G_PROTEIN_RECEP_F1_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7B6_LEIBR

TriTrypDb:

LbrM.13.1100 , LBRM2903_130017500

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4H7B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7B6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.667
CLV_C14_Caspase3-7	434	438	PF00656	0.368
CLV_C14_Caspase3-7	9	13	PF00656	0.490
CLV_NRD_NRD_1	143	145	PF00675	0.435
CLV_NRD_NRD_1	341	343	PF00675	0.388
CLV_NRD_NRD_1	399	401	PF00675	0.515
CLV_NRD_NRD_1	405	407	PF00675	0.482
CLV_PCSK_KEX2_1	143	145	PF00082	0.435
CLV_PCSK_KEX2_1	341	343	PF00082	0.388
CLV_PCSK_KEX2_1	398	400	PF00082	0.523
CLV_PCSK_KEX2_1	405	407	PF00082	0.472
CLV_PCSK_SKI1_1	185	189	PF00082	0.412
CLV_PCSK_SKI1_1	224	228	PF00082	0.670
CLV_PCSK_SKI1_1	29	33	PF00082	0.494
DEG_APCC_DBOX_1	60	68	PF00400	0.582
DEG_Nend_UBRbox_3	1	3	PF02207	0.401
DEG_SCF_FBW7_1	390	396	PF00400	0.695
DEG_SPOP_SBC_1	186	190	PF00917	0.388
DEG_SPOP_SBC_1	353	357	PF00917	0.593
DEG_SPOP_SBC_1	375	379	PF00917	0.634
DOC_CKS1_1	390	395	PF01111	0.695
DOC_MAPK_gen_1	59	67	PF00069	0.588
DOC_MAPK_MEF2A_6	33	41	PF00069	0.231
DOC_PP4_FxxP_1	288	291	PF00568	0.692
DOC_USP7_MATH_1	187	191	PF00917	0.388
DOC_USP7_MATH_1	250	254	PF00917	0.436
DOC_USP7_MATH_1	353	357	PF00917	0.598
DOC_USP7_MATH_1	384	388	PF00917	0.689
DOC_USP7_MATH_1	467	471	PF00917	0.457
DOC_USP7_MATH_1	68	72	PF00917	0.599
DOC_WW_Pin1_4	122	127	PF00397	0.654
DOC_WW_Pin1_4	147	152	PF00397	0.567
DOC_WW_Pin1_4	224	229	PF00397	0.503
DOC_WW_Pin1_4	299	304	PF00397	0.654
DOC_WW_Pin1_4	312	317	PF00397	0.588
DOC_WW_Pin1_4	356	361	PF00397	0.651
DOC_WW_Pin1_4	370	375	PF00397	0.668
DOC_WW_Pin1_4	389	394	PF00397	0.697
DOC_WW_Pin1_4	407	412	PF00397	0.568
DOC_WW_Pin1_4	43	48	PF00397	0.285
LIG_14-3-3_CanoR_1	143	148	PF00244	0.602
LIG_14-3-3_CanoR_1	169	174	PF00244	0.559
LIG_14-3-3_CanoR_1	185	195	PF00244	0.342
LIG_14-3-3_CanoR_1	341	348	PF00244	0.632
LIG_BRCT_BRCA1_1	268	272	PF00533	0.580
LIG_CaM_NSCaTE_8	464	471	PF13499	0.366
LIG_EH1_1	25	33	PF00400	0.337
LIG_EH1_1	318	326	PF00400	0.596
LIG_eIF4E_1	319	325	PF01652	0.595
LIG_FHA_1	221	227	PF00498	0.422
LIG_FHA_1	235	241	PF00498	0.445
LIG_FHA_1	252	258	PF00498	0.329
LIG_FHA_1	287	293	PF00498	0.685
LIG_FHA_1	362	368	PF00498	0.621
LIG_FHA_1	371	377	PF00498	0.601
LIG_FHA_1	390	396	PF00498	0.699
LIG_FHA_1	44	50	PF00498	0.439
LIG_FHA_1	469	475	PF00498	0.471
LIG_LIR_Gen_1	170	181	PF02991	0.590
LIG_LIR_Gen_1	189	200	PF02991	0.349
LIG_LIR_Gen_1	280	288	PF02991	0.707
LIG_LIR_Gen_1	308	319	PF02991	0.588
LIG_LIR_Nem_3	170	176	PF02991	0.588
LIG_LIR_Nem_3	189	195	PF02991	0.349
LIG_LIR_Nem_3	253	258	PF02991	0.428
LIG_LIR_Nem_3	269	275	PF02991	0.540
LIG_LIR_Nem_3	280	285	PF02991	0.658
LIG_LIR_Nem_3	308	314	PF02991	0.589
LIG_LIR_Nem_3	422	428	PF02991	0.328
LIG_LIR_Nem_3	457	462	PF02991	0.403
LIG_PDZ_Class_2	472	477	PF00595	0.477
LIG_Pex14_1	268	272	PF04695	0.580
LIG_SH2_CRK	154	158	PF00017	0.610
LIG_SH2_CRK	179	183	PF00017	0.475
LIG_SH2_CRK	425	429	PF00017	0.231
LIG_SH2_SRC	435	438	PF00017	0.415
LIG_SH2_STAP1	258	262	PF00017	0.231
LIG_SH2_STAT5	319	322	PF00017	0.592
LIG_SH2_STAT5	462	465	PF00017	0.468
LIG_SH3_1	297	303	PF00018	0.578
LIG_SH3_3	123	129	PF00018	0.676
LIG_SH3_3	145	151	PF00018	0.640
LIG_SH3_3	210	216	PF00018	0.360
LIG_SH3_3	243	249	PF00018	0.457
LIG_SH3_3	297	303	PF00018	0.643
LIG_SH3_3	323	329	PF00018	0.663
LIG_SH3_3	387	393	PF00018	0.635
LIG_SH3_3	443	449	PF00018	0.488
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.231
LIG_SUMO_SIM_par_1	448	454	PF11976	0.454
LIG_TRAF2_1	90	93	PF00917	0.706
LIG_TYR_ITIM	423	428	PF00017	0.231
LIG_WRC_WIRS_1	257	262	PF05994	0.388
MOD_CDK_SPK_2	122	127	PF00069	0.517
MOD_CDK_SPK_2	312	317	PF00069	0.470
MOD_CDK_SPxxK_3	356	363	PF00069	0.619
MOD_CDK_SPxxK_3	407	414	PF00069	0.534
MOD_CK1_1	125	131	PF00069	0.593
MOD_CK1_1	194	200	PF00069	0.368
MOD_CK1_1	230	236	PF00069	0.577
MOD_CK1_1	330	336	PF00069	0.423
MOD_CK1_1	356	362	PF00069	0.615
MOD_CK1_1	379	385	PF00069	0.679
MOD_CK1_1	99	105	PF00069	0.534
MOD_CK2_1	87	93	PF00069	0.487
MOD_Cter_Amidation	141	144	PF01082	0.591
MOD_GlcNHglycan	122	125	PF01048	0.522
MOD_GlcNHglycan	132	135	PF01048	0.511
MOD_GlcNHglycan	232	235	PF01048	0.635
MOD_GlcNHglycan	243	246	PF01048	0.464
MOD_GlcNHglycan	262	265	PF01048	0.312
MOD_GlcNHglycan	356	359	PF01048	0.484
MOD_GlcNHglycan	378	381	PF01048	0.761
MOD_GlcNHglycan	89	92	PF01048	0.480
MOD_GSK3_1	143	150	PF00069	0.569
MOD_GSK3_1	187	194	PF00069	0.351
MOD_GSK3_1	216	223	PF00069	0.480
MOD_GSK3_1	226	233	PF00069	0.614
MOD_GSK3_1	256	263	PF00069	0.340
MOD_GSK3_1	306	313	PF00069	0.553
MOD_GSK3_1	352	359	PF00069	0.530
MOD_GSK3_1	361	368	PF00069	0.553
MOD_GSK3_1	370	377	PF00069	0.599
MOD_GSK3_1	389	396	PF00069	0.675
MOD_GSK3_1	431	438	PF00069	0.518
MOD_N-GLC_1	102	107	PF02516	0.487
MOD_N-GLC_1	251	256	PF02516	0.388
MOD_N-GLC_1	78	83	PF02516	0.452
MOD_NEK2_1	167	172	PF00069	0.464
MOD_NEK2_1	240	245	PF00069	0.559
MOD_NEK2_1	260	265	PF00069	0.335
MOD_NEK2_1	306	311	PF00069	0.538
MOD_NEK2_1	320	325	PF00069	0.408
MOD_NEK2_1	376	381	PF00069	0.521
MOD_NEK2_1	430	435	PF00069	0.503
MOD_NEK2_2	187	192	PF00069	0.245
MOD_PIKK_1	127	133	PF00454	0.604
MOD_PIKK_1	14	20	PF00454	0.448
MOD_PIKK_1	286	292	PF00454	0.542
MOD_PK_1	341	347	PF00069	0.432
MOD_PKA_1	143	149	PF00069	0.518
MOD_PKA_1	341	347	PF00069	0.432
MOD_PKA_2	143	149	PF00069	0.443
MOD_PKA_2	340	346	PF00069	0.586
MOD_Plk_1	251	257	PF00069	0.478
MOD_Plk_4	132	138	PF00069	0.584
MOD_Plk_4	143	149	PF00069	0.524
MOD_Plk_4	19	25	PF00069	0.616
MOD_Plk_4	227	233	PF00069	0.504
MOD_Plk_4	277	283	PF00069	0.507
MOD_Plk_4	306	312	PF00069	0.583
MOD_Plk_4	320	326	PF00069	0.413
MOD_ProDKin_1	122	128	PF00069	0.560
MOD_ProDKin_1	147	153	PF00069	0.433
MOD_ProDKin_1	224	230	PF00069	0.627
MOD_ProDKin_1	299	305	PF00069	0.560
MOD_ProDKin_1	312	318	PF00069	0.466
MOD_ProDKin_1	356	362	PF00069	0.562
MOD_ProDKin_1	370	376	PF00069	0.586
MOD_ProDKin_1	389	395	PF00069	0.622
MOD_ProDKin_1	407	413	PF00069	0.438
MOD_ProDKin_1	43	49	PF00069	0.285
MOD_SUMO_rev_2	22	31	PF00179	0.570
TRG_DiLeu_BaEn_1	93	98	PF01217	0.484
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.662
TRG_ENDOCYTIC_2	154	157	PF00928	0.567
TRG_ENDOCYTIC_2	179	182	PF00928	0.478
TRG_ENDOCYTIC_2	319	322	PF00928	0.475
TRG_ENDOCYTIC_2	425	428	PF00928	0.231
TRG_ER_diArg_1	398	400	PF00400	0.641
TRG_ER_diArg_1	404	406	PF00400	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I976	Leptomonas seymouri	41%	93%
A0A3Q8ICY4	Leishmania donovani	70%	97%
A4HVR1	Leishmania infantum	71%	98%
E9APF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	96%
Q4QG21	Leishmania major	68%	100%