Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA domain/Dpy-30 motif containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7B8_LEIBR

TriTrypDb:

LbrM.13.1120 , LBRM2903_130017700

Length:

1169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7B8

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0044237	cellular metabolic process	2	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004017	adenylate kinase activity	6	11
GO:0004127	cytidylate kinase activity	6	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0019205	nucleobase-containing compound kinase activity	5	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050145	nucleoside monophosphate kinase activity	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.290
CLV_C14_Caspase3-7	296	300	PF00656	0.539
CLV_C14_Caspase3-7	654	658	PF00656	0.707
CLV_C14_Caspase3-7	782	786	PF00656	0.550
CLV_C14_Caspase3-7	9	13	PF00656	0.460
CLV_NRD_NRD_1	1001	1003	PF00675	0.536
CLV_NRD_NRD_1	1116	1118	PF00675	0.419
CLV_NRD_NRD_1	1143	1145	PF00675	0.252
CLV_NRD_NRD_1	320	322	PF00675	0.399
CLV_NRD_NRD_1	414	416	PF00675	0.389
CLV_NRD_NRD_1	430	432	PF00675	0.348
CLV_NRD_NRD_1	529	531	PF00675	0.442
CLV_NRD_NRD_1	610	612	PF00675	0.421
CLV_NRD_NRD_1	617	619	PF00675	0.483
CLV_PCSK_FUR_1	608	612	PF00082	0.539
CLV_PCSK_KEX2_1	1001	1003	PF00082	0.536
CLV_PCSK_KEX2_1	1143	1145	PF00082	0.258
CLV_PCSK_KEX2_1	17	19	PF00082	0.246
CLV_PCSK_KEX2_1	191	193	PF00082	0.372
CLV_PCSK_KEX2_1	320	322	PF00082	0.399
CLV_PCSK_KEX2_1	430	432	PF00082	0.448
CLV_PCSK_KEX2_1	529	531	PF00082	0.442
CLV_PCSK_KEX2_1	610	612	PF00082	0.434
CLV_PCSK_KEX2_1	615	617	PF00082	0.464
CLV_PCSK_KEX2_1	966	968	PF00082	0.494
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.269
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.372
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.448
CLV_PCSK_PC1ET2_1	966	968	PF00082	0.501
CLV_PCSK_PC7_1	611	617	PF00082	0.468
CLV_PCSK_SKI1_1	1064	1068	PF00082	0.500
CLV_PCSK_SKI1_1	1135	1139	PF00082	0.296
CLV_PCSK_SKI1_1	155	159	PF00082	0.472
CLV_PCSK_SKI1_1	17	21	PF00082	0.269
CLV_PCSK_SKI1_1	192	196	PF00082	0.378
CLV_PCSK_SKI1_1	415	419	PF00082	0.436
CLV_PCSK_SKI1_1	431	435	PF00082	0.249
CLV_PCSK_SKI1_1	617	621	PF00082	0.474
CLV_PCSK_SKI1_1	748	752	PF00082	0.462
CLV_PCSK_SKI1_1	801	805	PF00082	0.609
CLV_PCSK_SKI1_1	81	85	PF00082	0.580
CLV_PCSK_SKI1_1	845	849	PF00082	0.363
DEG_APCC_DBOX_1	400	408	PF00400	0.330
DEG_APCC_DBOX_1	747	755	PF00400	0.468
DEG_MDM2_SWIB_1	725	732	PF02201	0.319
DOC_ANK_TNKS_1	643	650	PF00023	0.500
DOC_CKS1_1	203	208	PF01111	0.422
DOC_CKS1_1	233	238	PF01111	0.500
DOC_CKS1_1	758	763	PF01111	0.699
DOC_CYCLIN_RxL_1	1058	1071	PF00134	0.536
DOC_CYCLIN_RxL_1	1096	1110	PF00134	0.321
DOC_CYCLIN_RxL_1	1132	1139	PF00134	0.536
DOC_CYCLIN_RxL_1	188	198	PF00134	0.458
DOC_CYCLIN_RxL_1	341	350	PF00134	0.387
DOC_CYCLIN_yClb3_PxF_3	238	244	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	1016	1019	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.440
DOC_MAPK_DCC_7	399	407	PF00069	0.247
DOC_MAPK_gen_1	1001	1007	PF00069	0.552
DOC_MAPK_gen_1	399	407	PF00069	0.247
DOC_MAPK_MEF2A_6	399	407	PF00069	0.247
DOC_PP1_RVXF_1	369	375	PF00149	0.510
DOC_PP1_RVXF_1	843	849	PF00149	0.375
DOC_PP2B_LxvP_1	1016	1019	PF13499	0.498
DOC_PP2B_LxvP_1	516	519	PF13499	0.516
DOC_PP2B_LxvP_1	856	859	PF13499	0.427
DOC_USP7_MATH_1	1083	1087	PF00917	0.543
DOC_USP7_MATH_1	113	117	PF00917	0.551
DOC_USP7_MATH_1	136	140	PF00917	0.545
DOC_USP7_MATH_1	204	208	PF00917	0.589
DOC_USP7_MATH_1	303	307	PF00917	0.661
DOC_USP7_MATH_1	505	509	PF00917	0.581
DOC_USP7_MATH_1	574	578	PF00917	0.459
DOC_USP7_MATH_1	724	728	PF00917	0.324
DOC_USP7_MATH_1	738	742	PF00917	0.316
DOC_USP7_MATH_1	93	97	PF00917	0.748
DOC_USP7_MATH_2	902	908	PF00917	0.365
DOC_USP7_UBL2_3	55	59	PF12436	0.451
DOC_USP7_UBL2_3	780	784	PF12436	0.637
DOC_WW_Pin1_4	132	137	PF00397	0.564
DOC_WW_Pin1_4	202	207	PF00397	0.424
DOC_WW_Pin1_4	23	28	PF00397	0.409
DOC_WW_Pin1_4	232	237	PF00397	0.610
DOC_WW_Pin1_4	385	390	PF00397	0.545
DOC_WW_Pin1_4	47	52	PF00397	0.382
DOC_WW_Pin1_4	757	762	PF00397	0.695
LIG_14-3-3_CanoR_1	169	175	PF00244	0.469
LIG_14-3-3_CanoR_1	972	977	PF00244	0.354
LIG_APCC_ABBA_1	699	704	PF00400	0.605
LIG_BIR_III_2	423	427	PF00653	0.445
LIG_Clathr_ClatBox_1	1007	1011	PF01394	0.546
LIG_eIF4E_1	1151	1157	PF01652	0.496
LIG_eIF4E_1	924	930	PF01652	0.294
LIG_EVH1_1	237	241	PF00568	0.689
LIG_EVH1_2	240	244	PF00568	0.632
LIG_FHA_1	1032	1038	PF00498	0.501
LIG_FHA_1	203	209	PF00498	0.451
LIG_FHA_1	348	354	PF00498	0.353
LIG_FHA_1	389	395	PF00498	0.476
LIG_FHA_1	477	483	PF00498	0.467
LIG_FHA_1	486	492	PF00498	0.404
LIG_FHA_1	584	590	PF00498	0.500
LIG_FHA_1	738	744	PF00498	0.307
LIG_FHA_1	838	844	PF00498	0.495
LIG_FHA_1	921	927	PF00498	0.378
LIG_FHA_1	948	954	PF00498	0.581
LIG_FHA_2	136	142	PF00498	0.449
LIG_FHA_2	171	177	PF00498	0.477
LIG_FHA_2	249	255	PF00498	0.491
LIG_FHA_2	268	274	PF00498	0.587
LIG_FHA_2	533	539	PF00498	0.325
LIG_FHA_2	713	719	PF00498	0.466
LIG_FHA_2	780	786	PF00498	0.625
LIG_FHA_2	787	793	PF00498	0.545
LIG_FHA_2	859	865	PF00498	0.456
LIG_FHA_2	995	1001	PF00498	0.503
LIG_Integrin_RGD_1	265	267	PF01839	0.645
LIG_Integrin_RGD_1	633	635	PF01839	0.431
LIG_LIR_Apic_2	1023	1029	PF02991	0.587
LIG_LIR_Apic_2	186	190	PF02991	0.503
LIG_LIR_Apic_2	201	206	PF02991	0.304
LIG_LIR_Apic_2	234	240	PF02991	0.690
LIG_LIR_Apic_2	666	670	PF02991	0.494
LIG_LIR_Apic_2	678	683	PF02991	0.479
LIG_LIR_Gen_1	1163	1169	PF02991	0.603
LIG_LIR_Gen_1	144	154	PF02991	0.553
LIG_LIR_Gen_1	162	171	PF02991	0.377
LIG_LIR_Gen_1	443	451	PF02991	0.359
LIG_LIR_Gen_1	971	979	PF02991	0.485
LIG_LIR_Nem_3	1163	1169	PF02991	0.603
LIG_LIR_Nem_3	144	149	PF02991	0.558
LIG_LIR_Nem_3	162	166	PF02991	0.393
LIG_LIR_Nem_3	28	33	PF02991	0.401
LIG_LIR_Nem_3	443	447	PF02991	0.498
LIG_LIR_Nem_3	468	472	PF02991	0.457
LIG_LIR_Nem_3	5	10	PF02991	0.382
LIG_LIR_Nem_3	727	732	PF02991	0.326
LIG_LIR_Nem_3	971	977	PF02991	0.503
LIG_Pex14_2	370	374	PF04695	0.376
LIG_Pex14_2	725	729	PF04695	0.534
LIG_REV1ctd_RIR_1	143	152	PF16727	0.501
LIG_SH2_CRK	1026	1030	PF00017	0.527
LIG_SH2_CRK	203	207	PF00017	0.427
LIG_SH2_CRK	571	575	PF00017	0.342
LIG_SH2_CRK	667	671	PF00017	0.496
LIG_SH2_CRK	680	684	PF00017	0.622
LIG_SH2_CRK	974	978	PF00017	0.426
LIG_SH2_GRB2like	327	330	PF00017	0.393
LIG_SH2_GRB2like	585	588	PF00017	0.274
LIG_SH2_GRB2like	870	873	PF00017	0.539
LIG_SH2_NCK_1	1026	1030	PF00017	0.582
LIG_SH2_NCK_1	203	207	PF00017	0.427
LIG_SH2_SRC	10	13	PF00017	0.450
LIG_SH2_SRC	1026	1029	PF00017	0.521
LIG_SH2_STAP1	1074	1078	PF00017	0.389
LIG_SH2_STAP1	585	589	PF00017	0.428
LIG_SH2_STAT3	1074	1077	PF00017	0.429
LIG_SH2_STAT5	10	13	PF00017	0.332
LIG_SH2_STAT5	1124	1127	PF00017	0.442
LIG_SH2_STAT5	1151	1154	PF00017	0.496
LIG_SH2_STAT5	327	330	PF00017	0.517
LIG_SH2_STAT5	432	435	PF00017	0.332
LIG_SH2_STAT5	562	565	PF00017	0.378
LIG_SH2_STAT5	585	588	PF00017	0.447
LIG_SH2_STAT5	924	927	PF00017	0.368
LIG_SH2_STAT5	969	972	PF00017	0.492
LIG_SH3_1	753	759	PF00018	0.484
LIG_SH3_2	238	243	PF14604	0.631
LIG_SH3_3	1012	1018	PF00018	0.526
LIG_SH3_3	1142	1148	PF00018	0.442
LIG_SH3_3	182	188	PF00018	0.346
LIG_SH3_3	230	236	PF00018	0.695
LIG_SH3_3	460	466	PF00018	0.512
LIG_SH3_3	499	505	PF00018	0.440
LIG_SH3_3	550	556	PF00018	0.388
LIG_SH3_3	642	648	PF00018	0.797
LIG_SH3_3	753	759	PF00018	0.543
LIG_SH3_3	805	811	PF00018	0.531
LIG_SH3_3	967	973	PF00018	0.598
LIG_SH3_CIN85_PxpxPR_1	238	243	PF14604	0.643
LIG_SUMO_SIM_anti_2	635	640	PF11976	0.470
LIG_SUMO_SIM_anti_2	747	753	PF11976	0.456
LIG_SUMO_SIM_par_1	1006	1011	PF11976	0.493
LIG_SUMO_SIM_par_1	192	198	PF11976	0.344
LIG_TRAF2_1	1068	1071	PF00917	0.501
LIG_TRAF2_1	207	210	PF00917	0.642
LIG_TRAF2_1	717	720	PF00917	0.451
LIG_TRAF2_1	789	792	PF00917	0.539
LIG_TRAF2_1	861	864	PF00917	0.484
LIG_TRAF2_1	935	938	PF00917	0.640
LIG_UBA3_1	1103	1108	PF00899	0.481
LIG_UBA3_1	797	801	PF00899	0.464
LIG_WRC_WIRS_1	11	16	PF05994	0.237
LIG_WRC_WIRS_1	348	353	PF05994	0.457
LIG_WW_3	240	244	PF00397	0.632
MOD_CK1_1	105	111	PF00069	0.605
MOD_CK1_1	198	204	PF00069	0.398
MOD_CK1_1	306	312	PF00069	0.488
MOD_CK1_1	375	381	PF00069	0.411
MOD_CK1_1	508	514	PF00069	0.480
MOD_CK1_1	577	583	PF00069	0.531
MOD_CK1_1	663	669	PF00069	0.728
MOD_CK1_1	678	684	PF00069	0.612
MOD_CK1_1	87	93	PF00069	0.738
MOD_CK1_1	975	981	PF00069	0.482
MOD_CK1_1	992	998	PF00069	0.692
MOD_CK2_1	1029	1035	PF00069	0.493
MOD_CK2_1	170	176	PF00069	0.479
MOD_CK2_1	204	210	PF00069	0.585
MOD_CK2_1	532	538	PF00069	0.323
MOD_CK2_1	591	597	PF00069	0.599
MOD_CK2_1	712	718	PF00069	0.496
MOD_CK2_1	786	792	PF00069	0.552
MOD_CK2_1	858	864	PF00069	0.452
MOD_CK2_1	975	981	PF00069	0.439
MOD_CK2_1	994	1000	PF00069	0.630
MOD_Cter_Amidation	15	18	PF01082	0.240
MOD_DYRK1A_RPxSP_1	757	761	PF00069	0.673
MOD_GlcNHglycan	1023	1026	PF01048	0.666
MOD_GlcNHglycan	106	110	PF01048	0.640
MOD_GlcNHglycan	1096	1099	PF01048	0.313
MOD_GlcNHglycan	295	298	PF01048	0.617
MOD_GlcNHglycan	307	311	PF01048	0.540
MOD_GlcNHglycan	374	377	PF01048	0.533
MOD_GlcNHglycan	396	399	PF01048	0.507
MOD_GlcNHglycan	448	451	PF01048	0.474
MOD_GlcNHglycan	507	510	PF01048	0.731
MOD_GlcNHglycan	680	683	PF01048	0.673
MOD_GlcNHglycan	95	98	PF01048	0.724
MOD_GSK3_1	123	130	PF00069	0.725
MOD_GSK3_1	132	139	PF00069	0.698
MOD_GSK3_1	144	151	PF00069	0.473
MOD_GSK3_1	194	201	PF00069	0.367
MOD_GSK3_1	2	9	PF00069	0.435
MOD_GSK3_1	436	443	PF00069	0.420
MOD_GSK3_1	558	565	PF00069	0.455
MOD_GSK3_1	591	598	PF00069	0.486
MOD_GSK3_1	691	698	PF00069	0.775
MOD_GSK3_1	989	996	PF00069	0.574
MOD_N-GLC_1	130	135	PF02516	0.620
MOD_N-GLC_1	275	280	PF02516	0.656
MOD_NEK2_1	195	200	PF00069	0.440
MOD_NEK2_1	583	588	PF00069	0.437
MOD_NEK2_1	695	700	PF00069	0.624
MOD_NEK2_1	712	717	PF00069	0.477
MOD_NEK2_1	84	89	PF00069	0.644
MOD_NEK2_1	918	923	PF00069	0.416
MOD_NEK2_1	990	995	PF00069	0.664
MOD_PIKK_1	1077	1083	PF00454	0.539
MOD_PIKK_1	712	718	PF00454	0.513
MOD_PK_1	148	154	PF00069	0.286
MOD_PK_1	972	978	PF00069	0.280
MOD_PKA_1	766	772	PF00069	0.663
MOD_PKA_1	779	785	PF00069	0.494
MOD_PKA_2	293	299	PF00069	0.541
MOD_PKA_2	663	669	PF00069	0.637
MOD_PKB_1	593	601	PF00069	0.544
MOD_Plk_1	634	640	PF00069	0.622
MOD_Plk_2-3	311	317	PF00069	0.411
MOD_Plk_2-3	476	482	PF00069	0.445
MOD_Plk_4	141	147	PF00069	0.549
MOD_Plk_4	170	176	PF00069	0.494
MOD_Plk_4	195	201	PF00069	0.345
MOD_Plk_4	25	31	PF00069	0.303
MOD_Plk_4	347	353	PF00069	0.429
MOD_Plk_4	518	524	PF00069	0.511
MOD_Plk_4	558	564	PF00069	0.386
MOD_Plk_4	577	583	PF00069	0.218
MOD_Plk_4	6	12	PF00069	0.315
MOD_Plk_4	634	640	PF00069	0.688
MOD_Plk_4	691	697	PF00069	0.531
MOD_Plk_4	87	93	PF00069	0.644
MOD_Plk_4	920	926	PF00069	0.479
MOD_Plk_4	972	978	PF00069	0.502
MOD_ProDKin_1	132	138	PF00069	0.564
MOD_ProDKin_1	202	208	PF00069	0.438
MOD_ProDKin_1	23	29	PF00069	0.409
MOD_ProDKin_1	232	238	PF00069	0.601
MOD_ProDKin_1	385	391	PF00069	0.534
MOD_ProDKin_1	47	53	PF00069	0.389
MOD_ProDKin_1	757	763	PF00069	0.701
MOD_SUMO_rev_2	1101	1109	PF00179	0.376
MOD_SUMO_rev_2	78	83	PF00179	0.627
MOD_SUMO_rev_2	886	894	PF00179	0.628
TRG_DiLeu_BaEn_1	747	752	PF01217	0.452
TRG_DiLeu_BaEn_1	793	798	PF01217	0.486
TRG_DiLeu_BaEn_1	842	847	PF01217	0.495
TRG_DiLeu_BaEn_2	175	181	PF01217	0.508
TRG_DiLeu_BaEn_3	720	726	PF01217	0.521
TRG_DiLeu_BaEn_4	79	85	PF01217	0.483
TRG_DiLeu_BaEn_4	793	799	PF01217	0.543
TRG_DiLeu_BaLyEn_6	1099	1104	PF01217	0.481
TRG_DiLeu_BaLyEn_6	1128	1133	PF01217	0.279
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.401
TRG_DiLeu_BaLyEn_6	615	620	PF01217	0.500
TRG_DiLeu_BaLyEn_6	986	991	PF01217	0.550
TRG_ENDOCYTIC_2	472	475	PF00928	0.444
TRG_ENDOCYTIC_2	570	573	PF00928	0.484
TRG_ENDOCYTIC_2	974	977	PF00928	0.457
TRG_ER_diArg_1	1061	1064	PF00400	0.450
TRG_ER_diArg_1	1143	1145	PF00400	0.243
TRG_ER_diArg_1	320	322	PF00400	0.383
TRG_ER_diArg_1	399	402	PF00400	0.511
TRG_ER_diArg_1	430	432	PF00400	0.453
TRG_ER_diArg_1	528	530	PF00400	0.427
TRG_ER_diArg_1	592	595	PF00400	0.467
TRG_ER_diArg_1	608	611	PF00400	0.344
TRG_ER_diArg_1	616	618	PF00400	0.473
TRG_ER_diArg_1	642	645	PF00400	0.609
TRG_NLS_Bipartite_1	766	783	PF00514	0.726
TRG_NLS_MonoCore_2	614	619	PF00514	0.551
TRG_NLS_MonoExtN_4	765	770	PF00514	0.739
TRG_Pf-PMV_PEXEL_1	1051	1055	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	1064	1069	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	1135	1139	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	617	622	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAY4	Leptomonas seymouri	56%	99%
A0A1X0NK96	Trypanosomatidae	31%	100%
A0A3Q8I8L6	Leishmania donovani	78%	100%
A0A3S5ISP3	Trypanosoma rangeli	34%	100%
A4HVR3	Leishmania infantum	78%	100%
D0A6H7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9APF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QG19	Leishmania major	77%	98%
V5BHK4	Trypanosoma cruzi	34%	100%