRS_1	472	477	PF05994	0.248
LIG_WRC_WIRS_1	501	506	PF05994	0.314
LIG_WW_3	438	442	PF00397	0.383
MOD_CDC14_SPxK_1	168	171	PF00782	0.383
MOD_CDK_SPxK_1	165	171	PF00069	0.383
MOD_CK1_1	2	8	PF00069	0.539
MOD_CK1_1	207	213	PF00069	0.260
MOD_CK1_1	227	233	PF00069	0.172
MOD_CK1_1	301	307	PF00069	0.411
MOD_CK1_1	471	477	PF00069	0.314
MOD_CK2_1	17	23	PF00069	0.497
MOD_CK2_1	186	192	PF00069	0.423
MOD_CK2_1	66	72	PF00069	0.378
MOD_GlcNHglycan	130	133	PF01048	0.307
MOD_GlcNHglycan	160	163	PF01048	0.172
MOD_GlcNHglycan	259	263	PF01048	0.328
MOD_GlcNHglycan	293	296	PF01048	0.332
MOD_GlcNHglycan	325	328	PF01048	0.322
MOD_GlcNHglycan	332	335	PF01048	0.294
MOD_GlcNHglycan	452	455	PF01048	0.400
MOD_GlcNHglycan	494	497	PF01048	0.172
MOD_GSK3_1	160	167	PF00069	0.314
MOD_GSK3_1	176	183	PF00069	0.250
MOD_GSK3_1	196	203	PF00069	0.346
MOD_GSK3_1	207	214	PF00069	0.358
MOD_GSK3_1	227	234	PF00069	0.263
MOD_GSK3_1	463	470	PF00069	0.376
MOD_GSK3_1	492	499	PF00069	0.248
MOD_GSK3_1	77	84	PF00069	0.359
MOD_LATS_1	513	519	PF00433	0.240
MOD_N-GLC_1	216	221	PF02516	0.292
MOD_NEK2_1	146	151	PF00069	0.335
MOD_NEK2_1	164	169	PF00069	0.322
MOD_NEK2_1	180	185	PF00069	0.280
MOD_NEK2_1	186	191	PF00069	0.304
MOD_NEK2_1	215	220	PF00069	0.365
MOD_NEK2_1	224	229	PF00069	0.292
MOD_NEK2_1	231	236	PF00069	0.212
MOD_NEK2_1	291	296	PF00069	0.366
MOD_NEK2_1	379	384	PF00069	0.234
MOD_NEK2_1	450	455	PF00069	0.299
MOD_NEK2_1	467	472	PF00069	0.314
MOD_NEK2_1	484	489	PF00069	0.169
MOD_NEK2_1	521	526	PF00069	0.250
MOD_NEK2_1	539	544	PF00069	0.250
MOD_NEK2_1	573	578	PF00069	0.397
MOD_NEK2_2	457	462	PF00069	0.298
MOD_NEK2_2	523	528	PF00069	0.194
MOD_PIKK_1	245	251	PF00454	0.314
MOD_PIKK_1	285	291	PF00454	0.380
MOD_PIKK_1	380	386	PF00454	0.194
MOD_PKA_2	104	110	PF00069	0.274
MOD_PKA_2	195	201	PF00069	0.401
MOD_PKA_2	245	251	PF00069	0.181
MOD_PKA_2	306	312	PF00069	0.332
MOD_PKA_2	417	423	PF00069	0.349
MOD_PKB_1	209	217	PF00069	0.328
MOD_Plk_1	186	192	PF00069	0.289
MOD_Plk_1	216	222	PF00069	0.292
MOD_Plk_1	463	469	PF00069	0.298
MOD_Plk_2-3	187	193	PF00069	0.314
MOD_Plk_4	173	179	PF00069	0.308
MOD_Plk_4	180	186	PF00069	0.258
MOD_Plk_4	196	202	PF00069	0.258
MOD_Plk_4	2	8	PF00069	0.551
MOD_Plk_4	211	217	PF00069	0.186
MOD_Plk_4	298	304	PF00069	0.398
MOD_Plk_4	315	321	PF00069	0.170
MOD_Plk_4	338	344	PF00069	0.241
MOD_Plk_4	468	474	PF00069	0.288
MOD_Plk_4	496	502	PF00069	0.321
MOD_Plk_4	523	529	PF00069	0.181
MOD_ProDKin_1	165	171	PF00069	0.383
MOD_SUMO_for_1	170	173	PF00179	0.314
MOD_SUMO_for_1	242	245	PF00179	0.314
MOD_SUMO_rev_2	135	143	PF00179	0.172
TRG_DiLeu_BaEn_1	106	111	PF01217	0.172
TRG_DiLeu_BaEn_2	32	38	PF01217	0.300
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.257
TRG_DiLeu_BaLyEn_6	439	444	PF01217	0.240
TRG_ENDOCYTIC_2	120	123	PF00928	0.189
TRG_ENDOCYTIC_2	182	185	PF00928	0.328
TRG_ENDOCYTIC_2	267	270	PF00928	0.260
TRG_ENDOCYTIC_2	317	320	PF00928	0.233
TRG_ENDOCYTIC_2	335	338	PF00928	0.293
TRG_ENDOCYTIC_2	4	7	PF00928	0.374
TRG_ENDOCYTIC_2	481	484	PF00928	0.255
TRG_ENDOCYTIC_2	491	494	PF00928	0.260
TRG_ENDOCYTIC_2	51	54	PF00928	0.263
TRG_ENDOCYTIC_2	532	535	PF00928	0.265
TRG_ER_diArg_1	209	212	PF00400	0.296
TRG_ER_diArg_1	417	419	PF00400	0.259
TRG_ER_diArg_1	422	424	PF00400	0.300
TRG_ER_diArg_1	440	442	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	442	447	PF00026	0.219

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	23%	88%
A0A0N1I2B1	Leptomonas seymouri	26%	93%
A0A0N1I6Y7	Leptomonas seymouri	23%	95%
A0A0N1IME8	Leptomonas seymouri	61%	100%
A0A0S4IV41	Bodo saltans	27%	92%
A0A0S4J9X2	Bodo saltans	23%	91%
A0A0S4JBB1	Bodo saltans	26%	92%
A0A0S4JCH7	Bodo saltans	25%	86%
A0A0S4JEU5	Bodo saltans	22%	92%
A0A0S4JIF4	Bodo saltans	25%	92%
A0A0S4JWZ9	Bodo saltans	22%	96%
A0A0S4JZ31	Bodo saltans	28%	100%
A0A1X0NJN3	Trypanosomatidae	37%	99%
A0A1X0NK64	Trypanosomatidae	25%	94%
A0A1X0NLM6	Trypanosomatidae	26%	100%
A0A1X0NZX5	Trypanosomatidae	25%	91%
A0A1X0P2G3	Trypanosomatidae	23%	93%
A0A1X0P6M4	Trypanosomatidae	24%	77%
A0A1X0PA12	Trypanosomatidae	24%	93%
A0A3Q8IBT4	Leishmania donovani	71%	100%
A0A3Q8IFM1	Leishmania donovani	22%	92%
A0A3Q8IHT3	Leishmania donovani	22%	92%
A0A3R7MBZ3	Trypanosoma rangeli	23%	94%
A0A3S7X2L7	Leishmania donovani	25%	86%
A0A422NED2	Trypanosoma rangeli	25%	91%
A0A422NMS9	Trypanosoma rangeli	23%	90%
A0A422P482	Trypanosoma rangeli	37%	98%
A4HHH4	Leishmania braziliensis	24%	87%
A4HHY3	Leishmania braziliensis	23%	92%
A4HVR6	Leishmania infantum	71%	100%
A4I4M3	Leishmania infantum	25%	87%
A4I563	Leishmania infantum	22%	92%
A4IAD3	Leishmania infantum	22%	92%
A4IFE9	Bos taurus	28%	97%
A5D7E2	Bos taurus	27%	92%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	81%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	93%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	94%
D0A6H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9AE21	Leishmania major	24%	87%
E9ALR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	87%
E9APG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
E9B0G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	90%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	92%
F4HW17	Arabidopsis thaliana	28%	100%
F4JRE0	Arabidopsis thaliana	27%	90%
F4KIB2	Arabidopsis thaliana	23%	91%
O15321	Homo sapiens	28%	97%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	88%
P40071	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	83%
P58021	Mus musculus	23%	89%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	88%
Q4KLL4	Rattus norvegicus	27%	92%
Q4Q2H8	Leishmania major	22%	100%
Q4Q7S3	Leishmania major	23%	100%
Q4QG16	Leishmania major	70%	100%
Q54ZW0	Dictyostelium discoideum	26%	100%
Q55FP0	Dictyostelium discoideum	22%	92%
Q5R8F1	Pongo abelii	28%	97%
Q5R8Y6	Pongo abelii	24%	89%
Q5RDY2	Pongo abelii	27%	92%
Q66HF2	Rattus norvegicus	27%	100%
Q66HG5	Rattus norvegicus	23%	89%
Q7YTA6	Dictyostelium discoideum	24%	90%
Q8BH24	Mus musculus	27%	92%
Q8RWW1	Arabidopsis thaliana	24%	92%
Q92544	Homo sapiens	27%	92%
Q940G0	Arabidopsis thaliana	29%	100%
Q940S0	Arabidopsis thaliana	28%	99%
Q99805	Homo sapiens	24%	89%
Q9C5N2	Arabidopsis thaliana	23%	91%
Q9C720	Arabidopsis thaliana	24%	92%
Q9DBU0	Mus musculus	28%	97%
Q9ET30	Mus musculus	30%	100%
Q9FHT4	Arabidopsis thaliana	26%	99%
Q9FYQ8	Arabidopsis thaliana	30%	90%
Q9HD45	Homo sapiens	30%	100%
Q9LIC2	Arabidopsis thaliana	25%	92%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	94%
Q9ZPS7	Arabidopsis thaliana	28%	99%
V5BCD5	Trypanosoma cruzi	24%	93%
V5BHS7	Trypanosoma cruzi	24%	100%
V5D9U0	Trypanosoma cruzi	24%	91%
V5DII3	Trypanosoma cruzi	37%	98%