Sin-like_protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Sin-like_protein

Gene product:

Sin-like protein conserved region, putative

Species:

Leishmania braziliensis

UniProt:

A4H7C0_LEIBR

TriTrypDb:

LbrM.13.1140 , LBRM2903_130017900

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0000428	DNA-directed RNA polymerase complex	4	2
GO:0005666	RNA polymerase III complex	4	1
GO:0005737	cytoplasm	2	1
GO:0030880	RNA polymerase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	2
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

A4H7C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7C0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006351	DNA-templated transcription	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:0097659	nucleic acid-templated transcription	6	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034062	5'-3' RNA polymerase activity	5	1
GO:0097747	RNA polymerase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	537	541	PF00656	0.501
CLV_NRD_NRD_1	197	199	PF00675	0.480
CLV_NRD_NRD_1	284	286	PF00675	0.399
CLV_NRD_NRD_1	392	394	PF00675	0.335
CLV_NRD_NRD_1	40	42	PF00675	0.359
CLV_NRD_NRD_1	415	417	PF00675	0.411
CLV_NRD_NRD_1	453	455	PF00675	0.447
CLV_NRD_NRD_1	97	99	PF00675	0.227
CLV_PCSK_KEX2_1	197	199	PF00082	0.480
CLV_PCSK_KEX2_1	39	41	PF00082	0.355
CLV_PCSK_KEX2_1	392	394	PF00082	0.335
CLV_PCSK_KEX2_1	414	416	PF00082	0.358
CLV_PCSK_KEX2_1	452	454	PF00082	0.408
CLV_PCSK_KEX2_1	635	637	PF00082	0.507
CLV_PCSK_KEX2_1	97	99	PF00082	0.454
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.378
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.507
CLV_PCSK_SKI1_1	393	397	PF00082	0.335
CLV_PCSK_SKI1_1	434	438	PF00082	0.357
CLV_PCSK_SKI1_1	551	555	PF00082	0.426
CLV_PCSK_SKI1_1	582	586	PF00082	0.553
CLV_PCSK_SKI1_1	644	648	PF00082	0.596
CLV_Separin_Metazoa	318	322	PF03568	0.227
CLV_Separin_Metazoa	639	643	PF03568	0.596
DEG_APCC_DBOX_1	378	386	PF00400	0.237
DEG_APCC_DBOX_1	415	423	PF00400	0.447
DEG_SCF_FBW7_1	143	150	PF00400	0.335
DEG_SCF_FBW7_1	478	485	PF00400	0.742
DEG_SPOP_SBC_1	161	165	PF00917	0.441
DEG_SPOP_SBC_1	482	486	PF00917	0.500
DOC_CKS1_1	137	142	PF01111	0.434
DOC_CKS1_1	153	158	PF01111	0.265
DOC_CYCLIN_RxL_1	547	556	PF00134	0.425
DOC_MAPK_FxFP_2	34	37	PF00069	0.335
DOC_MAPK_gen_1	562	570	PF00069	0.554
DOC_MAPK_JIP1_4	615	621	PF00069	0.493
DOC_MAPK_MEF2A_6	298	306	PF00069	0.424
DOC_MAPK_MEF2A_6	469	476	PF00069	0.562
DOC_MAPK_MEF2A_6	615	623	PF00069	0.494
DOC_PP2B_LxvP_1	158	161	PF13499	0.440
DOC_PP2B_LxvP_1	256	259	PF13499	0.355
DOC_PP4_FxxP_1	34	37	PF00568	0.335
DOC_PP4_FxxP_1	527	530	PF00568	0.713
DOC_USP7_MATH_1	161	165	PF00917	0.442
DOC_USP7_MATH_1	173	177	PF00917	0.317
DOC_USP7_MATH_1	178	182	PF00917	0.266
DOC_USP7_MATH_1	226	230	PF00917	0.366
DOC_USP7_MATH_1	273	277	PF00917	0.417
DOC_USP7_MATH_1	313	317	PF00917	0.406
DOC_USP7_MATH_1	334	338	PF00917	0.480
DOC_USP7_MATH_1	391	395	PF00917	0.410
DOC_USP7_MATH_1	410	414	PF00917	0.447
DOC_USP7_UBL2_3	562	566	PF12436	0.442
DOC_WW_Pin1_4	136	141	PF00397	0.358
DOC_WW_Pin1_4	143	148	PF00397	0.301
DOC_WW_Pin1_4	152	157	PF00397	0.259
DOC_WW_Pin1_4	239	244	PF00397	0.419
DOC_WW_Pin1_4	478	483	PF00397	0.698
DOC_WW_Pin1_4	497	502	PF00397	0.442
DOC_WW_Pin1_4	522	527	PF00397	0.666
DOC_WW_Pin1_4	645	650	PF00397	0.619
DOC_WW_Pin1_4	70	75	PF00397	0.265
LIG_14-3-3_CanoR_1	114	119	PF00244	0.340
LIG_14-3-3_CanoR_1	230	240	PF00244	0.365
LIG_14-3-3_CanoR_1	285	289	PF00244	0.313
LIG_14-3-3_CanoR_1	368	377	PF00244	0.428
LIG_14-3-3_CanoR_1	452	462	PF00244	0.396
LIG_14-3-3_CanoR_1	644	649	PF00244	0.612
LIG_14-3-3_CanoR_1	81	85	PF00244	0.324
LIG_Actin_RPEL_3	386	405	PF02755	0.480
LIG_BIR_II_1	1	5	PF00653	0.519
LIG_BRCT_BRCA1_1	123	127	PF00533	0.355
LIG_BRCT_BRCA1_1	92	96	PF00533	0.324
LIG_CaM_IQ_9	189	204	PF13499	0.480
LIG_CtBP_PxDLS_1	533	539	PF00389	0.559
LIG_EH1_1	627	635	PF00400	0.557
LIG_eIF4E_1	22	28	PF01652	0.480
LIG_FHA_1	153	159	PF00498	0.335
LIG_FHA_1	163	169	PF00498	0.335
LIG_FHA_1	290	296	PF00498	0.445
LIG_FHA_1	399	405	PF00498	0.420
LIG_FHA_1	598	604	PF00498	0.414
LIG_FHA_2	208	214	PF00498	0.354
LIG_FHA_2	313	319	PF00498	0.415
LIG_FHA_2	385	391	PF00498	0.296
LIG_LIR_Apic_2	525	530	PF02991	0.718
LIG_LIR_Apic_2	612	616	PF02991	0.509
LIG_LIR_Nem_3	18	22	PF02991	0.335
LIG_LIR_Nem_3	93	99	PF02991	0.441
LIG_PCNA_yPIPBox_3	626	634	PF02747	0.525
LIG_Pex14_1	346	350	PF04695	0.447
LIG_Pex14_2	436	440	PF04695	0.447
LIG_PTB_Apo_2	251	258	PF02174	0.447
LIG_REV1ctd_RIR_1	214	222	PF16727	0.480
LIG_SH2_GRB2like	464	467	PF00017	0.575
LIG_SH2_NCK_1	186	190	PF00017	0.227
LIG_SH2_PTP2	137	140	PF00017	0.480
LIG_SH2_PTP2	620	623	PF00017	0.533
LIG_SH2_SRC	464	467	PF00017	0.575
LIG_SH2_STAP1	22	26	PF00017	0.383
LIG_SH2_STAT3	120	123	PF00017	0.335
LIG_SH2_STAT3	350	353	PF00017	0.480
LIG_SH2_STAT5	120	123	PF00017	0.447
LIG_SH2_STAT5	133	136	PF00017	0.447
LIG_SH2_STAT5	137	140	PF00017	0.447
LIG_SH2_STAT5	314	317	PF00017	0.496
LIG_SH2_STAT5	350	353	PF00017	0.480
LIG_SH2_STAT5	464	467	PF00017	0.529
LIG_SH2_STAT5	549	552	PF00017	0.456
LIG_SH2_STAT5	620	623	PF00017	0.533
LIG_SH3_3	123	129	PF00018	0.355
LIG_SH3_3	603	609	PF00018	0.448
LIG_SH3_3	659	665	PF00018	0.451
LIG_SH3_5	609	613	PF00018	0.525
LIG_SUMO_SIM_anti_2	401	409	PF11976	0.410
LIG_TRAF2_1	210	213	PF00917	0.480
LIG_TRAF2_1	441	444	PF00917	0.447
LIG_TYR_ITIM	618	623	PF00017	0.525
LIG_WRC_WIRS_1	16	21	PF05994	0.447
LIG_WRC_WIRS_1	88	93	PF05994	0.335
MOD_CK1_1	181	187	PF00069	0.377
MOD_CK1_1	2	8	PF00069	0.505
MOD_CK1_1	221	227	PF00069	0.327
MOD_CK1_1	244	250	PF00069	0.308
MOD_CK1_1	503	509	PF00069	0.797
MOD_CK1_1	510	516	PF00069	0.773
MOD_CK1_1	525	531	PF00069	0.551
MOD_CK1_1	80	86	PF00069	0.346
MOD_CK1_1	87	93	PF00069	0.353
MOD_CK2_1	105	111	PF00069	0.349
MOD_CK2_1	156	162	PF00069	0.456
MOD_CK2_1	207	213	PF00069	0.327
MOD_CK2_1	231	237	PF00069	0.427
MOD_CK2_1	284	290	PF00069	0.447
MOD_CK2_1	312	318	PF00069	0.436
MOD_CK2_1	384	390	PF00069	0.385
MOD_CK2_1	391	397	PF00069	0.380
MOD_CK2_1	443	449	PF00069	0.482
MOD_CK2_1	529	535	PF00069	0.522
MOD_CK2_1	602	608	PF00069	0.456
MOD_CK2_1	645	651	PF00069	0.594
MOD_GlcNHglycan	101	104	PF01048	0.435
MOD_GlcNHglycan	180	183	PF01048	0.295
MOD_GlcNHglycan	223	226	PF01048	0.461
MOD_GlcNHglycan	24	27	PF01048	0.264
MOD_GlcNHglycan	263	266	PF01048	0.342
MOD_GlcNHglycan	267	270	PF01048	0.348
MOD_GlcNHglycan	512	515	PF01048	0.747
MOD_GlcNHglycan	517	520	PF01048	0.724
MOD_GlcNHglycan	522	525	PF01048	0.681
MOD_GlcNHglycan	531	534	PF01048	0.609
MOD_GlcNHglycan	651	654	PF01048	0.622
MOD_GlcNHglycan	77	80	PF01048	0.227
MOD_GSK3_1	101	108	PF00069	0.301
MOD_GSK3_1	114	121	PF00069	0.463
MOD_GSK3_1	143	150	PF00069	0.324
MOD_GSK3_1	152	159	PF00069	0.311
MOD_GSK3_1	173	180	PF00069	0.392
MOD_GSK3_1	2	9	PF00069	0.501
MOD_GSK3_1	226	233	PF00069	0.370
MOD_GSK3_1	261	268	PF00069	0.343
MOD_GSK3_1	369	376	PF00069	0.334
MOD_GSK3_1	478	485	PF00069	0.737
MOD_GSK3_1	496	503	PF00069	0.507
MOD_GSK3_1	506	513	PF00069	0.731
MOD_GSK3_1	515	522	PF00069	0.598
MOD_GSK3_1	525	532	PF00069	0.585
MOD_GSK3_1	645	652	PF00069	0.599
MOD_GSK3_1	80	87	PF00069	0.360
MOD_N-GLC_1	178	183	PF02516	0.434
MOD_N-GLC_1	520	525	PF02516	0.630
MOD_NEK2_1	118	123	PF00069	0.482
MOD_NEK2_1	231	236	PF00069	0.414
MOD_NEK2_1	306	311	PF00069	0.446
MOD_NEK2_1	436	441	PF00069	0.358
MOD_NEK2_1	483	488	PF00069	0.615
MOD_NEK2_1	52	57	PF00069	0.426
MOD_NEK2_1	534	539	PF00069	0.428
MOD_NEK2_1	584	589	PF00069	0.521
MOD_NEK2_1	99	104	PF00069	0.274
MOD_NEK2_2	391	396	PF00069	0.447
MOD_NEK2_2	92	97	PF00069	0.227
MOD_PIKK_1	105	111	PF00454	0.349
MOD_PIKK_1	121	127	PF00454	0.382
MOD_PIKK_1	173	179	PF00454	0.447
MOD_PIKK_1	290	296	PF00454	0.435
MOD_PIKK_1	443	449	PF00454	0.447
MOD_PIKK_1	453	459	PF00454	0.430
MOD_PIKK_1	503	509	PF00454	0.544
MOD_PIKK_1	569	575	PF00454	0.354
MOD_PK_1	218	224	PF00069	0.447
MOD_PK_1	6	12	PF00069	0.477
MOD_PK_1	658	664	PF00069	0.467
MOD_PKA_1	453	459	PF00069	0.266
MOD_PKA_2	231	237	PF00069	0.412
MOD_PKA_2	284	290	PF00069	0.324
MOD_PKA_2	391	397	PF00069	0.369
MOD_PKA_2	453	459	PF00069	0.266
MOD_PKA_2	80	86	PF00069	0.339
MOD_PKB_1	228	236	PF00069	0.380
MOD_PKB_1	642	650	PF00069	0.577
MOD_PKB_1	656	664	PF00069	0.642
MOD_Plk_1	178	184	PF00069	0.438
MOD_Plk_1	218	224	PF00069	0.447
MOD_Plk_1	534	540	PF00069	0.497
MOD_Plk_1	597	603	PF00069	0.413
MOD_Plk_4	252	258	PF00069	0.335
MOD_Plk_4	273	279	PF00069	0.369
MOD_Plk_4	306	312	PF00069	0.386
MOD_Plk_4	597	603	PF00069	0.407
MOD_ProDKin_1	136	142	PF00069	0.358
MOD_ProDKin_1	143	149	PF00069	0.301
MOD_ProDKin_1	152	158	PF00069	0.259
MOD_ProDKin_1	239	245	PF00069	0.419
MOD_ProDKin_1	478	484	PF00069	0.699
MOD_ProDKin_1	497	503	PF00069	0.443
MOD_ProDKin_1	522	528	PF00069	0.665
MOD_ProDKin_1	645	651	PF00069	0.628
MOD_ProDKin_1	70	76	PF00069	0.265
MOD_SUMO_rev_2	430	439	PF00179	0.480
MOD_SUMO_rev_2	46	53	PF00179	0.447
MOD_SUMO_rev_2	676	682	PF00179	0.494
TRG_DiLeu_BaEn_1	629	634	PF01217	0.522
TRG_ENDOCYTIC_2	620	623	PF00928	0.483
TRG_ER_diArg_1	196	198	PF00400	0.359
TRG_ER_diArg_1	200	203	PF00400	0.349
TRG_ER_diArg_1	227	230	PF00400	0.335
TRG_ER_diArg_1	38	41	PF00400	0.335
TRG_ER_diArg_1	415	417	PF00400	0.342
TRG_ER_diArg_1	451	454	PF00400	0.480
TRG_ER_diArg_1	476	479	PF00400	0.669
TRG_ER_diArg_1	641	644	PF00400	0.619
TRG_ER_diArg_1	655	658	PF00400	0.459
TRG_ER_diArg_1	96	98	PF00400	0.227
TRG_NLS_MonoExtC_3	413	418	PF00514	0.447
TRG_NLS_MonoExtN_4	412	418	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	551	556	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	635	639	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P885	Leptomonas seymouri	68%	100%
A0A1X0NJG7	Trypanosomatidae	42%	98%
A0A3R7MBV2	Trypanosoma rangeli	42%	100%
A0A3S7WSL2	Leishmania donovani	88%	100%
A4HVR5	Leishmania infantum	88%	100%
D0A6H5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	98%
E9APG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QG17	Leishmania major	86%	100%
V5BM32	Trypanosoma cruzi	42%	100%